Objective To summarize research progress of relationship between chloride intracellular channel protein 1 (CLIC1) and colonic cancer. Method The related literatures in recent years on the relationship between the CLIC1 and the colonic cancer were reviewed and analyzed. Results The CLIC1 could play its physiological function as a chloride ion channel, with a wide tissue distribution and high expression in many tumor tissues. The abnormal expression of CLIC1 could result in many diseases and participate in many processes such as the occurrence, development, metastasis, and treatment of the colonic cancer. Conclusions CLIC1 might be a biomarker for early diagnosis and a target for gene therapy of colonic cancer, key genes regulated its expression, signal transduction pathways involved in occurrence and progression of colonic cancer, and interaction with other related molecules are still unclear, and further study is needed.
ObjectiveTo summarize the experience in the treatment of anastomotic leakage after laparoscopic D2 radical gastrectomy.MethodThe clinicopathologic data of 11 patients with anastomotic leakage after the laparoscopic D2 radical gastrectomy in the Nanchong Central Hospital from May 2016 to January 2018 were analyzed retrospectively.ResultsAmong the 11 patients with anastomotic leakage, 3 were grade Ⅱ leakages and 8 were grade Ⅲa leakages. There were no symptoms in the 3 cases of anastomotic leakage, which were confirmed only by the gastrointestinal radiography and were healed after 7 d of conservative treatment. Among the 8 patients with the clinical symptoms, 5 cases were treated by the endoscopic drainage and negative pressure suction for 60–90 d, 3 cases were treated by the endoscopic covered stent, 2 cases were cured after 30–60 d, and 1 case died of massive bleeding after 45 d.ConclusionsDue to differences of location, time, limitation, and size of anastomotic leakage after laparoscopic D2 radical gastrectomy, individualized treatment should be performed according to specific situation of patients in local treatment. Endoluminal covered stent has certain clinical application value.