Correlation analysis between platelet-related parameters and inflammatory indicators in patients with acute pancreatitis_West China Medical Journal

Authors：

FU Yang , ZHANG Qi , LI Mengyu , MIAO Qiang , WEI Bin , JIANG Hong ,  NIU Qian

Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding?author：

NIU Qian, Email: niuqian991@126.com

Keywords：

Acute pancreatitis; Platelet-related parameters; Immature platelet fraction; Inflammatory indicators

DOI：

10.7507/1002-0179.202006249

Video：

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Objective To find out the diagnostic power and correlation between platelet-related parameters and inflammatory indicators in acute pancreatitis patients with different severity.Methods A total of 88 patients with acute pancreatitis diagnosed in West China Hospital of Sichuan University from January 2019 to August 2019 were enrolled in the retrospective study, including 58 mild acute pancreatitis patients and 30 severe acute pancreatitis patients. The patients’ platelet-related parameters and inflammatory indicators were collected. The platelet parameters and inflammatory indicators in different severity acute pancreatitis groups were compared and the diagnostic power and correlation were analyzed.Results The platelet count and plateletcrit of the severe group were lower than those of the mild group, the difference was statistically significant (Z=–5.502, –3.673; P<0.001). The immature platelet fraction, platelet distribution width, mean platelet volume and platelet-large cell ratio levels of the severe group were higher than those of the mild group (Z=–4.217, –2.998, –3.754, –3.816; P<0.05). Platelet-related parameters platelet count, immature platelet fraction, platelet distribution width, mean platelet volume, platelet-large cell ratio, plateletcrit and inflammatory indicators procalcitonin, interleukin-6 showed good diagnostic power with areas under under receiver operating characteristic curves greater than 0.75 in differentiating the severity of acute pancreatitis. Correlation analysis showed that immature platelet fraction was positively correlated with procalcitonin and interleukin-6 levels in patients with acute pancreatitis (r_s=0.457, 0.385; P<0.05).Conclusions Immature platelet fraction is correlated with the severity of acute pancreatitis, and positively correlated with the levels of inflammatory indicators procalcitonin and interleukin-6.

Citation： FU Yang, ZHANG Qi, LI Mengyu, MIAO Qiang, WEI Bin, JIANG Hong, NIU Qian. Correlation analysis between platelet-related parameters and inflammatory indicators in patients with acute pancreatitis. West China Medical Journal, 2020, 35(8): 943-947. doi: 10.7507/1002-0179.202006249 Copy

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9.	Huang L, Chen C, Yang L, <italic>et al</italic>. Neutrophil-to-lymphocyte ratio can specifically predict the severity of hypertriglyceridemia-induced acute pancreatitis compared with white blood cell. J Clin Lab Anal, 2019, 33(4): e22839.
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11.	金爽, 許智利, 陳建時. 急性胰腺炎患者早期凝血功能及血管內皮功能檢測及臨床意義. 中國中西醫結合消化雜志, 2019, 27(3): 215-218, 223.
12.	周仁偉, 劉鵬軍. PDW、PLT、MPV 及 BISAP 評分對急性胰腺炎病情程度的預測價值. 熱帶醫學雜志, 2017, 17(11): 1490-1493.
13.	陳國勝, 薛綺萍, 許海塵, 等. 烏司他丁對老年中重度急性胰腺炎患者血小板參數的影響. 胃腸病學, 2014, 19(11): 678-681.
14.	戴慶忠, 覃瑜. 急性胰腺炎患者凝血指標變化的臨床研究. 國際檢驗醫學雜志, 2014, 35(18): 2563-2564.
15.	Kaur M, Nibhoria S, Tiwana K, <italic>et al</italic>. Rapid transformation of chronic lymphocytic leukemia to acute lymphoblastic leukemia: a rare case report. J Basic Clin Pharm, 2016, 7(2): 60-63.
16.	張紅松, 馮芳, 付麗彬, 等. 不同炎性因子對重癥急性胰腺炎的預測價值研究. 中國全科醫學, 2017, 20(25): 3127-3131.
17.	Liang Y, Zhao X, Meng F. Procalcitonin, C-reactive protein, and neutrophil ratio contribute to the diagnosis and prognosis of severe acute pancreatitis. Iran J Public Health, 2019, 48(12): 2177-2186.

1. 殷躍文, 袁誠. 急性胰腺炎患者凝血功能指標改變的臨床意義. 實用臨床醫藥雜志, 2014, 18(15): 150-152.
2. 尹連杰, 徐英軍, 王乃存. 急性胰腺炎血清降鈣素原與血小板平均體積檢測臨床價值探討. 國際檢驗醫學雜志, 2018, 39(2): 240-243.
3. Yadav J, Yadav SK, Kumar S, <italic>et al</italic>. Predicting morbidity and mortality in acute pancreatitis in an Indian population: a comparative study of the BISAP score, Ranson’s score and CT severity index. Gastroenterol Rep (Oxf), 2016, 4(3): 216-220.
4. 常建同, 紀宗正, 白鄭海, 等. 急性胰腺炎血漿 D-二聚體和纖維蛋白(原)降解產物的動態變化及意義. 臨床外科雜志, 2014, 22(2): 108-110.
5. van der Linden N, Klinkenberg LJ, Meex SJ, <italic>et al</italic>. Immature platelet fraction measured on the Sysmex XN hemocytometer predicts thrombopoietic recovery after autologous stem cell transplantation. Eur J Haematol, 2014, 93(2): 150-156.
6. 羅媛. 急性胰腺炎與凝血功能及全身炎癥反應綜合征發生的相關性. 血栓與止血學, 2016, 22(4): 376-378.
7. 中華醫學會外科學分會胰腺外科學組. 急性胰腺炎診治指南(2014). 中國實用外科雜志, 2015, 35(1): 4-7.
8. 冀亮, 孫備, 程春東, 等. 創傷遞升式分階段治療重癥急性胰腺炎局部并發癥的臨床經驗總結. 中華外科雜志, 2016, 54(11): 839-843.
9. Huang L, Chen C, Yang L, <italic>et al</italic>. Neutrophil-to-lymphocyte ratio can specifically predict the severity of hypertriglyceridemia-induced acute pancreatitis compared with white blood cell. J Clin Lab Anal, 2019, 33(4): e22839.
10. Manohar M, Verma AK, Venkateshaiah SU, <italic>et al</italic>. Pathogenic mechanisms of pancreatitis. World J Gastrointest Pharmacol Ther, 2017, 8(1): 10-25.
11. 金爽, 許智利, 陳建時. 急性胰腺炎患者早期凝血功能及血管內皮功能檢測及臨床意義. 中國中西醫結合消化雜志, 2019, 27(3): 215-218, 223.
12. 周仁偉, 劉鵬軍. PDW、PLT、MPV 及 BISAP 評分對急性胰腺炎病情程度的預測價值. 熱帶醫學雜志, 2017, 17(11): 1490-1493.
13. 陳國勝, 薛綺萍, 許海塵, 等. 烏司他丁對老年中重度急性胰腺炎患者血小板參數的影響. 胃腸病學, 2014, 19(11): 678-681.
14. 戴慶忠, 覃瑜. 急性胰腺炎患者凝血指標變化的臨床研究. 國際檢驗醫學雜志, 2014, 35(18): 2563-2564.
15. Kaur M, Nibhoria S, Tiwana K, <italic>et al</italic>. Rapid transformation of chronic lymphocytic leukemia to acute lymphoblastic leukemia: a rare case report. J Basic Clin Pharm, 2016, 7(2): 60-63.
16. 張紅松, 馮芳, 付麗彬, 等. 不同炎性因子對重癥急性胰腺炎的預測價值研究. 中國全科醫學, 2017, 20(25): 3127-3131.
17. Liang Y, Zhao X, Meng F. Procalcitonin, C-reactive protein, and neutrophil ratio contribute to the diagnosis and prognosis of severe acute pancreatitis. Iran J Public Health, 2019, 48(12): 2177-2186.

West China Medical Journal

Correlation analysis between platelet-related parameters and inflammatory indicators in patients with acute pancreatitis

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