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      2. west china medical publishers
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        find Author "王亮" 19 results
        • 化學遺傳和光遺傳癲癇發作模型研究進展

          動物模型是癲癇機制研究的重要載體,目前廣泛應用的是化學性驚厥劑和電刺激模型,這些癲癇模型雖能模擬部分癲癇發作的癥狀和病理過程,但與人類的癲癇發作仍有很大差異。隨著化學遺傳和光遺傳技術在神經科學中的廣泛應用,使得特異性操控不同種類的神經元活動得以實現,已有研究利用光遺傳或化學遺傳的方法去構建癲癇發作模型,克服化學性驚厥劑和電刺激模型的局限性,便于更好地研究癲癇的神經環路機制。

          Release date:2021-06-24 01:24 Export PDF Favorites Scan
        • Pay attention to the study of spontaneous regression of retinopathy of prematurity

          Retinopathy of prematurity (ROP) has become the leading blinding eye disease in children worldwide. In recent years, the recognition and treatment of acute stage lesions have achieved remarkable results. Fundus lesions could spontaneously regress in most of children with ROP, while the understanding of the law of spontaneous regression is still very limited. Although the fundus morphology is significantly improved after spontaneous regression, the long-term prognosis of visual function is not optimistic. The introduction of new technologies such as fundus fluorescence angiography and optical coherence tomography and angiography will help further understanding the nature of the spontaneous regression. To increase the study about spontaneous regression of ROP, which has significance for rationally arranging an economical and efficient screening time, formulating a scientific and individual treatment and follow-up plan, and improving the prognosis of visual function.

          Release date:2022-08-16 03:23 Export PDF Favorites Scan
        • 預防小兒腹部Ⅲ類切口感染247例體會

          Release date:2016-08-28 04:08 Export PDF Favorites Scan
        • Treatment for Retinal Detachment in Silicone Oil-filled Eyes by Scleral Buckling and Retinal Laser Coagulation

          目的 研究鞏膜外墊壓手術聯合視網膜激光光凝對硅油眼視網膜脫離的治療效果。 方法 回顧性分析2009年1月-2012年1月,用鞏膜外墊壓聯合視網膜光凝手術治療36例硅油眼視網膜脫離的視網膜復位效果。 結果 全部患者均順利完成鞏膜外墊壓手術及隨后的視網膜激光光凝,行鞏膜外放液5只眼,手術中未發生視網膜嵌頓、眼內出血和眼壓顯著升高等并發癥;手術后1周視網膜復位21只眼(58.33%),剩下15只眼1個月后復位7只眼(19.44%),視網膜脫離總復位率為28只眼(77.77%);未復位8只眼(22.23%),改用玻璃體切割手術方式,視網膜成功復位;6個月后取出硅油,隨訪6個月視網膜無脫離或者脫離范圍增加;手術后眼壓≥30 mm Hg (1 mm Hg=0.133 kPa)3只眼,≥20 mm Hg 7只眼,對癥治療1周后眼壓均恢復到正常范圍。 結論 鞏膜外墊壓聯合視網膜激光光凝治療硅油眼視網膜脫離,手術簡單,復位率高,可為硅油眼視網膜脫離首選手術方式,對于鞏膜外墊壓手術失敗和復雜的硅油眼視網膜脫離,應當選擇玻璃體切割手術方式。

          Release date:2016-09-07 02:33 Export PDF Favorites Scan
        • Characteristics and Management of Massive Hemorrhage Secondary to Percutaneous Nephrolithotomy

          ObjectiveTo analyze the causes and characteristics of massive hemorrhage secondary to percutaneous nephrolithotomy (PCNL) and assess the value of superselective renal artery embolization in the management of this condition. MethodsThe imaging data and prognosis of 28 patients who developed repeated massive hemorrhage secondary to PCNL and underwent superselective renal artery embolization between April 2005 and June 2013 were reviewed. ResultsFollowing superselective renal artery embolization, hemorrhage was effectively controlled in all the 28 patients. Follow-up lasted from 6 to 62 months, averaging 41.6 months. No hematuria or other complications occurred during the follow-up period. ConclusionSuperselective renal artery embolization is safe and effective in managing massive hemorrhage secondary to PCNL, and it may be used as a preferred treatment for patients who are refractory to expectant treatments.

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        • 雌激素對視網膜主要細胞功能的影響

          雌激素通過與雌激素受體(ER)結合而發揮生理功能, ER亞型和特異性激動劑和拮抗劑的研究進展為進一步認識雌激素作用機制提供了可能。雌激素可能通過對視網膜血管內皮細胞、色素上皮細胞、神經節細胞、光感受器細胞和Müller細胞等主要視網膜細胞功能的影響, 改善血視網膜屏障、保護視網膜光感受器細胞、視神經, 減輕氧化應激反應對視網膜色素上皮細胞損害。詳盡研究ER各亞型在視網膜主要細胞的分布及特異性激動劑和拮抗劑對這些細胞的作用將為眼底病的防治開拓一個新的領域。

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        • IMPLANTATION OF CALCIUM PHOSPHATE CEMENT/DANSHEN DRUG DELIVERY SYSTEM FOR AVASCULARNECROSIS OF FEMORAL HEAD

          【Abstract】 Objective To introduce a new method using calcium phosphate cement/Danshen drug del ivery systemfor avascular necrosis of femoral head and to evaluate its cl inical outcome. Methods From May 2000 to June 2005, 48 patients (54 hips) with avascular necrosis of femoral head were treated with calcium phosphate cement/Danshen drug del ivery system implantation in the involved femoral head. There were 32 males(36 hips) and 16 females(18 hips) with an average age of 38.7 years (26-62 years). Twenty-one cases had the history of drinking or smoking, 15 cases had the history of receiving hormonotherapy and 2 had the history of injury in hip joint. The disease course was 2-32 months. According to standard of Association Research Circulation Osseous (ARCO) staging, 9 hips were classified as stage I, 31 as stage II and 14 as stage III. The operation consisted of removal of necrotic bone under weight-loading cartilage and the implantation of calcium phosphate cement/Danshen drug del ivery system, all mani pulations were done through a bone tunnel in trochanter. The function of hi p joint were evaluated and X-ray films were taken pre- and post-operatively. Results No phlebothrombosis of leg and foreign body action occurred in all cases, and incision healed by first intention. The postoperative follow-up averaged 42.5 months, ranging from 22 to 73 months. According to the evaluation criterion of Dandong 1995 for adult avascular necrosis of femoral head, the results were excellent in 33 hi ps, good in 17, fair in 3 and poor in 1, the excellent and good rate was92.6 %. Conclusion This method is relatively simple with less invasion, it not only improves the microcirculation of femoral head by local appl ication of traditional Chinese medicine, but also provide mechanic buttress in the weight-loaded area, which is beneficial to repair and reconstruction of femoral head. It may be a choice of minimally invasion surgery for femoral head necrosis.

          Release date:2016-09-01 09:10 Export PDF Favorites Scan
        • PLACEMENT OF DRAINAGE TUBE AND ITS POSTOPERATIVE MANAGEMENT OF PANCREATODUODENECTOMY(REPORT OF 88 CASES)

          目的 探討胰十二指腸切除術中引流管的放置與術后管理的方法。方法回顧性分析88例胰十二指腸切除術后管理經驗。結果 術后腹腔并發癥的發生率為10.2%(9/88),胃排空障礙發生率為3.4(3/88)%,其中保留幽門胰十二指腸切除術后胃排空障礙發生率為5.5%(3/55)。結論 胰十二指腸切除術后腹腔引流是預防術后并發癥的重要方法,術中合理放置引流管,術后加強腹腔引流的管理,能減少術后并發癥的發生。

          Release date:2016-09-08 02:01 Export PDF Favorites Scan
        • SURGICAL TREATMENT OF SPINAL TUBERCULOSIS ASSOCIATED WITH DIABETES MELLITS

          Objective To investigate the perioperative management and the results of surgical treatment of spinal tuberculosis associated with diabetes mellitus. Methods The cl inical data were analysed retrospectively from 42 patients with spinal tuberculosis associated with type 2 diabetes mell itus who were surgically treated between July 2001 and January 2009.There were 22 males and 20 females with an average age of 56.5 years (range, 41-78 years). The disease duration was 4-18 months (mean, 7.5 months). The involved vertebrae included 2 cervical vertebrae, 13 thoracic vertebrae, 17 thoracolumbar vertebrae, and 10 lumbar vertebrae. Of them, 18 patients compl icated by paraplegia, and 25 patients had more than one of concomitant diseases. Anterior debridement and bony grafting with anterior instrumentation fixation were performed in 16 patients; anterior debridement and bony grafting with posterior instrumentation fixation in 4 patients; posterolateral costotransversectomy debridement and interbody fusion with posterior instrumentation fixation in 8 patients; posterior debridement and bony grafting with posterior fixation in 7 patients; sinus resectomy and focus debridement in 2 patients; anterior debridement and bony grafting in 3 patients; and CT guided percutaneous catheter drainage in 2 patients. Postoperative anti-tuberculosis treatment was given for 12-24 months. Results The patients were followed up 1.5-5.0 years, with a mean period of 3.5 years. One patient died of pulmonary infection after 1 week of operation; 1 patient died of myocardial infarction after 2 years of operation; and other patients survived without tuberculosis recurrence. Among 38 patients who received bony grafting, 34 patients achieved bony fusion, 3 suffered bony grafting failure without kyphotic deformity or instabil ity except 1 patient who died from pulmonary infection. Among 18 cases compl icated by paraplegia, nerve function improved to a certain extent. The intraoperative and postoperativecompl ications occured in 28 cases. The systemic compl ications mainly included heart insufficiency in 5, heart rrhythmia in 3, pulmonary infection in 2, urinary tract infection in 2, and stree ulcer in 1; they were cured after medical treatment. The local complications mainly included sinus tract formation in 5, pleural tear in 2, neurologic injury in 2, intraoperative tear of inferior vena cava in 2, and the loosening of transpedicular screws in 4; they all were cured effectively. Conclusion Surgical treatment of spinal tuberculosis associated with diabetes mell itus appears to be a beneficial procedure on the condition that the blood glucose is controlled and the associated disorders and postoperative complications are properly handled, and reasonably selection of surgical procedures is very important. Instrumentation fixation provides adequate stabil ity to allow early mobilization.

          Release date:2016-09-01 09:04 Export PDF Favorites Scan
        • 直腸外翻拖出式腹腔鏡直腸癌根治術5例臨床分析

          目的分析經直腸外翻拖出式腹腔鏡直腸癌根治術的療效及安全性。 方法回顧性分析我院2013年10月至2014年10月期間應用直腸外翻拖出式腹腔鏡直腸癌根治術治療的5例直腸癌患者的臨床資料。 結果5例直腸癌患者中中分化腺癌4例,低分化腺癌1例。5例手術順利完成,手術時間平均為140.4 min,術中出血量平均為45 ml,腸管遠端切緣距腫瘤的距離平均為3.9 cm,術后腸蠕動恢復時間平均為2.5 d,術后住院時間平均為8 d。術后無出血、腸梗阻、吻合口漏等嚴重并發癥。5例患者術后隨訪時間8~22個月,無腫瘤轉移和局部復發。 結論直腸外翻拖出式腹腔鏡直腸癌根治術對腫瘤直徑<5 cm、不超過腸管周徑1/2、T3N0期以內的直腸癌患者無腹壁切口,安全可行,術后康復快。

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          2. 射丝袜