為了促進藥物的合理應用，本文從藥物相互作用、配伍禁忌、藥物選用、用法用量等方面對臨床常見的不合理用藥醫囑進行了探討，指出用藥不當的原因和可能的后果，幫助臨床有效地防范不合理用藥的發生，有利于針對性地提高臨床合理用藥水平。
隨著世界現代醫藥學和我國傳統醫藥學的深入發展,中藥和西藥的在臨床上的聯合應用非常普遍。而目前在臨床中西藥合用過程中往往只注重中西藥合用的有效性,卻忽視了因配伍禁忌而可能出現療效降低、產生或增加毒副作用的不合理用藥。這不僅造成資源的浪費,同時也增加藥源性疾病的發生。這應引起廣大醫藥工作者及患者的高度重視。筆者參考近年來有關文獻資料,就臨床中西藥合用的配伍禁忌問題進行歸納論述。
Objective Shuanghuanglian injection (SHLI) is a typical Chinese medicine injection which has been used for more than 20 years. This study aims to investigate the compatibility of SHLI with western intravenous agents. Methods An extensive literature search was executed to identify all experimental tests and clinical reports on the topics. Data on the types of infusion solutions and western medical injections, usage and dosage, outcome measures for physical and chemical properties, and changes of drug effect were searched for. The included data was analyzed and described by the category of included western drugs. Compatibility was tested through integrating the evaluations of physical properties, chemical composition, drug metabolism, and safety. Results Sixty articles (38 experimental tests and 22 clinical reports) were included after screening. Fifty–three western medical injections were identified from all the included articles. Most of the research was about the compatibility of SHLI with different types of antibiotics, including β-lactam, aminoglycoside, and quinolone etc. Thirty-one western medical injections were not recommended to be combined with SHLI. The quality of the experimental test design was low because of unbalanced evaluation indicators: more attention to physical changes than drug metabolism, effect, and safety. Conclusions A broad incompatibility exists in the combination of SHLI with western medical injections. Some results are still uncertain, but the combinations should still be avoided until researched clearly. The compatibility and interaction of Chinese herbal injections and western medicines is still a weak area. The pharmaceutical sector should strengthen post-market research to update evidence and improve its distribution.