Correlative analysis of obstructive sleep apnea hypopnea syndrome and biochemical markers in children_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

 ZHU Peiqiang ¹ , LIU Dezhong ² , PAN Chongping ³

1. Department of Clinical Laboratory, Heze Maternal and Child Health-Care Hospital, Heze, Shandong 274014, P. R. China;
2. Department of Clinical Laboratory, Heze Traditional Chinese Medicine Hospital, Heze, Shandong 274014, P. R. China;
3. Department of Clinical Laboratory, Heze Municipal Hospital, Heze, Shandong 274014, P. R. China;

Corresponding?author：

ZHU Peiqiang, Email: wangxue11w@163.com

Keywords：

Obstructive sleep apnea hypopnea syndrome; Children; Biochemical index; Relevance

DOI：

10.7507/1671-6205.201705030

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Objective To investigate the correlation between obstructive sleep apnea hypopnea syndrome (OSAHS) and biochemical indexes in children. Methods Seventy-eight children with OSAHS in our hospital from January 2015 to February 2017 were recruited as an observation group, and 100 normal children who underwent physical examination were selected as a control group in the same period. The mean values and positive rates of biochemical markers were compared between two groups including alanine aminotransferase (ALT), blood urea nitrogen (BUN), total cholesterol (TC), triglyceride (TG), creatine kinase isoenzyme (CK-MB), cardiac troponin I (cTnI), fasting blood glucose (FPG) level. Results The mean values of biochemical indexes showed significant differences between the observation group and the control group except BUN and FPG [ALT, (52.1±26.2) U/L vs. (41.3±18.5) U/L; TC, (4.9±0.9) mmol/L vs. (4.3±0.8) mmol/L; TG, (1.4±0.7) mmol/L vs. (1.0±0.4) mmol/L; CK-MB, (24.3±9.5) U/L vs. (11.2±8.2) U/L; cTnI, (1.4±0.7) μg/L vs. (1.0±0.6) μg/L] (all P<0.05). The positive rates also showed significant differences between the observation group and the control group except BUN and FPG [ALT (48.7%vs. 14.0%), TC (24.4% vs. 8.0%), TG (23.1% vs. 8.0%), CK-MB (41.0% vs. 11.0%), cTnI (34.6% vs. 7.0%) (all P<0.05). Conclusions The cardiac function and liver function are significantly impaired in children with OSAHS, showing the disorder of lipid metabolism to some extent. These abnormal indexes may be the occurrence and development of OSAHS. More attention should be paid to the detection of biochemical indexes in children with OSAHS.

Citation： ZHU Peiqiang, LIU Dezhong, PAN Chongping. Correlative analysis of obstructive sleep apnea hypopnea syndrome and biochemical markers in children. Chinese Journal of Respiratory and Critical Care Medicine, 2018, 17(2): 169-171. doi: 10.7507/1671-6205.201705030 Copy

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13.	侯冬青, 王湘富, 楊輝紅, 等. 阻塞性睡眠呼吸暫停低通氣綜合征的臨床流行病學調查及相關因素分析. 醫學臨床研究, 2006, 23(3): 297-299.
14.	尹雪玲, 孟杰, 張偉, 等. CPAP 聯合口腔矯治器治療阻塞型睡眠呼吸暫停低通氣綜合征伴高血壓療效觀察. 山東醫藥, 2014, 54(16): 45-46.
15.	黃家軍, 劉暢, 蘇炳澤, 等. 老年阻塞性睡眠呼吸暫停綜合征多導睡眠圖與認知功能的相關性. 中國老年學雜志, 2014, 34(20): 5700-5701.

1. 周艾. 兒童阻塞性睡眠呼吸暫停低通氣綜合征的腺樣體檢查. 臨床肺科雜志, 2010, 15(11): 1602-1604.
2. 中華醫學會耳鼻咽喉科學分會, 中華耳鼻咽喉頭頸外科雜志編委會. 兒童阻塞性睡眠呼吸暫停低通氣綜合征診療指南草案 (烏魯木齊). 中華耳鼻咽喉頭頸外科雜志, 2007, 42(2): 83-84.
3. 常麗, 曹玲. 兒童阻塞性睡眠呼吸暫停低通氣綜合征血氧飽和度變化分析. 中國實用兒科雜志, 2011, 26(2): 131-133.
4. 郭建梅, 曹潔, 崔明亮, 等. OSAHS 患者咽部解剖與呼吸驅動的關系研究. 臨床肺科雜志, 2012, 17(1): 18-19.
5. 張煥改, 蔡曉紅, 李美麗, 等. 鼾癥對兒童睡眠結構及生長發育的影響. 實用兒科臨床雜志, 2010, 25(4): 252-254.
6. 穆亞平, 趙方, 馬洪剛, 等. 兒童及青少年肥胖癥糖脂代謝異常早期診斷和干預的研究. 中國實用兒科雜志, 2011, 26(8):587-591.
7. 許志飛, 安嘉清, 李豫川, 等. 肥胖兒童睡眠呼吸障礙與肥胖相關性調查研究. 中國實用兒科雜志, 2011, 26(4): 260-263.
8. Hassid S, Afrapoli AH, Decaestecker C, et al. UPPP for snoring: long-term results and patient satisfaction. Acta Otorhinolaryngol Belg, 2012, 66(2): 157-162.
9. Friedman M, Ibrahim H, Bass L. Clinical staging for sleep disordered breathing. Otolaryngol Head Neck Surg, 2012, 137 (1): 13-21.
10. Kohler M, Bloch KE, Stradling JR. The role of the nose in the pathogenesis of obstructive sleep apnoea and snoring. Eur Respir J, 2014, 37(6): 1208-1215.
11. Bhat TA, Panzica L, Kalathil SG, et al. Immune dysfunction in patients with chronic obstructive pulmonary disease. Ann Am Thorac soc, 2015, 12(2): S169-S175.
12. 李正功, 張勇, 李濤平, 等. 阻塞性睡眠呼吸暫停低通氣綜合征患者免疫功能的損傷及相關機制研究. 中華肺部疾病病雜志: 電子版, 2011, 4(4): 276-280.
13. 侯冬青, 王湘富, 楊輝紅, 等. 阻塞性睡眠呼吸暫停低通氣綜合征的臨床流行病學調查及相關因素分析. 醫學臨床研究, 2006, 23(3): 297-299.
14. 尹雪玲, 孟杰, 張偉, 等. CPAP 聯合口腔矯治器治療阻塞型睡眠呼吸暫停低通氣綜合征伴高血壓療效觀察. 山東醫藥, 2014, 54(16): 45-46.
15. 黃家軍, 劉暢, 蘇炳澤, 等. 老年阻塞性睡眠呼吸暫停綜合征多導睡眠圖與認知功能的相關性. 中國老年學雜志, 2014, 34(20): 5700-5701.

Chinese Journal of Respiratory and Critical Care Medicine

Correlative analysis of obstructive sleep apnea hypopnea syndrome and biochemical markers in children

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