目的:探討簡化生長激素藥物激發實驗的可行性。方法:對單獨應用可樂定藥物激發實驗的結果和聯合應用可樂定與精氨酸藥物激發實驗結果進行對照研究。GH峰值gt;10ng/mL,正常;GH峰值lt;5ng/ml,為GH完全缺乏;GH峰值在5 -10ng/ml之間,為GH部分缺乏。結果:簡化藥物激發實驗與經典藥物激發實驗結果評估無顯著性差異。結論:單獨使用可樂定進行生長激素激發實驗的結果與可樂定聯合精氨酸進行生長激素激發實驗結果評價無顯著性差別。
目的:探討取出外耳道異物的方法。方法:2000～2007年對62例外耳道異物取出方法進行報告。結果:不同異物采取不同方法,異物種類多樣,因此取出的方法亦多樣。對于一些特殊異物采用特殊方法將取得很好的效果。結論:要提高外耳道異物取出的效率,就要采用不同方式。
Objective To compare the bone resorption between the proximal fixation of the anatomique benoist giraud（ABG） hip and the distal fixation of the anatomic medullary locking（AML） hip by the medium-term X-ray films, and to evaluate the clinical results of the two prostheses. Methods From January 1992 to December 1996, 298 patients (396 hips) underwent the total hip arthroplasty at Wilson Hospital in Korea. In 125 patients, 176 hips were ABG hips, including 103 avascularnecrosis hips, 57 dysplasia hips, and 16 other diseased hips; In the other 173 patient the remaining 220 hips were AML hips, including 147 avascular necrosis hips, 65 dysplasia hips, and 8 other diseased hips. The A-P X-ray imagings were followed up for 5-12 years averaged 8 years, and were compared with the immediate postoperative X-ray imagings. The bone resorption area was measured and the bone resorption cases were recorded according to the Gruen zone obsesvation. Results During operation, 2 ABG hips and 5 AML hips were cracked at the femoral diaphysis; 3 ABG hips and 1 AML hip were cracked at the metaphysis; 6 ABGhips and 3 AML hips were fractured because of trauma after operation; among them, 2 ABG hips needed the stem revision and the remaining hips underwent the openreduction and the internal fixation. During the follow-up, 9 ABG hips were revised, 7 hips of which developed the aseptic loosening. No AML hip was revised, but 3 AML hips developed the aseptic loosening. The bone resorption pattern in theABG and AML hips was similar. The bone resorption occurred most commonly in theGruen zones 1 and 7, and it extended from the metaphysis to the diaphysis. In the Guren zones 2, 5, 6 and 7, there were more AML hips than ABG hips that developed the bone resorption. The bone resorption area around the AML hip was larger than that around the ABG hip. Conclusion The stress shielding bone resorption usually occurs proximally to the union area of the bone and the prosthesis. The ABG prosthesis is a proximal fixation prosthesis, therefore, the stress shielding bone resorption can be reduced. The bone resorption around the AML prosthesis develops slowly within 10 years after operation. The stress shielding bone resoption may reach the summit within 10 years and it will not develop endlessly, so the prosthesis will be stable for a long time. The probabilityof the bone resorption in the ABG prosthesis is smaller than that in the AMLprosthesis. The bone resorption around the AML prosthesis may develop slowly after 10 years and will not affect the stability of the prosthesis for a long time.
Objective To introduce a new method for correction of deep nasolabial fold. Methods From May 1998 to May 2002, 20 patients( aging 32-48 years, female) with deep nasolabial fold were treated with the buried guiding suture appliance and method through oral incision. Results All patients recovered without complications , the scar is minimal. Six patients were followed up 6 to 12 months, stable and permanent result was achieved. Conclusion This method is simple and reliable for correction of nasolabial fold.
目的:探討不同治療方法對急性痛風性膝關節炎的治療效果。方法:自2006年9月～2008年3月共收治42例急性痛風性膝關節炎患者。對21例急性痛風性膝關節炎患者采取藥物保守治療,21例行關節鏡手術配合藥物治療。兩組治療前后采用WOMAC評分對膝關節功能進行評定,用student-t檢驗進行統計學分析。結果:保守組:隨訪發現關節癥狀好轉不明顯,復發率19.05％;WOMAC評分治療前49～72分,治療后69～85分。關節鏡手術配合藥物組:隨訪發現關節癥狀均明顯緩解,關節功能恢復良好,傷口甲級愈合,無術后并發癥,6個月無復發病例;WOMAC評分治療前49～71分,治療后75～96分。兩組治療前后及之間有顯著性差異,保守組(t=-9.864,Plt;0.001);關節鏡手術配合藥物組(t=-11.267,Plt;0.001);兩組之間(t=-2.366,Plt;0.023)。結論:比較以上2種治療方法,關節鏡手術治療急性痛風性膝關節炎具有創傷小、起效快、效果明顯、關節功能恢復滿意等特有優勢,結合藥物治療,能取得良好的治療效果。
Objective To design a novel stentless porcine aortic bioprosthesis and test the feasibility and its function in vitro after the valve was implanted by a modified method. Methods Six stentless porcine aortic bioprosthesis were divided into two groups according to different implantation, single layer suture group: new improvement stentless porcine aortic bioprosthesis sutured with single layer was implanted; double layer suture group: stentless porcine aortic bioprosthesis developmented by our laboratory used double layer suture was implanted. Each group contained three scales: 23 mm ,25 mm and 27 mm. Analogue ex vivo aortic valve replacement was performed , the feasibility of the new implantation was detected. Effective orifice area, transvalvular pressure gradient and regurgitation ratio were recorded at the cardiac output of 2.0 L/min, 3.5 L/min, 5.0 L/min and 7.0 L/min under the guideline of International Organization for tandardization （ISO）5840. Results The average aortic valve implantation time used for single layer suture and tradition double layer suture were 50 min and 70 min respectively. The transvalvular pressure gradient in the single layer suture group were significantly lower than those in double layer suture group under the flow of 5.0 L/min in 23 mm valve and 27 mm valve （13.51±0.51 mm Hg vs. 14.44±0.99 mm Hg, 7.36±0.19 mm Hg vs. 7.53±0.28 mm Hg；P＜0.01）;and the effective orifice area in the single layer suture group were larger than those in double layer suture group in the same case(1.87±0.06 cm2 vs. 1.76±0.08 cm2, 2.26±0.07 cm2 vs. 2.16±0.05 cm2；P＜0.01). There was no statistically difference in other parameters between both groups. Conclusion The novel design of new improvement stentless porcine aortic bioprosthesis used single layer suture has good hemodynamic characteristics as the nature structure . The modified suture method decrease the implantation time.Nemerical data of the evaluation in vitro show that the difference between single layer suture group and double layer suture group in effective orifice area,transvalvular pressure gradient and regurgitation ratio haveno statistical significance. This experiment is the foundation of the animal and clinical experiment in the future.
Cryptococcosis, mainly caused by Cryptococcus neoformans/gattii species complexes, is a lethal infection in both immunosuppressive and immunocompetent populations. With the upgrade of detection methods and the increase of clinical knowledge, the incidence rate of cryptococcosis is increasing, and it has become one of the most important fungi threatening human health. In recent years, great progress has been made in this field, including the taxonomy and nomenclature of Cryptococcus spp., laboratory diagnostic methods and antifungal susceptibility tests, as well as the characteristics and treatments of cryptococcosis. This article reviews the above contents, in order to improve the clinical and laboratory understanding of the Cryptococcus spp., and realize the timely diagnosis and early treatment of cryptococcosis.