系統性糖皮質激素在呼吸危重癥治療中的獲益與風險_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

肖永久 ,  汪建新

解放軍總醫院呼吸科（北京 100853）;

Corresponding?author：

汪建新, Email: wangjx301@126.com

Keywords：

DOI：

10.7507/1671-6205.2016142

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Citation： 肖永久, 汪建新. 系統性糖皮質激素在呼吸危重癥治療中的獲益與風險. Chinese Journal of Respiratory and Critical Care Medicine, 2016, 15(6): 619-624. doi: 10.7507/1671-6205.2016142 Copy

1.	Kiser TH, Allen RR, Valuck RJ, et al. Outcomes associated with corticosteroid dosage in critically ill patients with acute exacerbations of chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 2014, 189:1052-1064.
2.	Haskell RJ, Wong BM, Hansen JE. A double-blind, randomized clinical trial of methylprednisolone in status asthmaticus. Arch Intern Med, 1983, 143:1324-1327.
3.	Rowe BH, Sevcik W, Villa-Roel C. Management of severe acute asthma in the emergency department. Curr Opin Crit Care, 2011, 17:335-341.
4.	Umberto MG, Bell W, Sinclair S, et al. Pathophysiology of acute respiratory distress syndrome. Glucocorticoid receptor-mediated regulation of inflammation and response to prolonged glucocorticoid treatment. Presse Med, 2011, 40:543-560.
5.	Lemiale V, Debrumetz A, Delannoy A, et al. Adjunctive steroid in HIV-negative patients with severe Pneumocystis pneumonia. Respir Res, 2013, 14:87.
6.	Ranzani OT, Ferrer M, Esperatti M, et al. Association between systemic corticosteroids and outcomes of intensive care unit-acquired pneumonia. Crit Care Med, 2012, 40:2552-2561.
7.	王玲, 孫鴻展, 崔雪華, 等.醫院ICU獲得性肺炎相關因素調查分析.齊魯護理雜志, 2014, 20:67-68.
8.	孔慶玲, 馬先賓, 汪秀芹, 等.ICU患者深部真菌感染的調查與控制.中華醫院感染學雜志, 2014, 24:3717-3719.
9.	陳雪梅, 張欣, 庹田.ICU呼吸機相關性肺炎危險因素的Logistic回歸性分析以及病原菌研究.臨床合理用藥雜志, 2014, 7(7A):8-10.
10.	WHO:the Top 10 Causes of Death. 2013. Available from:http://www.who.int/mediacentre/factsheets/fs310/en/index.html.
11.	Dellinger RP, Levy MM, Rhodes A, et al. Surviving Sepsis Campaign:International Guidelines for Management of Severe Sepsis and Septic Shock, 2012. Intensive Care Med, 2013, 39:165-228.
12.	陳麗萍, 陳軍, 陳穎, 等.糖皮質激素治療社區獲得性肺炎療效及安全性Meta分析.中華急診醫學雜志, 2014, 23:65-70.
13.	宋志芳, 郭曉紅, 王樹云, 等.糖皮質激素在重癥社區獲得性肺炎致急性呼吸窘迫綜合征綜合救治中的價值探討.中國危重病急救醫學, 2003, 15:669-674.
14.	Torres A, Sibila O, Ferrer M, et al. Effect of corticosteroids on treatment failure among hospitalized patients with severe community-acquired pneumonia and high inflammatory response:a randomized clinical trial. JAMA, 2015, 313:677-686.
15.	田欣倫, 江梅, 孫雪峰, 等.糖皮質激素治療成人社區獲得性肺炎適應證的薈萃分析.中華結核和呼吸雜志, 2016, 39:280-285.
16.	Annane D, Bellissant E, Bollaert PE, et al. Corticosteroids in the treatment of severe sepsis and septic shock in adults:a systematic review. JAMA, 2009, 301:2362-2375.
17.	Magne D, Angoulvant A, Botterel F, et al. Pneumocystosis:a network survey in the Paris area 2003-2008. Eur J Clin Microbiol Infect Dis, 2011, 30:673-675.
18.	Azoulay E, Mokart D, Rabbat A, et al. Diagnostic bronchoscopy in hematology and oncology patients with acute respiratory failure:prospective multicenter data. Crit Care Med, 2008. 36:100-107.
19.	Bollée G, Sarfati C, Thiéry G, et al. Clinical picture of Pneumocystis jiroveci pneumonia in cancer patients. Chest, 2007, 132:1305-1310.
20.	Gagnon S, Boota AM, Fischl MA, et al. Corticosteroids as adjunctive therapy for severe Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome:a double-blind, placebo-controlled trial. N Engl J Med, 1990, 323:1444-1450.
21.	Bozzette SA, Sattler FR, Chiu J, et al. A controlled trial of early adjunctive treatment with corticosteroids for Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. California Collaborative Treatment Group. N Engl J Med, 1990, 323:1451-1457.
22.	Sethi S, Murphy TF. Infection in the pathogenesis and course of chronic obstructive pulmonary disease. N Engl J Med, 2008, 359:2355-2365.
23.	Walters JA, Tan DJ, White CJ, et al. Systemic corticosteroids for acute exacerbations of chronic obstructive pulmonary disease. Cochrane Database Syst Rev, 2014:Cd001288.
24.	Kiser TH, Vandivier RW. Severe acute exacerbations of chronic obstructive pulmonary disease:does the dosage of corticosteroids and type of antibiotic matter? Curr Opin Pulm Med, 2015, 21:142-148.
25.	Sun WP, Yuan GX, Hu YJ, et al. Effect of low-dose glucocorticoid on corticosteroid insufficient patients with acute exacerbation of chronic obstructive pulmonary disease. World J Emerg Med, 2015, 6:34-39.
26.	GINA. Global Strategy for Asthma Management and Prevention 2015. Available from:http://www.ginasthma.org/documents/4.
27.	Louie S, Morrissey BM, Kenyon NJ, et al. The critically ill asthmatic--from ICU to discharge. Clin Rev Allergy Immunol, 2012, 43(1-2):30-44.
28.	Schivo M, Phan C, Louie S, et al. Critical asthma syndrome in the ICU. Clin Rev Allergy Immunol, 2015, 48:31-44.
29.	Krishnan JA, Davis SQ, Naureckas ET, et al. An umbrella review:corticosteroid therapy for adults with acute asthma. Am J Med, 2009, 122:977-991.
30.	Rowe BH, Edmonds ML, Spooner CH, et al. Corticosteroid therapy for acute asthma. Respir Med, 2004, 98:275-284.
31.	Schatz M, Dombrowski MP, Wise R, et al. Asthma morbidity during pregnancy can be predicted by severity classification. J Allergy Clin Immunol, 2003, 112:283-288.
32.	Global strategy for asthma management and prevention.Global Initiative for Asthma (GINA). 2012. Available from:http://www.ginasthma.org[accessed 2014-01-17].
33.	British Thoracic Society & Scottish Intercollegiate Guidelines Network. British Guideline on the Management of Asthma. 2012, Available from:http://www.sign.ac.uk/pdf/sign101.pdf[accessed 2014-01-17].
34.	McCallister JW, Benninger CG, Frey HA, et al. Pregnancy related treatment disparities of acute asthma exacerbations in the emergency department. Respir Med, 2011, 105:1434-1440.
35.	Cossette B, Beauchesne MF, Forget A, et al. Systemic corticosteroids for the treatment of asthma exacerbations during and outside of pregnancy in an acute-care setting. Respir Med, 2014, 108:1260-1267.
36.	Meduri GU, Golden E, Freire AX, et al. Methylprednisolone infusion in early severe ARDS results of a randomized controlled trial. 2007. Chest, 2009, 136(5 Suppl):e30.
37.	Tang BM, Craig JC, Eslick GD, et al. Use of corticosteroids in acute lung injury and acute respiratory distress syndrome:a systematic review and meta-analysis. Crit Care Med, 2009, 37:1594-1603.
38.	Meduri GU, Bridges L, Shih MC, et al. Prolonged glucocorticoid treatment is associated with improved ARDS outcomes:analysis of individual patients' data from four randomized trials and trial-level meta-analysis of the updated literature. Intensive Care Med, 2016, 42:829-840.
39.	劉玲, 李佳, 黃英姿, 等.應激劑量糖皮質激素對合并危重病相關皮質醇不足的急性呼吸窘迫綜合征患者的影響.中華內科雜志, 2012, 51:599-603.

1. Kiser TH, Allen RR, Valuck RJ, et al. Outcomes associated with corticosteroid dosage in critically ill patients with acute exacerbations of chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 2014, 189:1052-1064.
2. Haskell RJ, Wong BM, Hansen JE. A double-blind, randomized clinical trial of methylprednisolone in status asthmaticus. Arch Intern Med, 1983, 143:1324-1327.
3. Rowe BH, Sevcik W, Villa-Roel C. Management of severe acute asthma in the emergency department. Curr Opin Crit Care, 2011, 17:335-341.
4. Umberto MG, Bell W, Sinclair S, et al. Pathophysiology of acute respiratory distress syndrome. Glucocorticoid receptor-mediated regulation of inflammation and response to prolonged glucocorticoid treatment. Presse Med, 2011, 40:543-560.
5. Lemiale V, Debrumetz A, Delannoy A, et al. Adjunctive steroid in HIV-negative patients with severe Pneumocystis pneumonia. Respir Res, 2013, 14:87.
6. Ranzani OT, Ferrer M, Esperatti M, et al. Association between systemic corticosteroids and outcomes of intensive care unit-acquired pneumonia. Crit Care Med, 2012, 40:2552-2561.
7. 王玲, 孫鴻展, 崔雪華, 等.醫院ICU獲得性肺炎相關因素調查分析.齊魯護理雜志, 2014, 20:67-68.
8. 孔慶玲, 馬先賓, 汪秀芹, 等.ICU患者深部真菌感染的調查與控制.中華醫院感染學雜志, 2014, 24:3717-3719.
9. 陳雪梅, 張欣, 庹田.ICU呼吸機相關性肺炎危險因素的Logistic回歸性分析以及病原菌研究.臨床合理用藥雜志, 2014, 7(7A):8-10.
10. WHO:the Top 10 Causes of Death. 2013. Available from:http://www.who.int/mediacentre/factsheets/fs310/en/index.html.
11. Dellinger RP, Levy MM, Rhodes A, et al. Surviving Sepsis Campaign:International Guidelines for Management of Severe Sepsis and Septic Shock, 2012. Intensive Care Med, 2013, 39:165-228.
12. 陳麗萍, 陳軍, 陳穎, 等.糖皮質激素治療社區獲得性肺炎療效及安全性Meta分析.中華急診醫學雜志, 2014, 23:65-70.
13. 宋志芳, 郭曉紅, 王樹云, 等.糖皮質激素在重癥社區獲得性肺炎致急性呼吸窘迫綜合征綜合救治中的價值探討.中國危重病急救醫學, 2003, 15:669-674.
14. Torres A, Sibila O, Ferrer M, et al. Effect of corticosteroids on treatment failure among hospitalized patients with severe community-acquired pneumonia and high inflammatory response:a randomized clinical trial. JAMA, 2015, 313:677-686.
15. 田欣倫, 江梅, 孫雪峰, 等.糖皮質激素治療成人社區獲得性肺炎適應證的薈萃分析.中華結核和呼吸雜志, 2016, 39:280-285.
16. Annane D, Bellissant E, Bollaert PE, et al. Corticosteroids in the treatment of severe sepsis and septic shock in adults:a systematic review. JAMA, 2009, 301:2362-2375.
17. Magne D, Angoulvant A, Botterel F, et al. Pneumocystosis:a network survey in the Paris area 2003-2008. Eur J Clin Microbiol Infect Dis, 2011, 30:673-675.
18. Azoulay E, Mokart D, Rabbat A, et al. Diagnostic bronchoscopy in hematology and oncology patients with acute respiratory failure:prospective multicenter data. Crit Care Med, 2008. 36:100-107.
19. Bollée G, Sarfati C, Thiéry G, et al. Clinical picture of Pneumocystis jiroveci pneumonia in cancer patients. Chest, 2007, 132:1305-1310.
20. Gagnon S, Boota AM, Fischl MA, et al. Corticosteroids as adjunctive therapy for severe Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome:a double-blind, placebo-controlled trial. N Engl J Med, 1990, 323:1444-1450.
21. Bozzette SA, Sattler FR, Chiu J, et al. A controlled trial of early adjunctive treatment with corticosteroids for Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. California Collaborative Treatment Group. N Engl J Med, 1990, 323:1451-1457.
22. Sethi S, Murphy TF. Infection in the pathogenesis and course of chronic obstructive pulmonary disease. N Engl J Med, 2008, 359:2355-2365.
23. Walters JA, Tan DJ, White CJ, et al. Systemic corticosteroids for acute exacerbations of chronic obstructive pulmonary disease. Cochrane Database Syst Rev, 2014:Cd001288.
24. Kiser TH, Vandivier RW. Severe acute exacerbations of chronic obstructive pulmonary disease:does the dosage of corticosteroids and type of antibiotic matter? Curr Opin Pulm Med, 2015, 21:142-148.
25. Sun WP, Yuan GX, Hu YJ, et al. Effect of low-dose glucocorticoid on corticosteroid insufficient patients with acute exacerbation of chronic obstructive pulmonary disease. World J Emerg Med, 2015, 6:34-39.
26. GINA. Global Strategy for Asthma Management and Prevention 2015. Available from:http://www.ginasthma.org/documents/4.
27. Louie S, Morrissey BM, Kenyon NJ, et al. The critically ill asthmatic--from ICU to discharge. Clin Rev Allergy Immunol, 2012, 43(1-2):30-44.
28. Schivo M, Phan C, Louie S, et al. Critical asthma syndrome in the ICU. Clin Rev Allergy Immunol, 2015, 48:31-44.
29. Krishnan JA, Davis SQ, Naureckas ET, et al. An umbrella review:corticosteroid therapy for adults with acute asthma. Am J Med, 2009, 122:977-991.
30. Rowe BH, Edmonds ML, Spooner CH, et al. Corticosteroid therapy for acute asthma. Respir Med, 2004, 98:275-284.
31. Schatz M, Dombrowski MP, Wise R, et al. Asthma morbidity during pregnancy can be predicted by severity classification. J Allergy Clin Immunol, 2003, 112:283-288.
32. Global strategy for asthma management and prevention.Global Initiative for Asthma (GINA). 2012. Available from:http://www.ginasthma.org[accessed 2014-01-17].
33. British Thoracic Society & Scottish Intercollegiate Guidelines Network. British Guideline on the Management of Asthma. 2012, Available from:http://www.sign.ac.uk/pdf/sign101.pdf[accessed 2014-01-17].
34. McCallister JW, Benninger CG, Frey HA, et al. Pregnancy related treatment disparities of acute asthma exacerbations in the emergency department. Respir Med, 2011, 105:1434-1440.
35. Cossette B, Beauchesne MF, Forget A, et al. Systemic corticosteroids for the treatment of asthma exacerbations during and outside of pregnancy in an acute-care setting. Respir Med, 2014, 108:1260-1267.
36. Meduri GU, Golden E, Freire AX, et al. Methylprednisolone infusion in early severe ARDS results of a randomized controlled trial. 2007. Chest, 2009, 136(5 Suppl):e30.
37. Tang BM, Craig JC, Eslick GD, et al. Use of corticosteroids in acute lung injury and acute respiratory distress syndrome:a systematic review and meta-analysis. Crit Care Med, 2009, 37:1594-1603.
38. Meduri GU, Bridges L, Shih MC, et al. Prolonged glucocorticoid treatment is associated with improved ARDS outcomes:analysis of individual patients' data from four randomized trials and trial-level meta-analysis of the updated literature. Intensive Care Med, 2016, 42:829-840.
39. 劉玲, 李佳, 黃英姿, 等.應激劑量糖皮質激素對合并危重病相關皮質醇不足的急性呼吸窘迫綜合征患者的影響.中華內科雜志, 2012, 51:599-603.

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系統性糖皮質激素在呼吸危重癥治療中的獲益與風險

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