多模態磁共振成像在兒童癲癇中的研究應用_Journal of Epilepsy

Authors：

楊偉明 ^1,2 , 孫丹 ² ,  劉智勝 ²

1. ;
2. ;

Corresponding?author：

劉智勝, Email: liuzsc@126.com

Keywords：

癲癇; 彌散張量成像; 擴散峰度成像; 神經突方向離散度和密度成像; 動脈自旋標記灌注成像; 磁共振波譜成像

DOI：

10.7507/2096-0247.20180067

Video：

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Abstract Full text Figures/Tables Video References Cited by

癲癇是常見的神經系統疾病，病理生理機制復雜，一部分患者難以找到病因。核磁共振成像（MRI）是癲癇診斷，尤其在癲癇灶定位方面的一項重要的影像學技術。隨著功能磁共振技術（fMRI）的不斷進步，在癲癇的診治中日益突出，可以從生化微結構水平及腦網絡方面探討其發病機制，對明確病因具有重要意義，從而有助于實施個體化精準治療，文章綜述了近年來多模態 MRI 技術在癲癇領域的應用。

Citation： 楊偉明, 孫丹, 劉智勝. 多模態磁共振成像在兒童癲癇中的研究應用. Journal of Epilepsy, 2018, 4(5): 406-410. doi: 10.7507/2096-0247.20180067 Copy

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2.	Widjaja E, Geibprasert S, Otsubo H, et al. Diffusion tensor imaging assessment of the epileptogenic zone in children with localization-related epilepsy. Am J Neuroradiol, 2011, 32(10): 1789-1794.
3.	Widjaja E, Kis A, Go C, et al. Abnormal white matter on diffusion tensor imaging in children with new-onset seizures. Epilepsy Res, 2013, 104(1-2): 105-111.
4.	Bao Y, He R, Zeng Q, et al. Investigation of microstructural abnormalities in white and gray matter around hippocampus with diffusion tensor imaging (DTI) in temporal lobe epilepsy (TLE). Epilepsy Behav, 2018, 83: 44-49.
5.	Prayer D, Barkovich AJ, Kirschner DA, et al. Visualization of non structural changes in early white matter development on diffusion weighted MR images: evidence supporting premyelinationanisotropy. Am J Neuroradiol, 2001, 22(8): 1572-1576.
6.	Slinger G, Sinke MRT, Braun KPJ, et al. White matter abnormalities at a regional and voxel level in focal and generalized epilepsy: A systematic review and meta-analysis. Neuroimage Clin, 2016, 12: 902-909.
7.	Mueller SG, Laxer KD, Cashdollar N, et al. Identification of abnormal neuronal metabolism outside the seizure focus in temporal lobe epilepsy. Epilepsia, 2004, 45(4): 355-366.
8.	Jr EJ, Thompson PM, Stern JM, et al. Connectomics and epilepsy. Curr Opin Neurol, 2013, 26(2): 186-194.
9.	Chiang S, Levin HS, Wilde E, et al. White matter structural connectivity changes correlate with epilepsy duration in temporal lobe epilepsy. Epilepsy Res, 2016, 120: 37-46.
10.	Liu Z, Xu Y, An J, et al. Altered brain white matter integrity in temporal lobe epilepsy: A TBSS study. J Neuroimaging, 2015, 25(3): 460-464.
11.	Ahmadi ME, Hagler DJ, McDonald CR, et al. Side matters: diffusion tensor imaging tractography in left and right temporal lobe epilepsy. Am J Neuroradiol, 2009, 30(9): 1740-1747.
12.	Lin JJ, Salamon N, Lee AD, et al. Reduced neocortical thickness and complexity mapped in mesial temporal lobe epilepsy with hippocampal sclerosis. Cereb Cortex, 2007, 17(9): 2007-2018.
13.	Otte WM, van Eijsden P, Sander JW, et al. A meta-analysis of white matter changes in temporal lobe epilepsy as studied with diffusion tensor imaging. Epilepsia, 2012, 53(4): 659-667.
14.	Concha L, Kim H, Bernasconi A, et al. Spatial patterns of water diffusion along white matter tracts in temporal lobe epilepsy. Neurology, 2012, 79(5): 455-462.
15.	Kelm ND, West KL, Carson RP, et al. Evaulation of diffusion kurtosis imaging in ex vivo hypomyelinated mouse brains. NeuroImage, 2016, 124: 612-626.
16.	Steven AJ, Zhuo J, Melhem ER. Diffusion kurtosis imaging: an emerging technique for evaluating the microstructural environment of the brain. Am J Roentgenol, 2014, 202(1): W26-33.
17.	Zhang Y, Yan X, Gao Y, et al. A preliminary study of epilepsy in children using diffusional kurtosis imaging. Clin Neuroradiol, 2013, 23(4): 293-300.
18.	Lee CY, Tbesh A, Spampinato MV, et al. Diffusion kurtosis imaging reveals a distinctive pattern of microstructural alternations in idiopathic generalized epiepsy. Acta Neurol Scand, 2014, 130(3): 48-155.
19.	Zhang Y, Gao Y, Zhou M, et al. A diffusional kurtosis imaging study of idiopathic generalized epilepsy with unilateral interictal epileptiform discharges in children. J Neuroradiol, 2016, 43(5): 339-345.
20.	薛冰, 于兵, 黃明珠, 等. 神經突方向分散度和密度成像技術的應用進展. 中國臨床醫學影像雜志, 2017, 28(12): 896-898.
21.	邵涵鈺. 利用新型擴散成像技術研究年老對大腦微觀結構的影響. 磁共振成像, 2016, 7(3): 218-225.
22.	Téllezzenteno JF, Hernández RL, Moienafshari F, et al. Surgical outcomes in lesional and non-lesional epilepsy: A systematic review and meta-analysis. Epilepsy Res, 2010, 89(2): 310-318.
23.	Fauser S, Sisodiya SM, Martinian L, et al. Multi-focal occurrence of cortical dysplasia in epilepsy patients. Brain A J Neurol, 2009, 132(8): 2079-2090.
24.	Barkovich AJ, Dobyns WB, Guerrini R. Malformations of cortical development and epilepsy. Neuropediatrics, 2005, 5(5): 2-11.
25.	Peng S, Vayenas N. Maintainability analysis of underground mining equipment using genetic algorithms: case studies with an lhd vehicle. J Min, 2014, 2014(1): 1-10.
26.	Zhang H, Schneider T, Wheeler-Kingshott CA, et al. NODDI: practical in vivo neurite orientation dispersion and density imaging of the human brain. Neuroimage, 2012, 61(4): 1000-1016.
27.	Winston GP, Micallef C, Symms MR, et al. Advanced diffusion imaging sequences could aid assessing patients with focal cortical dysplasia and epilepsy. Epilepsy Res, 2014, 108(2): 336-339.
28.	Rostampour M, Hashemi H, Najibi SM, et al. Detection of structural abnormalities of cortical and subcortical gray matter in patients with MRI-negative refractory epilepsy using neurite orientation dispersion and density imaging. Physica Medica, 2018, 48: 47-54.
29.	Chen TY, Chiu L, Wua TC, et al. Arteial spin-labeling inroutine clinical practice: a preliminary experience of 200 cases and correlation with MRI and clincial findings. Clin Imag, 2012, 36: 345-352.
30.	Urbach H. Imaging of the epilepsies. Eur Radio, 2005, 15(3): 495-500.
31.	Takanashi J, Oba H, Barkovich AJ, et al. Diffusion MRI abnormalities after prolonged febrile seizures with encephalopathy. Neurology, 2006, 66(9): 1304-1309.
32.	Kuya K, Fujii S, Miyoshi F, et al. A case of acute encephalopathy with biphasic seizures and late reduced diffusion: Utility of arterial spin labeling sequence. Brain Dev, 2016, 39(1): 84-88.
33.	Kamijo Y, Soma K, Kondo R, et al. Transient diffuse cerebral hypoperfusion in Tc-^99m HMPAO SPECT of the brain during withdrawal syndrome following acute barbiturate poisoning. Vet Hum Toxicol, 2002, 44(6): 348-350.
34.	Dierckx RA, Melis K, Dom L, et al. Technetium-^99m hexamethylpropylene amine oxime single photon emission tomography in febrile convulsions. EurJNucl Med, 1992, 19(4): 278-282.
35.	Wolf RL, Alsop DC, Levy-Reis I, et al. Detection of mesial temporal lobe hypoperfusion in patients with temporal lobe epilepsy by use of arterial spin labeled perfusion MRimaging. Am J Neuroradiol, 2001, 22(7): 1334-1341.
36.	沈連芳, 張志強, 王正閣, 等. 腦灌注磁共振成像觀察內側顳葉癲癇病部分及繼發全面發作. 中國醫學影像技術, 2012, 28(4): 626-629.
37.	Caruso PA, Johnson J, Thibert R, et al. The use of magnetic resonance spectroscopy in the evaluation of epilepsy. Neuroimag Clin N Am, 2013, 23(3): 407-424.
38.	Blümcke I. Neuropathology of focal epilepsies: A critical review. Epilepsy Behav, 2009, 15(1): 34-39.
39.	Obata T, Someya Y, Suhara T, et al. Neural damage due to temporal lobe epilepsy: dual-nuclei (proton and phosphorus) magnetic resonance spectroscopy study. Psychiatry Clin Neurosci, 2004, 58(1): 48-53.
40.	Xu MY, Ergene E, Zagardo M, et al. Proton MR spectroscopy in patients with structural MRI-negative temporal lobe epilepsy. J Neuroimaging, 2015, 25(6): 1030-1037.
41.	Swartz BE, Spitz J, Vu AL, et al. Heterogeneity of anatomic regions by MR volumetry in juvenile myoclonic epilepsy. Acta Neurol Scand, 2016, 134(4): 300-308.
42.	Jiang S, Cheng L, Liu Z, et al. Altered local spontaneous brain activity in juvenile myoclonic epilepsy: A preliminary resting-state fMRI study. Neural Plast, 2016, 5: 1-7.
43.	Lin K, Jr HC, Lin J, et al. Magnetic resonance spectroscopy reveals an epileptic network in juvenile myoclonic epilepsy. Epilepsia, 2009, 50(5): 1191-1200.
44.	Zhang L, Li H, Hong P, et al. Proton magnetic resonance spectroscopy in juvenile myoclonic epilepsy: A systematic review and meta-analysis. Epilepsy Res, 2016, 121: 33-38.

1. Winston GP. The potential role of novel diffusion imaging techniques in the understanding and treatment of epilepsy. Quant Imag Med Surg, 2015, 5(2): 279-287.
2. Widjaja E, Geibprasert S, Otsubo H, et al. Diffusion tensor imaging assessment of the epileptogenic zone in children with localization-related epilepsy. Am J Neuroradiol, 2011, 32(10): 1789-1794.
3. Widjaja E, Kis A, Go C, et al. Abnormal white matter on diffusion tensor imaging in children with new-onset seizures. Epilepsy Res, 2013, 104(1-2): 105-111.
4. Bao Y, He R, Zeng Q, et al. Investigation of microstructural abnormalities in white and gray matter around hippocampus with diffusion tensor imaging (DTI) in temporal lobe epilepsy (TLE). Epilepsy Behav, 2018, 83: 44-49.
5. Prayer D, Barkovich AJ, Kirschner DA, et al. Visualization of non structural changes in early white matter development on diffusion weighted MR images: evidence supporting premyelinationanisotropy. Am J Neuroradiol, 2001, 22(8): 1572-1576.
6. Slinger G, Sinke MRT, Braun KPJ, et al. White matter abnormalities at a regional and voxel level in focal and generalized epilepsy: A systematic review and meta-analysis. Neuroimage Clin, 2016, 12: 902-909.
7. Mueller SG, Laxer KD, Cashdollar N, et al. Identification of abnormal neuronal metabolism outside the seizure focus in temporal lobe epilepsy. Epilepsia, 2004, 45(4): 355-366.
8. Jr EJ, Thompson PM, Stern JM, et al. Connectomics and epilepsy. Curr Opin Neurol, 2013, 26(2): 186-194.
9. Chiang S, Levin HS, Wilde E, et al. White matter structural connectivity changes correlate with epilepsy duration in temporal lobe epilepsy. Epilepsy Res, 2016, 120: 37-46.
10. Liu Z, Xu Y, An J, et al. Altered brain white matter integrity in temporal lobe epilepsy: A TBSS study. J Neuroimaging, 2015, 25(3): 460-464.
11. Ahmadi ME, Hagler DJ, McDonald CR, et al. Side matters: diffusion tensor imaging tractography in left and right temporal lobe epilepsy. Am J Neuroradiol, 2009, 30(9): 1740-1747.
12. Lin JJ, Salamon N, Lee AD, et al. Reduced neocortical thickness and complexity mapped in mesial temporal lobe epilepsy with hippocampal sclerosis. Cereb Cortex, 2007, 17(9): 2007-2018.
13. Otte WM, van Eijsden P, Sander JW, et al. A meta-analysis of white matter changes in temporal lobe epilepsy as studied with diffusion tensor imaging. Epilepsia, 2012, 53(4): 659-667.
14. Concha L, Kim H, Bernasconi A, et al. Spatial patterns of water diffusion along white matter tracts in temporal lobe epilepsy. Neurology, 2012, 79(5): 455-462.
15. Kelm ND, West KL, Carson RP, et al. Evaulation of diffusion kurtosis imaging in ex vivo hypomyelinated mouse brains. NeuroImage, 2016, 124: 612-626.
16. Steven AJ, Zhuo J, Melhem ER. Diffusion kurtosis imaging: an emerging technique for evaluating the microstructural environment of the brain. Am J Roentgenol, 2014, 202(1): W26-33.
17. Zhang Y, Yan X, Gao Y, et al. A preliminary study of epilepsy in children using diffusional kurtosis imaging. Clin Neuroradiol, 2013, 23(4): 293-300.
18. Lee CY, Tbesh A, Spampinato MV, et al. Diffusion kurtosis imaging reveals a distinctive pattern of microstructural alternations in idiopathic generalized epiepsy. Acta Neurol Scand, 2014, 130(3): 48-155.
19. Zhang Y, Gao Y, Zhou M, et al. A diffusional kurtosis imaging study of idiopathic generalized epilepsy with unilateral interictal epileptiform discharges in children. J Neuroradiol, 2016, 43(5): 339-345.
20. 薛冰, 于兵, 黃明珠, 等. 神經突方向分散度和密度成像技術的應用進展. 中國臨床醫學影像雜志, 2017, 28(12): 896-898.
21. 邵涵鈺. 利用新型擴散成像技術研究年老對大腦微觀結構的影響. 磁共振成像, 2016, 7(3): 218-225.
22. Téllezzenteno JF, Hernández RL, Moienafshari F, et al. Surgical outcomes in lesional and non-lesional epilepsy: A systematic review and meta-analysis. Epilepsy Res, 2010, 89(2): 310-318.
23. Fauser S, Sisodiya SM, Martinian L, et al. Multi-focal occurrence of cortical dysplasia in epilepsy patients. Brain A J Neurol, 2009, 132(8): 2079-2090.
24. Barkovich AJ, Dobyns WB, Guerrini R. Malformations of cortical development and epilepsy. Neuropediatrics, 2005, 5(5): 2-11.
25. Peng S, Vayenas N. Maintainability analysis of underground mining equipment using genetic algorithms: case studies with an lhd vehicle. J Min, 2014, 2014(1): 1-10.
26. Zhang H, Schneider T, Wheeler-Kingshott CA, et al. NODDI: practical in vivo neurite orientation dispersion and density imaging of the human brain. Neuroimage, 2012, 61(4): 1000-1016.
27. Winston GP, Micallef C, Symms MR, et al. Advanced diffusion imaging sequences could aid assessing patients with focal cortical dysplasia and epilepsy. Epilepsy Res, 2014, 108(2): 336-339.
28. Rostampour M, Hashemi H, Najibi SM, et al. Detection of structural abnormalities of cortical and subcortical gray matter in patients with MRI-negative refractory epilepsy using neurite orientation dispersion and density imaging. Physica Medica, 2018, 48: 47-54.
29. Chen TY, Chiu L, Wua TC, et al. Arteial spin-labeling inroutine clinical practice: a preliminary experience of 200 cases and correlation with MRI and clincial findings. Clin Imag, 2012, 36: 345-352.
30. Urbach H. Imaging of the epilepsies. Eur Radio, 2005, 15(3): 495-500.
31. Takanashi J, Oba H, Barkovich AJ, et al. Diffusion MRI abnormalities after prolonged febrile seizures with encephalopathy. Neurology, 2006, 66(9): 1304-1309.
32. Kuya K, Fujii S, Miyoshi F, et al. A case of acute encephalopathy with biphasic seizures and late reduced diffusion: Utility of arterial spin labeling sequence. Brain Dev, 2016, 39(1): 84-88.
33. Kamijo Y, Soma K, Kondo R, et al. Transient diffuse cerebral hypoperfusion in Tc-^99m HMPAO SPECT of the brain during withdrawal syndrome following acute barbiturate poisoning. Vet Hum Toxicol, 2002, 44(6): 348-350.
34. Dierckx RA, Melis K, Dom L, et al. Technetium-^99m hexamethylpropylene amine oxime single photon emission tomography in febrile convulsions. EurJNucl Med, 1992, 19(4): 278-282.
35. Wolf RL, Alsop DC, Levy-Reis I, et al. Detection of mesial temporal lobe hypoperfusion in patients with temporal lobe epilepsy by use of arterial spin labeled perfusion MRimaging. Am J Neuroradiol, 2001, 22(7): 1334-1341.
36. 沈連芳, 張志強, 王正閣, 等. 腦灌注磁共振成像觀察內側顳葉癲癇病部分及繼發全面發作. 中國醫學影像技術, 2012, 28(4): 626-629.
37. Caruso PA, Johnson J, Thibert R, et al. The use of magnetic resonance spectroscopy in the evaluation of epilepsy. Neuroimag Clin N Am, 2013, 23(3): 407-424.
38. Blümcke I. Neuropathology of focal epilepsies: A critical review. Epilepsy Behav, 2009, 15(1): 34-39.
39. Obata T, Someya Y, Suhara T, et al. Neural damage due to temporal lobe epilepsy: dual-nuclei (proton and phosphorus) magnetic resonance spectroscopy study. Psychiatry Clin Neurosci, 2004, 58(1): 48-53.
40. Xu MY, Ergene E, Zagardo M, et al. Proton MR spectroscopy in patients with structural MRI-negative temporal lobe epilepsy. J Neuroimaging, 2015, 25(6): 1030-1037.
41. Swartz BE, Spitz J, Vu AL, et al. Heterogeneity of anatomic regions by MR volumetry in juvenile myoclonic epilepsy. Acta Neurol Scand, 2016, 134(4): 300-308.
42. Jiang S, Cheng L, Liu Z, et al. Altered local spontaneous brain activity in juvenile myoclonic epilepsy: A preliminary resting-state fMRI study. Neural Plast, 2016, 5: 1-7.
43. Lin K, Jr HC, Lin J, et al. Magnetic resonance spectroscopy reveals an epileptic network in juvenile myoclonic epilepsy. Epilepsia, 2009, 50(5): 1191-1200.
44. Zhang L, Li H, Hong P, et al. Proton magnetic resonance spectroscopy in juvenile myoclonic epilepsy: A systematic review and meta-analysis. Epilepsy Res, 2016, 121: 33-38.

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