This paper analyzed clinical studies, systematic reviews and clinical practice guidelines on the treatment of COVID-19 with antiviral drugs. It elaborated on the evidence ecosystems in these studies following the "efficacy, evidence-based practice, effectiveness" (3E) model that considered five elements: research hypothesis, research evidence, big data from healthcare facilities, real-world data, and real-world evidence. Finally, this paper summarized the experience in the production, transformation and application of evidence. This paper could help clinicians conduct high-quality clinical research and provide good clinical practice based on the best currently available evidence.
The first Global Evidence Summit (GES) was held in Cape Town in South Africa from September 13th to November 16th, 2017. This paper interprets the construction of digital and trustworthy evidence ecosystem which was proposed to be established by the GES.