Clinical analysis of benign childhood epilepsy with centrotemporal spikes_Journal of Epilepsy

Authors：

 CHENYin ¹ ,  HANYunli ²

1. Department of Pediatrics, Guangxi Matemal and Child Health Hospital, Mate Hospital, Nanning 530022, Guangxi, China;
2. Department of Pediatrics, First Affiliated Hospital of Guangxi Medical University, Nanning 530022, Guangxi, China;

Corresponding?author：

HANYunli, Email: ekyqchenyin@163.com

Keywords：

Childhood epilepsy; Rolandic; Antiepileptic drugs; Therapeutic use

DOI：

10.7507/2096-0247.20150019

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective Using retrospective study to analyze the data of 112 patients with benign childhood epilepsy with centrotemporal spikes (BECTS) and investigate the clinical characteristics and provide some clinical experience in treatment. Methods We collected the medical records of 112 cases of BECTS children in the First Affiliated Hospital of Guangxi Medical University of children's clinics from January 2011 to December 2012. According to whether taking antiepileptic drugs (AEDs) treatment regularly, the 112 cases with BECTS was divided into the treated group and the non-treated group, then analyzed the clinical characteristics between the two groups retrospectively, including age of onset, single episode duration, frequency of seizure, pattern of seizure and EEG performances. Results Through regular AEDs treatment, the duration of a single attack was shortened, generalized tonic-clonic seizure(GTCS) was decreased significantly in the treatment group (P < 0.05). For patients whose seizure frequency was≥3 times/3 months, AEDs could effectively control or reduce their seizure frequency (P < 0.05), while AEDs had no obvious effect on the seizure frequency of those whose seizure frequency was≤2 times/3 months (P > 0.05). In the treatment group, 29 cases whose age < 7 controlled their epilepsy attacks after taking AEDs for average of 13.76 months, while 35 cases whose age≥7 controlled their epilepsy attacks after taking AEDs for average of 6.36 months. Conclusion ①BECTS patients with a long duration of a single attack and seizure frequency more than 3 times/3 months could be effectively controlled after receiving early AEDs treatment.②The younger age of onset (< 7 years old) required longer AEDs treatment to control seizures.

Citation： CHENYin, HANYunli. Clinical analysis of benign childhood epilepsy with centrotemporal spikes. Journal of Epilepsy, 2015, 1(2): 127-131. doi: 10.7507/2096-0247.20150019 Copy

1.	Commission on Classification and Terminology of the International League Against Epilepsy. Proposal for revised classification of epilepsies and epileptic syndromes. Epilepsia, 1989, 30(4):389-399.
2.	Tovia E, Goldberg-stern H, Ben Zeev B, et al. The prevalence of atypical presentations and comorbidities of benign childhood epilepsy with centrotemporal spikes. Epilepsia, 2011, 52(8):1483-1488.
3.	陳彥, 廖建湘.睡眠中癲癇性電持續狀態的預后及神經心理發育.中國實用兒科學雜志, 2013, 28(2):96-98.
4.	Pal DK, Li W, Clarke T, et al. Pleiotropic effects of the 1 lpl3 locus on developmental verbal dyspraxia and EEG centrotemporal sharp waves.Genes Brain Behav, 2010, 9(2):1004-1012.
5.	Ibanez Mico S, Casas Fernandez C, Alarcon Martinez H. Rolandic epilepsy clinical variants and their influence on the prognosis. Neurologia, 201l, 9(3):1-4.
6.	吳希如, 林慶.小兒神經系統疾病基礎與臨床.第2版.北京:人民衛生出版社, 2009:497-498.
7.	錢小平.中央顳區棘波兒童癲癇藥物治療療效分析.鄭州:鄭州大學, 第一附屬醫院, 2012, 學位論文.
8.	Neubauer BA, Fielder B, Himmelein B, et al. Centrotemporal spikes in families with rolandic epilepsy linkage to chromosome 15q 14.Neurology, 1998, 51(6):1608.
9.	John R, Hughes. Benign epilepsy of childhood with centrotemporal spikes (BECTS):To treat or not to treat, hat is the question. Epilepsy Behavior, 2010, 12(19):197-203.
10.	Hirokazu Oguni. Treatment of benign focal epilepsies in children:When and how Should be treated? Brain Development, 2011, 30(33):207-212.
11.	Shields WD. SneadⅢOC. Benign epilepsy with centrotemporal spikes. Epilepsia, 2009, 50(8):5-10.
12.	You SJ, Kim DS, Ko TS. Benign childhood epilepsy with centrotemporal spikes (BECTS):early onset of seizures is associated with poorer response to initial treatment. Epileptic Disord, 2006, 8(2):285-288.
13.	13鄧大麗, 喻廉, 余鋒, 等. 65例伴中央顳區棘波的小兒良性癲癇(BECTS)臨床預后觀察.安徽醫學, 2011, 32(9):1240-1241.
14.	Roger J. Epileptic syndromes in infancy, childhood and adolescence. London:John Libbey, 2002:183.
15.	Schelters-de Boer M. Guidelines for EEG in encephalopathy related to ESES/CSWS in children. Epilepsia, 2009, 50(S7):13-17.
16.	張月華.兒童睡眠中癲癇性電持續狀態相關的癲癇綜合征.中國實用兒科學雜志, 2013, 28(2):85-87.

1. Commission on Classification and Terminology of the International League Against Epilepsy. Proposal for revised classification of epilepsies and epileptic syndromes. Epilepsia, 1989, 30(4):389-399.
2. Tovia E, Goldberg-stern H, Ben Zeev B, et al. The prevalence of atypical presentations and comorbidities of benign childhood epilepsy with centrotemporal spikes. Epilepsia, 2011, 52(8):1483-1488.
3. 陳彥, 廖建湘.睡眠中癲癇性電持續狀態的預后及神經心理發育.中國實用兒科學雜志, 2013, 28(2):96-98.
4. Pal DK, Li W, Clarke T, et al. Pleiotropic effects of the 1 lpl3 locus on developmental verbal dyspraxia and EEG centrotemporal sharp waves.Genes Brain Behav, 2010, 9(2):1004-1012.
5. Ibanez Mico S, Casas Fernandez C, Alarcon Martinez H. Rolandic epilepsy clinical variants and their influence on the prognosis. Neurologia, 201l, 9(3):1-4.
6. 吳希如, 林慶.小兒神經系統疾病基礎與臨床.第2版.北京:人民衛生出版社, 2009:497-498.
7. 錢小平.中央顳區棘波兒童癲癇藥物治療療效分析.鄭州:鄭州大學, 第一附屬醫院, 2012, 學位論文.
8. Neubauer BA, Fielder B, Himmelein B, et al. Centrotemporal spikes in families with rolandic epilepsy linkage to chromosome 15q 14.Neurology, 1998, 51(6):1608.
9. John R, Hughes. Benign epilepsy of childhood with centrotemporal spikes (BECTS):To treat or not to treat, hat is the question. Epilepsy Behavior, 2010, 12(19):197-203.
10. Hirokazu Oguni. Treatment of benign focal epilepsies in children:When and how Should be treated? Brain Development, 2011, 30(33):207-212.
11. Shields WD. SneadⅢOC. Benign epilepsy with centrotemporal spikes. Epilepsia, 2009, 50(8):5-10.
12. You SJ, Kim DS, Ko TS. Benign childhood epilepsy with centrotemporal spikes (BECTS):early onset of seizures is associated with poorer response to initial treatment. Epileptic Disord, 2006, 8(2):285-288.
13. 13鄧大麗, 喻廉, 余鋒, 等. 65例伴中央顳區棘波的小兒良性癲癇(BECTS)臨床預后觀察.安徽醫學, 2011, 32(9):1240-1241.
14. Roger J. Epileptic syndromes in infancy, childhood and adolescence. London:John Libbey, 2002:183.
15. Schelters-de Boer M. Guidelines for EEG in encephalopathy related to ESES/CSWS in children. Epilepsia, 2009, 50(S7):13-17.
16. 張月華.兒童睡眠中癲癇性電持續狀態相關的癲癇綜合征.中國實用兒科學雜志, 2013, 28(2):85-87.

Journal of Epilepsy

Clinical analysis of benign childhood epilepsy with centrotemporal spikes

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content