Aphasia is one of the common disabling lesions and sequelae in stroke patients. In post-stroke aphasia patients, impairments of non-verbal cognitive domain often occur, which seriously affect daily social contact and quality of life. Cognitive neuropsychological rehabilitation is a neuropsychological rehabilitation based on the development of cognitive neuropsychological theory. It is currently applied in the field of rehabilitation of brain cognitive function, opening up a new way for evaluation and treatment of post-stroke aphasia. This paper introduces the general features of the application of cognitive neuropsychological rehabilitation, expounds the evaluation model and treatment principles of cognitive neuropsychological rehabilitation, and discusses its application in the evaluation and treatment of post-stroke aphasia, so as to provide ideas for the linguistic and non-linguistic cognitive rehabilitation of post-stroke aphasia.