Association between the Insertion/Deletion Polymorphism of ACE Gene and Athletes' Sport Performance in Power Sports: A Meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

 AIJin-wei ^1,2 ^# ,  LIUYing ² ^# , LIDe-sheng ² , LIUYu ² ,  PEIBin ^1,2

1. Evidence-Based Medicine Center, Xiangyang Hospital, Hubei University of Medicine, Xiangyang 441000, China;
2. Department of Micro-orthopedic Surgery, Xiangyang Hospital, Hubei University of Medicine, Xiangyang 441000, China;

Corresponding?author：

PEIBin, Email: xyxzyxzx@163.com

Keywords：

Peptidyl-dipeptidase A; Polymorphism; Athlete; Power sports; Meta-analysis

DOI：

10.7507/1672-2531.20160043

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To systematically review the association between the insertion/deletion (I/D) polymorphism of angiotension-converting enzyme (ACE) gene and the athletes' performance in power sports. Methods Databases including PubMed, EMbase, CNKI, CBM, VIP and WanFang Data were searched up to August 1st, 2015 to collect case-control studies about the association between ACE I/D polymorphism and the athletes' performance in power sports. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Then, meta-analysis was performed using RevMan 5.3 software. Results A total of 26 case-control studies involving 2032 athletes and 10600 controls were included. The results of meta-analysis showed that no significant association was found between ACE I/D polymorphism and the athletes' performance in power sports (DD vs. DI+Ⅱ:OR=1.05, 95%CI 0.81 to 1.36, P=0.70; DD+DI vs. Ⅱ:OR=1.03, 95%CI 0.82 to 1.29, P=0.80; DD vs. Ⅱ:OR=1.04, 95%CI 0.74 to 1.47, P=0.82; DI vs. Ⅱ:OR=0.99, 95%CI 0.81 to 1.22, P=0.96; D vs. I:OR=1.04, 95%CI 0.88 to 1.24, P=0.62). Also, in subgroup analysis by ethnicity, no significant association was found between ACE I/D polymorphism and the performance of athletes of difference races in power sports. Conclusions Current evidence indicates that the ACE I/D polymorphism may not associate with the performance of athletes in power sports. Due to the quality limitations of included studies, more high quality case-control or cohort studies are needed to verify the above conclusions.

Citation： AIJin-wei, LIUYing, LIDe-sheng, LIUYu, PEIBin. Association between the Insertion/Deletion Polymorphism of ACE Gene and Athletes' Sport Performance in Power Sports: A Meta-analysis. Chinese Journal of Evidence-Based Medicine, 2016, 16(3): 263-269. doi: 10.7507/1672-2531.20160043 Copy

1.	Payne J, Montgomery H. Genetic variation and physical performance. World Rev Nutr Diet, 2004, 93:270-302.
2.	Jones A, Montgomery HE, Woods DR. Human performance:a role for the ACE genotype? Exerc Sport Sci Rev, 2002, 30(4):184-190.
3.	左彥方, 龍愛梅, 黃曉青, 等. 血管緊張素轉換酶基因多態性與2型糖尿病腎病相關性的Meta分析. 中國循證醫學雜志, 2012, 12(9):1071-1075.
4.	吳曉梅, 時玥, 時景璞. 中國漢族人群腦出血患者血管緊張素轉換酶基因插入/缺失多態性的Meta分析. 中國循證醫學雜志, 2009, 9(12):1323-1327.
5.	Woods D, Humphries S, Montgomery HE. The ACE I/D Polymorphism and Human Physical Performance. Trends Endocrinol Metab, 2000, 11(10):416-420.
6.	Sessa F, Chetta M, Petito A, et al. Gene polymorphisms and sport attitude in Italian athletes. Genet Test Mol Biomarkers, 2011, 15(4):285-290.
7.	Myerson S, Hemingway H, Budget R, et al. Human angiotensin I-converting enzyme gene and endurance performance. J Appl Physiol, 1999, 87(4):1313-1316.
8.	Costa A, Silva A, Garrido N, et al. Association between ACE D allele and elite short distance swimming. Eur J Appl Physiol, 2009, 106(6):785-790.
9.	Woods D, Hickman M, Jamshidi Y, et al. Elite swimmers and the D allele of the ACE I/D polymorphism. Hum Genet, 2001, 108(3):230-232.
10.	Cieszczyk P, Maciejewska A, Sawczuk M, et al. The angiotensin converting enzyme gene I/D polymorphism in ellite Polish and Lithuanian judo players. Biol Sport, 2010, 27(2):119-122.
11.	Ma F, Yang Y, Li X, et al. The association of sport performance with ACE and ACTN3 genetic polymorphisms:a systematic review and meta-analysis. PLoS One, 2013, 8(1):e54685.
12.	張明軍, 葉學球. 中國漢族成年運動員ACE基因多態性與運動能力的Meta分析. 惠州學院學報, 2015, 35(3):109-116.
13.	Moher D, Liberati A, Tetzlaff J, et al. Reprint——preferred reporting items for systematic reviews and meta-analyses:the PRISMA statement. Phys Ther, 2009, 89(9):873-880.
14.	曾憲濤, Joey S, 田國祥, 等. Meta分析系列之二:Meta分析的軟件. 中國循證心血管醫學雜志, 2012, 4(2):89-91.
15.	徐暢, 劉同族, 曾憲濤. Meta分析系列之十四:Stata實現單核苷酸多態性研究的Meta分析. 中國循證心血管醫學雜志, 2013, 5(5):445-448.
16.	王丹, 翟俊霞, 牟振云, 等. Meta分析中的異質性及其處理方法. 中國循證醫學雜志, 2009, 9(10):1115-1118.
17.	文進, 李幼平. Meta分析中效應尺度指標的選擇. 中國循證醫學雜志, 2007, 7(8):606-613.
18.	鄭輝烈, 王忠旭, 王增珍. Meta分析中發表偏倚的Begg's檢驗、Egger's檢驗及Macaskill's檢驗的SAS程序實現. 中國循證醫學雜志, 2009, 9(8):910-916.
19.	Amir O, Amir R, Yamin C, et al. The ACE deletion allele is associated with Israeli elite endurance athletes. Exp Physiol, 2007, 92(5):881-886.
20.	Nazarov IB, Woods DR, Montgomery HE, et al. The angiotensin converting enzyme I/D polymorphism in Russian athletes. Eur J Hum Genet, 2001, 9(10):797-801.
21.	Papadimitriou ID, Papadopoulos C, Kouvatsi A, et al. The ACE I/D polymorphism in elite Greek track and field athletes. J Sports Med Phys Fitness, 2009, 49(4):459-463.
22.	Ginevi?ien? V1, Pranculis A, Jakaitien? A, et al. Genetic variation of the human ACE and ACTN3 genes and their association with functional muscle properties in Lithuanian elite athletes. Medicina (Kaunas), 2011, 47(5):284-290.
23.	Scott RA, Irving R, Irwin L, et al. ACTN3 and ACE genotypes in elite jamaican and US sprinters. Med Sci Sport Exerc, 2010, 42(1):107-112.
24.	Ruiz JR, Arteta D, Buxens A, et al. Can we identify a power-oriented polygenic profile? J Appl Physiol, 2010, 108(3):561-566.
25.	Shahmoradi S, Ahmadalipour A, Salehi M. Evaluation of ACE gene I/D polymorphism in Iranian elite athletes. Adv Biomed Res, 2014, 3(1):207-213.
26.	Eynon N, Alves AJ, Yamin C, et al. Is there an ACE ID-ACTN3 R577X polymorphisms interaction that influences sprint performance? Int J Sports Med, 2009, 30(12):888-891.
27.	Drozdovska SB, Dosenko VE, Ahmetov Ⅱ, et al. The association of gene polymorphisms with athlete status in Ukrainians. Biol Sport, 2013, 30(3):163-167.
28.	Grenda A, Leońska-Duniec A, Kaczmarczyk M, et al. Interaction between ACE I/D and ACTN3 R557X polymorphisms in Polish competitive swimmers. J Hum Kinet, 2014, 42(1):127-136.
29.	Wang G, Mikami E, Chiu LL, et al. Association analysis of ACE and ACTN3 in elite Caucasian and East Asian swimmers. Med Sci Sportd Exerc, 2013, 45(5):892-900.
30.	Ash GI, Scott RA, Dawson TA, et al. No Association between ACE Gene Variation and Endurance Athlete Status in Ethiopians. Med Sci Sports Exerc, 2011, 43(4):590-597.
31.	孫小敏, 甄文娟, 王煜, 等. 運動員血管緊張素轉換酶基因插入或缺失多態性研究. 中國運動醫學雜志, 2004, 23(5):546-547.
32.	趙云, 馬力宏. 優秀力量運動員ACE基因I/D多態性與運動能力的關聯研究. 中國運動醫學雜志, 2000, 19(3):308-310.
33.	余黎霞, 宋磊剛. 武術散打運動員ACE基因I/D多態性研究. 現代預防醫學, 2010, 37(5):893-896.
34.	張坤, 江雪, 鮮貴平, 等. 跳遠運動員血管緊張素轉化酶基因插入/缺失多態性研究. 重慶醫學, 2015, 44(1):18-20.
35.	Kikuchi N, Min SK, Ueda D, et al. Higher frequency of the ACTN3 R allele + ACE DD genotype in Japanese elite wrestlers. J Strength Cond Res, 2012, 26(12):3275-3280.
36.	Kim CH, Cho JY, Jeon JY, et al. ACE DD genotype is unfavorable to Korean short-term muscle power athletes. Int J Sports Med, 2010, 31(1):65-71.
37.	Hagberg J, Rankinen T, Loos RJ, et al. Advances in exercise, fitness, and performance genomics in 2010. Med Sci Sports Exer, 2011, 43(5):743-752.
38.	Guth LM, Roth SM. Genetic influence on athletic performance. Curr Opin Pediatr, 2013, 25(6):653-658.
39.	Woods D. Angiotensin-converting enzyme, renin-angiotensin system and human performance. Med Sport Sci, 2009, 54:72-87.
40.	楊若愚, 王予彬, 沈勛章, 等. 杰出爆發力素質與基因多態性研究進展. 中國醫藥導報, 2014, 11(19):163-168.

1. Payne J, Montgomery H. Genetic variation and physical performance. World Rev Nutr Diet, 2004, 93:270-302.
2. Jones A, Montgomery HE, Woods DR. Human performance:a role for the ACE genotype? Exerc Sport Sci Rev, 2002, 30(4):184-190.
3. 左彥方, 龍愛梅, 黃曉青, 等. 血管緊張素轉換酶基因多態性與2型糖尿病腎病相關性的Meta分析. 中國循證醫學雜志, 2012, 12(9):1071-1075.
4. 吳曉梅, 時玥, 時景璞. 中國漢族人群腦出血患者血管緊張素轉換酶基因插入/缺失多態性的Meta分析. 中國循證醫學雜志, 2009, 9(12):1323-1327.
5. Woods D, Humphries S, Montgomery HE. The ACE I/D Polymorphism and Human Physical Performance. Trends Endocrinol Metab, 2000, 11(10):416-420.
6. Sessa F, Chetta M, Petito A, et al. Gene polymorphisms and sport attitude in Italian athletes. Genet Test Mol Biomarkers, 2011, 15(4):285-290.
7. Myerson S, Hemingway H, Budget R, et al. Human angiotensin I-converting enzyme gene and endurance performance. J Appl Physiol, 1999, 87(4):1313-1316.
8. Costa A, Silva A, Garrido N, et al. Association between ACE D allele and elite short distance swimming. Eur J Appl Physiol, 2009, 106(6):785-790.
9. Woods D, Hickman M, Jamshidi Y, et al. Elite swimmers and the D allele of the ACE I/D polymorphism. Hum Genet, 2001, 108(3):230-232.
10. Cieszczyk P, Maciejewska A, Sawczuk M, et al. The angiotensin converting enzyme gene I/D polymorphism in ellite Polish and Lithuanian judo players. Biol Sport, 2010, 27(2):119-122.
11. Ma F, Yang Y, Li X, et al. The association of sport performance with ACE and ACTN3 genetic polymorphisms:a systematic review and meta-analysis. PLoS One, 2013, 8(1):e54685.
12. 張明軍, 葉學球. 中國漢族成年運動員ACE基因多態性與運動能力的Meta分析. 惠州學院學報, 2015, 35(3):109-116.
13. Moher D, Liberati A, Tetzlaff J, et al. Reprint——preferred reporting items for systematic reviews and meta-analyses:the PRISMA statement. Phys Ther, 2009, 89(9):873-880.
14. 曾憲濤, Joey S, 田國祥, 等. Meta分析系列之二:Meta分析的軟件. 中國循證心血管醫學雜志, 2012, 4(2):89-91.
15. 徐暢, 劉同族, 曾憲濤. Meta分析系列之十四:Stata實現單核苷酸多態性研究的Meta分析. 中國循證心血管醫學雜志, 2013, 5(5):445-448.
16. 王丹, 翟俊霞, 牟振云, 等. Meta分析中的異質性及其處理方法. 中國循證醫學雜志, 2009, 9(10):1115-1118.
17. 文進, 李幼平. Meta分析中效應尺度指標的選擇. 中國循證醫學雜志, 2007, 7(8):606-613.
18. 鄭輝烈, 王忠旭, 王增珍. Meta分析中發表偏倚的Begg's檢驗、Egger's檢驗及Macaskill's檢驗的SAS程序實現. 中國循證醫學雜志, 2009, 9(8):910-916.
19. Amir O, Amir R, Yamin C, et al. The ACE deletion allele is associated with Israeli elite endurance athletes. Exp Physiol, 2007, 92(5):881-886.
20. Nazarov IB, Woods DR, Montgomery HE, et al. The angiotensin converting enzyme I/D polymorphism in Russian athletes. Eur J Hum Genet, 2001, 9(10):797-801.
21. Papadimitriou ID, Papadopoulos C, Kouvatsi A, et al. The ACE I/D polymorphism in elite Greek track and field athletes. J Sports Med Phys Fitness, 2009, 49(4):459-463.
22. Ginevi?ien? V1, Pranculis A, Jakaitien? A, et al. Genetic variation of the human ACE and ACTN3 genes and their association with functional muscle properties in Lithuanian elite athletes. Medicina (Kaunas), 2011, 47(5):284-290.
23. Scott RA, Irving R, Irwin L, et al. ACTN3 and ACE genotypes in elite jamaican and US sprinters. Med Sci Sport Exerc, 2010, 42(1):107-112.
24. Ruiz JR, Arteta D, Buxens A, et al. Can we identify a power-oriented polygenic profile? J Appl Physiol, 2010, 108(3):561-566.
25. Shahmoradi S, Ahmadalipour A, Salehi M. Evaluation of ACE gene I/D polymorphism in Iranian elite athletes. Adv Biomed Res, 2014, 3(1):207-213.
26. Eynon N, Alves AJ, Yamin C, et al. Is there an ACE ID-ACTN3 R577X polymorphisms interaction that influences sprint performance? Int J Sports Med, 2009, 30(12):888-891.
27. Drozdovska SB, Dosenko VE, Ahmetov Ⅱ, et al. The association of gene polymorphisms with athlete status in Ukrainians. Biol Sport, 2013, 30(3):163-167.
28. Grenda A, Leońska-Duniec A, Kaczmarczyk M, et al. Interaction between ACE I/D and ACTN3 R557X polymorphisms in Polish competitive swimmers. J Hum Kinet, 2014, 42(1):127-136.
29. Wang G, Mikami E, Chiu LL, et al. Association analysis of ACE and ACTN3 in elite Caucasian and East Asian swimmers. Med Sci Sportd Exerc, 2013, 45(5):892-900.
30. Ash GI, Scott RA, Dawson TA, et al. No Association between ACE Gene Variation and Endurance Athlete Status in Ethiopians. Med Sci Sports Exerc, 2011, 43(4):590-597.
31. 孫小敏, 甄文娟, 王煜, 等. 運動員血管緊張素轉換酶基因插入或缺失多態性研究. 中國運動醫學雜志, 2004, 23(5):546-547.
32. 趙云, 馬力宏. 優秀力量運動員ACE基因I/D多態性與運動能力的關聯研究. 中國運動醫學雜志, 2000, 19(3):308-310.
33. 余黎霞, 宋磊剛. 武術散打運動員ACE基因I/D多態性研究. 現代預防醫學, 2010, 37(5):893-896.
34. 張坤, 江雪, 鮮貴平, 等. 跳遠運動員血管緊張素轉化酶基因插入/缺失多態性研究. 重慶醫學, 2015, 44(1):18-20.
35. Kikuchi N, Min SK, Ueda D, et al. Higher frequency of the ACTN3 R allele + ACE DD genotype in Japanese elite wrestlers. J Strength Cond Res, 2012, 26(12):3275-3280.
36. Kim CH, Cho JY, Jeon JY, et al. ACE DD genotype is unfavorable to Korean short-term muscle power athletes. Int J Sports Med, 2010, 31(1):65-71.
37. Hagberg J, Rankinen T, Loos RJ, et al. Advances in exercise, fitness, and performance genomics in 2010. Med Sci Sports Exer, 2011, 43(5):743-752.
38. Guth LM, Roth SM. Genetic influence on athletic performance. Curr Opin Pediatr, 2013, 25(6):653-658.
39. Woods D. Angiotensin-converting enzyme, renin-angiotensin system and human performance. Med Sport Sci, 2009, 54:72-87.
40. 楊若愚, 王予彬, 沈勛章, 等. 杰出爆發力素質與基因多態性研究進展. 中國醫藥導報, 2014, 11(19):163-168.

Chinese Journal of Evidence-Based Medicine

Association between the Insertion/Deletion Polymorphism of ACE Gene and Athletes' Sport Performance in Power Sports: A Meta-analysis

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