Effectiveness of perfusion parameters of DCE-MRI in distinguishing different histological grades of rectal cancer: a meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

YANG Xinyue ¹ , XIAO Xiaojuan ² , LU Baolan ¹ ,  YU Shenping ¹

1. Department of Radiology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, P.R.China;
2. Department of Radiology, Peking University Shengzhen Hospital, Shenzhen, 518036, Guangdong, P.R.China;

Corresponding?author：

YU Shenping, Email: ethan_yu@sina.com

Keywords：

DCE-MRI; Perfusion parameters; K_trans; K_ep; Rectal cancer; Meta-analysis

DOI：

10.7507/1672-2531.201608005

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To systematically review the value of the perfusion paramenters of K_trans and K_ep of dynamic contrast enhanced MRI(DCE-MRI) in distinguishing different histological grades of rectal cancer. Methods Databases such as PubMed, EMbase, Web of Science, The Cochrane Library (Issue 1, 2017), CBM, CNKI, WanFang Data and VIP were searched from 1990 to Feb 6^th, 2017 to collect the studies according to the criteria. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies and then meta-analysis was performed by using STATA 12.0 software. Results A total of 11 studies involving 618 patients were included. The results of meta-analysis showed that there was significant difference of K_trans between poorly differentiated grade and moderately-well differentiated grade (SMD=1.123, 95% CI 0.334 to 1.911,P=0.005), but there was no significant difference of K_ep between these two groups (SMD=0.233, 95% CI –0.173 to 0.639,P=0.260). Conclusion Current evidence shows that K_trans can be used to distinguish different histological grades of rectal cancer. The clinical application value of K_ep still needs large sample original studies to further verify.

Citation： YANG Xinyue, XIAO Xiaojuan, LU Baolan, YU Shenping. Effectiveness of perfusion parameters of DCE-MRI in distinguishing different histological grades of rectal cancer: a meta-analysis. Chinese Journal of Evidence-Based Medicine, 2017, 17(5): 536-543. doi: 10.7507/1672-2531.201608005 Copy

1.	?Hylton N. Dynamic contrast-enhanced magnetic resonance imaging as an imaging biomarker. J Clin Oncol, 2006, 24(20): 3293-3298.
2.	Verma S, Turkbey B, Muradyan N, et al. Overview of Dynamic Contrast-Enhanced MRI in Prostate Cancer Diagnosis and Management. AJR Am J Roentgenol, 2012, 198(6): 1277-1288.
3.	de Vries A, Griebel J, Kremser C, et al. Monitoring of Tumor Microcirculation during Fractionated Radiation Therapy in Patients with Rectal Carcinoma: Preliminary Results and Implications for Therapy1. Radiology, 2000, 217(2): 385-391.
4.	Beaumont C, Pandey T, Gaines Fricke R, et al. MR Evaluation of Rectal Cancer: Current Concepts. Curr Probl Diagn Radiol, 2013, 42(3): 99-112.
5.	Kaur H, Choi H, You YN, et al. MR Imaging for Preoperative Evaluation of Primary Rectal Cancer: Practical Considerations. Radiographics, 2012, 32(2): 389-409.
6.	Nougaret S, Reinhold C, Mikhael HW, et al. The Use of MR Imaging in Treatment Planning for Patients with Rectal Carcinoma: Have You Checked the " DISTANCE”? Radiology, 2013, 268(2): 330-344.
7.	張文文, 黃剛, 周星, 等. DCE-MRI 定量參數與直腸癌病理分期及分級的相關性研究. 臨床放射學雜志, 2016, 35(7): 1058-1061.
8.	Yu J, Xu Q, Huang DY, et al. Prognostic aspects of dynamic contrast-enhanced magnetic resonance imaging in synchronous distant metastatic rectal cancer. Eur Radiol, 2017, 27(5): 1840-1847.
9.	岳倩. 直腸癌動態增強 MRI 定量參數與 Ki67、HER-2 的相關性研究. 蘭州: 蘭州大學, 2016.
10.	方夢詩. 基于 MR 多模態掃描技術的直腸癌分期/分級的前瞻性研究. 安徽: 蚌埠醫學院, 2016.
11.	陳露方. ADC 值和 DCE-MRI 定量參數值對直腸癌臨床病理的相關性研究. 蘭州: 蘭州大學, 2016.
12.	朱麗娜, 張曦, 顏社平, 等. 3.0T 動態對比增強磁共振與直腸癌組織分化程度關系的探討. 現代醫用影像學, 2016, 25(2): 292-294.
13.	沈浮, 陸建平, 陳錄廣, 等. 動態增強磁共振成像在直腸癌術前分化程度評估中的應用價值. 臨床放射學雜志, 2016, 35(1): 96-100.
14.	肖曉娟, 盧寶蘭, 楊心悅, 等. 定量磁共振灌注成像用于評價直腸癌的微血管灌注及滲透性. 中國病理生理雜志, 2015, 17(12): 2164-2168.
15.	謝宗源. 直腸癌 DCE-MRI 參數與病理特征的相關性研究. 寧夏: 寧夏醫科大學, 2015.
16.	李鵬. 直腸惡性腫瘤 CT 和 MRI 灌注成像研究. 天津: 天津醫科大學, 2014.
17.	Yao WW, Zhang H, Ding B, et al. Rectal cancer: 3D dynamic contrast-enhanced MRI; correlation with microvascular density and clinicopathological features. Radiol Med, 2011, 116(3): 366-374.
18.	文進, 李幼平. Meta 分析中效應尺度指標的選擇. 中國循證醫學雜志, 2007, 7(8): 606-613.
19.	王丹, 翟俊霞, 牟振云, 等. Meta 分析中的異質性及其處理方法. 中國循證醫學雜志, 2009, 9(10): 1115-1118.
20.	萬德森. 結直腸癌臨床病理學. 見: 萬德森, 鄭樹, 主編. 結直腸癌. 第一版. 北京大學醫學出版社, 北京: 2008.
21.	Mehrkhani F, Nasiri S, Donboli K, et al. Prognostic factors in survival of colorectal cancer patients after surgery. Colorectal Dis, 2009, 11(2): 157-161.
22.	劉彥龍, 趙發林, 王錫山. 2414 例直腸癌患者的臨床病理特征及預后分析. 中華胃腸外科雜志, 2010, 13(12): 913-916.
23.	陳創奇, 方樂堃, 馬晉平, 等. 結直腸癌 2042 例臨床病理特點及預后回歸分析. 中華醫學雜志, 2010, 90(26): 1804-1807.
24.	方偉崗, 賀慧穎. 腫瘤. 見: 孫保存主編. 病理學. 北京大學醫學出版社, 北京: 2009.
25.	Choi HJ, Hyun MS, Jung GJ, et al. Tumor angiogenesis as a prognostic predictor in colorectal carcinoma with special reference to mode of metastasis and recurrence. Oncology, 1998, 55(6): 575-581.
26.	Kim YE, Lim JS, Choi J, et al. Perfusion parameters of dynamic contrast-enhanced magnetic resonance imaging in patients with rectal cancer: Correlation with microvascular density and vascular endothelial growth factor expression. Korean J of Radiol, 2013, 14(6): 878-885.
27.	Jain RK. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science, 2005, 307(5706): 58-62.
28.	Tofts PS, Brix G, Buckley DL, et al. Estimating Kinetic Parameters From Dynamic Contrast-Enhanced T1-Weighted MRI of a Diffusable Tracer: Standardized Quantities and Symbols. J Magn Reson Imaging, 1999, 10(3): 223-232.
29.	Goldis DS, Sferdian MF, Tarta C, et al. Comparative analysis of microvessel density quantified through the immunohistochemistry expression of CD34 and CD105 in rectal cancer. Rom J Morphol Embryol, 2015, 56(2): 419-424.
30.	Atkin G, Taylor NJ, Daley FM, et al. Dynamic contrast-enhanced magnetic resonance imaging is a poor measure of rectal cancer angiogenesis? Br J Surg, 2006, 93(8): 992-1000.
31.	Kim DJ, Kim JH, Lim JS, et al. Restaging of Rectal Cancer with MR Imaging after Concurrent Chemotherapy and Radiation Therapy. Radiographics, 2010, 30(2): 503-516.
32.	Yeo D, Oh SN, Jung C, et al. Correlation of dynamic contrast-enhanced MRI perfusion parameters with angiogenesis and biologic aggressiveness of rectal cancer: Preliminary results. J Magn Reson Imaging, 2015, 41(2): 474-480.

1. ?Hylton N. Dynamic contrast-enhanced magnetic resonance imaging as an imaging biomarker. J Clin Oncol, 2006, 24(20): 3293-3298.
2. Verma S, Turkbey B, Muradyan N, et al. Overview of Dynamic Contrast-Enhanced MRI in Prostate Cancer Diagnosis and Management. AJR Am J Roentgenol, 2012, 198(6): 1277-1288.
3. de Vries A, Griebel J, Kremser C, et al. Monitoring of Tumor Microcirculation during Fractionated Radiation Therapy in Patients with Rectal Carcinoma: Preliminary Results and Implications for Therapy1. Radiology, 2000, 217(2): 385-391.
4. Beaumont C, Pandey T, Gaines Fricke R, et al. MR Evaluation of Rectal Cancer: Current Concepts. Curr Probl Diagn Radiol, 2013, 42(3): 99-112.
5. Kaur H, Choi H, You YN, et al. MR Imaging for Preoperative Evaluation of Primary Rectal Cancer: Practical Considerations. Radiographics, 2012, 32(2): 389-409.
6. Nougaret S, Reinhold C, Mikhael HW, et al. The Use of MR Imaging in Treatment Planning for Patients with Rectal Carcinoma: Have You Checked the " DISTANCE”? Radiology, 2013, 268(2): 330-344.
7. 張文文, 黃剛, 周星, 等. DCE-MRI 定量參數與直腸癌病理分期及分級的相關性研究. 臨床放射學雜志, 2016, 35(7): 1058-1061.
8. Yu J, Xu Q, Huang DY, et al. Prognostic aspects of dynamic contrast-enhanced magnetic resonance imaging in synchronous distant metastatic rectal cancer. Eur Radiol, 2017, 27(5): 1840-1847.
9. 岳倩. 直腸癌動態增強 MRI 定量參數與 Ki67、HER-2 的相關性研究. 蘭州: 蘭州大學, 2016.
10. 方夢詩. 基于 MR 多模態掃描技術的直腸癌分期/分級的前瞻性研究. 安徽: 蚌埠醫學院, 2016.
11. 陳露方. ADC 值和 DCE-MRI 定量參數值對直腸癌臨床病理的相關性研究. 蘭州: 蘭州大學, 2016.
12. 朱麗娜, 張曦, 顏社平, 等. 3.0T 動態對比增強磁共振與直腸癌組織分化程度關系的探討. 現代醫用影像學, 2016, 25(2): 292-294.
13. 沈浮, 陸建平, 陳錄廣, 等. 動態增強磁共振成像在直腸癌術前分化程度評估中的應用價值. 臨床放射學雜志, 2016, 35(1): 96-100.
14. 肖曉娟, 盧寶蘭, 楊心悅, 等. 定量磁共振灌注成像用于評價直腸癌的微血管灌注及滲透性. 中國病理生理雜志, 2015, 17(12): 2164-2168.
15. 謝宗源. 直腸癌 DCE-MRI 參數與病理特征的相關性研究. 寧夏: 寧夏醫科大學, 2015.
16. 李鵬. 直腸惡性腫瘤 CT 和 MRI 灌注成像研究. 天津: 天津醫科大學, 2014.
17. Yao WW, Zhang H, Ding B, et al. Rectal cancer: 3D dynamic contrast-enhanced MRI; correlation with microvascular density and clinicopathological features. Radiol Med, 2011, 116(3): 366-374.
18. 文進, 李幼平. Meta 分析中效應尺度指標的選擇. 中國循證醫學雜志, 2007, 7(8): 606-613.
19. 王丹, 翟俊霞, 牟振云, 等. Meta 分析中的異質性及其處理方法. 中國循證醫學雜志, 2009, 9(10): 1115-1118.
20. 萬德森. 結直腸癌臨床病理學. 見: 萬德森, 鄭樹, 主編. 結直腸癌. 第一版. 北京大學醫學出版社, 北京: 2008.
21. Mehrkhani F, Nasiri S, Donboli K, et al. Prognostic factors in survival of colorectal cancer patients after surgery. Colorectal Dis, 2009, 11(2): 157-161.
22. 劉彥龍, 趙發林, 王錫山. 2414 例直腸癌患者的臨床病理特征及預后分析. 中華胃腸外科雜志, 2010, 13(12): 913-916.
23. 陳創奇, 方樂堃, 馬晉平, 等. 結直腸癌 2042 例臨床病理特點及預后回歸分析. 中華醫學雜志, 2010, 90(26): 1804-1807.
24. 方偉崗, 賀慧穎. 腫瘤. 見: 孫保存主編. 病理學. 北京大學醫學出版社, 北京: 2009.
25. Choi HJ, Hyun MS, Jung GJ, et al. Tumor angiogenesis as a prognostic predictor in colorectal carcinoma with special reference to mode of metastasis and recurrence. Oncology, 1998, 55(6): 575-581.
26. Kim YE, Lim JS, Choi J, et al. Perfusion parameters of dynamic contrast-enhanced magnetic resonance imaging in patients with rectal cancer: Correlation with microvascular density and vascular endothelial growth factor expression. Korean J of Radiol, 2013, 14(6): 878-885.
27. Jain RK. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science, 2005, 307(5706): 58-62.
28. Tofts PS, Brix G, Buckley DL, et al. Estimating Kinetic Parameters From Dynamic Contrast-Enhanced T1-Weighted MRI of a Diffusable Tracer: Standardized Quantities and Symbols. J Magn Reson Imaging, 1999, 10(3): 223-232.
29. Goldis DS, Sferdian MF, Tarta C, et al. Comparative analysis of microvessel density quantified through the immunohistochemistry expression of CD34 and CD105 in rectal cancer. Rom J Morphol Embryol, 2015, 56(2): 419-424.
30. Atkin G, Taylor NJ, Daley FM, et al. Dynamic contrast-enhanced magnetic resonance imaging is a poor measure of rectal cancer angiogenesis? Br J Surg, 2006, 93(8): 992-1000.
31. Kim DJ, Kim JH, Lim JS, et al. Restaging of Rectal Cancer with MR Imaging after Concurrent Chemotherapy and Radiation Therapy. Radiographics, 2010, 30(2): 503-516.
32. Yeo D, Oh SN, Jung C, et al. Correlation of dynamic contrast-enhanced MRI perfusion parameters with angiogenesis and biologic aggressiveness of rectal cancer: Preliminary results. J Magn Reson Imaging, 2015, 41(2): 474-480.

Chinese Journal of Evidence-Based Medicine

Effectiveness of perfusion parameters of DCE-MRI in distinguishing different histological grades of rectal cancer: a meta-analysis

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content