Clinical analysis of 20 patients with electrical status epilepticus during sleep_Journal of Epilepsy

Authors：

GAO Jie , WANG Luojun ,  DENG Yanchun

Department of Neurology, Xijing Hospital of Airforce Military Medical School, Xi’an 710032, China;

Corresponding?author：

DENG Yanchun, Email: yanchund@fmmu.edu.cn

Keywords：

Epilepsy; ESES; Clinical Research; EEG; Epilepsy Syndrome

DOI：

10.7507/2096-0247.20210063

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To improve the clinicians’ understanding and treatment level of electrical status epilepticus during sleep by analyzing the clinical data of patients with ESES retrospectively.Methods We collected 20 cases from 2018 to 2019 diagnosed in our hospital by clinical and 24-hour video EEG confirmed and analyzed the clinical manifestations, EEG features, seizure type, classification of epilepsy syndrome as well as the imaging findings.Results Among the 20 patients, there were 12 males and 8 females, the mean age was (10.96±2.68) years old, and the first onset age was (8.90±1.93) years old. Epilepsy seizure as the first symptom is most common, the EEG showed a broad or localized sustained discharge, generalized tonic clonic seizure is the main form of seizure type in most patients, ECSWS is the most prominent in the epilepsy syndrome, for small lesion through MR can be found early.Conclusion Most patients have partial or generalized seizures, which have a range of cognitive impairment, mental decline or other issues. It is important to improve the cognitive function, behavior, neuropsychology of patients by long term video EEG monitoring in the early stage.

Citation： GAO Jie, WANG Luojun, DENG Yanchun. Clinical analysis of 20 patients with electrical status epilepticus during sleep. Journal of Epilepsy, 2021, 7(5): 392-396. doi: 10.7507/2096-0247.20210063 Copy

1.	Patry G, Lyagoubi S, Tassinari CA. Subclinical "electrical status epilepticus" induced by sleep in children. A clinical and electroencephalographic study of six cases. Arch Neurol, 1971, 24(3): 242-252.
2.	張瑋娜, 鄒麗萍. 兒童睡眠中癲癇性電持續狀態定義病因學及流行病學概述. 中國實用兒科雜志, 2013, 28(2): 81-82.
3.	劉曉燕, 秦炯, 包新華等. 兒童睡眠中癲癇性電持續狀態的臨床及腦電特征研究. 中國實用兒科雜志, 2000, 15(5): 285-287.
4.	Brazzo D, Pera MC, Fasce M, et al. epileptic encephalopathies with status epilepticus during sleep: new techniques for understanding pathophysiology and therapeutic options. Epilepsy Res Treat, 2012: 642725.
5.	劉曉燕. 兒童睡眠中癲癇性電持續狀態的腦電圖診斷. 中國實用兒科雜志, 2013, 28(2): 83-85.
6.	曹園園, 彭鋒, 王文杰等. Rolandic區放電的27例癲癇患兒長程視頻腦電圖及臨床特征分析. 中華神經醫學雜志, 2014, 13(12): 1264-1268.
7.	Guerrini R, Belmonte A, Genton P. Antiepileptic drug-induced worsening of seizures in children. Epilepsia, 1998, 39(Suppl 3): S2-10.
8.	Nikanorova M, Miranda MJ, Atkins M, et al. Ketogenic diet in the treatment of refractory continuous spikes and waves during slow sleep. Epilepsia, 2009, 50(5): 1127-1131.
9.	Kelley SA, Kossoff EH et al. How effective is the ketogenic diet for electrical status epilepticus of sleep? Epilepsy Res, 2016, 127: 339-343.
10.	梁展榮. 睡眠中癲癇性電持續狀態的治療進展. 癲癇與神經電生理學雜志, 2019, 28(1): 44-49.
11.	葛爭, 戴園園. 甲潑尼龍沖擊療法對睡眠中癲癇性電持續狀態患兒的臨床療效及血清細胞因子的影響. 中南藥學, 2020, 18(05): 877-881.
12.	陳靜, 楊志仙, 劉曉燕等. 甲潑尼龍沖擊治療對兒童睡眠中癲癇性電持續狀態的療效. 中華兒科雜志, 2014, 52(9): 678-682.
13.	Fainberg N, Harper A, Tchapyjnikov D, et al. Response to immunotherapy in a patient with Landau-Kleffner syndrome and GRIN2A mutation. Epileptic Disord, 2016, 18(1): 97-100.
14.	Geva-Dayan K, Shorer Z, Menascu S, et al. Immunoglobulin treatment for severe childhood epilepsy. ediatr Neurol, 2012, 46(6): 375-381.
15.	Altunel A, Sever A, et al. ACTH has beneficial effects on stuttering in ADHD and ASD patients with ESES: A retrospective study. Brain Dev, 2017, 39(2): 130-137.
16.	李慧, 王華. 甲潑尼龍沖擊治療對兒童睡眠中癲癇性電持續狀態免疫功能的影響. 中國小兒急救醫學, 2020, 27(2): 119-124.

1. Patry G, Lyagoubi S, Tassinari CA. Subclinical "electrical status epilepticus" induced by sleep in children. A clinical and electroencephalographic study of six cases. Arch Neurol, 1971, 24(3): 242-252.
2. 張瑋娜, 鄒麗萍. 兒童睡眠中癲癇性電持續狀態定義病因學及流行病學概述. 中國實用兒科雜志, 2013, 28(2): 81-82.
3. 劉曉燕, 秦炯, 包新華等. 兒童睡眠中癲癇性電持續狀態的臨床及腦電特征研究. 中國實用兒科雜志, 2000, 15(5): 285-287.
4. Brazzo D, Pera MC, Fasce M, et al. epileptic encephalopathies with status epilepticus during sleep: new techniques for understanding pathophysiology and therapeutic options. Epilepsy Res Treat, 2012: 642725.
5. 劉曉燕. 兒童睡眠中癲癇性電持續狀態的腦電圖診斷. 中國實用兒科雜志, 2013, 28(2): 83-85.
6. 曹園園, 彭鋒, 王文杰等. Rolandic區放電的27例癲癇患兒長程視頻腦電圖及臨床特征分析. 中華神經醫學雜志, 2014, 13(12): 1264-1268.
7. Guerrini R, Belmonte A, Genton P. Antiepileptic drug-induced worsening of seizures in children. Epilepsia, 1998, 39(Suppl 3): S2-10.
8. Nikanorova M, Miranda MJ, Atkins M, et al. Ketogenic diet in the treatment of refractory continuous spikes and waves during slow sleep. Epilepsia, 2009, 50(5): 1127-1131.
9. Kelley SA, Kossoff EH et al. How effective is the ketogenic diet for electrical status epilepticus of sleep? Epilepsy Res, 2016, 127: 339-343.
10. 梁展榮. 睡眠中癲癇性電持續狀態的治療進展. 癲癇與神經電生理學雜志, 2019, 28(1): 44-49.
11. 葛爭, 戴園園. 甲潑尼龍沖擊療法對睡眠中癲癇性電持續狀態患兒的臨床療效及血清細胞因子的影響. 中南藥學, 2020, 18(05): 877-881.
12. 陳靜, 楊志仙, 劉曉燕等. 甲潑尼龍沖擊治療對兒童睡眠中癲癇性電持續狀態的療效. 中華兒科雜志, 2014, 52(9): 678-682.
13. Fainberg N, Harper A, Tchapyjnikov D, et al. Response to immunotherapy in a patient with Landau-Kleffner syndrome and GRIN2A mutation. Epileptic Disord, 2016, 18(1): 97-100.
14. Geva-Dayan K, Shorer Z, Menascu S, et al. Immunoglobulin treatment for severe childhood epilepsy. ediatr Neurol, 2012, 46(6): 375-381.
15. Altunel A, Sever A, et al. ACTH has beneficial effects on stuttering in ADHD and ASD patients with ESES: A retrospective study. Brain Dev, 2017, 39(2): 130-137.
16. 李慧, 王華. 甲潑尼龍沖擊治療對兒童睡眠中癲癇性電持續狀態免疫功能的影響. 中國小兒急救醫學, 2020, 27(2): 119-124.

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