Knowledge, attitude and practice of hepatitis E among the residents of Anlu City_Chinese Journal of Evidence-Based Medicine

Authors：

ZHOU Sheng ^1,2 ,  ZHANG Zhijiang ¹ , YUAN Zhanpeng ¹ , WAN Qin ³ , ZHANG Xuefeng ³

1. Department of Preventive Medicine, School of Health Sciences, Wuhan University, Wuhan 430071, P.R.China;
2. Hannan District Center for Disease Control and Prevention, Wuhan 430090, P.R.China;
3. Anlu Center for Disease Control and Prevention, Xiaogan 432600, P.R.China;

Corresponding?author：

ZHANG Zhijiang, Email: zhang22968@163.com

Keywords：

Hepatitis E; Awareness rate; Knowledge, attitude, practice (KAP); Influencing factors

DOI：

10.7507/1672-2531.202003010

Video：

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Objectives To investigate the knowledge, attitude and practice (KAP) of hepatitis E among Anlu residents and to identify the influencing factors.Methods A stratified random sampling method was used and 1 840 Anlu residents were recruited between March 2019 and September 2019. Chi-square test and multivariate logistic regression model were used to analyze the influencing factors by SPSS 22.0 software.Results The overall awareness rate of residents was 36.32%. There were statistically significant differences in age, occupation category and education (P<0.05). Qualification rate of awareness increased with age until age 40, but not with age after 40. Individuals occupationally exposed to swines (swine breeders, sales staff, slaughterers) had the lowest rates. Education level was positively associated with the qualification rate of awareness. The overall positive attitude rate was 53.89%. The overall healthy behavior rate was 82.95%.Conclusions The overall knowledge and awareness of hepatitis E among Anlu residents is low, especially individuals who have been occupationally exposed to swines. Health education and promotion programs are necessary.

Citation： ZHOU Sheng, ZHANG Zhijiang, YUAN Zhanpeng, WAN Qin, ZHANG Xuefeng. Knowledge, attitude and practice of hepatitis E among the residents of Anlu City. Chinese Journal of Evidence-Based Medicine, 2020, 20(8): 923-929. doi: 10.7507/1672-2531.202003010 Copy

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2.	Simanavicius M, Juskaite K, Verbickaite A, et al. Detection of rat hepatitis E virus, but not human pathogenic hepatitis E virus genotype 1-4 infections in wild rats from Lithuania. Vet Microbiol, 2018, 221: 129-133.
3.	Wang L, Liu L, Wang L. An overview: Rabbit hepatitis E virus (HEV) and rabbit providing an animal model for HEV study. Rev Med Virol, 2018, 28(1): 10.
4.	Gerber PF, Hossain MF, Reynolds P, et al. Propagation of an avirulent turkey hemorrhagic enteritis virus isolate in chickens. Avian Dis, 2018, 62(1): 6-13.
5.	World Health Organization. Hepatitis E. Available from: https://www.who.int/news-room/fact-sheets/detail/hepatitis-e.
6.	黃曉麗. 被忽視的肝炎—戊型肝炎. 肝博士, 2019, (3): 43-44.
7.	Dagnew M, Belachew A, Tiruneh M, et al. Hepatitis E virus infection among pregnant women in Africa: systematic review and meta-analysis. BMC Infect Dis, 2019, 19(1): 519.
8.	Nimgaonkar I, Ding Q, Schwartz RE, et al. Hepatitis E virus: advances and challenges. Nat Rev Gastroenterol Hepatol, 2018, 15(2): 96-110.
9.	陳雪飛. 慢性乙型病毒性肝炎重疊戊肝病毒感染致肝功能衰竭1例. 醫學信息, 2019, 32(21): 187, 189.
10.	Denner J, Pischke S, Steinmann E, et al. Why all blood donations should be tested for hepatitis E virus (HEV). BMC Infect Dis, 2019, 19(1): 541.
11.	Purcell RH, Emerson SU. Hepatitis E: an emerging awareness of an old disease. J Hepatol, 2008, 48(3): 494-503.
12.	Khuroo MS, Khuroo MS. Hepatitis E: an emerging global disease - from discovery towards control and cure. J Viral Hepat, 2016, 23(2): 68-79.
13.	Fenaux H, Chassaing M, Berger S, et al. Transmission of hepatitis E virus by water: An issue still pending in industrialized countries. Water Res, 2019, 151: 144-157.
14.	Rein DB, Stevens GA, Theaker J, et al. The global burden of hepatitis E virus genotypes 1 and 2 in 2005. Hepatology, 2012, 55(4): 988-997.
15.	Capai L, Charrel R, Falchi A. Hepatitis E in high-income countries: what do we know? And what are the knowledge gaps? Viruses, 2018, 10(6): E285.
16.	Yue N, Wang Q, Zheng M, et al. Prevalence of hepatitis E virus infection among people and swine in mainland China: a systematic review and meta-analysis. Zoonoses Public Health, 2019, 66(3): 265-275.
17.	黃嬌鳳, 林蘇, 王挺, 等. 2004-2015 年我國病毒性肝炎發病及季節性趨勢分析. 中國人獸共患病學報, 2017, 33(12): 1144-1148.
18.	國家衛生健康委員會. 中國衛生健康統計年鑒. 北京: 中國協和醫科大學出版社, 2018.
19.	國家衛生計生委, 國家發展改革委, 教育部, 等. 中國病毒性肝炎防治規劃(2017-2020 年). 中國病毒病雜志, 2018, 8(1): 1-5.
20.	萬琴, 張守德, 張雪峰, 等. 2005-2015 年安陸市戊型病毒性肝炎流行病學分析. 熱帶醫學雜志, 2017, 17(4): 533-536.
21.	Shu Y, Chen Y, Zhou S, et al. Cross-sectional seroprevalence and genotype of hepatitis E virus in humans and swine in a high-density pig-farming area in central China. Virol Sin, 2019, 34(4): 367-376.
22.	陳雅夢. 湖北地區HIV人群HEV知信行及HEV感染流行病學調查. 武漢: 武漢科技大學, 2019.
23.	沈紅. 病毒性肝炎流行特征, 丙肝知曉率和戊肝感染危險因素研究. 上海: 復旦大學, 2012.
24.	Izopet J, Lhomme S, Chapuy-Regaud S, et al. HEV and transfusion-recipient risk. Transfus Clin Biol, 2017, 24(3): 176-181.
25.	盧敏芳, 常全娥. 甘肅某高校學生甲肝防治知識知曉率調查. 衛生職業教育, 2017, 35(23): 92-94.
26.	Lee GY, Poovorawan K, Intharasongkroh D, et al. Hepatitis E virus infection: Epidemiology and treatment implications. World J Virol, 2015, 4(4): 343-355.
27.	楊錕, 方大春, 秦其榮, 等. 馬鞍山市常住人口乙肝相關知識知曉及疫苗接種情況調查. 現代預防醫學, 2019, 46(20): 3772-3776, 3798.
28.	高日紅, 姜濤. 2017 年海陽市大學新生戊型肝炎知識態度調查. 中國校醫, 2018, 32(7): 495-496.
29.	王冬梅, 于旭亞, 馮國躍, 等. 煙臺市 2014 年大學新生戊型肝炎病毒感染狀況和認知度調查. 中國病毒病雜志, 2016, 6(5): 356-359.
30.	劉甲野, 張麗, 呂靜靜, 等. 山東省大學新生戊型肝炎流行及相關知識態度行為現狀. 中國學校衛生, 2016, 37(11): 1739-1742.
31.	Doceul V, Bagdassarian E, Demange A, et al. Zoonotic hepatitis E virus: classification, animal reservoirs and transmission routes. Viruses, 2016, 8(10): E270.
32.	Grodzki M, Schaeffer J, Piquet JC, et al. Bioaccumulation efficiency, tissue distribution, and environmental occurrence of hepatitis E virus in bivalve shellfish from France. Appl Environ Microbiol, 2014, 80(14): 4269-4276.
33.	Crossan C, Baker PJ, Craft J, et al. Hepatitis E virus genotype 3 in shellfish, United Kingdom. Emerg Infect Dis, 2012, 18(12): 2085-2087.
34.	張雪峰, 疏義林, 周昇, 等. 湖北孝感地區戊型肝炎感染因素及其臨床特征分析. 醫學動物防制, 2017, 33(10): 1091-1093.

1. Jemer?i? L, Prpi? J, Brni? D, et al. Genetic diversity of hepatitis E virus (HEV) strains derived from humans, swine and wild boars in Croatia from 2010 to 2017. BMC Infect Dis, 2019, 19(1): 269.
2. Simanavicius M, Juskaite K, Verbickaite A, et al. Detection of rat hepatitis E virus, but not human pathogenic hepatitis E virus genotype 1-4 infections in wild rats from Lithuania. Vet Microbiol, 2018, 221: 129-133.
3. Wang L, Liu L, Wang L. An overview: Rabbit hepatitis E virus (HEV) and rabbit providing an animal model for HEV study. Rev Med Virol, 2018, 28(1): 10.
4. Gerber PF, Hossain MF, Reynolds P, et al. Propagation of an avirulent turkey hemorrhagic enteritis virus isolate in chickens. Avian Dis, 2018, 62(1): 6-13.
5. World Health Organization. Hepatitis E. Available from: https://www.who.int/news-room/fact-sheets/detail/hepatitis-e.
6. 黃曉麗. 被忽視的肝炎—戊型肝炎. 肝博士, 2019, (3): 43-44.
7. Dagnew M, Belachew A, Tiruneh M, et al. Hepatitis E virus infection among pregnant women in Africa: systematic review and meta-analysis. BMC Infect Dis, 2019, 19(1): 519.
8. Nimgaonkar I, Ding Q, Schwartz RE, et al. Hepatitis E virus: advances and challenges. Nat Rev Gastroenterol Hepatol, 2018, 15(2): 96-110.
9. 陳雪飛. 慢性乙型病毒性肝炎重疊戊肝病毒感染致肝功能衰竭1例. 醫學信息, 2019, 32(21): 187, 189.
10. Denner J, Pischke S, Steinmann E, et al. Why all blood donations should be tested for hepatitis E virus (HEV). BMC Infect Dis, 2019, 19(1): 541.
11. Purcell RH, Emerson SU. Hepatitis E: an emerging awareness of an old disease. J Hepatol, 2008, 48(3): 494-503.
12. Khuroo MS, Khuroo MS. Hepatitis E: an emerging global disease - from discovery towards control and cure. J Viral Hepat, 2016, 23(2): 68-79.
13. Fenaux H, Chassaing M, Berger S, et al. Transmission of hepatitis E virus by water: An issue still pending in industrialized countries. Water Res, 2019, 151: 144-157.
14. Rein DB, Stevens GA, Theaker J, et al. The global burden of hepatitis E virus genotypes 1 and 2 in 2005. Hepatology, 2012, 55(4): 988-997.
15. Capai L, Charrel R, Falchi A. Hepatitis E in high-income countries: what do we know? And what are the knowledge gaps? Viruses, 2018, 10(6): E285.
16. Yue N, Wang Q, Zheng M, et al. Prevalence of hepatitis E virus infection among people and swine in mainland China: a systematic review and meta-analysis. Zoonoses Public Health, 2019, 66(3): 265-275.
17. 黃嬌鳳, 林蘇, 王挺, 等. 2004-2015 年我國病毒性肝炎發病及季節性趨勢分析. 中國人獸共患病學報, 2017, 33(12): 1144-1148.
18. 國家衛生健康委員會. 中國衛生健康統計年鑒. 北京: 中國協和醫科大學出版社, 2018.
19. 國家衛生計生委, 國家發展改革委, 教育部, 等. 中國病毒性肝炎防治規劃(2017-2020 年). 中國病毒病雜志, 2018, 8(1): 1-5.
20. 萬琴, 張守德, 張雪峰, 等. 2005-2015 年安陸市戊型病毒性肝炎流行病學分析. 熱帶醫學雜志, 2017, 17(4): 533-536.
21. Shu Y, Chen Y, Zhou S, et al. Cross-sectional seroprevalence and genotype of hepatitis E virus in humans and swine in a high-density pig-farming area in central China. Virol Sin, 2019, 34(4): 367-376.
22. 陳雅夢. 湖北地區HIV人群HEV知信行及HEV感染流行病學調查. 武漢: 武漢科技大學, 2019.
23. 沈紅. 病毒性肝炎流行特征, 丙肝知曉率和戊肝感染危險因素研究. 上海: 復旦大學, 2012.
24. Izopet J, Lhomme S, Chapuy-Regaud S, et al. HEV and transfusion-recipient risk. Transfus Clin Biol, 2017, 24(3): 176-181.
25. 盧敏芳, 常全娥. 甘肅某高校學生甲肝防治知識知曉率調查. 衛生職業教育, 2017, 35(23): 92-94.
26. Lee GY, Poovorawan K, Intharasongkroh D, et al. Hepatitis E virus infection: Epidemiology and treatment implications. World J Virol, 2015, 4(4): 343-355.
27. 楊錕, 方大春, 秦其榮, 等. 馬鞍山市常住人口乙肝相關知識知曉及疫苗接種情況調查. 現代預防醫學, 2019, 46(20): 3772-3776, 3798.
28. 高日紅, 姜濤. 2017 年海陽市大學新生戊型肝炎知識態度調查. 中國校醫, 2018, 32(7): 495-496.
29. 王冬梅, 于旭亞, 馮國躍, 等. 煙臺市 2014 年大學新生戊型肝炎病毒感染狀況和認知度調查. 中國病毒病雜志, 2016, 6(5): 356-359.
30. 劉甲野, 張麗, 呂靜靜, 等. 山東省大學新生戊型肝炎流行及相關知識態度行為現狀. 中國學校衛生, 2016, 37(11): 1739-1742.
31. Doceul V, Bagdassarian E, Demange A, et al. Zoonotic hepatitis E virus: classification, animal reservoirs and transmission routes. Viruses, 2016, 8(10): E270.
32. Grodzki M, Schaeffer J, Piquet JC, et al. Bioaccumulation efficiency, tissue distribution, and environmental occurrence of hepatitis E virus in bivalve shellfish from France. Appl Environ Microbiol, 2014, 80(14): 4269-4276.
33. Crossan C, Baker PJ, Craft J, et al. Hepatitis E virus genotype 3 in shellfish, United Kingdom. Emerg Infect Dis, 2012, 18(12): 2085-2087.
34. 張雪峰, 疏義林, 周昇, 等. 湖北孝感地區戊型肝炎感染因素及其臨床特征分析. 醫學動物防制, 2017, 33(10): 1091-1093.

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