目的:探討皮下脂膜炎樣T細胞淋巴瘤(SPTL)中P27及Cyclin D3的表達和意義。方法:應用免疫組化檢測20例SPTL標本中P27及Cyclin D3的表達。結果:P27及Cyclin D3在SPTL均出現較高表達,且P27蛋白與腫瘤細胞浸潤血管有關(Plt;005);P27與Cyclin D3蛋白表達之間無相關性(Pgt;005)。結論:P27及Cyclin D3在SPTL發生發展中起著一定作用。
ObjectiveTo investigate the clinical characteristics of pancreatitis, panniculitis, and polyarthritis syndrome (PPP syndrome). MethodsA patient with PPP syndrome in July 2013 was reported. The clinical features of 33 cases of PPP syndrome at home and abroad were reviewed. ResultsOur patient with panniculitis and arthritis as the first manifestation had few abdominal symptoms despite high serum levels of pancreatic enzymes. In the 34 PPP cases, 70.6% (24/34) had absent or mild abdominal symptoms, easily leading to misdiagnosis. Multi-joint involvement was more common, and in almost 1/3 of the patients, joint symptoms with poor NSAIDs and/or hormonal responses predated the identification of pancreatic disease. Panniculitis biopsy found characteristic "ghost cells". Ten patients died of complications of pancreatic disease (including 2 cases of cancer), and the mortality rate was as high as 29.4% (10/34). ConclusionPPP syndrome with mild abdominal symptoms and high mortality should be taken for the treatment of pancreatic disease, to prevent misdiagnosis and mistreatment.