Efficacy and safety of oral polyethylene glycol versus sodium phosphate solution in capsule endoscopy: a systematic review_Chinese Journal of Evidence-Based Medicine

Authors：

TANG Ying ¹ , GE Long ² ,  ZHANG Zhigang ³ , ZHANG Caiyun ³ , TIAN Jinhui ²

1. The First Clinical Medical College, Lanzhou University, Lanzhou, 730000, P.R.China;
2. Evidence-based Medicine Center, Lanzhou University, Lanzhou, 730000, P.R.China;
3. The First Hospital, Lanzhou University, Lanzhou, 730000, P.R.China;

Corresponding?author：

ZHANG Zhigang, Email: zzg3444@163.com

Keywords：

Polyethylene glycol solution; Sodium phosphate solution; Capsule endoscopy; Systematic review; Meta-analysis; Randomized controlled trial

DOI：

10.7507/1672-2531.201611042

Video：

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Objective To systematically review the efficacy and safety of polyethylene glycol and sodium phosphate in bowel preparation of capsule endoscopy. Methods We searched CNKI, CBM, WanFang Data, PubMed, EMbase, and The Cochrane Library (Issue 6, 2016) up to June 2016, to collect randomized controlled trials (RCTs) about polyethylene glycol and sodium phosphate in bowel preparation of capsule endoscopy. Two reviewers independently screened literatures, extracted data and assessed the risk of bias of included studies, and then meta-analysis was performed by using RevMan 5.0 software. Results A total of six RCTs involving 531 patients were included. The results of meta-analysis showed that: compared with the sodium phosphate solution group, the polyethylene glycol solution group had poor intestinal cleansing effect (OR=0.43, 95%CI 0.21 to 0.88,P=0.02), higher incidence of adverse reaction (OR=3.20, 95%CI 1.13 to 9.06,P=0.03); but shorter gastric retention time (OR=–11.61, 95%CI –13.71 to –9.51,P<0.000 01) and residence time in the small intestine (OR=–4.17, 95%CI –7.74 to –0.60,P=0.02). Conclusion The efficacy of oral polyethylene glycol is poor in cleaning effect and adverse reaction than sodium phosphate solution, but better in the digestive tract residence time for capsule endoscopy. Due to the limited quality and quantity of included studies, the above conclusion is still needed to be proved by more high-quality studies.

Citation： TANG Ying, GE Long, ZHANG Zhigang, ZHANG Caiyun, TIAN Jinhui. Efficacy and safety of oral polyethylene glycol versus sodium phosphate solution in capsule endoscopy: a systematic review. Chinese Journal of Evidence-Based Medicine, 2017, 17(1): 52-57. doi: 10.7507/1672-2531.201611042 Copy

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2.	楊建民, 鄭衛華, 張駿, 等. 國產 OMOM 膠囊內鏡對小腸疾病的診斷價值. 中華消化雜志, 2006, 26(10): 697-698.
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13.	張愛芳, 楊志杰, 繆學勤. 膠囊內鏡檢查前應用復方聚乙二醇電解質散行腸道清潔的臨床價值. 黑龍江醫藥, 2013, 6(26): 1065-1066.
14.	丁列敏. 復方聚乙二醇電解質散在老年腸道準備中的觀察及護理. 海峽藥學, 2010, 22(7): 203-204.
15.	王新丹, 王華芬. 聚乙二醇電解質溶液在結腸鏡檢查前腸道準備中的應用與護理. 護士進修雜志, 2006, 3(3): 212-214．.
16.	李麗君, 申曉靜. 聚乙二醇電解質散 (和爽) 在腸道準備中的應用與護理體會. 中國實用醫藥, 2007, 6(18): 111-112．.
17.	李耀東, 王一平, 潘濤, 等. 磷酸鈉法與聚乙二醇電解質液法在結腸鏡檢前腸道準備中應用效果的系統評價. 中國循證醫學雜志, 2005, 5(7): 555-561.
18.	王寧. 聚乙二醇與磷酸鈉鹽清潔腸道安全性和有效性的 Meta 分析. 醫學綜述, 2015, 21(15): 2823-2827.
19.	Viazis N, Sgouros S, Papaxoinis K,et al. Bowel preparation increases the diagnostic yield of capsule endoscopy: a prospective, randomized, controlled study. Gastrointestinal Endoscopy, 2004, 4(60): 534-539.

1. ?樓杰. 膠囊內鏡檢查前不同腸道準備方法的效果比較. 現代實用醫學, 2012, 24(2): 182-183.
2. 楊建民, 鄭衛華, 張駿, 等. 國產 OMOM 膠囊內鏡對小腸疾病的診斷價值. 中華消化雜志, 2006, 26(10): 697-698.
3. Loftus EVJr. Capsule endoscopy for Crohn’s disease: ready for prime time. Clin Gastroenterol Hepatol, 2004, 2(1): 14-16.
4. 徐青麗, 黃春美, 鄭雪芬, 等. OMOM 膠囊內鏡檢查前腸道準備的臨床研究. 護士進修雜志, 2014, 29(6): 575-576.
5. Higgins JPT, Green S. Cochrane handbook for systematic reviews of interventions version 5.0.0. London: The Cochrane Collaboration, 2008. Available at: http://handbook.cochrane.org/.
6. 楊曉強, 趙亞剛, 孫大勇. 兩種清腸劑在膠囊內鏡檢查中應用的對比研究. 中國內鏡雜志, 2009, 15(10): 1043-1046.
7. 陳濤, 劉輝. 3 種方法在膠囊內鏡腸道準備中的清潔效果比較. 現代臨床護理, 2012, 11(5): 50-51.
8. Pons Beltrán V, González Suárez B, González Asanza C,et al. Evaluation of different bowel preparations for small bowel capsule endoscopy: a prospective, randomized, controlled study. Dig Dis Sci, 2011, 56(10): 2900-2905.
9. 鄧源, 江雪. 不同腸道準備方法對膠囊內鏡檢查圖像的影響. 中國醫院用藥評價與分析, 2010, 10(10): 931-932.
10. 羅文基, 黃麗娟, 陳鴻江. 膠囊內鏡檢查術前老年人腸道清潔準備方法研究. 中國實用醫藥, 2012, 7(8): 116-118.
11. Wi J, Moon E, Choi M,et al. Bowel preparation for capsule endoscopy: a prospective randomized multicenter study. Gut and Liver, 2009, 3(3): 180-185.
12. 李運紅, 徐肇敏, 盧曉云, 等. 膠囊內鏡檢查前腸道準備方法的臨床研究. 生物醫學工程與臨床, 2006, 10(6): 372-374.
13. 張愛芳, 楊志杰, 繆學勤. 膠囊內鏡檢查前應用復方聚乙二醇電解質散行腸道清潔的臨床價值. 黑龍江醫藥, 2013, 6(26): 1065-1066.
14. 丁列敏. 復方聚乙二醇電解質散在老年腸道準備中的觀察及護理. 海峽藥學, 2010, 22(7): 203-204.
15. 王新丹, 王華芬. 聚乙二醇電解質溶液在結腸鏡檢查前腸道準備中的應用與護理. 護士進修雜志, 2006, 3(3): 212-214．.
16. 李麗君, 申曉靜. 聚乙二醇電解質散 (和爽) 在腸道準備中的應用與護理體會. 中國實用醫藥, 2007, 6(18): 111-112．.
17. 李耀東, 王一平, 潘濤, 等. 磷酸鈉法與聚乙二醇電解質液法在結腸鏡檢前腸道準備中應用效果的系統評價. 中國循證醫學雜志, 2005, 5(7): 555-561.
18. 王寧. 聚乙二醇與磷酸鈉鹽清潔腸道安全性和有效性的 Meta 分析. 醫學綜述, 2015, 21(15): 2823-2827.
19. Viazis N, Sgouros S, Papaxoinis K,et al. Bowel preparation increases the diagnostic yield of capsule endoscopy: a prospective, randomized, controlled study. Gastrointestinal Endoscopy, 2004, 4(60): 534-539.

Chinese Journal of Evidence-Based Medicine

Efficacy and safety of oral polyethylene glycol versus sodium phosphate solution in capsule endoscopy: a systematic review

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