新生兒癲癇病因、臨床表現及腦電圖特點概述_Journal of Epilepsy

Authors：

李露瑩 ,  陳錦

重慶醫科大學附屬兒童醫院神經內科, 國家兒童健康與疾病臨床醫學研究中心, 兒童發育疾病研究教育部重點實驗室, 兒科學重慶市重點實驗室（重慶 400014）;

Corresponding?author：

陳錦, Email: chenjinsuper@hotmail.com

Keywords：

新生兒癲癇; 病因; 臨床表現; 腦電圖

DOI：

10.7507/2096-0247.202211010

Video：

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新生兒癲癇被認為是新生兒期常見的神經系統急癥，病因復雜，以急性腦損傷為主，但隨著基因檢測技術的開展，更多遺傳相關的病因被發現。發作類型按照新的分類方法可分為電發作及電-臨床發作，其中電-臨床發作包括運動性發作和非運動性發作，均為局灶性發作。視頻腦電圖作為重要的監測手段能為診斷及預后判斷方面帶來極大幫助。除此，頭顱超聲（Cranial ultrasound，CUS）、頭顱核磁共振（Magnetic resonance imaging，MRI）、核磁共振波譜也有各自優點。早期識別與確定病因對判斷病情及改善預后有重要作用。

Citation： 李露瑩, 陳錦. 新生兒癲癇病因、臨床表現及腦電圖特點概述. Journal of Epilepsy, 2023, 9(2): 156-159. doi: 10.7507/2096-0247.202211010 Copy

1.	吳靜, 姜毅, 侯新琳, 等. 新生兒驚厥臨床及視頻腦電圖特點分析. 中國新生兒科雜志, 2015, 30(6): 418-422.
2.	馬思敏, 楊琳, 周文浩. 新生兒驚厥診斷和治療進展. 中國循證兒科雜志, 2015, 10(02): 126-135.
3.	楊會陽, 束曉梅. 新生兒驚厥的遺傳代謝性病因及預后. 中華實用兒科臨床雜志, 2019, (14): 1109-1112.
4.	Glass HC, Shellhaas RA, Tsuchida TN, et al. Seizures in preterm neonates: a multicenter observational cohort study. Pediatr Neurol, 2017, 72: 19-24.
5.	Pellegrin S, Munoz FM, Padula M, et al. Neonatal seizures: case definition & guidelines for data collection, analysis, and presentation of immunization safety data. Vaccine, 2019, 37(52): 7596-7609.
6.	Pressler RM, Cilio MR, Mizrahi EM, et al. The ILAE classification of seizures and the epilepsies: Modification for seizures in the neonate. Position paper by the ILAE Task Force on Neonatal Seizures. Epilepsia, 2021, 62(3): 615-628.
7.	劉曉燕. 臨床腦電圖學. 2 版. 北京:人民衛生出版社, 2017: 590-635.
8.	Donovan MD, Griffin BT, Kharoshankaya L, et al. Pharmacotherapy for neonatal seizures: current knowledge and future perspectives. Drugs, 2016, 76(6): 647-661.
9.	Pisani F, Spagnoli C, Falsaperla R, et al. Seizures in the neonate: a review of etiologies and outcomes. Seizure, 2021, 85: 48-56.
10.	Glass HC, Shellhaas RA, Wusthoff CJ, et al. Contemporary profile of seizures in neonates: a prospective cohort study. J Pediatr, 2016, 174: 98-103.e1.
11.	Kaminiów K, Kozak S, Paprocka J. Neonatal seizures revisited. Children (Basel), 2021, 8(2): 155.
12.	Ramantani G, Schmitt B, Plecko B, et al. Neonatal seizures-are we there yet? Neuropediatrics, 2019, 50（5）: 280-293.
13.	Soul JS. Acute symptomatic seizures in term neonates: etiologies and treatments. Semin Fetal Neonatal Med, 2018, 23(3): 183-190.
14.	Ziobro J, Shellhaas RA. Neonatal seizures: diagnosis, etiologies, and management. Semin Neurol, 2020, 40(2): 246-256.
15.	Rafay MF, Cortez MA, de Veber GA, et al. Predictive value of clinical and EEG features in the diagnosis of stroke and hypoxic ischemic encephalopathy in neonates with seizures. Stroke, 2009, 40(7): 2402-2407.
16.	于灝婷. 新生兒驚厥預后相關因素的研究進展. 國際兒科學雜志, 2020, 24(3): 197-201.
17.	鄭俠, 陳嬌陽, 黑明燕, 等. 不明原因新生兒驚厥基因分析的臨床研究. 中華新生兒科雜志, 2020, 35(5): 346-351.
18.	Massey SL, Jensen FE, Abend NS. Electroencephalographic monitoring for seizure identification and prognosis in term neonates. Semin Fetal Neonatal Med, 2018, 23(3): 168-174.
19.	Sansevere AJ, Kapur K, Peters JM, et al. Seizure prediction models in the neonatal intensive care unit. J Clin Neurophysiol, 2019, 36(3): 186-194.
20.	Shellhaas RA, Chang T, Tsuchida T, et al. The American Clinical Neurophysiology Society's guideline on continuous electroencephalography monitoring in neonates. J Clin Neurophysiol, 2011, 28(6): 611-617.
21.	Malone A, Ryan CA, Fitzgerald A, et al. Interobserver agreement in neonatal seizure identification. Epilepsia, 2009, 50(9): 2097-2101.
22.	Shellhaas RA. Continuous long-term electroencephalography: the gold standard for neonatal seizure diagnosis. Semin Fetal Neonatal Med, 2015, 20(3): 149-153.
23.	Shellhaas RA. Neonatal seizures reach the mainstream: The ILAE classification of seizures in the neonate. Epilepsia, 2021, 62(3): 629-631.
24.	Zuberi SM, Wirrell E, Yozawitz E, et al. ILAE classification and definition of epilepsy syndromes with onset in neonates and infants: Position statement by the ILAE Task Force on Nosology and Definitions. Epilepsia, 2022, 63(6): 1349-1397.
25.	Hirsch LJ, Fong MWK, Leitinger M, et al. American Clinical Neurophysiology Society's standardized critical care EEG terminology: 2021 version. J Clin Neurophysiol, 2021, 38(1): 1-29.
26.	韓燁, 符娜, 秦炯. 腦電圖在新生兒驚厥診斷中的應用. 癲癇雜志, 2018, 4(3): 234-237.
27.	Nunes ML, Yozawitz EG, Zuberi S, et al. Neonatal seizures: Is there a relationship between ictal electroclinical features and etiology? A critical appraisal based on a systematic literature review. Epilepsia Open, 2019, 4(1): 10-29.
28.	陳新, 陸亞東, 周曉光, 等. 視頻腦電圖對新生兒驚厥的診斷價值及預后評估意義. 中華新生兒科雜志, 2019, 34(1): 24-28.
29.	馬源培, 郝佳, 楊志仙, 等. 新生兒驚厥視頻腦電圖特點及其與臨床表現和預后關系的研究. 中華新生兒科雜志, 2021, 36(1): 3-7.
30.	Fitzgerald MP, Massey SL, Fung FW, et al. High electroencephalographic seizure exposure is associated with unfavorable outcomes in neonates with hypoxic-ischemic encephalopathy. Seizure, 2018, 61: 221-226.
31.	Sharpe C, Reiner GE, Davis SL, et al. Levetiracetam versus phenobarbital for neonatal seizures: a randomized controlled trial. Pediatrics, 2020, 145(6): e20193182.

1. 吳靜, 姜毅, 侯新琳, 等. 新生兒驚厥臨床及視頻腦電圖特點分析. 中國新生兒科雜志, 2015, 30(6): 418-422.
2. 馬思敏, 楊琳, 周文浩. 新生兒驚厥診斷和治療進展. 中國循證兒科雜志, 2015, 10(02): 126-135.
3. 楊會陽, 束曉梅. 新生兒驚厥的遺傳代謝性病因及預后. 中華實用兒科臨床雜志, 2019, (14): 1109-1112.
4. Glass HC, Shellhaas RA, Tsuchida TN, et al. Seizures in preterm neonates: a multicenter observational cohort study. Pediatr Neurol, 2017, 72: 19-24.
5. Pellegrin S, Munoz FM, Padula M, et al. Neonatal seizures: case definition & guidelines for data collection, analysis, and presentation of immunization safety data. Vaccine, 2019, 37(52): 7596-7609.
6. Pressler RM, Cilio MR, Mizrahi EM, et al. The ILAE classification of seizures and the epilepsies: Modification for seizures in the neonate. Position paper by the ILAE Task Force on Neonatal Seizures. Epilepsia, 2021, 62(3): 615-628.
7. 劉曉燕. 臨床腦電圖學. 2 版. 北京:人民衛生出版社, 2017: 590-635.
8. Donovan MD, Griffin BT, Kharoshankaya L, et al. Pharmacotherapy for neonatal seizures: current knowledge and future perspectives. Drugs, 2016, 76(6): 647-661.
9. Pisani F, Spagnoli C, Falsaperla R, et al. Seizures in the neonate: a review of etiologies and outcomes. Seizure, 2021, 85: 48-56.
10. Glass HC, Shellhaas RA, Wusthoff CJ, et al. Contemporary profile of seizures in neonates: a prospective cohort study. J Pediatr, 2016, 174: 98-103.e1.
11. Kaminiów K, Kozak S, Paprocka J. Neonatal seizures revisited. Children (Basel), 2021, 8(2): 155.
12. Ramantani G, Schmitt B, Plecko B, et al. Neonatal seizures-are we there yet? Neuropediatrics, 2019, 50（5）: 280-293.
13. Soul JS. Acute symptomatic seizures in term neonates: etiologies and treatments. Semin Fetal Neonatal Med, 2018, 23(3): 183-190.
14. Ziobro J, Shellhaas RA. Neonatal seizures: diagnosis, etiologies, and management. Semin Neurol, 2020, 40(2): 246-256.
15. Rafay MF, Cortez MA, de Veber GA, et al. Predictive value of clinical and EEG features in the diagnosis of stroke and hypoxic ischemic encephalopathy in neonates with seizures. Stroke, 2009, 40(7): 2402-2407.
16. 于灝婷. 新生兒驚厥預后相關因素的研究進展. 國際兒科學雜志, 2020, 24(3): 197-201.
17. 鄭俠, 陳嬌陽, 黑明燕, 等. 不明原因新生兒驚厥基因分析的臨床研究. 中華新生兒科雜志, 2020, 35(5): 346-351.
18. Massey SL, Jensen FE, Abend NS. Electroencephalographic monitoring for seizure identification and prognosis in term neonates. Semin Fetal Neonatal Med, 2018, 23(3): 168-174.
19. Sansevere AJ, Kapur K, Peters JM, et al. Seizure prediction models in the neonatal intensive care unit. J Clin Neurophysiol, 2019, 36(3): 186-194.
20. Shellhaas RA, Chang T, Tsuchida T, et al. The American Clinical Neurophysiology Society's guideline on continuous electroencephalography monitoring in neonates. J Clin Neurophysiol, 2011, 28(6): 611-617.
21. Malone A, Ryan CA, Fitzgerald A, et al. Interobserver agreement in neonatal seizure identification. Epilepsia, 2009, 50(9): 2097-2101.
22. Shellhaas RA. Continuous long-term electroencephalography: the gold standard for neonatal seizure diagnosis. Semin Fetal Neonatal Med, 2015, 20(3): 149-153.
23. Shellhaas RA. Neonatal seizures reach the mainstream: The ILAE classification of seizures in the neonate. Epilepsia, 2021, 62(3): 629-631.
24. Zuberi SM, Wirrell E, Yozawitz E, et al. ILAE classification and definition of epilepsy syndromes with onset in neonates and infants: Position statement by the ILAE Task Force on Nosology and Definitions. Epilepsia, 2022, 63(6): 1349-1397.
25. Hirsch LJ, Fong MWK, Leitinger M, et al. American Clinical Neurophysiology Society's standardized critical care EEG terminology: 2021 version. J Clin Neurophysiol, 2021, 38(1): 1-29.
26. 韓燁, 符娜, 秦炯. 腦電圖在新生兒驚厥診斷中的應用. 癲癇雜志, 2018, 4(3): 234-237.
27. Nunes ML, Yozawitz EG, Zuberi S, et al. Neonatal seizures: Is there a relationship between ictal electroclinical features and etiology? A critical appraisal based on a systematic literature review. Epilepsia Open, 2019, 4(1): 10-29.
28. 陳新, 陸亞東, 周曉光, 等. 視頻腦電圖對新生兒驚厥的診斷價值及預后評估意義. 中華新生兒科雜志, 2019, 34(1): 24-28.
29. 馬源培, 郝佳, 楊志仙, 等. 新生兒驚厥視頻腦電圖特點及其與臨床表現和預后關系的研究. 中華新生兒科雜志, 2021, 36(1): 3-7.
30. Fitzgerald MP, Massey SL, Fung FW, et al. High electroencephalographic seizure exposure is associated with unfavorable outcomes in neonates with hypoxic-ischemic encephalopathy. Seizure, 2018, 61: 221-226.
31. Sharpe C, Reiner GE, Davis SL, et al. Levetiracetam versus phenobarbital for neonatal seizures: a randomized controlled trial. Pediatrics, 2020, 145(6): e20193182.

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