Analysis on the Causes of Death of Patients with Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

PengQi ,  NiGaoshun

Department of Internal Medicine, Central Hospital of Shangluo, Shangluo, Shaanxi, 726000, China;

Corresponding?author：

NiGaoshun, Email: 1019177300@qq.com

Keywords：

Asthma-chronic obstructive pulmonary disease overlap syndrome; Mortality; Malignant diseases; Pneumonia

DOI：

10.7507/1671-6205.2016126

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To analyze the causes of death of patients with asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS). Methods A total of 493 patients admitted between January 2006 and Octomber 2015 were respectively analyzed, including 348 asthma patients and 145 ACOS patients. The patients was divided into a survival group and a death group based on the outcome. The ACOS patients were divided into three subgroups based on FEV₁% pred level (≥80%, 50%-80%, and < 50%, respectively). The basic characteristics and causes of death were analyzed using χ²-test, t-test and Fish-test based on data type. Results The age (t=3.457, P < 0.001), male proportion (χ²=15.394, P < 0.001) and smoking history (χ²=12.418, P=0.002) had significant differences between the survival group and the death group. The proportion of ACOS patients was higher in the death group (42% vs. 27%, χ²=7.033, P=0.008), and the mortality was also higher in the ACOS patients (21% vs. 12%). The proportion of male patients was higher in the ACOS patients than that in the asthma patients (86% vs. 38%, P < 0.001). The leading three causes of death in the ACOS patients were malignant diseases (45%), pneumonia (26%), and cardiovascular diseases (16%). Malignant diseases were the main cause of death in the ACOS patients with FEV₁% pred≥50%, while pneumonia was the main cause of death in those with FEV₁% pred≥50%. There was no significant difference in cause of death distribution between three subgroups with different FEV₁% pred (P=0.318). Conclusion The main cause of death of ACOS patients is malignant diseases, the followed are pneumonia and cardiovascular diseases.

Citation： PengQi, NiGaoshun. Analysis on the Causes of Death of Patients with Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome. Chinese Journal of Respiratory and Critical Care Medicine, 2016, 15(6): 548-551. doi: 10.7507/1671-6205.2016126 Copy

1.	林江濤, 蘇楠, 農英.中國哮喘患者402例現狀調查及與亞太地區的比較.中華結核和呼吸雜志, 2015, 38:136-137.
2.	中華醫學會呼吸病學分會哮喘學組.支氣管哮喘防治指南(支氣管哮喘的定義、診斷、治療和管理方案).中華結核和呼吸雜志, 2008, 31:177-185.
3.	任成山, 白莉, 錢桂生.慢性阻塞性肺疾病合并肺癌臨床特征及新理念.中華肺部疾病雜志(電子版), 2015, 8:1-5.
4.	Barrecheguren M, Esquinas C, Miravitlles M. The asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS):opportunities and challenges. Curr Opin Pulm Med, 2015, 21:74-79.
5.	Louie S, Zeki AA, Schivo M, et al. The asthma-chronic obstructive pulmonary disease overlap syndrome:pharmacotherapeutic considerations. Expert Rev Clin Pharmacol, 2013, 6:197-219.
6.	Papaiwannou A, Zarogoulidis P, Porpodis K, et al. Asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS):current literature review. J Thorac Dis, 2014, 6:S146-S151.
7.	Bateman ED, Reddel HK, van Zyl-Smit RN, et al. The asthma-COPD overlap syndrome:towards a revised taxonomy of chronic airways diseases? Lancet Respir Med, 2015, 3:719-728.
8.	Babaoglu E, Kilic H, Hezer H, et al. Comparison of thiol/disulphide homeostasis parameters in patients with COPD, asthma and ACOS. Eur Rev Med Pharmacol Sci, 2016, 20:1537-1543.
9.	Bini F, De Bernardi G, Grassi N, et al. Comparison between anticholinergic and beta-2 agonist treatments by using pletismography and impulse oscillometry. Eur Respir J, 2015, 46(Suppl 59):PA3942.
10.	Andreeva E, Pokhaznikova M, Lebedev A, et al. Bronchodilator response in adults 35-70 years old in North-West Russia. Eur Respir J, 2015, 46(Suppl 59):PA1040.
11.	孟珊珊, 閆冰迪, 王艷軍, 等.支氣管哮喘-慢性阻塞性肺疾病重疊綜合征265例.實用醫學雜志, 2015, 31:437-438.
12.	Brzostek D, Kokot M. Asthma-chronic obstructive pulmonary disease overlap syndrome in Poland. Findings of an epidemiological study. Postep Derm Alergol, 2014, 31:372-379.
13.	Walters JA, Walters EH, Nelson M, et al. Factors associated with misdiagnosis of COPD in primary care. Prim Care Respir J, 2011, 20:396-402.
14.	Alfarroba S, Rodrigues F, Papoila AL, et al. Pulmonary rehabilitation in COPD according to global initiative for chronic obstructive lung disease categories. respiratory Care, 2016, 61:1331-1340.
15.	王文秀, 邵玉霞.哮喘-慢性阻塞性肺疾病重疊綜合征診療研究進展.疑難病雜志, 2015, 14:759-762.

1. 林江濤, 蘇楠, 農英.中國哮喘患者402例現狀調查及與亞太地區的比較.中華結核和呼吸雜志, 2015, 38:136-137.
2. 中華醫學會呼吸病學分會哮喘學組.支氣管哮喘防治指南(支氣管哮喘的定義、診斷、治療和管理方案).中華結核和呼吸雜志, 2008, 31:177-185.
3. 任成山, 白莉, 錢桂生.慢性阻塞性肺疾病合并肺癌臨床特征及新理念.中華肺部疾病雜志(電子版), 2015, 8:1-5.
4. Barrecheguren M, Esquinas C, Miravitlles M. The asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS):opportunities and challenges. Curr Opin Pulm Med, 2015, 21:74-79.
5. Louie S, Zeki AA, Schivo M, et al. The asthma-chronic obstructive pulmonary disease overlap syndrome:pharmacotherapeutic considerations. Expert Rev Clin Pharmacol, 2013, 6:197-219.
6. Papaiwannou A, Zarogoulidis P, Porpodis K, et al. Asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS):current literature review. J Thorac Dis, 2014, 6:S146-S151.
7. Bateman ED, Reddel HK, van Zyl-Smit RN, et al. The asthma-COPD overlap syndrome:towards a revised taxonomy of chronic airways diseases? Lancet Respir Med, 2015, 3:719-728.
8. Babaoglu E, Kilic H, Hezer H, et al. Comparison of thiol/disulphide homeostasis parameters in patients with COPD, asthma and ACOS. Eur Rev Med Pharmacol Sci, 2016, 20:1537-1543.
9. Bini F, De Bernardi G, Grassi N, et al. Comparison between anticholinergic and beta-2 agonist treatments by using pletismography and impulse oscillometry. Eur Respir J, 2015, 46(Suppl 59):PA3942.
10. Andreeva E, Pokhaznikova M, Lebedev A, et al. Bronchodilator response in adults 35-70 years old in North-West Russia. Eur Respir J, 2015, 46(Suppl 59):PA1040.
11. 孟珊珊, 閆冰迪, 王艷軍, 等.支氣管哮喘-慢性阻塞性肺疾病重疊綜合征265例.實用醫學雜志, 2015, 31:437-438.
12. Brzostek D, Kokot M. Asthma-chronic obstructive pulmonary disease overlap syndrome in Poland. Findings of an epidemiological study. Postep Derm Alergol, 2014, 31:372-379.
13. Walters JA, Walters EH, Nelson M, et al. Factors associated with misdiagnosis of COPD in primary care. Prim Care Respir J, 2011, 20:396-402.
14. Alfarroba S, Rodrigues F, Papoila AL, et al. Pulmonary rehabilitation in COPD according to global initiative for chronic obstructive lung disease categories. respiratory Care, 2016, 61:1331-1340.
15. 王文秀, 邵玉霞.哮喘-慢性阻塞性肺疾病重疊綜合征診療研究進展.疑難病雜志, 2015, 14:759-762.

Chinese Journal of Respiratory and Critical Care Medicine

Analysis on the Causes of Death of Patients with Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content