Influence of Paternal Serum HBV-DNA Load Levels and Pregnant Women's HBsAb on Paternal Vertical Transmission of Hepatitis B Virus_Chinese Journal of Evidence-Based Medicine

Authors：

 CHENShun-ping ¹ ,  ZHANGRong-lian ² , RENKun-hai ²

1. Department of Nursing, Fujian Health College, Fuzhou 350101, China;
2. Department of Healthcare, Fujian Maternal and Children's Health Care Hospital, Fuzhou 350101, China;

Corresponding?author：

ZHANGRong-lian, Email: wpxzrl@163.com

Keywords：

Hepatitis B virus; Father to infant vertical transmission; DNA; HBsAb; Case-control study

DOI：

10.7507/1672-2531.20140152

Video：

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Objective To explore the influence of paternal serum HBV-DNA load levels and pregnant women's HBsAb on vertical transmission of hepatitis B virus (HBV) from HBsAg positive fathers to infants in order to provide effective methods for paternal-fetal ventrical transmission of HBV prevention. Methods Using HBsAg and HBV-DNA as indicators to screen pregnant women and their husbands after gained consent, 121 families with HBVM negative or only HBsAb positive and HBV-DNA negative pregnant women, HBsAg positive husbands and their newborns were selected. In this case-control study, according to neonatal cord blood HBV-DNA detection, 23 newborns with cord blood HBV-DNA positive were selected as cases, 98 newborns as controls. Results The positive rate of neonatal cord blood HBV-DNA was 19.0% (23/121); and there was dose-response relationship between paternal serum HBV-DNA load levels and neonatal cord blood HBV-DNA positive (trend χ²=60.108, P=0.000). The analysis of ROC curve showed that paternal serum HBV-DNA load level (10⁶ copies/mL) is a better demarcation point to forecast the occurrence of vertical transmission of HBV from HBsAg positive fathers to infants, because there was a better sensitivity and specificity during forecast; and HBsAb negative pregnant women's were statistically significant (χ²=12.399, P=0.000). There was no significant difference at the positive rate of neonatal cord blood HBV-DNA between the case group and control group when paternal serum HBV-DNA load levels exceed 10⁷ copies/mL (P > 0.05). Conclusion Paternal serum HBV-DNA load levels and HBsAb negative pregnant women are the risk factors of vertical transmission of HBV from HBsAg positive father to infants. Paternal serum HBV-DNA load level (10⁶ copies/mL) is an appropriate index of the occurrence of vertical transmission.

Citation： CHENShun-ping, ZHANGRong-lian, RENKun-hai. Influence of Paternal Serum HBV-DNA Load Levels and Pregnant Women's HBsAb on Paternal Vertical Transmission of Hepatitis B Virus. Chinese Journal of Evidence-Based Medicine, 2014, 14(8): 915-918. doi: 10.7507/1672-2531.20140152 Copy

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17.	夏良斌, 敖良飛, 楊菁, 等.不同方案阻斷乙型肝炎病毒父嬰垂直傳播的初步研究.實用醫學雜志, 2010, 26(4): 583-584.
18.	葛曉英, 徐云萍, 蔡東飛, 等.預防免疫阻斷乙肝病毒父嬰傳播效果觀察.浙江臨床醫學, 2006, 8(5): 458-459.
19.	張海青.乙型肝炎病毒父嬰垂直傳播的臨床分析.中國優生與遺傳雜志, 2010, 18(6): 27, 30.
20.	張國民, 孫校金, 王富珍, 等.中國18～59歲人群乙型病毒性肝炎流行病學特征分析及乙型肝炎疫苗免疫策略探討.中國疫苗和免疫, 2013, 19(3): 266-270.
21.	陳順萍, 林翔.重視圍生期孕產婦乙肝防治的健康教育.中國婦幼保健, 2012, 18(2): 4355-4357.

1. ?中國人民共和國衛生部.中國衛生統計年鑒.北京:中國協和醫科大學出社, 2006: 236-237.
2. 中華人民共和國國家衛生和計劃生育委員會. 2012年度全國法定傳染病疫情概況. 2013. Available at: http://www.chinapop.gov.cn/zhuzhan/yqxx/201304/b540269c8e5141e6bb2d00ca539bb9f7.shtml.
3. 王建設, 朱啟镕, 張鴻飛.中華醫學會感染病學分會第八次全國小兒肝病學術會議紀要.中國循證兒科雜志, 2007, 2(3): 238-239.
4. Ali BA, Huang TH, Saleml HH, et al. Expression of hepatitis B virus genes in early embryonic cells originated from hamster ova and human spermatozoa transfected with the complete viral genome. Asian J Androl, 2006, 8(3): 273.
5. 孟慶舉, 肖小敏.產前乙型肝炎病毒父嬰垂直傳播幾率的Meta分析.中國優生與遺傳雜志, 2008, 16(5): 62-63.
6. 李穗湘.人乙肝免疫球蛋白聯合重組乙肝疫苗對乙型肝炎父嬰傳播控制的臨床研究.中國初級衛生保健, 2006, 20(6): 65-66.
7. 楊靜, 邵興蘭, 尤世剛.乙肝免疫球蛋白阻斷HBV父嬰、母嬰傳播的觀察.現代預防醫學, 2006, 33(5): 806-813.
8. 練云, 陸曉梅, 崔琰, 等.乙型肝炎病毒父嬰垂直傳播及預防免疫的臨床研究.中國婦幼保健, 2007, 22(7): 4122-4123.
9. 陳紅, 李小鷗, 雷艷喆.阻斷乙型肝炎病毒父嬰傳播的研究.中國優生與遺傳雜志, 2009, 17(2): 80-81.
10. 張俊明, 李國敏, 洪寶林, 等.預防免疫阻斷乙型肝炎父嬰傳播的臨床研究.實用臨床醫藥雜志, 2009, 13(12): 134-135.
11. 張榮蓮, 羅穎, 謝婧嫻, 等. HBV父嬰垂直傳播水平與HBV-DNA載量的相關研究.中華流行病學雜志, 2010, 31(5): 159-162.
12. 潘大虎, 翟海燕, 宋農, 等. HBV-DNA的定量檢測對乙肝父嬰與母嬰傳播的研究.右江民族醫學院學報, 2007, 2(5): 211-212.
13. 高穎, 李峰. HBV父嬰傳播的分子生物學研究.中國醫藥指南, 2008, 6(1): 1-2.
14. 盧銀平, 曹偉, 洪梅, 等.父親HBV攜帶與嬰兒HBV感染的關系.中國婦幼保健, 2011, 26(2): 220-221.
15. 王文龍, 唐曉鵬, 丁依玲, 等.妊娠晚期母嬰乙型肝炎表面抗體濃度相關性研究.中國感染控制雜志, 2004, 3(2): 106-108.
16. 朱科倫, 朱郇憫, 曾文鋌, 等.乙型肝炎病毒經生殖細胞傳播的研究.廣州醫藥, 2008, 9(2): 3-5.
17. 夏良斌, 敖良飛, 楊菁, 等.不同方案阻斷乙型肝炎病毒父嬰垂直傳播的初步研究.實用醫學雜志, 2010, 26(4): 583-584.
18. 葛曉英, 徐云萍, 蔡東飛, 等.預防免疫阻斷乙肝病毒父嬰傳播效果觀察.浙江臨床醫學, 2006, 8(5): 458-459.
19. 張海青.乙型肝炎病毒父嬰垂直傳播的臨床分析.中國優生與遺傳雜志, 2010, 18(6): 27, 30.
20. 張國民, 孫校金, 王富珍, 等.中國18～59歲人群乙型病毒性肝炎流行病學特征分析及乙型肝炎疫苗免疫策略探討.中國疫苗和免疫, 2013, 19(3): 266-270.
21. 陳順萍, 林翔.重視圍生期孕產婦乙肝防治的健康教育.中國婦幼保健, 2012, 18(2): 4355-4357.

Chinese Journal of Evidence-Based Medicine

Influence of Paternal Serum HBV-DNA Load Levels and Pregnant Women's HBsAb on Paternal Vertical Transmission of Hepatitis B Virus

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