細胞外囊泡在急性呼吸窘迫綜合征中的研究進展_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

祁夢雷 ¹ ,  劉維英 ² , 劉茹悅 ¹ , 閆燕羽 ¹

1. ;
2. ;

Corresponding?author：

劉維英, Email: lwy70828@126.com

Keywords：

DOI：

10.7507/1671-6205.202010068

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Citation： 祁夢雷, 劉維英, 劉茹悅, 閆燕羽. 細胞外囊泡在急性呼吸窘迫綜合征中的研究進展. Chinese Journal of Respiratory and Critical Care Medicine, 2021, 20(5): 372-375. doi: 10.7507/1671-6205.202010068 Copy

1.	Huppert LA, Matthay MA, Ware LB. Pathogenesis of acute respiratory distress syndrome. Semin Respir Crit Care Med, 2019, 40(1): 31-39.
2.	Théry C, Witwer KW, Aikawa E, et al. Minimal information for studies of extracellular vesicles 2018(MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles, 2018, 7(1): 1535750.
3.	Yá?ez-Mó M, Siljander PR, Andreu Z, et al. Biological properties of extracellular vesicles and their physiological functions. J Extracell Vesicles, 2015, 4: 27066.
4.	Holtzman J, Lee H. Emerging role of extracellular vesicles in the respiratory system. Exp Mol Med, 2020, 52(6): 887-895.
5.	Chen R, Xu X, Qian Z, et al. The biological functions and clinical applications of exosomes in lung cancer. Cell Mol Life Sci, 2019, 76(23): 4613-4633.
6.	Crescitelli R, L?sser C, Szabó TG, et al. Distinct RNA profiles in subpopulations of extracellular vesicles: apoptotic bodies, microvesicles and exosomes. J Extracell Vesicles, 2013, 2: 20677.
7.	Kalluri R, LeBleu VS. The biology, function, and biomedical applications of exosomes. Science, 2020, 367(6478): eaau6977.
8.	Colombo M, Raposo G, Théry C. Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. Annu Rev Cell Dev Biol, 2014, 30: 255-289.
9.	Admyre C, Grunewald J, Thyberg J, et al. Exosomes with major histocompatibility complex class II and co-stimulatory molecules are present in human BAL fluid. Eur Respir J, 2003, 22(4): 578-583.
10.	EL Andaloussi S, M?ger I, Breakefield XO, et al. Extracellular vesicles: biology and emerging therapeutic opportunities. Nat Rev Drug Discov, 2013, 12(5): 347-357.
11.	Lo Cicero A, Stahl PD, Raposo G. Extracellular vesicles shuffling intercellular messages: for good or for bad. Curr Opin Cell Biol, 2015, 35: 69-77.
12.	Tricarico C, Clancy J, D'Souza-Schorey C. Biology and biogenesis of shed microvesicles. Small GTPases, 2017, 8(4): 220-232.
13.	McVey MJ, Maishan M, Blokland KEC, et al. Extracellular vesicles in lung health, disease, and therapy. Am J Physiol Lung Cell Mol Physiol, 2019, 316(6): L977-L989.
14.	Lee H, Zhang D, Laskin DL, et al. Functional evidence of pulmonary extracellular vesicles in infectious and noninfectious lung inflammation. J Immunol, 2018, 201(5): 1500-1509.
15.	Huang XF, Xiu HQ, Zhang SF, et al. The role of macrophages in the pathogenesis of ALI/ARDS. Mediators Inflamm, 2018, 2018: 1264913.
16.	鄭伯俊, 張月, 孫娜娜, 等. 脂多糖誘導巨噬細胞釋放的外泌體在小鼠急性肺損傷中的作用及其機制. 中華醫學雜志, 2018, 98(22): 1780-1785.
17.	Lee H, Zhang D, Wu J, et al. Lung epithelial cell-derived microvesicles regulate macrophage migration via microRNA-17/221-induced integrin β1 recycling. J Immunol, 2017, 199(4): 1453-1464.
18.	Reyes-Reyes M, Mora N, Gonzalez G, et al. beta1 and beta2 integrins activate different signalling pathways in monocytes. Biochem J, 2002, 363(Pt 2): 273-280.
19.	Moon HG, Cao Y, Yang J, et al. Lung epithelial cell-derived extracellular vesicles activate macrophage-mediated inflammatory responses via ROCK1 pathway. Cell Death Dis, 2015, 6(12): 116.
20.	Lee H, Zhang D, Zhu Z, et al. Epithelial cell-derived microvesicles activate macrophages and promote inflammation via microvesicle-containing microRNAs. Sci Rep, 2016, 6: 35250.
21.	Matthay MA, Zemans RL, Zimmerman GA, et al. Acute respiratory distress syndrome. Nat Rev Dis Primers, 2019, 5(1): 18.
22.	Mitra S, Wewers MD, Sarkar A. Mononuclear phagocyte-derived microparticulate caspase-1 induces pulmonary vascular endothelial cell injury. PLoS One, 2015, 10(12): e0145607.
23.	Scheller N, Herold S, Kellner R, et al. Proviral microRNAs detected in extracellular vesicles from bronchoalveolar lavage fluid of patients with influenza virus-induced acute respiratory distress syndrome. J Infect Dis, 2019, 219(4): 540-543.
24.	Yuan ZH, Bedi B, Sadikot RT. Bronchoalveolar lavage exosomes in lipopolysaccharide-induced septic lung injury. J Vis Exp, 2018, (135): 57737.
25.	Ye C, Li H, Bao M, et al. Alveolar macrophage - derived exosomes modulate severity and outcome of acute lung injury. Aging (Albany NY), 2020, 12(7): 6120-6128.
26.	Wang L, Liu J, Xie W, et al. miR-425 reduction causes aberrant proliferation and collagen synthesis through modulating TGF-β/Smad signaling in acute respiratory distress syndrome. Int J Clin Exp Pathol, 2019, 12(7): 2604-2612.
27.	Kim TH, Hong SB, Lim CM, et al. The role of exosomes in bronchoalveloar lavage from patients with acute respiratory distress syndrome. J Clin Med, 2019, 8(8): 1148.
28.	Wu X, Wu CZ, Gu WY, et al. Serum exosomal microRNAs predict acute respiratory distress syndrome events in patients with severe community-acquired pneumonia. Biomed Res Int, 2019, 2019: 3612020.
29.	Guervilly C, Lacroix R, Forel JM, et al. High levels of circulating leukocyte microparticles are associated with better outcome in acute respiratory distress syndrome. Crit Care, 2011, 15(1): R31.
30.	Sun X, Singleton PA, Letsiou E, et al. Sphingosine-1-phosphate receptor-3 is a novel biomarker in acute lung injury. Am J Respir Cell Mol Biol, 2012, 47(5): 628-636.
31.	Le Blanc K, Mougiakakos D. Multipotent mesenchymal stromal cells and the innate immune system. Nat Rev Immunol, 2012, 12(5): 383-396.
32.	Maumus M, Jorgensen C, No?l D. Mesenchymal stem cells in regenerative medicine applied to rheumatic diseases: role of secretome and exosomes. Biochimie, 2013, 95(12): 2229-2234.
33.	Zhu YG, Feng XM, Abbott J, et al. Human mesenchymal stem cell microvesicles for treatment of Escherichia coli endotoxin-induced acute lung injury in mice. Stem Cells, 2014, 32(1): 116-125.
34.	Tang XD, Shi L, Monsel A, et al. Mesenchymal stem cell microvesicles attenuate acute lung injury in mice partly mediated by Ang-1 mRNA. Stem Cells, 2017, 35(7): 1849-1859.
35.	Wei X, Yi X, Lv H, et al. MicroRNA-377-3p released by mesenchymal stem cell exosomes ameliorates lipopolysaccharide-induced acute lung injury by targeting RPTOR to induce autophagy. Cell Death Dis, 2020, 11(8): 657.
36.	Yi X, Wei X, Lv H, et al. Exosomes derived from microRNA-30b-3p-overexpressing mesenchymal stem cells protect against lipopolysaccharide-induced acute lung injury by inhibiting SAA3. Exp Cell Res, 2019, 383(2): 111454.
37.	Monsel A, Zhu YG, Gennai S, et al. Therapeutic effects of human mesenchymal stem cell-derived microvesicles in severe pneumonia in mice. Am J Respir Crit Care Med, 2015, 192(3): 324-336.
38.	Hao Q, Gudapati V, Monsel A, et al. Mesenchymal stem cell-derived extracellular vesicles decrease lung injury in mice. J Immunol, 2019, 203(7): 1961-1972.
39.	Loy H, Kuok DIT, Hui KPY, et al. Therapeutic implications of human umbilical cord mesenchymal stromal cells in attenuating influenza A (H5N1) virus-associated acute lung injury. J Infect Dis, 2019, 219(2): 186-196.
40.	Sengupta V, Sengupta S, Lazo A, et al. Exosomes derived from bone marrow mesenchymal stem cells as treatment for severe COVID-19. Stem Cells Dev, 2020, 29(12): 747-754.
41.	Li QC, Liang Y, Su ZB. Prophylactic treatment with MSC-derived exosomes attenuates traumatic acute lung injury in rats. Am J Physiol Lung Cell Mol Physiol, 2019, 316(6): L1107-L1117.
42.	Zhou Y, Li P, Goodwin AJ, et al. Exosomes from endothelial progenitor cells improve outcomes of the lipopolysaccharide-induced acute lung injury. Crit Care, 2019, 23(1): 44.
43.	Li ZG, Scott MJ, Brzóska T, et al. Lung epithelial cell-derived IL-25 negatively regulates LPS-induced exosome release from macrophages. Mil Med Res, 2018, 5(1): 24.

1. Huppert LA, Matthay MA, Ware LB. Pathogenesis of acute respiratory distress syndrome. Semin Respir Crit Care Med, 2019, 40(1): 31-39.
2. Théry C, Witwer KW, Aikawa E, et al. Minimal information for studies of extracellular vesicles 2018(MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles, 2018, 7(1): 1535750.
3. Yá?ez-Mó M, Siljander PR, Andreu Z, et al. Biological properties of extracellular vesicles and their physiological functions. J Extracell Vesicles, 2015, 4: 27066.
4. Holtzman J, Lee H. Emerging role of extracellular vesicles in the respiratory system. Exp Mol Med, 2020, 52(6): 887-895.
5. Chen R, Xu X, Qian Z, et al. The biological functions and clinical applications of exosomes in lung cancer. Cell Mol Life Sci, 2019, 76(23): 4613-4633.
6. Crescitelli R, L?sser C, Szabó TG, et al. Distinct RNA profiles in subpopulations of extracellular vesicles: apoptotic bodies, microvesicles and exosomes. J Extracell Vesicles, 2013, 2: 20677.
7. Kalluri R, LeBleu VS. The biology, function, and biomedical applications of exosomes. Science, 2020, 367(6478): eaau6977.
8. Colombo M, Raposo G, Théry C. Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. Annu Rev Cell Dev Biol, 2014, 30: 255-289.
9. Admyre C, Grunewald J, Thyberg J, et al. Exosomes with major histocompatibility complex class II and co-stimulatory molecules are present in human BAL fluid. Eur Respir J, 2003, 22(4): 578-583.
10. EL Andaloussi S, M?ger I, Breakefield XO, et al. Extracellular vesicles: biology and emerging therapeutic opportunities. Nat Rev Drug Discov, 2013, 12(5): 347-357.
11. Lo Cicero A, Stahl PD, Raposo G. Extracellular vesicles shuffling intercellular messages: for good or for bad. Curr Opin Cell Biol, 2015, 35: 69-77.
12. Tricarico C, Clancy J, D'Souza-Schorey C. Biology and biogenesis of shed microvesicles. Small GTPases, 2017, 8(4): 220-232.
13. McVey MJ, Maishan M, Blokland KEC, et al. Extracellular vesicles in lung health, disease, and therapy. Am J Physiol Lung Cell Mol Physiol, 2019, 316(6): L977-L989.
14. Lee H, Zhang D, Laskin DL, et al. Functional evidence of pulmonary extracellular vesicles in infectious and noninfectious lung inflammation. J Immunol, 2018, 201(5): 1500-1509.
15. Huang XF, Xiu HQ, Zhang SF, et al. The role of macrophages in the pathogenesis of ALI/ARDS. Mediators Inflamm, 2018, 2018: 1264913.
16. 鄭伯俊, 張月, 孫娜娜, 等. 脂多糖誘導巨噬細胞釋放的外泌體在小鼠急性肺損傷中的作用及其機制. 中華醫學雜志, 2018, 98(22): 1780-1785.
17. Lee H, Zhang D, Wu J, et al. Lung epithelial cell-derived microvesicles regulate macrophage migration via microRNA-17/221-induced integrin β1 recycling. J Immunol, 2017, 199(4): 1453-1464.
18. Reyes-Reyes M, Mora N, Gonzalez G, et al. beta1 and beta2 integrins activate different signalling pathways in monocytes. Biochem J, 2002, 363(Pt 2): 273-280.
19. Moon HG, Cao Y, Yang J, et al. Lung epithelial cell-derived extracellular vesicles activate macrophage-mediated inflammatory responses via ROCK1 pathway. Cell Death Dis, 2015, 6(12): 116.
20. Lee H, Zhang D, Zhu Z, et al. Epithelial cell-derived microvesicles activate macrophages and promote inflammation via microvesicle-containing microRNAs. Sci Rep, 2016, 6: 35250.
21. Matthay MA, Zemans RL, Zimmerman GA, et al. Acute respiratory distress syndrome. Nat Rev Dis Primers, 2019, 5(1): 18.
22. Mitra S, Wewers MD, Sarkar A. Mononuclear phagocyte-derived microparticulate caspase-1 induces pulmonary vascular endothelial cell injury. PLoS One, 2015, 10(12): e0145607.
23. Scheller N, Herold S, Kellner R, et al. Proviral microRNAs detected in extracellular vesicles from bronchoalveolar lavage fluid of patients with influenza virus-induced acute respiratory distress syndrome. J Infect Dis, 2019, 219(4): 540-543.
24. Yuan ZH, Bedi B, Sadikot RT. Bronchoalveolar lavage exosomes in lipopolysaccharide-induced septic lung injury. J Vis Exp, 2018, (135): 57737.
25. Ye C, Li H, Bao M, et al. Alveolar macrophage - derived exosomes modulate severity and outcome of acute lung injury. Aging (Albany NY), 2020, 12(7): 6120-6128.
26. Wang L, Liu J, Xie W, et al. miR-425 reduction causes aberrant proliferation and collagen synthesis through modulating TGF-β/Smad signaling in acute respiratory distress syndrome. Int J Clin Exp Pathol, 2019, 12(7): 2604-2612.
27. Kim TH, Hong SB, Lim CM, et al. The role of exosomes in bronchoalveloar lavage from patients with acute respiratory distress syndrome. J Clin Med, 2019, 8(8): 1148.
28. Wu X, Wu CZ, Gu WY, et al. Serum exosomal microRNAs predict acute respiratory distress syndrome events in patients with severe community-acquired pneumonia. Biomed Res Int, 2019, 2019: 3612020.
29. Guervilly C, Lacroix R, Forel JM, et al. High levels of circulating leukocyte microparticles are associated with better outcome in acute respiratory distress syndrome. Crit Care, 2011, 15(1): R31.
30. Sun X, Singleton PA, Letsiou E, et al. Sphingosine-1-phosphate receptor-3 is a novel biomarker in acute lung injury. Am J Respir Cell Mol Biol, 2012, 47(5): 628-636.
31. Le Blanc K, Mougiakakos D. Multipotent mesenchymal stromal cells and the innate immune system. Nat Rev Immunol, 2012, 12(5): 383-396.
32. Maumus M, Jorgensen C, No?l D. Mesenchymal stem cells in regenerative medicine applied to rheumatic diseases: role of secretome and exosomes. Biochimie, 2013, 95(12): 2229-2234.
33. Zhu YG, Feng XM, Abbott J, et al. Human mesenchymal stem cell microvesicles for treatment of Escherichia coli endotoxin-induced acute lung injury in mice. Stem Cells, 2014, 32(1): 116-125.
34. Tang XD, Shi L, Monsel A, et al. Mesenchymal stem cell microvesicles attenuate acute lung injury in mice partly mediated by Ang-1 mRNA. Stem Cells, 2017, 35(7): 1849-1859.
35. Wei X, Yi X, Lv H, et al. MicroRNA-377-3p released by mesenchymal stem cell exosomes ameliorates lipopolysaccharide-induced acute lung injury by targeting RPTOR to induce autophagy. Cell Death Dis, 2020, 11(8): 657.
36. Yi X, Wei X, Lv H, et al. Exosomes derived from microRNA-30b-3p-overexpressing mesenchymal stem cells protect against lipopolysaccharide-induced acute lung injury by inhibiting SAA3. Exp Cell Res, 2019, 383(2): 111454.
37. Monsel A, Zhu YG, Gennai S, et al. Therapeutic effects of human mesenchymal stem cell-derived microvesicles in severe pneumonia in mice. Am J Respir Crit Care Med, 2015, 192(3): 324-336.
38. Hao Q, Gudapati V, Monsel A, et al. Mesenchymal stem cell-derived extracellular vesicles decrease lung injury in mice. J Immunol, 2019, 203(7): 1961-1972.
39. Loy H, Kuok DIT, Hui KPY, et al. Therapeutic implications of human umbilical cord mesenchymal stromal cells in attenuating influenza A (H5N1) virus-associated acute lung injury. J Infect Dis, 2019, 219(2): 186-196.
40. Sengupta V, Sengupta S, Lazo A, et al. Exosomes derived from bone marrow mesenchymal stem cells as treatment for severe COVID-19. Stem Cells Dev, 2020, 29(12): 747-754.
41. Li QC, Liang Y, Su ZB. Prophylactic treatment with MSC-derived exosomes attenuates traumatic acute lung injury in rats. Am J Physiol Lung Cell Mol Physiol, 2019, 316(6): L1107-L1117.
42. Zhou Y, Li P, Goodwin AJ, et al. Exosomes from endothelial progenitor cells improve outcomes of the lipopolysaccharide-induced acute lung injury. Crit Care, 2019, 23(1): 44.
43. Li ZG, Scott MJ, Brzóska T, et al. Lung epithelial cell-derived IL-25 negatively regulates LPS-induced exosome release from macrophages. Mil Med Res, 2018, 5(1): 24.

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細胞外囊泡在急性呼吸窘迫綜合征中的研究進展

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