ILAE 發作和癲癇分類：對新生兒癲癇發作的調整—ILAE 新生兒癲癇特別工作組制定_Journal of Epilepsy

Authors：

 Ronit MPressler , Maria RobertaCilio , Eli MMizrahi , 劉旸　譯 , 吳遜　審

Corresponding?author：

Ronit MPressler, Email: ronit.pressler@gosh.nhs.uk

Keywords：

分類; EEG（腦電圖）; 癲癇; 新生兒發作; 癥狀學

DOI：

10.7507/2096-0247.20210074

Video：

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Abstract Full text Figures/Tables Video References Cited by

發作是新生兒期最常見的神經急癥，與嬰兒和兒童不同，癲癇通常是由急性病因引起的誘發性發作，并且可能僅僅表現為腦電圖異常。特別需要提出的是，年齡較大的兒童和成人癲癇發作和癲癇的分類方案可能不適用于新生兒發作。因此，國際抗癲癇聯盟（ILAE）成立了新生兒癲癇工作組，改進 2017 年 ILAE 發作和癲癇分類，以適用于新生兒。新生兒分類框架強調了腦電圖（EEG）在新生兒發作診斷中的作用，并包括了與該年齡組適應的發作類型的分類。發作的類型是由主要的臨床特征決定的。許多新生兒發作僅有腦電圖表現，沒有明顯的臨床特征；因此，這些都包括在推薦的分類中。沒有相關腦電圖的臨床事件不包括在內。由于新生兒期發作已被證明有局灶性起源的發作，因此沒有必要將其劃分為局灶性和廣泛性。發作可以有運動（自發性、陣攣性、癲癇性痙攣、肌陣攣、強直）、非運動性（自主神經、行為停止）或繼發表現。該分類允許用戶在對這個年齡組的癲癇發作進行分類時選擇詳細程度。

Citation： Ronit MPressler, Maria RobertaCilio, Eli MMizrahi, 劉旸　譯, 吳遜　審. ILAE 發作和癲癇分類：對新生兒癲癇發作的調整—ILAE 新生兒癲癇特別工作組制定. Journal of Epilepsy, 2021, 7(5): 445-456. doi: 10.7507/2096-0247.20210074 Copy

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2. WHO. Pretermbirth, fact sheet, 2016.
3. Lanska MJ, Lanska DJ, Baumann RJ, et al. A population-based study of neonatal seizures in Fayette County, Kentucky. Neurology, 1995, 45(4): 724-732.
4. Pellegrin S, Munoz FM, Padula M, et al. Neonatal seizures: Case definition & guidelines for data collection, analysis, and presentation of immunization safety data. Vaccine, 2019, 37(52): 7596-7609.
5. Ronen GM, Penney S, Andrews W. The epidemiology of clinical neonatal seizures in Newfoundland: a population-based study. J Pediatr, 1999, 134(1): 71-75.
6. Fisher RS, Cross JH, D'Souza C, et al. Instruction manual for the ILAE 2017 operational classification of seizure types. Epilepsia, 2017, 58(4): 531-542.
7. Fisher RS, Cross JH, French JA, et al. Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology. Epilepsia, 2017, 58(4): 522-530.
8. Glass HC, Shellhaas RA, Wusthoff CJ, et al. Contemporary profile of seizures in neonates: a prospective cohort study. J Pediatr, 2016, 174: 98-103.
9. Mizrahi EM, Kellaway P. Characterization and classification of neonatal seizures. Neurology, 1987, 37(12): 1837-1844.
10. Scher MS, Alvin J, Gaus L, et al. Uncoupling of EEG-clinical neonatal seizures after antiepileptic drug use. Pediatr Neurol, 2003, 28(4): 277-280.
11. Nash KB, Bonifacio SL, Glass HC, et al. Video-EEG monitoring in newborns with hypoxic-ischemic encephalopathy treated with hypothermia. Neurology, 2011, 76(6): 556-262.
12. Malone A, Ryan CA, Fitzgerald A, et al. Interobserver agreement in neonatal seizure identification. Epilepsia, 2009, 50(9): 2097-2101.
13. Galanopoulou AS, Moshe SL. In search of epilepsy biomarkers in the immature brain: goals, challenges and strategies. Biomarkers Med, 2011, 5(5): 615-628.
14. Haut SR, Veliskova J, Moshe SL. Susceptibility of immature and adult brains to seizure effects. Lancet Neurol, 2004, 3(10): 608-617.
15. Murray DM, Boylan GB, Ali I, et al. Defining the gap between electrographic seizure burden, clinical expression and staff recognition of neonatal seizures. Arch Dis Child Fetal Neonatal Ed, 2008, 93(3): F187-F191.
16. Boylan GB, Pressler RM, Pressler RM, et al. Outcome of electroclinical, electrographic, andclinical seizures in the newborn infant. Dev Med Child Neurol, 1999, 41(12): 819-825.
17. Boylan GB, Rennie JM, Pressler RM, et al. Phenobarbitone, neonatal seizures, and video-EEG. Arch Dis Child Fetal Neonatal Ed, 2002, 86(3): F165-F170.
18. Shellhaas RA, Chang T, Tsuchida T, et al. The American clinical neurophysiology society's guideline on continuous electroencephalography monitoring in neonates. J Clin Neurophysiol, 2011, 28(6): 611-607.
19. Hahn CD, Riviello JJ. Neonatal Seizures and EEG. NeoReviews, 2004, 5(8): e350-e355.
20. Mathieson SR, Livingstone V, Low E, et al. Phenobarbital reduces EEG amplitude and propagation of neonatal seizures but does not alter performance of automated seizure detection. Clin Neurophysiol, 2016, 127(10): 3343-3350.
21. Weiner SP, Painter MJ, Geva D, et al. Neonatal seizures: electroclinical dissociation. Pediatr Neurol, 1991, 7(5): 363-368.
22. Kharoshankaya L, Stevenson NJ, Livingstone V, et al. Seizure burden and neurodevelopmental outcome in neonates with hypoxic-ischemic encephalopathy. Dev Med Child Neurol, 2016, 58(12): 1242-1208.
23. McBride MC, Laroia N, Guillet R. Electrographic seizures in neonates correlate with poor neurodevelopmental outcome. Neurology, 2000, 55(4): 506-513.
24. Miller SP, Weiss J, Barnwell A, et al. Seizure-associated brain injury in term newborns with perinatal asphyxia. Neurology, 2002, 58(4): 542-548.
25. Srinivasakumar P, Zempel J, Trivedi S, et al. Treating EEG seizures in hypoxic ischemic encephalopathy: a randomized controlled trial. Pediatrics, 2015, 136(5): e1302-e1309.
26. van Rooij LGM, Toet MC, van Huffelen AC, et al. Effect of treatment of subclinical neonatal seizures detected with aEEG: randomized, controlled trial. Pediatrics, 2010, 125(2): e358-e366.
27. Tsuchida TN, Wusthoff CJ, Shellhaas RA, et al. American clinical neurophysiology society standardized EEG terminology and categorization for the description of continuous EEG monitoring in neonates: report of the american clinical neurophysiology society critical care monitoring committee. J Clin Neurophysiol, 2013, 30(2): 161-173.
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