ObjectiveTo investigate the effects of thyroid globulin antibody (TgAb) and thyroid peroxidase antibody (TPOAb) statuses on central lymph node (CLN) metastasis in patients with differentiated thyroid cancer (DTC).MethodsA retrospective analysis was performed on 526 patients with DTC confirmed by pathology from nine participating institutions, who underwent the bilateral thyroidectomy plus bilateral CLN dissection. The clinicopathologic characteristics of different TGAb and TPOAb statuses of patients with DTC were compared, and whether the TGAb and TPOAb statuses were the independent risk factors of CLN metastasis in DTC patients or not was analyzed.ResultsAll of 526 patients with DTC were included in this study, 152 were males and 374 were females. The age was (44±11) years old. There were 63 cases of TgAb＋TPOAb＋, 60 cases of TgAb＋TPOAb－, 30 cases of TgAb－TPOAb＋, and 373 cases of TgAb－TPOAb－. It was found that there was a significant difference in the gender among the four different antibody statuses of patients, that was, women with abnormal antibodies were more common (P<0.001), not found that there were related to the tumor size, blood vessel invasion, nerve invasion, CLN metastasis, tumor multifocality, and bilateral tumor or not (P>0.050). In this study, there were 389 cases of CLN with metastasis and 137 cases of CLN without metastasis. The results of multivariate analysis found that the age and gender of the patients were the independent risk factors (P<0.001), but didn’t find the TgAb and TPOAb Statuses and other factors were related to the CLN metastasis (P>0.050).ConclusionsStatuses of TGAb and TPOAb aren’t obviously associated with CLN metastasis in patients with DTC, which is inconsistent with other studies. It needs to be further researched after expanding existing sample size and determining new predictive factors.
【Abstract】 Objective To investigate the protective effect of early motion on articular cartilage after joint allograft by performing a controlled trial between different post-operation strategies after joint allograft in an animal model. Methods Twenty hemi-knee joints were harvested from 10 6-month-old New Zealand white rabbits (male or female, weighing 2.5-3.0 kg); 10 hemi-knee joints by deep frozen treatment (donors) were transplanted to unilateral knee joints (recipients) of 10 6-month-old Chinchilla rabbits (male or female, weighing 2.5-3.0 kg), which were divided into early motion group (n=5) and sustained fixation group (n=5); and 10 hemi-knee joints were used as blank control (n=5) and frozen control (n=5). The articular cartilage of allogenic joints was detected by X-ray film, gross, and histology at 6 weeks after operation. Results Gross observation: no obvious limitation of joint movements was observed in early motion group, but obvious limitation in sustained fixation group. X-ray films: the bone ends between donor and recipient healed well with good paraposition and alignment on the operation day and 2 weeks after operation; at 6 weeks, angulation deformity was observed in early motion group of 3 rabbits, and paraposition and alignment were satisfactory in sustained fixation group. Histological observation: HE staining showed that the chondrocytes had normal quantity and morphology with few nuclear fragmentation and karyolysis in early motion group, but the quantity of chondrocytes sharply decreased with dissolved nuclei and numerous fibrous tissues in the cartilage matrix in sustained fixation group. The cell survival rate of the early motion group (49.66% ± 2.15%) was significantly higher than that of the sustained fixation group (20.68% ± 1.24%) (P lt; 0.05). Scanning electron microscopy observation: nuclear membrane was intact with chromatin condensation and edema of mitochondria and rough surfaced endoplasmic reticulum in early motion group, and that the membrane of chondrocyte vanished with blurring border between chondrocyte and matrix, rupture of nuclear membrane and the disappearance of chromatin and organelles could be found in sustained fixation group. Conclusion Early motion has protective effect on articular cartilage after joint allograft, but cannot completely prevent degeneration of the allogenic articular cartilage.
Acute kidney injury is a worldwide public health issue, and its treatment and management strategies continue to advance. In addition to traditional kidney replacement therapy, research in recent years has been focused on whole organ engineering and biofabrication of kidney assistive devices and bioinjections for in-body regeneration. Hydrogel materials show great potential in renal tissue engineering because of their good biocompatibility, thermal stability and controllable biochemical and mechanical properties. This article reviews the application of various hydrogel materials in renal tissue engineering to promote kidney regeneration and discusses the characteristics and applications of natural hydrogels and synthetic hydrogels, which is expected to further promote their clinical applications.
【Abstract】 Objective To explore the reasons of tendon adhesions post tendon allograft. Methods From May1990 to June 2000, 85 cases receiving tendon allograft were given tenolysis because of tendon adhesions. There were 76 males and 9 females, with an average age of 24.5 years (8-46 years). Injury was caused by machine in 38 cases, electric in 32 cases, cut in 4 cases, explosion in 4 cases and extremity mutilation in 7 cases; including 66 cases of flexor tendon deficit and 19 cases of extensor tendon deficit. Six cases had 1 tendon deficit, 79 cases had tendon deficit of more than 2. The defect region ranged from I to V. The total mobil ity of the joint was less than 220° in 73 cases. The impairment of skin, bone, nerve and vascular were treated before tendon allograft. Results Because TAM was less than 50% of TPM, the patients were given tenolysis 4-15 months after operation. And the mobil ization began at the first day after operation to improve the range of active movement. Patients were followed up 7-17 years (mean 12.7 years). TAM and TPM were in accord. Mean total mobil ity of joint was200°. Conclusion The serious of primary hurt is the important factors of tendon adhesion. Improvement of tendon selected, treatment and early mobil ization can rel ieve the tendon adhesion.
Implantable cardioverter defibrillator (ICD) is the most effective measure to prevent sudden cardiac death. However, ICD patients frequently have problems such as decline of exercise tolerance and quality of life, anxiety and depression after operation, which require cardiac rehabilitation (CR). A considerable amount of studies have proved that CR is an effective secondary prevention measure for patients with cardiovascular disease. Its safety and effectiveness have been supported by evidence-based medicine research, which can prevent the recurrence of cardiovascular events, reduce the readmisson rate, and promote healthy behavior and active lifestyle formation of patients, so as to improve the quality of life of patients. This review mainly summarized the necessity, safety, exercise program and economic benefits of CR in ICD patients.
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social communication and repetitive behaviors. With the rapid development of computer vision, visual behavior analysis aided diagnosis of ASD has got more and more attention. This paper reviews the research on visual behavior analysis aided diagnosis of ASD. First, the core symptoms and clinical diagnostic criteria of ASD are introduced briefly. Secondly, according to clinical diagnostic criteria, the interaction scenes are classified and introduced. Then, the existing relevant datasets are discussed. Finally, we analyze and compare the advantages and disadvantages of visual behavior analysis aided diagnosis methods for ASD in different interactive scenarios. The challenges in this research field are summarized and the prospects of related research are presented to promote the clinical application of visual behavior analysis in ASD diagnosis.
At present, transeatheter aortic valve replacement is an effective treatment for elderly patients with severe aortic valve stenosis. Cardiac rehabilitation after transeatheter aortic valve replacement can effectively improve cardiopulmonary endurance and exercise capacity, and improve the quality of life. In order to better carry out cardiac rehabilitation for patients undergoing transeatheter aortic valve replacement, the Structural Heart Disease Professional Committee of Chinese College of Cardiovascular Physicians has drawn up Expert Consensus on Motor Rehabilitation after Transeatheter Aortic Valve Replacement. This consensus mainly elaborates the specific implementation process and methods of cardiac rehabilitation from three time periods of perioperative rehabilitation, outpatient rehabilitation and home rehabilitation. This article will interpret the main content of the consensus.
This review thoroughly investigates the application and advancements of artificial intelligence (AI) technology in the comprehensive management of lung cancer. AI is utilized at various stages of lung cancer diagnosis and treatment through techniques such as computer vision, deep learning, and natural language processing. In the early diagnosis stage, AI assists in identifying high-risk populations and, in conjunction with pathological techniques, accomplishes functions like histological classification of lung cancer tissues, prediction of molecular markers, and quantitative analysis of immunohistochemistry. During the treatment stage, AI integrates multimodal data to aid in formulating individualized treatment plans and enhances efficiency via clinical decision support systems (CDSS). In the follow-up stage, continuous patient monitoring and optimization of follow-up strategies are realized through imaging, remote monitoring, and intelligent follow-up systems. The prospects for AI medical technology are promising. However, it still confronts challenges such as weak generalizability, poor interpretability of AI decisions, and ethical and legal issues.
Early screening of skin cancer is crucial to the survival rate of patients. Although deep learning has made significant progress in dermoscopic image analysis, the blurred edge of the lesion, the vulnerability to noise interference, and the limited computing resources at the time of model deployment are still the main bottlenecks. To this end, this paper proposes a frequency-space collaborative enhancement network (FSC-Net) based on lightweight classification. Aiming at the problem of blurred lesion edge and noise interference, the network first constructs a learning frequency enhancement module. Through the dynamic selective enhancement of frequency domain features, the lesion edge is finely characterized while suppressing high-frequency artifacts. Secondly, aiming at the scale heterogeneity of lesion morphology, this paper proposes a multi-scale aggregation module, which uses multi-branch pooling to reduce the loss of deep semantic features in the lightweight network. Finally, in order to solve the problem of difficult localization of complex lesion areas, this paper introduces a directional spatial calibration mechanism, which realizes accurate localization of lesion features through orthogonal decoupling coding and asymmetry factors. The experimental results on the 2019 international skin image collaboration challenge (ISIC2019) and the human against machine with 10000 training images (HAM10000) dataset show that FSC-Net achieves 93.41% eight-classification accuracy and 95.84% seven-classification accuracy with a lower number of parameters. Compared with the existing advanced models, the proposed method achieves a better balance between computational overhead and diagnostic performance, and provides a robust and efficient solution for auxiliary diagnosis in resource-constrained environments.
Objective This study aims to analyze the current epidemiological status of cancer in China and worldwide, based on global cancer statistics released by GLOBOCAN 2024. MethodsCancer incidence and mortality data stratified by age, sex, cancer site, human development index (HDI) tier and geographic region were extracted from the GLOBOCAN 2024 database. Indicators including incidence, mortality rates were compared between China and the world. ResultsGlobally, there were an estimated 20.637 million new cases and 9.763 million cancer deaths in 2024. The age-standardized incidence rate (ASIR) was 194.9 per 100 000 and the age-standardized mortality rate (ASMR) was 87.8 per 100 000 in 2024. The age specific incidence rate and mortality rate both increased with age. The ASIR of all cancers increased with the increase of HDI, peaking at 279.6 per 100 000 in very high HDI regions. The ASMR of all cancers was highest in very high HDI regions (92.2 per 100 000) and lowest in medium HDI regions (68.6 per 100 000). The top five most commonly diagnosed cancers worldwide were lung, breast, colorectal, prostate and stomach cancer, while the five leading causes of cancer death globally were lung, colorectal, liver, breast and stomach cancer. Globally, men exhibited higher numbers of new cases, ASIR, death counts and ASMR compared with women. Lung cancer ranked first in both incidence and mortality among men, whereas breast cancer was the leading cancer in terms of incidence and mortality among women. In China, there were an estimated 5.151 million new cases and 2.582 million cancer deaths. The ASIR was 207.7 per 100 000 and the ASMR was 90.9 per 100 000 in 2024. The ASIR and ASMR in China ranked 63rd and 66th respectively across 186 countries. The five commonly diagnosed cancers in China were lung, thyroid, colorectal, breast and liver cancer, while the five leading causes of cancer death in China were lung, liver, colorectal, stomach and esophageal cancer. ConclusionsThe global cancer burden remains substantial, with marked disparities in cancer spectra across regions at varying levels of development. New cases and deaths from cancer in China accounted for approximately a quarter of the global total, with the incidence and mortality burden of cancers such as lung, liver and colorectal cancer being particularly pronounced, reflecting a situation where the cancer profiles of both developing and developed countries coexist. Analyzing China’s cancer burden can provide scientific evidence to inform the development of cancer prevention and control strategies tailored to national conditions.