Epilepsia is the official journal of the International League Against Epilepsy. This paper aimed to review and report the literatures published in 2024. A total of 348 articles were published in the journal Epilepsia in 2024, including 6 editorials, 41 critical reviews (systematic reviews and meta-analyses), 11 commentaries, 223 research articles, 31 brief communications, 30 others (including announcements, correspondences and corrections), and 6 special reports. Epilepsia is a journal focusing on epilepsy in clinical neurology, and the literatures published in 2024 are still dominated by clinical studies, although the number of randomized controlled trials is limitted. Chinese authors have published 10 original studies, some of which are important studies, and have contributed Chinese wisdom to the clinical and scientific research of epilepsy. In 2024, the editorials of Epilepsia reported first editor-in-chief in history from outside the USA and Europe, who advocated for strengthening cooperation with epilepsy organizations and associations around the world, promoting the continuous development and progress of Epilepsia.
This article reviewed the literature published in Epilepsia in 2025. A total of 449 articles were published in 2025, representing a 29.0% increase compared to 2024 (348 articles). All the publications included 3 editorials, 38 critical reviews (systematic reviews and meta-analyses), 12 commentaries, 319 original research articles, 39 brief reports, 28 others (announcements, correspondence, and errata), and 10 special reports. The increase in publications in 2025 compared to 2024 was primarily driven by clinical studies (314 vs. 221, a 42.1% growth). Independently published articles by Chinese authors also saw a substantial rise, totaling 29 papers, which marked a 190% increase over 2024. This annual report focused on epilepsy and artificial intelligence, annual special reports and researches by chinese authors, highlighting innovations and developments in both clinical and basic epilepsy research domestically and internationally. It aimed to provide valuable insights for specialists to refine diagnostic and therapeutic techniques and broaden their academic horizons.
ObjectiveTo summarize the clinical phenotype, electrophysiological characteristics, imaging characteristics, surgical treatment and prognosis of Rasmussen encephalitis (RE), so as to deepen the understanding of the disease. MethodsThe clinical data of patients with RE who underwent surgical therapy from October 2014 to October 2019 at Children's Epilepsy Center in Peking University First Hospital were retrospectively reviewed. Demographic characteristics, seizure forms, electroencephalogram (EEG), cranial nuclear magnetic resonance (MRI), operative methods as well as surgical outcomes evaluated by Engel classification during follow-up of the subjects were collected and analyzed. ResultsTotally 21 pediatric patients were enrolled, including 8 males and 13 females. The age at onset was (5.0±2.0) years old, the age at the time of surgery was (6.9±2.7) years old, and the disease duration at the time of surgery was (1.7±1.3) years. Twenty (20/21, 95.2%) patients had focal motor seizures, and 10 (10/21, 47.6%) patients had 2 or 3 forms of focal motor seizures. Fifteen patients (15/21, 71.4%) had epilepsia partialis continua (EPC), which occurred (0.7±0.6) years after the onset. All patients had hemiplegia, which appeared at (0.9±0.6) years after the onset. All patients showed a slow rhythm at their affected hemispheres during the EEG monitoring and 4 of them also showed slow rhythm at the contralateral hemispheres as the disease progressed. All patients had epileptiform discharges at the involved hemisphere, and 6 patients also had independent epileptiform discharges on the contralateral side. All 21 patients underwent hemispheric disconnection. The duration of follow-up was 2 to 7 years, and all patients achieved Engel class I after the surgery. The neurological dysfunction recovered to varying degrees during the postoperative period. ConclusionRE mostly occurs around the school age. Focal motor seizures are the main manifestations and the most common onset symptoms. With the progress of the disease, the condition of patients worsened gradually. The EEG of patients was mainly characterized by broad slow wave and spike wave in the affected hemisphere. Some patients can also have bilateral involvement, which was obviously asymmetrical. Through surgical treatment, the patients all achieved good results in terms of seizures and development.