血管內皮生長因子和神經菌毛素-1 在肺爆震傷診療中的應用_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

潘建光 ,  賴國祥

福建醫科大學福總臨床醫學院南京軍區福州總醫院呼吸與危重癥醫學科（福建福州 350025）;

Corresponding?author：

賴國祥, Email: laiguoxiang2007@163.com

Keywords：

DOI：

10.7507/1671-6205.201607024

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Citation： 潘建光, 賴國祥. 血管內皮生長因子和神經菌毛素-1 在肺爆震傷診療中的應用. Chinese Journal of Respiratory and Critical Care Medicine, 2017, 16(3): 296-299. doi: 10.7507/1671-6205.201607024 Copy

1.	Smith JE. The epidemiology of blast lung injury during recent military conflicts: a retrospective database review of cases presenting to deployed military hospitals, 2003-2009. Philos Trans R Soc Lond B Biol Sci, 2011, 366(1562): 291-294.
2.	劉軍, 趙富麗, 吳健, 等. 昆山" 8·2”爆炸事故存活傷員損傷特點及救治分析. 中華急診醫學雜志, 2015, 24(9): 952-957.
3.	Clapson P, Pasquie rP, Perez JP, et al. Blast lung injuries. Rev Pneumol Clin, 2010, 66(4): 245-253.
4.	Mellor SG, Cooper GJ. Analysis of 828 servicemen killed or injured by explosion in Northern Ireland 1970-84: the Hostile Action Casualty System. Br J Surg, 1989, 76(10): 1006-1010.
5.	Bauman RA, Ling G, Tong L, et al. An introductory characterization of a combat-casualty-care relevant swine model of closed head injury resulting from exposure to explosive blast. J Neurotrauma, 2009, 26(6): 841-860.
6.	Wolf SJ, Bebarta VS, Bonnett CJ, et al. Blast injuries. Lancet, 2009, 374(9687): 405-415.
7.	Skotak M, Wang F, Alai A, et al. Rat injury model under controlled field-relevant primary blast conditions: acute response to a wide range of peak overpressures. J Neurotrauma, 2013, 30(13): 1147-1160.
8.	Kirkman E, Watts S, Cooper G. Blast injury research models. Phil Trans R Soc B, 2011, 366(1652): 144-159.
9.	Joseph B, Bentley TL, Wessner KA, et al. Blast Overpressure in rats: recreating a battlefield injury in the laboratory. J Neurotrauma, 2009, 26(6): 827-840.
10.	Wong JM, Marsh D, Abu-Sitta G, et al. Biological foreign body implantation in victims of the London July 7th suicide bombings. J Trauma 2006, 60(2): 402-404.
11.	Chapman LE, Sullivent EE, Grohskopf LA, et al. Postexposure interventions to prevent infection with HBV, HCV, or HIV, and tetanus in people wounded during bombings and other mass casualty events-United States, 2008: recommendations of the Centers for Disease Control and Prevention and Disaster Medicine and Public Health Preparedness. Disaster Med Public Health Prep, 2008, 2(3): 150-165.
12.	Clint BD. Force protection and infectious risk mitigation from suicide bombers. Mil Med, 2009, 174(7): 709-714.
13.	Eshkol Z, Katz K. Injuries from biologic material of suicide bombers. Injury, 2005, 36(2): 271-274.
14.	Yeh DD, Schecter WP. Primary blast injuries-an updated concise review. World J Surg, 2012, 36(5): 966-972.
15.	Kirkman E, Watts S. Characterization of the response to primary blast injury. Philos Trans R Soc Lond B Biol Sci, 2011, 366(1562): 286-290.
16.	Medford AR, Millar AB. Vascular endothelial growth factor (VEGF) in acute lung injury (ALI) and acute respiratory distress syndrome (ARDS): paradox or paradigm?. Thorax 2006, 61(7): 621-626.
17.	Kaner RJ, Crystal RG. Compartmentalization of vascular endothelial growth factor to the epithelial surface of the human lung. Mol Med, 2001, 7(4): 240-246.
18.	Foster RR, Hole R, Anderson K, et al. Functional evidence that vascular endothelial growth factor may act as an autocrine factor on human podocytes. Am J Physiol Renal Physiol, 2003, 284(6): F1263-F1273.
19.	Andrew RL, Nassif BN, Ann B, et al. Vascular endothelial growth factor receptor and coreceptor expression in human acute respiratory distress syndrome. J Crit Care, 2009, 24(2): 236-242.
20.	Wild JR, Staton CA, Chapple K, et al. Neuropilins: expression and roles in the epithelium. Int J Exp Pathol, 2012, 93(2): 81-103.
21.	Barratt S, Medford A R, Millar AB. Vascular endothelial growth factor in acute lung injury and acute respiratory distress syndrome. Respiration, 2014, 87(4): 329-342.
22.	Jia H, Cheng L, Tickner M, et al. Neuropilin-1 antagonism in human carcinoma cells inhibits migration and enhances chemosensitivity. Br J Cancer, 2010, 102(3): 541-552.
23.	Fantin A, Herzog B, Mahmoud M, et al. Neuropilin 1 (NRP1) hypomorphism combined with defective VEGF-A binding reveals novel roles for NRP1 in developmental and pathological angiogenesis. Development, 2014, 141(3): 556-562.
24.	Ding MH, Liu L, Hu CX, et al. Expression of VEGF R2 and NRP-1 in non-small cell lung cancer and their clinical significance. Chin J Cancer Res, 2014, 26(6): 669-677.
25.	Shim EJ, Chun E, Kang HR, et al. Expression of semaphorin 3A and neuropilin 1 in asthma. J Korean Med Sci, 2013, 28(10): 1435-1442.
26.	Ferrara N, Gerber HP, Lecouter J. The biology of VEGF and its receptors. Nat Med, 2003, 9(6): 669-676.
27.	Song J, Lu H, Zheng X, et al. Effects of vascular endothelial growth factor in recovery phase of acute lung injury in mice. Lung, 2015, 193(6): 1029-1036.
28.	Yang Y, Hu SL, Xu XP, et al. The vascular endothelial growth factors-expressing character of mesenchymal stem cells plays a positive role in treatment of acute lung injury in vivo. Mediators Inflamm, 2016: ID2347938. Available at: https://www.hindawi. com/journals/mi/2016/2347938/.
29.	Le A, Zielinski R, He C, et al. Pulmonary epithelial neuropilin-1 deletion enhances development of cigarette smoke-induced emphysema. Am J Respir Crit Care Med, 2009, 180(5): 396-406.
30.	Kasahara Y, Tuder RM, Tarasevicienestewart L, et al. Inhibition of VEGF receptors causes lung cell apoptosis and emphysema. J Clin Invest, 2000, 106(11): 1311-1319.
31.	馬強, 吳占慶, 楊培雄, 等. 急性呼吸窘迫綜合征患者血清中血管內皮生長因子、腫瘤壞死因子-α 和降鈣素原的表達. 中國老年學雜志, 2015, 35(20): 5842-5843.
32.	Cross LJ, Matthay MA. Biomarkers in acute lung injury: insights into the pathogenesis of acute lung injury. Crit Care Clin, 2011, 27(2): 355-377.
33.	張曌, 張師海. 血管內皮生長因子在急性肺損傷中的表達及作用機制[畢業論文]. 華中科技大學, 2010.
34.	Thickett DR, Armstrong L, Millar AB. A role for vascular endothelial growth factor in acute and resolving lung injury. Am J Respir Crit Care Med, 2002, 166(10): 1332-1337.
35.	蔣云書, 陳建榮, 張文彬, 等. 急性肺損傷/急性呼吸窘迫綜合征患者呼出氣冷凝液中血管內皮生長因子 A 檢測的臨床意義. 中國呼吸與危重監護雜志, 2011, 10(2): 135-138.
36.	Koh H, Tasaka S, Hasegawa N, et al. Vascular endothelial growth factor in epithelial lining fluid of patients with acute respiratory distress syndrome. Respirology, 2008, 13(2): 281-284.
37.	Iain MJ, Mackenzie B, Tunnicliffe B. Blast injuries to the lung: epidemiology and management. Phil Trans R Soc B, 2011, 366(1562): 295-299.
38.	李毅, 鄒曰坤, 蔣富強. 大劑量氨溴索對海水浸泡致急性肺損傷犬體內 SP-A、SP-B 含量的影響. 海南醫學院學報, 2014, 20(8): 1038-1040.
39.	李自強, 林慶安, 張雷, 等. 山莨菪堿對海水淹溺性肺水腫的治療作用. 中國醫師雜志, 2005, 7(5): 592-594.
40.	侯曉彬, 李廷慧, 金文波, 等. 地塞米松和山莨菪堿在胸部爆炸傷致急性肺損傷中的防治作用. 中國急救醫學, 2008, 28(6): 531-535.
41.	潘珍, 黎嘉文. 大劑量鹽酸氨溴索對肺部的保護作用的 Meta 分析. 中國藥房, 2014, 25(32): 3041-3045.
42.	Seam N, Meduri GU, Wang H, et al. Effects of methylprednisolone infusion on markers of inflammation, coagulation, and angiogenesis in early acute respiratory distress syndrome. Crit Care Med, 2012, 40(2): 495-501.
43.	Weekes CD, Beeram M, Tolcher AW, et al. A phase Ⅰ study of the human monoclonal anti-NRP1 antibody MNRP1685A in patients with advanced solid tumors. Invest New Drugs, 2014, 32(4): 653-660.
44.	Jarvis A, Allerston CK, Jia H, et al. Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction. J Med Chem, 2010, 53(5): 2215-2226.
45.	Eichholz A, Merchant S, Gaya AM, et al. Anti-angiogenesis therapies: their potential in cancer management. Onco Targets Ther, 2010, 3: 69-82.
46.	Sandler A, Gray R, Perry MC, et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med, 2006, 355(24): 2542-2550.
47.	佟昌慈, 柳云恩, 張玉彪, 等. 體外膜肺氧合對撞擊傷致急性肺損傷細胞因子表達影響. 創傷與急危重病醫學, 2016, 4(1): 6-9.
48.	Hua F, Wang X, Zhu L. Terlipressin decreases vascular endothelial growth factor expression and improves oxygenation in patients with acute respiratory distress syndrome and shock. J Emerg Med, 2013, 44(2): 434-439.

1. Smith JE. The epidemiology of blast lung injury during recent military conflicts: a retrospective database review of cases presenting to deployed military hospitals, 2003-2009. Philos Trans R Soc Lond B Biol Sci, 2011, 366(1562): 291-294.
2. 劉軍, 趙富麗, 吳健, 等. 昆山" 8·2”爆炸事故存活傷員損傷特點及救治分析. 中華急診醫學雜志, 2015, 24(9): 952-957.
3. Clapson P, Pasquie rP, Perez JP, et al. Blast lung injuries. Rev Pneumol Clin, 2010, 66(4): 245-253.
4. Mellor SG, Cooper GJ. Analysis of 828 servicemen killed or injured by explosion in Northern Ireland 1970-84: the Hostile Action Casualty System. Br J Surg, 1989, 76(10): 1006-1010.
5. Bauman RA, Ling G, Tong L, et al. An introductory characterization of a combat-casualty-care relevant swine model of closed head injury resulting from exposure to explosive blast. J Neurotrauma, 2009, 26(6): 841-860.
6. Wolf SJ, Bebarta VS, Bonnett CJ, et al. Blast injuries. Lancet, 2009, 374(9687): 405-415.
7. Skotak M, Wang F, Alai A, et al. Rat injury model under controlled field-relevant primary blast conditions: acute response to a wide range of peak overpressures. J Neurotrauma, 2013, 30(13): 1147-1160.
8. Kirkman E, Watts S, Cooper G. Blast injury research models. Phil Trans R Soc B, 2011, 366(1652): 144-159.
9. Joseph B, Bentley TL, Wessner KA, et al. Blast Overpressure in rats: recreating a battlefield injury in the laboratory. J Neurotrauma, 2009, 26(6): 827-840.
10. Wong JM, Marsh D, Abu-Sitta G, et al. Biological foreign body implantation in victims of the London July 7th suicide bombings. J Trauma 2006, 60(2): 402-404.
11. Chapman LE, Sullivent EE, Grohskopf LA, et al. Postexposure interventions to prevent infection with HBV, HCV, or HIV, and tetanus in people wounded during bombings and other mass casualty events-United States, 2008: recommendations of the Centers for Disease Control and Prevention and Disaster Medicine and Public Health Preparedness. Disaster Med Public Health Prep, 2008, 2(3): 150-165.
12. Clint BD. Force protection and infectious risk mitigation from suicide bombers. Mil Med, 2009, 174(7): 709-714.
13. Eshkol Z, Katz K. Injuries from biologic material of suicide bombers. Injury, 2005, 36(2): 271-274.
14. Yeh DD, Schecter WP. Primary blast injuries-an updated concise review. World J Surg, 2012, 36(5): 966-972.
15. Kirkman E, Watts S. Characterization of the response to primary blast injury. Philos Trans R Soc Lond B Biol Sci, 2011, 366(1562): 286-290.
16. Medford AR, Millar AB. Vascular endothelial growth factor (VEGF) in acute lung injury (ALI) and acute respiratory distress syndrome (ARDS): paradox or paradigm?. Thorax 2006, 61(7): 621-626.
17. Kaner RJ, Crystal RG. Compartmentalization of vascular endothelial growth factor to the epithelial surface of the human lung. Mol Med, 2001, 7(4): 240-246.
18. Foster RR, Hole R, Anderson K, et al. Functional evidence that vascular endothelial growth factor may act as an autocrine factor on human podocytes. Am J Physiol Renal Physiol, 2003, 284(6): F1263-F1273.
19. Andrew RL, Nassif BN, Ann B, et al. Vascular endothelial growth factor receptor and coreceptor expression in human acute respiratory distress syndrome. J Crit Care, 2009, 24(2): 236-242.
20. Wild JR, Staton CA, Chapple K, et al. Neuropilins: expression and roles in the epithelium. Int J Exp Pathol, 2012, 93(2): 81-103.
21. Barratt S, Medford A R, Millar AB. Vascular endothelial growth factor in acute lung injury and acute respiratory distress syndrome. Respiration, 2014, 87(4): 329-342.
22. Jia H, Cheng L, Tickner M, et al. Neuropilin-1 antagonism in human carcinoma cells inhibits migration and enhances chemosensitivity. Br J Cancer, 2010, 102(3): 541-552.
23. Fantin A, Herzog B, Mahmoud M, et al. Neuropilin 1 (NRP1) hypomorphism combined with defective VEGF-A binding reveals novel roles for NRP1 in developmental and pathological angiogenesis. Development, 2014, 141(3): 556-562.
24. Ding MH, Liu L, Hu CX, et al. Expression of VEGF R2 and NRP-1 in non-small cell lung cancer and their clinical significance. Chin J Cancer Res, 2014, 26(6): 669-677.
25. Shim EJ, Chun E, Kang HR, et al. Expression of semaphorin 3A and neuropilin 1 in asthma. J Korean Med Sci, 2013, 28(10): 1435-1442.
26. Ferrara N, Gerber HP, Lecouter J. The biology of VEGF and its receptors. Nat Med, 2003, 9(6): 669-676.
27. Song J, Lu H, Zheng X, et al. Effects of vascular endothelial growth factor in recovery phase of acute lung injury in mice. Lung, 2015, 193(6): 1029-1036.
28. Yang Y, Hu SL, Xu XP, et al. The vascular endothelial growth factors-expressing character of mesenchymal stem cells plays a positive role in treatment of acute lung injury in vivo. Mediators Inflamm, 2016: ID2347938. Available at: https://www.hindawi. com/journals/mi/2016/2347938/.
29. Le A, Zielinski R, He C, et al. Pulmonary epithelial neuropilin-1 deletion enhances development of cigarette smoke-induced emphysema. Am J Respir Crit Care Med, 2009, 180(5): 396-406.
30. Kasahara Y, Tuder RM, Tarasevicienestewart L, et al. Inhibition of VEGF receptors causes lung cell apoptosis and emphysema. J Clin Invest, 2000, 106(11): 1311-1319.
31. 馬強, 吳占慶, 楊培雄, 等. 急性呼吸窘迫綜合征患者血清中血管內皮生長因子、腫瘤壞死因子-α 和降鈣素原的表達. 中國老年學雜志, 2015, 35(20): 5842-5843.
32. Cross LJ, Matthay MA. Biomarkers in acute lung injury: insights into the pathogenesis of acute lung injury. Crit Care Clin, 2011, 27(2): 355-377.
33. 張曌, 張師海. 血管內皮生長因子在急性肺損傷中的表達及作用機制[畢業論文]. 華中科技大學, 2010.
34. Thickett DR, Armstrong L, Millar AB. A role for vascular endothelial growth factor in acute and resolving lung injury. Am J Respir Crit Care Med, 2002, 166(10): 1332-1337.
35. 蔣云書, 陳建榮, 張文彬, 等. 急性肺損傷/急性呼吸窘迫綜合征患者呼出氣冷凝液中血管內皮生長因子 A 檢測的臨床意義. 中國呼吸與危重監護雜志, 2011, 10(2): 135-138.
36. Koh H, Tasaka S, Hasegawa N, et al. Vascular endothelial growth factor in epithelial lining fluid of patients with acute respiratory distress syndrome. Respirology, 2008, 13(2): 281-284.
37. Iain MJ, Mackenzie B, Tunnicliffe B. Blast injuries to the lung: epidemiology and management. Phil Trans R Soc B, 2011, 366(1562): 295-299.
38. 李毅, 鄒曰坤, 蔣富強. 大劑量氨溴索對海水浸泡致急性肺損傷犬體內 SP-A、SP-B 含量的影響. 海南醫學院學報, 2014, 20(8): 1038-1040.
39. 李自強, 林慶安, 張雷, 等. 山莨菪堿對海水淹溺性肺水腫的治療作用. 中國醫師雜志, 2005, 7(5): 592-594.
40. 侯曉彬, 李廷慧, 金文波, 等. 地塞米松和山莨菪堿在胸部爆炸傷致急性肺損傷中的防治作用. 中國急救醫學, 2008, 28(6): 531-535.
41. 潘珍, 黎嘉文. 大劑量鹽酸氨溴索對肺部的保護作用的 Meta 分析. 中國藥房, 2014, 25(32): 3041-3045.
42. Seam N, Meduri GU, Wang H, et al. Effects of methylprednisolone infusion on markers of inflammation, coagulation, and angiogenesis in early acute respiratory distress syndrome. Crit Care Med, 2012, 40(2): 495-501.
43. Weekes CD, Beeram M, Tolcher AW, et al. A phase Ⅰ study of the human monoclonal anti-NRP1 antibody MNRP1685A in patients with advanced solid tumors. Invest New Drugs, 2014, 32(4): 653-660.
44. Jarvis A, Allerston CK, Jia H, et al. Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction. J Med Chem, 2010, 53(5): 2215-2226.
45. Eichholz A, Merchant S, Gaya AM, et al. Anti-angiogenesis therapies: their potential in cancer management. Onco Targets Ther, 2010, 3: 69-82.
46. Sandler A, Gray R, Perry MC, et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med, 2006, 355(24): 2542-2550.
47. 佟昌慈, 柳云恩, 張玉彪, 等. 體外膜肺氧合對撞擊傷致急性肺損傷細胞因子表達影響. 創傷與急危重病醫學, 2016, 4(1): 6-9.
48. Hua F, Wang X, Zhu L. Terlipressin decreases vascular endothelial growth factor expression and improves oxygenation in patients with acute respiratory distress syndrome and shock. J Emerg Med, 2013, 44(2): 434-439.

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血管內皮生長因子和神經菌毛素-1 在肺爆震傷診療中的應用

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