目的觀察鹽酸沙格雷酯治療血栓閉塞性脈管炎的近期療效。 方法回顧性分析筆者所在醫院2009年7月至2012年7月期間采用鹽酸沙格雷酯治療的28例血栓閉塞性脈管炎患者的臨床資料，比較服藥前后患者間歇性跛行距離、靜息痛評分、冷感評分及潰瘍面積的差異。 結果用藥4周后，患者的無痛跛行距離〔（287±32）m比（167±28）m〕和最長跛行距離〔（315±40）m比（187±34）m〕延長，靜息痛得分（1分比2分）和冷感得分（1分比2分）降低，潰瘍面積縮小〔（6.18±3.28）cm2比（10.06±4.25）cm2〕，差異均具有統計學意義（P<0.05）。 結論鹽酸沙格雷酯能改善血栓閉塞性脈管炎的缺血癥狀。
Objective To explore the clinical experience on treatment of thromboangitis obliterans (TAO) by embolectomy. Methods Fourteen of 121 patients with TAO treated in our hospital from March 2000 to March 2010 were included in this study. Total 14 limbs consisted of 2 upper extremities and 12 lower extremities. Among these cases, 8 cases underwent embolectomy and 6 cases received embolectomy combined the stem cell transplantation. Results Of 14 cases of TAO patients, 11 cases were successfully treated by surgery and 3 cases failed. After successful operation, patient’s pain disappeared and anklebrachial index improved obviously. Seven patients treated successfully by surgery were followed up from 5 months to 8.5 years (mean 4 years), in whom the intermittent claudication and rest pain disappeared in 4 cases, and disease deteriorated in 2 cases who always smoked, and one case had intermittent claudication who stopped smoking. For 3 cases patients failed to operation, one lost followup, one had to receive a below knee amputation due to keep smoking after operation, and one case who stopped smoking underwent alleviative symptoms for 3 years. Conclusion Embolectomy is a safe and effective technique for treating TAO.