Objective To investigate and explore the clinical effect of preoperative exercise intervention on total hip arthroplasty. Methods Seventy-three patients who underwent primary unilateral total hip replacement (THR) in the Orthopedics Department, the Second Hospital of Jilin University between March 2017 and January 2018 were divided into 2 groups: treatment group (n=37) and control group (n=36). Patients in treatment group received exercise intervention and routine education since 4 weeks before surgery; the control group just received routine education before surgery and both groups underwent the same routine rehabilitation training. The Visual Analogue Scale (VAS) was evaluated and compared separately between the two groups at 4 weeks before surgery (T0), 1 day before surgery (T1), before discharge (T2), 1 month after discharge (T3), and 3 months after discharge (T4). The results of Hip Harris score and Time Up and Go test (TUG) were evaluated and compared separately between the two groups at T0, T1, T3 and T4. Results Time of TUG of the treatment group and the control group at T1, T3 and T4 were (14.59±3.15) vs. (16.31±3.31) s, (13.61±2.76)vs. (15.25±3.08) s, (12.49±2.37)vs. (14.22±2.65) s, respectively, and the differences between the two groups at T1, T3 and T4 were all statistically significant (P<0.05). In terms of VAS and Harris scores, both groups showed significant improvement after surgery at different time nodes (P<0.05), but the differences between the two groups was not statistically significant (P>0.05). Conclusion Preoperative exercise intervention can effectively improve the walking ability of THR patients and reduce the risk of falls after discharge, but it did not reduce postoperative pain or improve postoperative hip Harris score after discharge.
Due to the aging population intensifies, the number of people suffering from mild cognitive impairment (MCI) or dementia is expected to increase, which may lead to a series of public health and social health problems. In the absence of drugs to prevent the transformation of MCI into dementia, it is urgent to find effective non-pharmacological therapies to delay the progress of cognitive impairment. This article will review the diagnosis of MCI and the research progress of non-pharmacological therapies, focusing on the non-pharmacological therapies related to MCI in recent years, including exercise intervention, cognitive intervention, physical and mental exercise, dietary intervention, electroacupuncture, repeated transcranial magnetic stimulation, and multi-component intervention, in order to provide an effective treatment for preventing or delaying the progression of MCI to dementia.
In 2026, the European Society for Medical Oncology issued an express update to its Clinical Practice Guideline for Localised Colon Cancer. On the basis of randomised evidence from the CHALLENGE (CCTG CO.21) trial, patients with stage Ⅲ or high-risk stage Ⅱ colon cancer who had undergone curative resection and completed standard adjuvant chemotherapy. This article interprets the new recommendations, eligible population, exercise dose, level of evidence, key findings of the CHALLENGE trial, and practical implications for translation into general surgical practice in China. The guideline emphasises that healthcare professionals should inform eligible patients of the potential survival benefit of structured exercise and, after assessing their physical fitness, comorbidities, personal preferences, adherence barriers and financial burden, use shared decision-making to determine whether to recommend participation in a structured exercise programme. The CHALLENGE trial showed that a 3-year structured exercise programme improved disease-free survival and overall survival; however, its target population mainly comprised patients with good performance status who had completed standard adjuvant chemotherapy, and implementation requires trained personnel, behavioural support and integration into follow-up systems. This update indicates that postoperative management of localised colon cancer is moving beyond recurrence surveillance toward quantifiable and evaluable proactive rehabilitation. In China, localised exercise-prescription pathways should be explored through multidisciplinary collaboration, taking into account surgical recovery, anastomotic or stoma-related issues, baseline physical function and available healthcare resources.