Progress in biocompatibility and surface modification of nickel titanium shape memory alloys_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

BAI Jiyue ¹ ,  XU Yongqing ² , HE Xiaoqing ² , Li Chuan ² , ZHU Min ²

1. Graduate Management Brigade, Army Medical University, Chongqing, 400038, P.R.China;
2. Department of Orthopedics, Kunming General Hospital of Chengdu Military Command, Kunming Yunnan, 650032, P.R.China;

Corresponding?author：

XU Yongqing, Email: xuyongqingkm@163.net

Keywords：

Nickel titanium shape memory alloys; biocampatibility; surface modification

DOI：

10.7507/1002-1892.201709089

Video：

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Objective To summarize the research progress of biocompatibility and surface modification of nickel titanium shape memory alloys (Ni-Ti SMA). Methods The relative researches about Ni-Ti SMA at home and abroad were reviewed, collated, analyzed, and summarized. Results At present, Ni-Ti SMA as an internal fixation material has been widely used in clinic. It has the following advantages: the super elasticity, the shape memory characteristic, the good wear resistance, and the strong corrosion resistance. It also can effectively avoid the internal fixator rupture caused by stress shielding. After surface modification, the biocompatibility of Ni-Ti SMA has been improved. Conclusion The Ni-Ti SMA is the most promising alloy material for the long-term internal fixator because of its excellent material properties.

Citation： BAI Jiyue, XU Yongqing, HE Xiaoqing, Li Chuan, ZHU Min. Progress in biocompatibility and surface modification of nickel titanium shape memory alloys. Chinese Journal of Reparative and Reconstructive Surgery, 2018, 32(8): 1091-1095. doi: 10.7507/1002-1892.201709089 Copy

1.	蔡興博, 丁晶, 徐永清. 鎳鈦記憶合金在骨科臨床中的應用. 國際骨科學雜志, 2017, 38(6): 364-367.
2.	Leitner T, Sabirov I, Pippan R, et al. The effect of severe grain refinement on the damage tolerance of a superelastic NiTi shape memory alloy. J Mech Behav Biomed Mater, 2017, 71: 337-348.
3.	黃亦成, 宓蓉. 鎳鈦合金在醫療領域應用研究進展. 生物醫學工程學進展, 2015, 36(3): 169-172.
4.	馬嘉麗, 于振華, 朱明, 等. 鎳鈦合金血管支架性能研究綜述. 金屬功能材料, 2015, 22(2): 56-59.
5.	Habijan T, Glogowski T, Kuhn S, et al. Can human mesenchymal stem cells survive on a NiTi implant material subjected to cyclic loading? Acta Biomater, 2011, 7(6): 2733-2739.
6.	郭靜, 米叢波, 譚雪英. 4 種鎳鈦正畸弓絲鎳離子析出的體外實驗. 中國組織工程研究與臨床康復, 2009, 13(21): 4141-4144.
7.	張賀佳, 張揚, 孫曉菊, 等. 3 種正畸用鎳鈦形狀記憶合金弓絲細胞毒性評價. 中國實用口腔科雜志, 2010, 3(8): 477-480.
8.	Kapanen A, Ilvesaro J, Danilov A, et al. Behaviour of nitinol in osteoblast-like ROS-17 cell cultures. Biomaterials, 2002, 23(3): 645-650.
9.	Bogdanski D, K?ller M, Müller D, et al. Easy assessment of the biocompatibility of Ni-Ti alloys by in vitro cell culture experiments on a functionally graded Ni-NiTi-Ti material[J]. Biomaterials. 2002, 23(23): 4549-4555.
10.	El Medawar L, Rocher P, Hornez JC, et al. Electrochemical and cytocompatibility assessment of NiTiNOL memory shape alloy for orthodontic use. Biomol Eng, 2002, 19(2-6): 153-160.
11.	Wever DJ, Elstrodt JA, Veldhuizen AG, et al. Scoliosis correction with shape-memory metal: results of an experimental study. Eur Spine J, 2002, 11(2): 100-106.
12.	Olson JL, Velez-Montoya R, Erlanger M. Ocular biocompatibility of nitinol intraocular clips. Invest Ophthalmol Vis Sci, 2012, 53(1): 354-360.
13.	李強, 夏亞一, 劉文忠, 等. 彈性鎳鈦合金內固定材料表面修飾及其持續動力壓應力對骨折愈合的影響. 中國組織工程研究與臨床康復, 2007, 11(5): 811-814.
14.	張媛媛, 肖自安, 李周, 等. 鎳鈦合金在豚鼠聽泡的生物相容性觀察. 聽力學及言語疾病雜志, 2010, 18(3): 211-214.
15.	Assad M, Yahia LH, Rivard CH, et al. In vitro biocompatibility assessment of a nickel-titanium alloy using electron microscopy in situ end-labeling (EM-ISEL). J Biomed Mater Res, 1998, 41(1): 154-161.
16.	馮翠娟, 張雪, 王強, 等. 表面氧化鎳鈦合金對L-929細胞凋亡、總RNA量及caspase-3, 8, 9 mRNA表達影響的研究. 口腔醫學, 2011, 31(1): 19-22.
17.	馮翠娟, 王強, 張雪, 等. 鎳鈦合金表面氧化處理對L-929細胞凋亡相關基因bax/bcl-2 mRNA表達的影響. 中國組織工程研究與臨床康復, 2010, 14(12): 2145-2148.
18.	李慧萍. Cr離子注入鎳鈦合金的表面改性研究. 北京: 北方工業大學, 2014.
19.	Dudek K, Goryczka T. Electrophoretic deposition and characterization of thin hydroxyapatite coatings formed on the surface of NiTi shape memory alloy. Ceramics International, 2016, 42(16): 19124-19132.
20.	張海軍, 王栓科, 趙斌. HAP涂層鎳鈦記憶合金的組織相容性. 中國修復重建外科雜志, 2009, 23(4): 468-472.
21.	朱姿虹. NiTi合金表面無鎳層及生物改性層制備與表征. 鎮江: 江蘇大學, 2016.
22.	Choi J, Bogdanski D, K?ller M, et al. Calcium phosphate coating of nickel-titanium shape-memory alloys. Coating procedure and adherence of leukocytes and platelets. Biomaterials, 2003, 24(21): 3689-3696.
23.	Chu CL, Guo C, Sheng XB, et al. Microstructure, nickel suppression and mechanical characteristics of electropolished and photoelectrocatalytically oxidized biomedical nickel titanium shape memory alloy. Acta Biomater, 2009, 5(6): 2238-2245.
24.	Thierry B, Tabrizian M, Trepanier C, et al. Effect of surface treatment and sterilization processes on the corrosion behavior of NiTi shape memory alloy. J Biomed Mater Res, 2000, 51(4): 685-693.
25.	Trépanier C, Tabrizian M, Yahia LH, et al. Effect of modification of oxide layer on NiTi stent corrosion resistance. J Biomed Mater Res, 1998, 43(4): 433-440.
26.	Armitage DA, Parker TL, Grant DM. Biocompatibility and hemocompatibility of surface-modified NiTi alloys. J Biomed Mater Res A, 2003, 66(1): 129-137.
27.	Xu JL, Zhong ZC, Yu DZ, et al. Effect of micro-arc oxidation surface modification on the properties of the NiTi shape memory alloy. J Mater Sci Mater Med, 2012, 23(12): 2839-2846.
28.	Kobayashi S, Ohgoe Y, Ozeki K, et al. Dissolution effect and cytotoxicity of diamond-like carbon coatings on orthodontic archwires. J Mater Sci Mater Med, 2007, 18(12): 2263-2268.
29.	Kapanen A, Kinnunen A, Ryh?nen J, et al. TGF-beta1 secretion of ROS-17/2.8 cultures on NiTi implant material. Biomaterials, 2002, 23(16): 3341-3346.
30.	汪愛媛, 李永濱, 許文靜, 等. 鈦鈮涂層鎳鈦記憶合金的生物安全性及生物相容性. 中國醫藥生物技術, 2010, 5(1): 32-37.
31.	蘇向東, 韓鋒, 何力, 等. 低溫去合金化脫鎳處理鎳鈦記憶合金的表面特性. 稀有金屬材料與工程, 2011, 40(8): 1446-1449.
32.	袁凌偉, 蘇向東, 魯茂森, 等. 低溫去合金化鎳鈦形狀記憶合金的血液相容性.中國組織工程研究與臨床康復, 2009, 13(34): 6663-6666.
33.	K?hl M, Habijan T, Bram M, et al. Powder metallurgical near-net-shape fabrication of porous NiTi shape memory alloys for use as long-term implants by the combination of the metal injection molding process with the space-holder technique. Advanced Engineering Materials, 2009, 11(12): 959-968.
34.	Wu S, Liu X, Wu G, et al. Wear mechanism and tribological characteristics of porous NiTi shape memory alloy for bone scaffold. J Biomed Mater Res A, 2013, 101(9): 2586-2601.

1. 蔡興博, 丁晶, 徐永清. 鎳鈦記憶合金在骨科臨床中的應用. 國際骨科學雜志, 2017, 38(6): 364-367.
2. Leitner T, Sabirov I, Pippan R, et al. The effect of severe grain refinement on the damage tolerance of a superelastic NiTi shape memory alloy. J Mech Behav Biomed Mater, 2017, 71: 337-348.
3. 黃亦成, 宓蓉. 鎳鈦合金在醫療領域應用研究進展. 生物醫學工程學進展, 2015, 36(3): 169-172.
4. 馬嘉麗, 于振華, 朱明, 等. 鎳鈦合金血管支架性能研究綜述. 金屬功能材料, 2015, 22(2): 56-59.
5. Habijan T, Glogowski T, Kuhn S, et al. Can human mesenchymal stem cells survive on a NiTi implant material subjected to cyclic loading? Acta Biomater, 2011, 7(6): 2733-2739.
6. 郭靜, 米叢波, 譚雪英. 4 種鎳鈦正畸弓絲鎳離子析出的體外實驗. 中國組織工程研究與臨床康復, 2009, 13(21): 4141-4144.
7. 張賀佳, 張揚, 孫曉菊, 等. 3 種正畸用鎳鈦形狀記憶合金弓絲細胞毒性評價. 中國實用口腔科雜志, 2010, 3(8): 477-480.
8. Kapanen A, Ilvesaro J, Danilov A, et al. Behaviour of nitinol in osteoblast-like ROS-17 cell cultures. Biomaterials, 2002, 23(3): 645-650.
9. Bogdanski D, K?ller M, Müller D, et al. Easy assessment of the biocompatibility of Ni-Ti alloys by in vitro cell culture experiments on a functionally graded Ni-NiTi-Ti material[J]. Biomaterials. 2002, 23(23): 4549-4555.
10. El Medawar L, Rocher P, Hornez JC, et al. Electrochemical and cytocompatibility assessment of NiTiNOL memory shape alloy for orthodontic use. Biomol Eng, 2002, 19(2-6): 153-160.
11. Wever DJ, Elstrodt JA, Veldhuizen AG, et al. Scoliosis correction with shape-memory metal: results of an experimental study. Eur Spine J, 2002, 11(2): 100-106.
12. Olson JL, Velez-Montoya R, Erlanger M. Ocular biocompatibility of nitinol intraocular clips. Invest Ophthalmol Vis Sci, 2012, 53(1): 354-360.
13. 李強, 夏亞一, 劉文忠, 等. 彈性鎳鈦合金內固定材料表面修飾及其持續動力壓應力對骨折愈合的影響. 中國組織工程研究與臨床康復, 2007, 11(5): 811-814.
14. 張媛媛, 肖自安, 李周, 等. 鎳鈦合金在豚鼠聽泡的生物相容性觀察. 聽力學及言語疾病雜志, 2010, 18(3): 211-214.
15. Assad M, Yahia LH, Rivard CH, et al. In vitro biocompatibility assessment of a nickel-titanium alloy using electron microscopy in situ end-labeling (EM-ISEL). J Biomed Mater Res, 1998, 41(1): 154-161.
16. 馮翠娟, 張雪, 王強, 等. 表面氧化鎳鈦合金對L-929細胞凋亡、總RNA量及caspase-3, 8, 9 mRNA表達影響的研究. 口腔醫學, 2011, 31(1): 19-22.
17. 馮翠娟, 王強, 張雪, 等. 鎳鈦合金表面氧化處理對L-929細胞凋亡相關基因bax/bcl-2 mRNA表達的影響. 中國組織工程研究與臨床康復, 2010, 14(12): 2145-2148.
18. 李慧萍. Cr離子注入鎳鈦合金的表面改性研究. 北京: 北方工業大學, 2014.
19. Dudek K, Goryczka T. Electrophoretic deposition and characterization of thin hydroxyapatite coatings formed on the surface of NiTi shape memory alloy. Ceramics International, 2016, 42(16): 19124-19132.
20. 張海軍, 王栓科, 趙斌. HAP涂層鎳鈦記憶合金的組織相容性. 中國修復重建外科雜志, 2009, 23(4): 468-472.
21. 朱姿虹. NiTi合金表面無鎳層及生物改性層制備與表征. 鎮江: 江蘇大學, 2016.
22. Choi J, Bogdanski D, K?ller M, et al. Calcium phosphate coating of nickel-titanium shape-memory alloys. Coating procedure and adherence of leukocytes and platelets. Biomaterials, 2003, 24(21): 3689-3696.
23. Chu CL, Guo C, Sheng XB, et al. Microstructure, nickel suppression and mechanical characteristics of electropolished and photoelectrocatalytically oxidized biomedical nickel titanium shape memory alloy. Acta Biomater, 2009, 5(6): 2238-2245.
24. Thierry B, Tabrizian M, Trepanier C, et al. Effect of surface treatment and sterilization processes on the corrosion behavior of NiTi shape memory alloy. J Biomed Mater Res, 2000, 51(4): 685-693.
25. Trépanier C, Tabrizian M, Yahia LH, et al. Effect of modification of oxide layer on NiTi stent corrosion resistance. J Biomed Mater Res, 1998, 43(4): 433-440.
26. Armitage DA, Parker TL, Grant DM. Biocompatibility and hemocompatibility of surface-modified NiTi alloys. J Biomed Mater Res A, 2003, 66(1): 129-137.
27. Xu JL, Zhong ZC, Yu DZ, et al. Effect of micro-arc oxidation surface modification on the properties of the NiTi shape memory alloy. J Mater Sci Mater Med, 2012, 23(12): 2839-2846.
28. Kobayashi S, Ohgoe Y, Ozeki K, et al. Dissolution effect and cytotoxicity of diamond-like carbon coatings on orthodontic archwires. J Mater Sci Mater Med, 2007, 18(12): 2263-2268.
29. Kapanen A, Kinnunen A, Ryh?nen J, et al. TGF-beta1 secretion of ROS-17/2.8 cultures on NiTi implant material. Biomaterials, 2002, 23(16): 3341-3346.
30. 汪愛媛, 李永濱, 許文靜, 等. 鈦鈮涂層鎳鈦記憶合金的生物安全性及生物相容性. 中國醫藥生物技術, 2010, 5(1): 32-37.
31. 蘇向東, 韓鋒, 何力, 等. 低溫去合金化脫鎳處理鎳鈦記憶合金的表面特性. 稀有金屬材料與工程, 2011, 40(8): 1446-1449.
32. 袁凌偉, 蘇向東, 魯茂森, 等. 低溫去合金化鎳鈦形狀記憶合金的血液相容性.中國組織工程研究與臨床康復, 2009, 13(34): 6663-6666.
33. K?hl M, Habijan T, Bram M, et al. Powder metallurgical near-net-shape fabrication of porous NiTi shape memory alloys for use as long-term implants by the combination of the metal injection molding process with the space-holder technique. Advanced Engineering Materials, 2009, 11(12): 959-968.
34. Wu S, Liu X, Wu G, et al. Wear mechanism and tribological characteristics of porous NiTi shape memory alloy for bone scaffold. J Biomed Mater Res A, 2013, 101(9): 2586-2601.

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