皮下脂膜炎樣T細胞淋巴瘤中P27及Cyclin D3的表達及其意義_《華西醫學》

作者：

四川大學華西醫院皮膚性病科研究生,四川成都 610041;2重慶市第九人民醫院,重慶 400700;3成都鐵路局成都鐵路中心醫院,四川成都 610081;4江西省皮膚病專科醫院,江西南昌 330001;5四川大學華西醫院皮膚性病科,四川成都 610041;6成都市第二人民醫院,四川成都 610017;7四川大學華西醫院病理科,四川成都;

關鍵詞：

淋巴瘤 T細胞皮膚腫瘤脂膜炎 P27 Cyclin D3

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目的:探討皮下脂膜炎樣T細胞淋巴瘤(SPTL)中P27及Cyclin D3的表達和意義。方法:應用免疫組化檢測20例SPTL標本中P27及Cyclin D3的表達。結果:P27及Cyclin D3在SPTL均出現較高表達,且P27蛋白與腫瘤細胞浸潤血管有關(P lt;005);P27與Cyclin D3蛋白表達之間無相關性(P gt;005)。結論:P27及Cyclin D3在SPTL發生發展中起著一定作用。

引用本文： 楊翰君,徐晨,鄒宇,萬川,王琳,闞蓓,李俸媛,廖殿英,劉衛平,李甘地. 皮下脂膜炎樣T細胞淋巴瘤中P27及Cyclin D3的表達及其意義. 華西醫學, 2009, 24(5): 1115-1118. doi: 復制

1.	WILLEMZE R, JAFFE ES, BURG G, et al. WHOEORTC classification for cutaneous lymphomas[J]. Blood,2005,105(10):37683785.
2.	張冬梅,路建新,沈愛國,等.P27kip1與細胞周期素D3在非霍奇金淋巴瘤中的表達、定位及相互關系[J].中華血液學雜志,2005,26(12):723727.
3.	MOLLER MB, NIELSEN O, PEDERSEN NT. Cyclin D3 expression in nonHodgkin lymphoma. Correlation with other cell cycle regulators and clinical features[J]. Am J Clin Pathol,2001,115(3):404412.
4.	GLOGHINI A, GAIDANO G, LAROCCA LM, et al. Expression of cyclindependent kinase inhibitor p27 (Kip1) in AIDSrelated diffuse largecell lymphomas is associated with EpsteinBarr virusencoded latent membrane protein 1[J]. Am J Pathol,2002,161(1):16371.
5.	KIM DH, LEE HI, NAM ES, et al. Reduced expression of the cellcycle inhibitor p27Kip1 is associated with progression and lymph node metastasis of gastric carcinoma[J]. Histopathology,2000,36(3):245251.
6.	SHIN JY, KIM HS, PARK J, et al. Mechanism for inactivation of the KIP family cyclindependent kinase inhibitor genes in gastric cancer cells[J]. Cancer Res,2000,60(2):262265.
7.	LLOYD RV, ERICKSON LA, JIN L, et al. p27kip1: a multifunctional cyclindependent kinase inhibitor with prognostic significance in human cancers[J]. Am J Pathol,1999,154(2):313323.
8.	TAN P, CADY B, WANNER M, et al. The cell cycle inhibitor p27 is an independent prognostic marker in small (T1a, b) invasive breast carcinomas[J]. Cancer Res,1997,57(7):12591263.
9.	ESPOSITO V, BALDI A, DE LUCA A, et al. Prognostic role of the cyclindependent kinaseinhibitor p27 in nonsmall cell lung cancer[J]. Cancer Res,1997,57(16):33813385.
10.	SANCHEZBEATO M, CAMACHO FI, MARTINEZMONTERO JC, et al. Anomalous high p27/KIP1expression in a subset of aggressive Bcell lymphomas is associated with cyclin D3 overexpression. p27/KIP1cyclin D3 colocalization in tumor cells[J]. Blood,1999,94(2):765772.
11.	QUINTANILLAMARTINEZ L, THIEBLEMONT C, FEND F, et al. Mantle cell lymphoma lack expression of p27kip1, a cyclindependent kinase inhibitor[J]. Am J Pathol,1998,153(1):175182.
12.	MOREIRA JúNIOR G, COLLEONI GW, CANGI MG, et al. Reciprocal Cdc25A and p27 expression in Bcell nonHodgkin lymphomas[J]. Diagn Mol Pathol,2003,12(3):128132.
13.	KANGDECKER N, TONG C, BOUSSOUAR F, et al. Loss of CBP causes T cell lymphomagenesis in synergy with p27Kip1 insufficiency[J]. Cancer Cell,2004,5(2):177189.
14.	VEGA F, CHANG CC, MEDEIROS LJ, et al. Plasmablastic lymphomas and plasmablastic plasma cell myelomas have nearly identical immunophenotypic profiles[J]. Modern Pathol,2005,18(6):806815.
15.	NAKAYAMA KI, HATAKEYAMA S, NAKAYAMA K. Regulation of the cell cycle at the G1S transition by proteolysis of cyclin E and p27Kip1[J]. Biochem Biophys Res Commun,2001,282(4):853860.
16.	CHIARLE R, FAN Y, PIVA R, et al. Sphase kinaseassociated protein 2 expression in nonHodgkin’s lymphoma inversely correlates with p27 expression and defines cells in S phase[J]. Am J Pathol,2002,160(4):14571466.
17.	MAMILLAPALLI R, GAVRILOVA N, MIHAYLOVA VT, et al. PTEN regulates the ubiquitindependent degradation of the CDK inhibitor p27(KIP1) through the ubiquitin E3 ligase SCF(SKP2) [J]. Curr Biol,2001,11(4):263267.
18.	PRUITT K, DER CJ. Ras and Rho regulation of the cell cycle and oncogenesis[J]. Cancer Lett,2001,171(1):110.
19.	HURTEAU JA, ALLISON, BM, BRUTKIEWICZ SA, et al. Expression and subcellular localization of the cyclindependent kinase inhibitor p27(Kip1) in epithelial ovarian cancer[J]. Gynecol Oncol,2001,83(2):292298.
20.	LIN Z, LIM S, LIM MS. Growth regulation by p27Kip1 is abrogated by multiple mechanisms in aggressive malignant lymphomas[J]. Br J Haematol,2003,121(5):739748.
21.	FILIPITS M, JAEGER U, POHL G, et al. Cyclin D3 is a predictive and prognostic factor in diffuse large Bcell lymphoma[J]. Clin Cancer Res,2002,8(3):729733.
22.	程純,邵曉軼,沈愛國,等.Cyclin D3與淋巴細胞增殖相關性的初步研究[J].中國免疫學雜志,2005,21(9):666669,673 .

1. WILLEMZE R, JAFFE ES, BURG G, et al. WHOEORTC classification for cutaneous lymphomas[J]. Blood,2005,105(10):37683785.
2. 張冬梅,路建新,沈愛國,等.P27kip1與細胞周期素D3在非霍奇金淋巴瘤中的表達、定位及相互關系[J].中華血液學雜志,2005,26(12):723727.
3. MOLLER MB, NIELSEN O, PEDERSEN NT. Cyclin D3 expression in nonHodgkin lymphoma. Correlation with other cell cycle regulators and clinical features[J]. Am J Clin Pathol,2001,115(3):404412.
4. GLOGHINI A, GAIDANO G, LAROCCA LM, et al. Expression of cyclindependent kinase inhibitor p27 (Kip1) in AIDSrelated diffuse largecell lymphomas is associated with EpsteinBarr virusencoded latent membrane protein 1[J]. Am J Pathol,2002,161(1):16371.
5. KIM DH, LEE HI, NAM ES, et al. Reduced expression of the cellcycle inhibitor p27Kip1 is associated with progression and lymph node metastasis of gastric carcinoma[J]. Histopathology,2000,36(3):245251.
6. SHIN JY, KIM HS, PARK J, et al. Mechanism for inactivation of the KIP family cyclindependent kinase inhibitor genes in gastric cancer cells[J]. Cancer Res,2000,60(2):262265.
7. LLOYD RV, ERICKSON LA, JIN L, et al. p27kip1: a multifunctional cyclindependent kinase inhibitor with prognostic significance in human cancers[J]. Am J Pathol,1999,154(2):313323.
8. TAN P, CADY B, WANNER M, et al. The cell cycle inhibitor p27 is an independent prognostic marker in small (T1a, b) invasive breast carcinomas[J]. Cancer Res,1997,57(7):12591263.
9. ESPOSITO V, BALDI A, DE LUCA A, et al. Prognostic role of the cyclindependent kinaseinhibitor p27 in nonsmall cell lung cancer[J]. Cancer Res,1997,57(16):33813385.
10. SANCHEZBEATO M, CAMACHO FI, MARTINEZMONTERO JC, et al. Anomalous high p27/KIP1expression in a subset of aggressive Bcell lymphomas is associated with cyclin D3 overexpression. p27/KIP1cyclin D3 colocalization in tumor cells[J]. Blood,1999,94(2):765772.
11. QUINTANILLAMARTINEZ L, THIEBLEMONT C, FEND F, et al. Mantle cell lymphoma lack expression of p27kip1, a cyclindependent kinase inhibitor[J]. Am J Pathol,1998,153(1):175182.
12. MOREIRA JúNIOR G, COLLEONI GW, CANGI MG, et al. Reciprocal Cdc25A and p27 expression in Bcell nonHodgkin lymphomas[J]. Diagn Mol Pathol,2003,12(3):128132.
13. KANGDECKER N, TONG C, BOUSSOUAR F, et al. Loss of CBP causes T cell lymphomagenesis in synergy with p27Kip1 insufficiency[J]. Cancer Cell,2004,5(2):177189.
14. VEGA F, CHANG CC, MEDEIROS LJ, et al. Plasmablastic lymphomas and plasmablastic plasma cell myelomas have nearly identical immunophenotypic profiles[J]. Modern Pathol,2005,18(6):806815.
15. NAKAYAMA KI, HATAKEYAMA S, NAKAYAMA K. Regulation of the cell cycle at the G1S transition by proteolysis of cyclin E and p27Kip1[J]. Biochem Biophys Res Commun,2001,282(4):853860.
16. CHIARLE R, FAN Y, PIVA R, et al. Sphase kinaseassociated protein 2 expression in nonHodgkin’s lymphoma inversely correlates with p27 expression and defines cells in S phase[J]. Am J Pathol,2002,160(4):14571466.
17. MAMILLAPALLI R, GAVRILOVA N, MIHAYLOVA VT, et al. PTEN regulates the ubiquitindependent degradation of the CDK inhibitor p27(KIP1) through the ubiquitin E3 ligase SCF(SKP2) [J]. Curr Biol,2001,11(4):263267.
18. PRUITT K, DER CJ. Ras and Rho regulation of the cell cycle and oncogenesis[J]. Cancer Lett,2001,171(1):110.
19. HURTEAU JA, ALLISON, BM, BRUTKIEWICZ SA, et al. Expression and subcellular localization of the cyclindependent kinase inhibitor p27(Kip1) in epithelial ovarian cancer[J]. Gynecol Oncol,2001,83(2):292298.
20. LIN Z, LIM S, LIM MS. Growth regulation by p27Kip1 is abrogated by multiple mechanisms in aggressive malignant lymphomas[J]. Br J Haematol,2003,121(5):739748.
21. FILIPITS M, JAEGER U, POHL G, et al. Cyclin D3 is a predictive and prognostic factor in diffuse large Bcell lymphoma[J]. Clin Cancer Res,2002,8(3):729733.
22. 程純,邵曉軼,沈愛國,等.Cyclin D3與淋巴細胞增殖相關性的初步研究[J].中國免疫學雜志,2005,21(9):666669,673 .

《華西醫學》

皮下脂膜炎樣T細胞淋巴瘤中P27及Cyclin D3的表達及其意義

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《華西醫學》

皮下脂膜炎樣T細胞淋巴瘤中P27及Cyclin D3的表達及其意義

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

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