ORMDL3 rs72l6389 Polymorphism and the Susceptibility to Asthma in Chinese Population: A Meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

 LIULi-hong ¹ , GUOWen-cai ¹ , ZHOUJiang ¹ ,  LIXiao-bo ²

1. Department of Respiratory Medicine, Central Hospital of Bazhong City, Bazhong 636600, China;
2. Department of Respiratory Medicine, 452 nd Military Hospital, Chengdu 610021, China;

Corresponding?author：

LIXiao-bo, Email: 739409535@qq.com

Keywords：

ORMDL3; Polymorphism; Asthma; Systematic review; Meta-analysis; Case-control study; Chinese

DOI：

10.7507/1672-2531.20150030

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To systematically review the association between ORMDL3 gene rs7216389 polymorphism and the susceptibility to asthma among Chinese population. Methods Such databases as PubMed, EMbase, The Cochrane Library (Issue 8, 2014), CBM, CNKI, VIP and WanFang Data were systemically searched to collect casecontrol studies published to August 2013. Two reviewers independently screened literature according to the inclusion and exclusion criteria, extracted data, and evaluated methodological quality of included studies. Meta-analysis was then performed using RevMan 5.2 software. Stata 11.0 software were used for publication bias evaluation. Results A total of 7 case-control studies were included, which involved 1 711 cases and 1 763 controls. The results of meta-analysis showed that, ORMDL3 gene rs7216389 polymorphism was associated with the susceptibility to asthma among Chinese population (OR=0.71, 95%CI 0.62 to 0.81, P<0.000 01). In the subgroup analysis by age, ORMDL3 gene rs7216389 polymorphism was associated with the susceptibility to adult asthma (OR=0.71, 95%CI 0.61 to 0.83, P<0.000 1) and children asthma (OR=0.69, 95%CI 0.52 to 0.90, P=0.006). Conclusion ORMDL3 gene rs7216389 polymorphism is a risk factor of adult and children asthma among Chinese population.

Citation： LIULi-hong, GUOWen-cai, ZHOUJiang, LIXiao-bo. ORMDL3 rs72l6389 Polymorphism and the Susceptibility to Asthma in Chinese Population: A Meta-analysis. Chinese Journal of Evidence-Based Medicine, 2015, 15(2): 170-175. doi: 10.7507/1672-2531.20150030 Copy

1.	Ierodiakonou D, Postma DS, Koppelman GH, et al. TGF-beta1 polymorphisms and asthma severity, airway inflammation, and remodeling. J Allergy Clin Immunol, 2013, 131(2):582-585.
2.	Birbian N, Singh J, Jindal SK. Protective role of IL-18-137G/C polymorphism in a North Indian population with asthma:a pilot study. Cytokine, 2013, 61(1):188-193.
3.	Yamaide F, Undarmaa S, Mashimo Y, et al. Association study of matrix metalloproteinase-12 gene polymorphisms and asthma in a Japanese population. Int Arch Allergy Immunol, 2013, 160(3):287-296.
4.	Binia A, Khorasani N, Bhavsar PK, et al. Chromosome 17q21 SNP and severe asthma. J Hum Genet, 2011, 56(1):97-98.
5.	Galanter J, Choudhry S, Eng C, et al. ORMDL3 gene is associated with asthma in three ethnically diverse populations. Am J Respir Crit Care Med, 2008, 177(11):1194-1200.
6.	Kang MJ, Yu HS, Seo JH, et al. GSDMB/ORMDL3 variants contribute to asthma susceptibility and eosinophil-mediated bronchial hyperresponsiveness. Hum Immunol, 2012, 73(9):954-959.
7.	Moffatt MF, Kabesch M, Liang L, et al. Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature, 2007, 448(7152):470-473.
8.	Fang Q, Zhao H, Wang A, et al. Association of genetic variants in chromosome 17q21 and adult-onset asthma in a Chinese Han population. BMC Med Genet, 2011, 12:133.
9.	Sy HY, Ko FW, Chu HY, et al. Asthma and bronchodilator responsiveness are associated with polymorphic markers of ARG1, CRHR2 and chromosome 17q21. Pharmacogenet Genomics, 2012, 22(7):517-524.
10.	Yang FF, Huang Y, Li QB, et al. Single nucleotide polymorphisms in the ORM1-like 3 gene associated with childhood asthma in a Chinese population. Genet Mol Res, 2012, 11(4):4646-4653.
11.	丁毅鵬, 何海武, 石慧芳, 等. 海南黎族哮喘ORMDL3基因多態性研究. 海南醫學, 2012, 23(11):1-2.
12.	黃漢琮, 曾林祥, 杜哲明. ORMDL3基因多態性與支氣管哮喘患者發病及肺功能的相關性研究. 中華結核和呼吸雜志, 2011, 34(10):780-781.
13.	金哲. ORMDL3基因單核苷酸多態性及表達水平與北京地區兒童哮喘關聯性研究. 中國人民解放軍軍事醫學科學院, 2010.
14.	陽愛梅. 湖南省哮喘兒童ORMDL3基因多態性分析及與OPN、TGF-βl水平相關性探討. 中南大學, 2012.
15.	Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in metaanalyses. Eur J Epidemiol, 2010, 25(9):603-605.
16.	陳甲, 和儒林, 朗瑩, 等. 中國人群MTHFR基因C677T多態性與青中年缺血性腦卒中相關性的Meta分析. 中國循證醫學雜志, 2014, 14(4):435-442.
17.	刁敏, 柳慧, 林雪梅. 腰硬聯合麻醉用于剖宮產有效性及安全性的系統評價. 中國循證醫學雜志, 2014, 14(10):1218-1224.
18.	Daley D, Park JE, He JQ, et al. Associations and interactions of genetic polymorphisms in innate immunity genes with early viral infections and susceptibility to asthma and asthma-related phenotypes. J Allergy Clin Immunol, 2012, 130(6):1284-1293.
19.	Burkhardt J, Kirsten H, Wolfram G, et al. Differential allelic expression of IL13 and CSF2 genes associated with asthma. Genet Mol Biol, 2012, 35(3):567-574.
20.	Toncheva AA, Suttner K, Michel S, et al. Genetic variants in Protocadherin-1, bronchial hyper-responsiveness, and asthma subphenotypes in German children. Pediatr Allergy Immunol, 2012, 23(7):636-641.

1. Ierodiakonou D, Postma DS, Koppelman GH, et al. TGF-beta1 polymorphisms and asthma severity, airway inflammation, and remodeling. J Allergy Clin Immunol, 2013, 131(2):582-585.
2. Birbian N, Singh J, Jindal SK. Protective role of IL-18-137G/C polymorphism in a North Indian population with asthma:a pilot study. Cytokine, 2013, 61(1):188-193.
3. Yamaide F, Undarmaa S, Mashimo Y, et al. Association study of matrix metalloproteinase-12 gene polymorphisms and asthma in a Japanese population. Int Arch Allergy Immunol, 2013, 160(3):287-296.
4. Binia A, Khorasani N, Bhavsar PK, et al. Chromosome 17q21 SNP and severe asthma. J Hum Genet, 2011, 56(1):97-98.
5. Galanter J, Choudhry S, Eng C, et al. ORMDL3 gene is associated with asthma in three ethnically diverse populations. Am J Respir Crit Care Med, 2008, 177(11):1194-1200.
6. Kang MJ, Yu HS, Seo JH, et al. GSDMB/ORMDL3 variants contribute to asthma susceptibility and eosinophil-mediated bronchial hyperresponsiveness. Hum Immunol, 2012, 73(9):954-959.
7. Moffatt MF, Kabesch M, Liang L, et al. Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature, 2007, 448(7152):470-473.
8. Fang Q, Zhao H, Wang A, et al. Association of genetic variants in chromosome 17q21 and adult-onset asthma in a Chinese Han population. BMC Med Genet, 2011, 12:133.
9. Sy HY, Ko FW, Chu HY, et al. Asthma and bronchodilator responsiveness are associated with polymorphic markers of ARG1, CRHR2 and chromosome 17q21. Pharmacogenet Genomics, 2012, 22(7):517-524.
10. Yang FF, Huang Y, Li QB, et al. Single nucleotide polymorphisms in the ORM1-like 3 gene associated with childhood asthma in a Chinese population. Genet Mol Res, 2012, 11(4):4646-4653.
11. 丁毅鵬, 何海武, 石慧芳, 等. 海南黎族哮喘ORMDL3基因多態性研究. 海南醫學, 2012, 23(11):1-2.
12. 黃漢琮, 曾林祥, 杜哲明. ORMDL3基因多態性與支氣管哮喘患者發病及肺功能的相關性研究. 中華結核和呼吸雜志, 2011, 34(10):780-781.
13. 金哲. ORMDL3基因單核苷酸多態性及表達水平與北京地區兒童哮喘關聯性研究. 中國人民解放軍軍事醫學科學院, 2010.
14. 陽愛梅. 湖南省哮喘兒童ORMDL3基因多態性分析及與OPN、TGF-βl水平相關性探討. 中南大學, 2012.
15. Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in metaanalyses. Eur J Epidemiol, 2010, 25(9):603-605.
16. 陳甲, 和儒林, 朗瑩, 等. 中國人群MTHFR基因C677T多態性與青中年缺血性腦卒中相關性的Meta分析. 中國循證醫學雜志, 2014, 14(4):435-442.
17. 刁敏, 柳慧, 林雪梅. 腰硬聯合麻醉用于剖宮產有效性及安全性的系統評價. 中國循證醫學雜志, 2014, 14(10):1218-1224.
18. Daley D, Park JE, He JQ, et al. Associations and interactions of genetic polymorphisms in innate immunity genes with early viral infections and susceptibility to asthma and asthma-related phenotypes. J Allergy Clin Immunol, 2012, 130(6):1284-1293.
19. Burkhardt J, Kirsten H, Wolfram G, et al. Differential allelic expression of IL13 and CSF2 genes associated with asthma. Genet Mol Biol, 2012, 35(3):567-574.
20. Toncheva AA, Suttner K, Michel S, et al. Genetic variants in Protocadherin-1, bronchial hyper-responsiveness, and asthma subphenotypes in German children. Pediatr Allergy Immunol, 2012, 23(7):636-641.

Chinese Journal of Evidence-Based Medicine

ORMDL3 rs72l6389 Polymorphism and the Susceptibility to Asthma in Chinese Population: A Meta-analysis

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content