Body mass index of patients with colorectal cancer will affect tumor characteristics: a real world study based on DACCA_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

ZHAN Wenyi ^1,2 , LIU Guina ^1,2 , LIU Ying ^1,2 , ZHAO Tianlang ^1,2 ,  WANG Xiaodong ¹ , LI Li ¹

1. Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;
2. West China School of Medicine in Sichuan University, Chengdu 610041, P. R. China;

Corresponding?author：

WANG Xiaodong, Email: wangxiaodong@wchscu.cn

Keywords：

colorectal cancer; tumor feature; database; big data; the label; structured

DOI：

10.7507/1007-9424.202201001

Video：

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Objective To analyze the impact of body mass index (BMI) on tumor characteristics of colorectal patients served by West China Hospital as a regional center in the current version of Database from Colorectal Cancer (DACCA). Methods The data of DACCA was updated on October 16, 2021. All data items included BMI, precancerous lesions, cancer family, tumor site, tumor morphology, location, differentiation, pathological properties of tumor, obstruction, overlap, perforation, pain, edema, and bleeding. The patients were divided into lean (BMI<18.5 kg/m²), normal (BMI 18.5–23.9 kg/m²), overweight (BMI 24.0–27.9 kg/m²) and obesity (BMI≥28.0 kg/m²) by Chinese classification methods. Results After scanning, 5 761 data rows were analyzed. Chi-square test showed that there was significant difference in the type composition ratio of tumor location in colorectal cancer patients under different BMI groups (χ²=31.477, P<0.001). Rank sum test showed that there was significant difference in the degree of obstruction (H=42.490, P<0.001), intussusception (H=8.179, P=0.042), edema (H=14.795, P=0.002), and bleeding (H=9.884, P=0.020) among different BMI groups. Conclusions The BMI classification of colorectal cancer patients is related to the location of tumor and the occurrence of some tumor complications. Patients with tumor involving intestinal lumens for one week are more likely to have low BMI. The patients with low BMI are more likely to have severe bleeding, obstruction, intestinal intussusception, and severe intestinal wall edema.

Citation： ZHAN Wenyi, LIU Guina, LIU Ying, ZHAO Tianlang, WANG Xiaodong, LI Li. Body mass index of patients with colorectal cancer will affect tumor characteristics: a real world study based on DACCA. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2022, 29(2): 232-238. doi: 10.7507/1007-9424.202201001 Copy

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1. 汪曉東, 劉健博, 李立. 數據庫建設第五部分: 結直腸癌的腫瘤特征—模塊的設計 (一). 中國普外基礎與臨床雜志, 2020, 27(3): 345-349.
2. 汪曉東, 劉健博, 李立. 數據庫建設第五部分·結直腸癌的腫瘤特征—模塊的設計 (二). 中國普外基礎與臨床雜志, 2020, 27(4): 483-488.
3. Ochs-Balcom HM, Kanth P, Farnham JM, et al. Colorectal cancer risk based on extended family history and body mass index. Genet Epidemiol, 2020, 44(7): 778-784.
4. Hanyuda A, Cao Y, Hamada T, et al. Body mass index and risk of colorectal carcinoma subtypes classified by tumor differentiation status. Eur J Epidemiol, 2017, 32(5): 393-407.
5. 國際生命科學學會中國辦事處中國肥胖問題工作組聯合數據匯總分析協作組. 中國成人體質指數分類的推薦意見簡介. 中華預防醫學雜志, 2001, 35(5): 349-350.
6. Song EY, Swanson J, Patel A, et al. Colorectal cancer risk factors and screening among the uninsured of tampa bay: a free clinic study. Prev Chronic Dis, 2021, 18: E16. doi: 10.5888/pcd18.200496.
7. Micu SI, Oraiopoulou I, Manea ME, et al. Five years retrospective review of colorectal cancer risk factors in the black sea coast population. Revista de Chimie, 2020, 71(1): 355-359.
8. Bou-abboud C, Cooper G. The increasing incidence of young-onset colorectal cancer: risk factors and presentation. Am J Gastroenterol, 2016, 111: S125-S126.
9. 任建松, 石菊芳, 張洪召, 等. 2012–2013年中國城市人群大腸癌篩查結果初步分析. 中華預防醫學雜志, 2015, 49(5): 441-443.
10. 張敏, 劉思達, 刁敏, 等. 體質量指數對腹腔鏡結直腸癌手術結果的影響. 腹部外科, 2020, 33(3): 223-226.
11. 趙世棟, 申占龍, 葉穎江. 肥胖結直腸癌患者腹腔鏡手術要點. 結直腸肛門外科, 2021, 27(3): 300-303.
12. van den Berg I, Coebergh van den Braak RRJ, van Vugt JLA, et al. Actual survival after resection of primary colorectal cancer: results from a prospective multicenter study. World J Surg Oncol, 2021, 19(1): 96. doi: 10.1186/s12957-021-02207-4.
13. Fransgaard T, Caspar Thygesen L, G?genur I. The impact of postoperative complications and delay of adjuvant chemotherapy on oncological outcomes in patients with colorectal cancer. Colorectal Dis, 2021, 23(5): 1132-1140.
14. Mualla NM, Hussain MR, Akrmah M, et al. The impact of postoperative complications on long-term oncological outcomes following curative resection of colorectal cancer (Stage Ⅰ-Ⅲ): a systematic review and meta-analysis. Cureus, 2021, 13(1): e12837. doi: 10.7759/cureus.12837.
15. Robsahm TE, Aagnes B, Hjart?ker A, et al. Body mass index, physical activity, and colorectal cancer by anatomical subsites: a systematic review and meta-analysis of cohort studies. Eur J Cancer Prev, 2013, 22(6): 492-505.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Body mass index of patients with colorectal cancer will affect tumor characteristics: a real world study based on DACCA

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