Mini health technology assessment (mini-HTA) is a decision support tool based on the principle and method of evidence-based medicine and traditional HTAs. It systematically reviews healthy technologies and provides references for decision makers at the hospital level in terms of introducing relevant health technologies. In order to provide a new insight to the decision makers, this paper briefly introduces the features of mini-HTA.
ObjectiveTo systematically review the association between-174G/C polymorphism in interleukin-6 (IL-6) gene and the risk of chronic obstructive pulmonary disease (COPD). MethodsWe electronically searched PubMed, EMbase, CBM, WanFang Data, CNKI and VIP for case-control studies on the correlation between IL-6 gene-174G/C polymorphism and the risk of COPD. Two reviewers independently screened the studies according to the inclusion and exclusion criteria and extracted data. Then meta-analysis was conducted using RevMan 5.2 software. ResultsA total of 5 studies involving 487 COPD cases and 786 controls were included. The results of meta-analysis showed that, there was no significant association between IL-6 gene SNP-174G/C and risks of COPD:GC+CC vs. GG:OR=1.01, 95%CI 0.76 to 1.34, P=0.95; CC vs. GC+GG:OR=1.04, 95%CI 0.70 to 1.54, P=0.85:CC vs. GG:OR=1.05, 95%CI 0.69 to 1.61, P=0.81; GC vs. GG:OR=1.00, 95%CI 0.74 to 1.35, P=0.99; C vs. G:OR=1.02, 95%CI 0.83 to 1.24, P=0.88. ConclusionIL-6-174G/C gene polymorphism may not be a risk factor that causes COPD.