ObjectiveTo systematically review the association between ORMDL3 gene rs7216389 polymorphism and the susceptibility to asthma among Chinese population. MethodsSuch databases as PubMed, EMbase, The Cochrane Library (Issue 8, 2014), CBM, CNKI, VIP and WanFang Data were systemically searched to collect casecontrol studies published to August 2013. Two reviewers independently screened literature according to the inclusion and exclusion criteria, extracted data, and evaluated methodological quality of included studies. Meta-analysis was then performed using RevMan 5.2 software. Stata 11.0 software were used for publication bias evaluation. ResultsA total of 7 case-control studies were included, which involved 1 711 cases and 1 763 controls. The results of meta-analysis showed that, ORMDL3 gene rs7216389 polymorphism was associated with the susceptibility to asthma among Chinese population (OR=0.71, 95%CI 0.62 to 0.81, P<0.000 01). In the subgroup analysis by age, ORMDL3 gene rs7216389 polymorphism was associated with the susceptibility to adult asthma (OR=0.71, 95%CI 0.61 to 0.83, P<0.000 1) and children asthma (OR=0.69, 95%CI 0.52 to 0.90, P=0.006). ConclusionORMDL3 gene rs7216389 polymorphism is a risk factor of adult and children asthma among Chinese population.
ObjectiveTo explore the early outcomes of the surgical treatment for patent ductus arteriosus (PDA) combined with intracardiac abnormities via right vertical infra-axillary thoracotomy (RVIAT).MethodsA total of 7 children with PDA combined with intracardiac defects underwent surgery through RVIAT at the Second Affiliated Hospital of Nanjing Medical University from 2016 to 2018. There were 4 males and 3 females, with an average age of 5.3±4.5 years and weight of 18.0±11.2 kg.ResultsIn all patients, PDA was ligated before the repair of intracardiac abnormities. No patient died in hospital. All patients were followed up, with a mean follow-up time of 18.0±8.0 months. No other complications such as residual shunts, arrhythmias, hemorrhaging or wound infection occurred after operations or during the follow-up period.ConclusionRVIAT is an emerging technique used for the surgical repair of PDA combined with intracardiac defects. It yields satisfying cosmetic results, without increasing postoperative complications or mortality.
Objective To systematically review perioperative safety and middle-term and long-term complications of Roux-en-Y anastomosis and Billroth-Ⅰ anastomosis after distal subtotal gastrectomy by a meta-analysis. Methods Literatures about Roux-en-Y and Billroth-Ⅰ anastomoses after distal subtotal gastrectomy in Embase, PubMed, MedLine, and the Cochrane Library databases were searched. Retrieval time was from December 1, 2015 to March 1, 2016. According to the inclusion and exclusion criteria, two reviewers independently screened literatures, extracted data, and evaluated the qualities of the included studies. Then meta-analysis was performed using Review Manager Version 5.1 software. Results Five randomized controlled trials (RCTs) were finally included involving 600 patients, of which 302 patients were underwent Roux-en-Y anasomosis, 298 patients were underwent Billroth-Ⅰ anasomosis. The results of meta-analysis showed that the Billroth-Ⅰ anastomosis operation had more advantages in the operative time 〔WMD: 38.95; 95%CI: (19.86, 58.04);P<0.000 1〕 and the intraoperative bleeding 〔WMD: 34.85; 95%CI: (2.13, 67.56);P=0.04〕. However, the Roux-en-Y anastomosis had more significant effects in the prevention of bile reflux 〔OR: 0.03; 95%CI: (0.01, 0.11);P<0.000 01〕 and the residual gastritis 〔OR: 0.37; 95%CI: (0.25, 0.54);P<0.000 01〕. There were no differences in the hospital stay 〔WMD: 2.96; 95%CI: (–0.00, 5.93);P=0.05〕, anastomotic leakage 〔OR: 0.43; 95%CI: (0.11, 1.68);P=0.23〕, anastomotic stricture 〔OR: 1.84; 95%CI: (0.61, 5.53);P=0.27〕, reflux esophagitis〔OR: 0.63; 95%CI: (0.28, 1.44);P=0.27〕, and delayed gastric emptying 〔OR: 1.24; 95%CI: (0.46, 3.30);P=0.67〕 between the Roux-en-Y anastomosis and Billroth-Ⅰ anastomosis. Conclusions Billroth- I anastomosis and Roux-en-Y anastomosis have their own advantages and disadvantages, in term of safety of Billroth- I anastomosis is better, but it’s quality of life is worse as compared with Roux-en-Y anastomosis. However, more high-quality, well-designed, adequate RCTs data are needed to validate.
ObjectivesTo systematically review the prevalence of methicillin-resistant staphylococcus aureus (MRSA) in healthy Chinese population.MethodsPubMed, EMbase, WanFang Data and CNKI databases were electronically searched to collect cross-sectional studies of the prevalence of MRSA in China from inception to December 16th, 2018. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies, and then, meta-analysis was performed by using Stata 12.0 software.ResultsA total of 25 cross-sectional studies were included. The results of meta-analysis showed that: the pooled prevalence of MRSA in healthy population was 13.9% (95%CI 9.6% to 18.2%). The results of subgroup analysis showed that: the prevalence of MRSA in children was 16% (95%CI 8% to 24%), and that in adults (non-children) was 13% (95%CI 9% to 16%). The prevalence of MRSA in individuals with occupational livestock exposure was 28% (95%CI 5% to 51%), in medical staff it was 16% (95%CI 8% to 25%), in medical students it was 12% (95%CI 3% to 20%) and in community residents it was 5% (95%CI 2% to 8%).ConclusionsThe overall prevalence of MRSA in healthy Chinese population is approximately 13.9%. Effective prevention and control measures are required to reduce the spread of MRSA.
ObjectiveTo systematically review the association between LIG4 gene T9I polymorphism and cancer susceptibility. MethodsSuch databases as PubMed, EMbase, The Cochrane Library (Issue 10, 2013), CBM, CNKI, VIP and WanFang Data were electronically searched to collect case-control studies published up to Oct. 2013 on the association between LIG4 gene T9I polymorphism and cancer susceptibility. According to inclusion and exclusion criteria, two reviewers independently screened literature, extracted data, and assessed methodological quality of included studies. Then meta-analysis was performed using RevMan 5.0 software. ResultsA total of 11 case-control studies were included, which involved 5 016 cancer cases and 4 860 controls. The results of meta-analysis showed that, no significant association was found between LIG4 gene T9I polymorphism and the risk of cancer in the total analysis (TT+CT vs. CC:OR=0.96, 95%CI 0.80 to 1.15, P=0.63; TT vs. CT+CC:OR=1.10, 95%CI 0.78 to 1.56, P=0.59; TT vs. CC:OR=1.10, 95%CI 0.73 to 1.64, P=0.65; CT vs. CC:OR=0.94, 95%CI 0.80 to 1.11, P=0.48; T vs. C:OR=0.97, 95%CI 0.82 to 1.15, P=0.75). In the subgroup analysis, significant association was found in Caucasians (TT+CT vs. CC:OR=0.87, 95%CI 0.77 to 0.98, P=0.02) but not in Asians. ConclusionLIG4 gene T9I polymorphism could be associated with cancer susceptibility in Caucasians.
ObjectiveTo investigate the diagnostic value of bronchial provocation test in patients with chronic cough. MethodsA total of 550 chronic cough patients were selected in the 452nd Military Hospital from March 2011 to February 2012. These patients all underwent the basic lung function test and the bronchial provocation test (BPT) to acetylcholine so as to assess the bronchial hyper-reactivity by inhaling methacholine. The diagnostic value of BPT was then evaluated. ResultsAll included patients had normal lung function. There were 267 patients (48.5%) who showed positive results in BPT, of whom, 236 BPT-positive patients were finally diagnosed as cough variant asthma. After regular treatment, the cough symptoms were well controlled. ConclusionCough variant asthma is one of the main causes of chronic cough. The BPT is an important method of aiding the diagnosis of cough variant asthma which helps early diagnosis of it.
ObjectiveTo systematically review the association between the IL-6 gene -634G/C polymorphism and the risk of lung cancer. MethodsDatabases including the PubMed, EMbase, CNKI and WanFang Data were searched from inception to October 2015 to collect case-control studies about the correlation between the IL-6 gene -634G/C polymorphism and the risk of lung cancer. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Then, meta-analysis was performed by using RevMan 5.3 software. ResultsA total of 12 case-control studies concerning 3 657 lung cancer cases and 4 100 controls from 11 articles were included. The results of meta-analysis showed that there was no significant association between the -634G/C polymorphism and the risk of lung cancer (GG+GC vs. CC: OR=1.11, 95%CI 0.89 to 1.39, P=0.37; GG vs. CC+GC: OR=1.17, 95%CI 0.88 to 1.55, P=0.27; GG vs. CC: OR=1.27, 95%CI 0.93 to 1.72, P=0.13; GC vs. CC: OR=1.12, 95%CI 0.89 to 1.40, P=0.33; G vs. C: OR=1.08, 95%CI 0.89 to 1.30, P=0.43). ConclusionIL-6 gene -634G/C polymorphism may not be a risk factor of lung cancer. Due to the limited quality and quantity of included studies, more high quality studies are needed to verify the above conclusion.