【摘要】 目的 探討無癥狀人群高尿酸血癥與高甘油三酯血癥的相關性，為臨床疾病的預防和治療提供實驗基礎研究。 方法 回顧分析2008年5月-2009年5月門診體檢中200名無臨床癥狀高血尿酸者（A組）的血脂檢查情況，并與同期200例血尿酸正常者（B組）的血脂檢查情況進行比較分析。A組：男121例，女79例；年齡20～60歲，平均43歲。男性患者血尿酸gt;420 mmol/L，女性患者gt;360 mmol/L。 B組：男115例，女85例；年齡20～60歲，平均41歲。男性患者血尿酸為99～420 mmol /L，女性患者為99～360 mmol/L。兩組性別和年齡差異無統計學意義（Pgt;0.05）。 結果 A組甘油三酯、總膽固醇、低密度脂蛋白、高密度脂蛋白分別為（3.09±0.98）、（4.05±1.07）、（3.38±0.98）、（1.30±0.51）mmol /L；B組為（1.65±0.86）、（3.99±0.99）、（2.97±0.89）、（1.41±0.66）mmol /L。 A組甘油三酯較B組比較，差異有統計學意義（Plt;0.01）；總膽固醇、低密度脂蛋白、高密度脂蛋白比較，差異無統計學意義（Pgt;0.05）。經相關性分析，A組血尿酸與甘油三酯呈正相關（r=0.69， Plt;0.01）。 結論 血尿酸代謝與甘油三酯代謝之間有一定的聯系。【Abstract】 Objective To explore the correlation between hyperuricemia and hypertriglyceridemia in asymptomatic people to provide the basic information for clinical prevention and treatment. Methods The blood lipid (TG, TC, LDL, and HDL) levels in 200 asymptomatic individuals with high uric acid (A group) and 200 sex-and age-matched ones with normal serum uric acid (B group) were examined and the results of the two groups were compared. Results The concentration of triacylglycerol, total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol were (3.09±0.98), (4.05±1.07), (3.38±0.98), and (1.30±0.51) mmol/L, respectively in group A; and were (1.65±0.86), (3.99±0.99), (2.97±0.89), and (1.41±0.66) mmol /L, respectively in group B. The concentration of TG in group A was obvious higher than that in group B (Plt;0.01). However, the differences of their total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol were not significant (Pgt;0.05). The increase of TG was obvious compared with TC(Plt;0.01), LDL (Plt;0.01), and HDL (Plt;0.01) in group A; while the comparisons in group B were not significant (Pgt;0.05). Conclusion Uric acid metabolism correlates with triacylglycerol metabolism.
目的:對無明顯心血管病(CVD)臨床癥狀者的高甘油三酯(TG)≥1.60 mmol/L低高密度脂蛋白膽固醇(HDL-C)≤1.18 mmol/L伴有活動平板運動試驗(TET)心電圖(ECG)陽性和TET ECG陰性的缺血性心臟病(IHD)的危險因素進行了對比觀察。〖HTH〗方法:〖HT5”SS〗對無明顯CVD臨床癥狀的2900例受試者檢測TG/HDL-C、其中伴有TET ECG陽性(缺血型ST-T改變)者500例和TET ECG陰性(不伴有缺血型ST-T改變)者2500例進行了5年對比觀察, 預測其預后。〖HTH〗結果〖HTSS〗:在 5年隨訪的觀察中高TG(≥1.60 mmol/L)/低HDL-C(≤1.18 mmmol/L)伴有TET ECG陽性者500例的IHD的發生(30例)率為6.00%;IHD死亡(14例)率為2.80%。而高TG/低HDL-C TET ECG 陰性者2500例的IHD發生(25例)率為2.80%, 死亡(8例)率為0.32%, Plt;0.001。表明高TG/低HDL-C伴有TET ECG陽性者是IHD的較大危險因素。結論:高TG/低H DL-C, 伴有TET ECG陽性對IHD者的死亡率的預測有重要意義, 提示二者指標共同作用對IHD者極為不利。
ObjectiveTo summarize the research progress of diagnosis and treatment in hypertriglyceridemia pancreatitis in recent years.MethodsThrough the retrieval of relevant literatures, the progress of diagnosis and treatment in hypertriglyceridemia pancreatitis were reviewed.ResultsHypertriglyceridemia pancreatitis is a rare acute pancreatitis, but with the improvement of living standard and the change of diet structure, the incidence of this disease in recent years was increasing, and more likely to lead to complications, causing serious consequences. The treatment of hypertriglyceridemia pancreatitis in addition to the routine treatment of pancreatitis, attention should also be paid to the rapid reduction of blood triglyceride levels, including plasma exchange, the use of low molecular weight heparin and insulin, and the use of lipid-lowering drugs.ConclusionsHypertriglyceridemia pancreatitis is more severe than acute pancreatitis caused by other causes, and the incidence of complications is higher. Maintaining a lower level of blood triglycerides is of great significance for the improvement of this pancreatitis and the prevention of the recurrence of pancreatitis.