肝細胞癌合并微血管癌栓的早期診斷研究現狀_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

張努 ,  莢衛東

中國科學技術大學附屬第一醫院，安徽省立醫院肝臟外科，肝膽胰外科安徽省重點實驗室（合肥 230001）;

Corresponding?author：

莢衛東, Email: jwd1968@sina.com

Keywords：

DOI：

10.7507/1007-9424.201904075

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Citation： 張努, 莢衛東. 肝細胞癌合并微血管癌栓的早期診斷研究現狀. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2019, 26(5): 528-531. doi: 10.7507/1007-9424.201904075 Copy

1.	Wang FS, Fan JG, Zhang Z, et al. The global burden of liver disease: the major impact of China. Hepatology, 2014, 60(6): 2099-2108.
2.	Shindoh J, Hasegawa K, Inoue Y, et al. Risk factors of post-operative recurrence and adequate surgical approach to improve long-term outcomes of hepatocellular carcinoma. HPB (Oxford), 2013, 15(1): 31-39.
3.	陳星, 李強, 荀曉冬, 等. 微血管侵犯對單發小肝癌患者術后無進展生存期的影響. 中華肝膽外科雜志, 2016, 22(2): 94-98.
4.	中國抗癌協會肝癌專業委員會, 中華醫學會肝病學分會肝癌學組, 中國抗癌協會病理專業委員, 等. 原發性肝癌規范化病理診斷指南(2015年版). 中華肝臟病雜志, 2015, 23(5): 321-327.
5.	Parfitt JR, Marotta P, Alghamdi M, et al. Recurrent hepatocellular carcinoma after transplantation: use of a pathological score on explanted livers to predict recurrence. Liver Transpl, 2007, 13(4): 543-551.
6.	Strilic B, Yang L, Albarrán-Juárez J, et al. Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis. Nature, 2016, 536(7615): 215-218.
7.	Lei Z, Li J, Wu D, et al. Nomogram for preoperative estimation of microvascular invasion risk in hepatitis B virus-related hepatocellular carcinoma within the Milan criteria. JAMA Surg, 2016, 151(4): 356-363.
8.	Rodríguez-Perálvarez M, Luong TV, Andreana L, et al. A systematic review of microvascular invasion in hepatocellular carcinoma: diagnostic and prognostic variability. Ann Surg Oncol, 2013, 20(1): 325-339.
9.	馮龍海, 叢文銘. 肝細胞癌微血管侵犯新型分級系統的建立及其臨床病理學意義的研究. 第二軍醫大學, 2016.
10.	Iguchi T, Shirabe K, Aishima S, et al. New pathologic stratification of microvascular invasion in hepatocellular carcinoma: predicting prognosis after living-donor liver transplantation. Transplantation, 2015, 99(6): 1236-1242.
11.	Zhou Y, Xu D, Wu L, et al. Meta-analysis of anatomic resection versus nonanatomic resection for hepatocellular carcinoma. Langenbecks Arch Surg, 2011, 396(7): 1109-1117.
12.	雷正清, 沈鋒. 早期肝癌微血管侵犯的術前預測和對肝切除切緣選擇的影響. 第二軍醫大學, 2016.
13.	Minami Y, Nishida N, Kudo M. Therapeutic response assessment of RFA for HCC: contrast-enhanced US, CT and MRI. World J Gastroenterol, 2014, 20(15): 4160-4166.
14.	劉學, 沈鋒. MVI作為肝細胞癌術后輔助性TACE治療指征的研究. 第二軍醫大學, 2012.
15.	Cheng AL, Kang YK, Chen Z, et al. Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase Ⅲ randomised, double-blind, placebo-controlled trial. Lancet Oncol, 2009, 10(1): 25-34.
16.	Banerjee S, Wang DS, Kim HJ, et al. A computed tomography radiogenomic biomarker predicts microvascular invasion and clinical outcomes in hepatocellular carcinoma. Hepatology, 2015, 62(3): 792-800.
17.	Kobayashi T, Aikata H, Honda F, et al. Preoperative fluorine 18 fluorodeoxyglucose positron emission tomography/computed tomography for prediction of microvascular invasion in small hepatocellular carcinoma. J Comput Assist Tomogr, 2016, 40(4): 524-530.
18.	李文柱, 蘇丹柯. 能譜CT預測肝細胞癌微血管侵犯的可能性研究. 廣西醫科大學, 2016.
19.	Renzulli M, Brocchi S, Cucchetti A, et al. Can current preoperative imaging be used to detect microvascular invasion of hepatocellular carcinoma? Radiology, 2016, 279(2): 432-442.
20.	Han MA, Lee DH, Woo SM, et al. Galangin sensitizes TRAIL-induced apoptosis through down-regulation of anti-apoptotic proteins in renal carcinoma Caki cells. Sci Rep, 2016, 6: 18642.
21.	Shirabe K, Kajiyama K, Abe T, et al. Predictors of microscopic portal vein invasion by hepatocellular carcinoma: measurement of portal perfusion defect area ratio. J Gastroenterol Hepatol, 2009, 24(8): 1431-1436.
22.	Xu P, Zeng M, Liu K, et al. Microvascular invasion in small hepatocellular carcinoma: is it predictable with preoperative diffusion-weighted imaging? J Gastroenterol Hepatol, 2014, 29(2): 330-336.
23.	Min JH, Kim YK, Lim S, et al. Prediction of microvascular invasion of hepatocellular carcinomas with gadoxetic acid-enhanced MR imaging: Impact of intra-tumoral fat detected on chemical-shift images. Eur J Radiol, 2015, 84(6): 1036-1043.
24.	賈叢叢, 周瑋, 何國濃. 原發性肝癌彩色多普勒超聲血流分級與微血管生成的關系. 中國現代醫生, 2016, 54(9): 103-105, 109, 封3.
25.	You Z, Chen LP, Ye H. Predictors of microvascular invasion in patients with solitary small hepatitis B related hepatocellular carcinoma. Pak J Med Sci, 2014, 30(2): 331-334.
26.	Imura S, Teraoku H, Yoshikawa M, et al. Potential predictive factors for microvascular invasion in hepatocellular carcinoma classified within the Milan criteria. Int J Clin Oncol, 2018, 23(1): 98-103.
27.	Poté N, Cauchy F, Albuquerque M, et al. Performance of PIVKA-Ⅱ for early hepatocellular carcinoma diagnosis and prediction of microvascular invasion. J Hepatol, 2015, 62(4): 848-854.
28.	Poon RT, Ng IO, Lau C, et al. Serum vascular endothelial growth factor predicts venous invasion in hepatocellular carcinoma: a prospective study. Ann Surg, 2001, 233(2): 227-235.
29.	Zhu PP, Yuan SG, Liao Y, et al. High level of intercellular adhesion molecule-1 affects prognosis of patients with hepatocellular carcinoma. World J Gastroenterol, 2015, 21(23): 7254-7263.
30.	汪宇, 李錫鋒, 張小峰, 等. 術前外周血循環腫瘤細胞檢測對原發性肝細胞肝癌微血管侵犯的預測價值. 山東醫藥, 2017, 57(18): 33-35.
31.	Liu M, Wang L, Zhu H, et al. A preoperative measurement of serum microRNA-125b may predict the presence of microvascular invasion in hepatocellular carcinomas patients. Transl Oncol, 2016, 9(3): 167-172.
32.	Enooku K, Uranbileg B, Ikeda H, et al. Higher LPA2 and LPA6 mRNA levels in hepatocellular carcinoma are associated with poorer differentiation, microvascular invasion and earlier recurrence with higher serum autotaxin levels. PLoS One, 2016, 11(9): e0161825.
33.	Zhuang LP, Meng ZQ. Serum miR-224 reflects stage of hepatocellular carcinoma and predicts survival. Biomed Res Int, 2015, 2015: 731781.
34.	Yoon EL, Yeon JE, Ko E, et al. Significance of serum miR-10b-3p in predicting presence of microvascular invasion of hepatocellular carcinoma. Hepatol, 2014, 60(1): 85-86.
35.	Meng FL, Wang W, Jia WD. Diagnostic and prognostic significance of serum miR-24-3p in HBV-related hepatocellular carcinoma. Med Oncol, 2014, 31(9): 177.
36.	毛毳, 吳建軍, 王建新, 等. 乙肝病毒感染狀態與乙肝相關肝細胞癌微血管侵犯形成的關系. 交通醫學, 2017, 31(5): 455-457, 460.
37.	Huang C, Wang Y, Liu S, et al. Quantitative proteomic analysis identified paraoxonase 1 as a novel serum biomarker for microvascular invasion in hepatocellular carcinoma. J Proteome Res, 2013, 12(4): 1838-1846.
38.	趙偉, 劉文廣, 劉華平, 等. 肝癌微血管密度、微血管面積和Piezo1的表達與微血管侵犯的相關性. 臨床與病理雜志, 2017, 37(8): 1593-1600.
39.	趙暉, 仇毓東. 肝細胞癌微血管侵犯的預后評估及術前預測模型的建立. 南京醫科大學, 2018.

1. Wang FS, Fan JG, Zhang Z, et al. The global burden of liver disease: the major impact of China. Hepatology, 2014, 60(6): 2099-2108.
2. Shindoh J, Hasegawa K, Inoue Y, et al. Risk factors of post-operative recurrence and adequate surgical approach to improve long-term outcomes of hepatocellular carcinoma. HPB (Oxford), 2013, 15(1): 31-39.
3. 陳星, 李強, 荀曉冬, 等. 微血管侵犯對單發小肝癌患者術后無進展生存期的影響. 中華肝膽外科雜志, 2016, 22(2): 94-98.
4. 中國抗癌協會肝癌專業委員會, 中華醫學會肝病學分會肝癌學組, 中國抗癌協會病理專業委員, 等. 原發性肝癌規范化病理診斷指南(2015年版). 中華肝臟病雜志, 2015, 23(5): 321-327.
5. Parfitt JR, Marotta P, Alghamdi M, et al. Recurrent hepatocellular carcinoma after transplantation: use of a pathological score on explanted livers to predict recurrence. Liver Transpl, 2007, 13(4): 543-551.
6. Strilic B, Yang L, Albarrán-Juárez J, et al. Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis. Nature, 2016, 536(7615): 215-218.
7. Lei Z, Li J, Wu D, et al. Nomogram for preoperative estimation of microvascular invasion risk in hepatitis B virus-related hepatocellular carcinoma within the Milan criteria. JAMA Surg, 2016, 151(4): 356-363.
8. Rodríguez-Perálvarez M, Luong TV, Andreana L, et al. A systematic review of microvascular invasion in hepatocellular carcinoma: diagnostic and prognostic variability. Ann Surg Oncol, 2013, 20(1): 325-339.
9. 馮龍海, 叢文銘. 肝細胞癌微血管侵犯新型分級系統的建立及其臨床病理學意義的研究. 第二軍醫大學, 2016.
10. Iguchi T, Shirabe K, Aishima S, et al. New pathologic stratification of microvascular invasion in hepatocellular carcinoma: predicting prognosis after living-donor liver transplantation. Transplantation, 2015, 99(6): 1236-1242.
11. Zhou Y, Xu D, Wu L, et al. Meta-analysis of anatomic resection versus nonanatomic resection for hepatocellular carcinoma. Langenbecks Arch Surg, 2011, 396(7): 1109-1117.
12. 雷正清, 沈鋒. 早期肝癌微血管侵犯的術前預測和對肝切除切緣選擇的影響. 第二軍醫大學, 2016.
13. Minami Y, Nishida N, Kudo M. Therapeutic response assessment of RFA for HCC: contrast-enhanced US, CT and MRI. World J Gastroenterol, 2014, 20(15): 4160-4166.
14. 劉學, 沈鋒. MVI作為肝細胞癌術后輔助性TACE治療指征的研究. 第二軍醫大學, 2012.
15. Cheng AL, Kang YK, Chen Z, et al. Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase Ⅲ randomised, double-blind, placebo-controlled trial. Lancet Oncol, 2009, 10(1): 25-34.
16. Banerjee S, Wang DS, Kim HJ, et al. A computed tomography radiogenomic biomarker predicts microvascular invasion and clinical outcomes in hepatocellular carcinoma. Hepatology, 2015, 62(3): 792-800.
17. Kobayashi T, Aikata H, Honda F, et al. Preoperative fluorine 18 fluorodeoxyglucose positron emission tomography/computed tomography for prediction of microvascular invasion in small hepatocellular carcinoma. J Comput Assist Tomogr, 2016, 40(4): 524-530.
18. 李文柱, 蘇丹柯. 能譜CT預測肝細胞癌微血管侵犯的可能性研究. 廣西醫科大學, 2016.
19. Renzulli M, Brocchi S, Cucchetti A, et al. Can current preoperative imaging be used to detect microvascular invasion of hepatocellular carcinoma? Radiology, 2016, 279(2): 432-442.
20. Han MA, Lee DH, Woo SM, et al. Galangin sensitizes TRAIL-induced apoptosis through down-regulation of anti-apoptotic proteins in renal carcinoma Caki cells. Sci Rep, 2016, 6: 18642.
21. Shirabe K, Kajiyama K, Abe T, et al. Predictors of microscopic portal vein invasion by hepatocellular carcinoma: measurement of portal perfusion defect area ratio. J Gastroenterol Hepatol, 2009, 24(8): 1431-1436.
22. Xu P, Zeng M, Liu K, et al. Microvascular invasion in small hepatocellular carcinoma: is it predictable with preoperative diffusion-weighted imaging? J Gastroenterol Hepatol, 2014, 29(2): 330-336.
23. Min JH, Kim YK, Lim S, et al. Prediction of microvascular invasion of hepatocellular carcinomas with gadoxetic acid-enhanced MR imaging: Impact of intra-tumoral fat detected on chemical-shift images. Eur J Radiol, 2015, 84(6): 1036-1043.
24. 賈叢叢, 周瑋, 何國濃. 原發性肝癌彩色多普勒超聲血流分級與微血管生成的關系. 中國現代醫生, 2016, 54(9): 103-105, 109, 封3.
25. You Z, Chen LP, Ye H. Predictors of microvascular invasion in patients with solitary small hepatitis B related hepatocellular carcinoma. Pak J Med Sci, 2014, 30(2): 331-334.
26. Imura S, Teraoku H, Yoshikawa M, et al. Potential predictive factors for microvascular invasion in hepatocellular carcinoma classified within the Milan criteria. Int J Clin Oncol, 2018, 23(1): 98-103.
27. Poté N, Cauchy F, Albuquerque M, et al. Performance of PIVKA-Ⅱ for early hepatocellular carcinoma diagnosis and prediction of microvascular invasion. J Hepatol, 2015, 62(4): 848-854.
28. Poon RT, Ng IO, Lau C, et al. Serum vascular endothelial growth factor predicts venous invasion in hepatocellular carcinoma: a prospective study. Ann Surg, 2001, 233(2): 227-235.
29. Zhu PP, Yuan SG, Liao Y, et al. High level of intercellular adhesion molecule-1 affects prognosis of patients with hepatocellular carcinoma. World J Gastroenterol, 2015, 21(23): 7254-7263.
30. 汪宇, 李錫鋒, 張小峰, 等. 術前外周血循環腫瘤細胞檢測對原發性肝細胞肝癌微血管侵犯的預測價值. 山東醫藥, 2017, 57(18): 33-35.
31. Liu M, Wang L, Zhu H, et al. A preoperative measurement of serum microRNA-125b may predict the presence of microvascular invasion in hepatocellular carcinomas patients. Transl Oncol, 2016, 9(3): 167-172.
32. Enooku K, Uranbileg B, Ikeda H, et al. Higher LPA2 and LPA6 mRNA levels in hepatocellular carcinoma are associated with poorer differentiation, microvascular invasion and earlier recurrence with higher serum autotaxin levels. PLoS One, 2016, 11(9): e0161825.
33. Zhuang LP, Meng ZQ. Serum miR-224 reflects stage of hepatocellular carcinoma and predicts survival. Biomed Res Int, 2015, 2015: 731781.
34. Yoon EL, Yeon JE, Ko E, et al. Significance of serum miR-10b-3p in predicting presence of microvascular invasion of hepatocellular carcinoma. Hepatol, 2014, 60(1): 85-86.
35. Meng FL, Wang W, Jia WD. Diagnostic and prognostic significance of serum miR-24-3p in HBV-related hepatocellular carcinoma. Med Oncol, 2014, 31(9): 177.
36. 毛毳, 吳建軍, 王建新, 等. 乙肝病毒感染狀態與乙肝相關肝細胞癌微血管侵犯形成的關系. 交通醫學, 2017, 31(5): 455-457, 460.
37. Huang C, Wang Y, Liu S, et al. Quantitative proteomic analysis identified paraoxonase 1 as a novel serum biomarker for microvascular invasion in hepatocellular carcinoma. J Proteome Res, 2013, 12(4): 1838-1846.
38. 趙偉, 劉文廣, 劉華平, 等. 肝癌微血管密度、微血管面積和Piezo1的表達與微血管侵犯的相關性. 臨床與病理雜志, 2017, 37(8): 1593-1600.
39. 趙暉, 仇毓東. 肝細胞癌微血管侵犯的預后評估及術前預測模型的建立. 南京醫科大學, 2018.

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CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

肝細胞癌合并微血管癌栓的早期診斷研究現狀

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