宮頸卵巢原發性雙癌和宮頸癌卵巢轉移的臨床分析_West China Medical Journal

Authors：

莫小雨 , 郭清民 , 唐慧蕓 ,  鄭艾

四川大學華西第二醫院婦產科/出生缺陷與相關婦兒疾病教育部重點實驗室（成都 610041）;

Corresponding?author：

鄭艾, Email: 894591422@qq.com

Keywords：

多部位原發性腫瘤; 轉移性腫瘤; 宮頸; 卵巢

DOI：

10.7507/1002-0179.201604233

Video：

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女性生殖系統多部位原發惡性腫瘤（multiple primary malignant carcinomas，MPMC）是指在同一女性生殖系統器官中，同時或先后原發于同一器官不同部位、或 2 個甚至多個器官的惡性腫瘤，其中以卵巢內膜原發性雙癌發病率最高，宮頸卵巢原發性雙癌較為罕見。然而與轉移性癌相比較，MPMC 通常期別較早，預后較好，目前尚無國際公認的標準治療模式。因此在臨床診療過程中，要注意鑒別多個腫瘤發生關系的原發性和轉移性，做到及時診斷、及時治療，盡量減少誤診、漏診。該文就宮頸卵巢原發性雙癌及宮頸癌卵巢轉移方面的臨床特點進行了綜述。

Citation： 莫小雨, 郭清民, 唐慧蕓, 鄭艾. 宮頸卵巢原發性雙癌和宮頸癌卵巢轉移的臨床分析. West China Medical Journal, 2017, 32(7): 1108-1111. doi: 10.7507/1002-0179.201604233 Copy

1.	Gursel B, Meydan D, ?zbek N, et al. Multiple primary malignant neoplasms from the Black Sea region of Turkey. J Int Med Res, 2011, 39(2): 667-674.
2.	潘源, 王家倉, 梁寒. 消化系多原發癌 116 例臨床分析. 中華腫瘤雜志, 2002, 24(2): 191-193.
3.	Tong SY, Lee YS, Park JS, et al. Clinical analysis of synchronous primary neoplasms of the female reproductive tract. Eur J Obstet Gynecol Reprod Biol, 2008, 136(1): 78-82.
4.	Moertel CG, Dockerty MB, Baggenstoss AH. Multiple primary malignant neoplasms. I. Introduction and presentation of data. Cancer, 1961, 14(2): 221-230.
5.	Kaminski PF, Norris HJ. Coexistence of ovarian neoplasms and endocervical adenocarcinoma. Obstet Gynecol, 1984, 64(4): 553-556.
6.	呂偉超, 鄭紅楓. 卵巢漿液性囊腺癌合并宮頸鱗癌 1 例報告. 醫藥論壇雜志, 1995(4): 49.
7.	Srivastava KR, Zahra F. Synchronous primary malignancy of ovary and cervix with different histopathology: a rare presentation. Int J Gynecol Obstet, 2009, 12(2): 16-19.
8.	高潔, 王輝, 錫林高娃, 等. 罕見女性生殖器官雙原發癌 1 例分析. 中國誤診學雜志, 2011, 11(13): 3238.
9.	Guzin K, Sahin S, Goynumer G, et al. A rare coexistence of villoglandular papillary adenocarcinoma of the uterine cervix and brenner tumor of the ovary. Case Rep Obstet Gynecol, 2014: 342040.
10.	楊東, 曹保利, 薛鳳霞. 女性生殖道雙原發癌 1 例報道并文獻復習. 中華實用診斷與治療雜志, 2014, 28(2): 203-204.
11.	Huang YD, Hung YC, Yeh LS, et al. Synchronous ovarian endometrioid adenocarcinoma and endocervical mucinous adenocarcinoma. Taiwan J Obstet Gynecol, 2006, 45(3): 264-267.
12.	Kavitha N, Who TS, Kanagasabai S, et al. A case of two synchronous tumour of different histology-advanced cervical adenocarcinoma with borderline mucinous ovarian tumour in a 22 year old virgin. Int J Gynecol Obstet, 2012, 119(3): 179-180.
13.	石莉, 周樹林, 姜旖, 等. 婦科惡性腫瘤相關的多發性原發性惡性腫瘤 30 例臨床分析. 中華婦產科雜志, 2014, 49(3): 199-203.
14.	沈鏗. 女性生殖道多部位原發癌//曹澤毅. 中華婦產科學(下冊). 北京: 人民衛生出版社, 1999: 2085-2092.
15.	程易凡, 彭芝蘭, 王平, 等. 女性生殖系統多部位原發惡性腫瘤 15 例分析. 四川大學學報: 醫學版, 2003, 34(2): 374-375.
16.	沈鏗. 女性生殖道多部位原發癌//曹澤毅. 中華婦產科學(下冊). 3版. 北京: 人民衛生出版社, 2014: 2549-2553.
17.	Woodruff JD, Solomon D, Sullivant H. Multifocal disease in the upper genital canal. Obstet Gynecol, 1985, 65(5): 695-698.
18.	Zaino R, Whitney C, Brady MF, et al. Simultaneously detected endometrial and ovarian carcinomas--a prospective clinicopathologic study of 74 cases: a gynecologic oncology group study. Gynecol Oncol, 2001, 83(2): 355-362.
19.	Alfsen GC, Thoresen SO, Kristensen GB, et al. Histopathologic subtyping of cervical adenocarcinoma reveals increasing incidence rates of endometrioid tumors in all age groups: a population based study with review of all nonsquamous cervical carcinomas in norway from 1966 to 1970, 1976 to 1980, and 1986 to 1990. Cancer, 2000, 89(6): 1291-1299.
20.	Chung HH, Hwang S Y, Jung KW, et al. Ovarian cancer incidence and survival in Korea: 1993-2002. Int J Gynecol Cancer, 2007, 17(3): 595-600.
21.	馬紹康, 孫建衡. 子宮頸癌卵巢轉移 17 例分析. 中華婦產科雜志, 1996, 31(5): 305-305.
22.	聞強, 邵株燕, 方素華. 宮頸腺癌 321 例卵巢轉移情況的臨床分析. 現代婦產科進展, 2015, 24(7): 501-503.
23.	Samaila M, Adesiyun AG, Oluwole P. Metastatic ovarian squamous cell carcinoma. Singapore Med J, 2008, 49(5): E139-E141.
24.	Ronnett BM, Yemelyanova AV, Vang R, et al. Endocervical adenocarcinomas with ovarian metastases: analysis of 29 cases with emphasis on minimally invasive cervical tumors and the ability of the metastases to simulate primary ovarian neoplasms. Am J Surg Pathol, 2008, 32(12): 1835-1853.
25.	梅泉, 李雙, 馬丁. 宮頸癌卵巢轉移研究進展. 中國實用婦科與產科雜志, 2010(3): 238-240.
26.	Shimada M, Kigawa J, Nishimura R, et al. Ovarian metastasis in carcinoma of the uterine cervix. Gynecol Oncol, 2006, 101(2): 234-237.
27.	Yamamoto R, Okamoto K, Yukiharu T, et al. A study of risk factors for ovarian metastases in stage Ⅰb-Ⅲb cervical carcinoma and analysis of ovarian function after a transposition. Gynecol Oncol, 2001, 82(2): 312-316.
28.	Ivanov S, Zervoudis S. Metastatic cancer in transposed ovaries after radical Wertheim-Meigs hysterectomy for a stageⅠB and ⅡA cervical cancer. Akush Ginekol(Sofiia), 2003, 42(5): 22-24.
29.	Sanjuán A, Martínez Román S, Martínez-Zamora MA, et al. Bilateral ovarian metastasis on transposed ovaries from cervical carcinoma. Int J Gynaecol Obstet, 2007, 99(1): 64-65.
30.	Piketty M, Barranger E, Najat M, et al. Ovarian recurrence after radical trachelectomy for adenocarcinoma of the cervix. Am J Obstet Gynecol, 2005, 193(4): 1382-1383.
31.	Krasevi? M, Haller H, Rupci? S, et al. Massive edema of the ovary: a report of two cases due to lymphatic permeation by metastatic carcinoma from the uterine cervix. Gynecol Oncol, 2004, 93(2): 564-567.
32.	Landoni F, Zanagnolo V, Lovato-Diaz L, et al. Ovarian metastases in early-stage cervical cancer (ⅠA 2-ⅡA): a multicenter retrospective study of 1965 patients (a cooperative task force study). Int J Gynecol Cancer, 2007, 17(3): 623-628.
33.	Nakanishi T, Wakai K, Ishikawa H, et al. A comparison of ovarian metastasis between squamous cell carcinoma and adenocarcinoma of the uterine cervix. Gynecol Oncol, 2001, 82(3): 504-509.
34.	勾金海, 李征宇. 宮頸癌診治中的幾個熱點問題. 華西醫學, 2014, 29(2): 377-381.

1. Gursel B, Meydan D, ?zbek N, et al. Multiple primary malignant neoplasms from the Black Sea region of Turkey. J Int Med Res, 2011, 39(2): 667-674.
2. 潘源, 王家倉, 梁寒. 消化系多原發癌 116 例臨床分析. 中華腫瘤雜志, 2002, 24(2): 191-193.
3. Tong SY, Lee YS, Park JS, et al. Clinical analysis of synchronous primary neoplasms of the female reproductive tract. Eur J Obstet Gynecol Reprod Biol, 2008, 136(1): 78-82.
4. Moertel CG, Dockerty MB, Baggenstoss AH. Multiple primary malignant neoplasms. I. Introduction and presentation of data. Cancer, 1961, 14(2): 221-230.
5. Kaminski PF, Norris HJ. Coexistence of ovarian neoplasms and endocervical adenocarcinoma. Obstet Gynecol, 1984, 64(4): 553-556.
6. 呂偉超, 鄭紅楓. 卵巢漿液性囊腺癌合并宮頸鱗癌 1 例報告. 醫藥論壇雜志, 1995(4): 49.
7. Srivastava KR, Zahra F. Synchronous primary malignancy of ovary and cervix with different histopathology: a rare presentation. Int J Gynecol Obstet, 2009, 12(2): 16-19.
8. 高潔, 王輝, 錫林高娃, 等. 罕見女性生殖器官雙原發癌 1 例分析. 中國誤診學雜志, 2011, 11(13): 3238.
9. Guzin K, Sahin S, Goynumer G, et al. A rare coexistence of villoglandular papillary adenocarcinoma of the uterine cervix and brenner tumor of the ovary. Case Rep Obstet Gynecol, 2014: 342040.
10. 楊東, 曹保利, 薛鳳霞. 女性生殖道雙原發癌 1 例報道并文獻復習. 中華實用診斷與治療雜志, 2014, 28(2): 203-204.
11. Huang YD, Hung YC, Yeh LS, et al. Synchronous ovarian endometrioid adenocarcinoma and endocervical mucinous adenocarcinoma. Taiwan J Obstet Gynecol, 2006, 45(3): 264-267.
12. Kavitha N, Who TS, Kanagasabai S, et al. A case of two synchronous tumour of different histology-advanced cervical adenocarcinoma with borderline mucinous ovarian tumour in a 22 year old virgin. Int J Gynecol Obstet, 2012, 119(3): 179-180.
13. 石莉, 周樹林, 姜旖, 等. 婦科惡性腫瘤相關的多發性原發性惡性腫瘤 30 例臨床分析. 中華婦產科雜志, 2014, 49(3): 199-203.
14. 沈鏗. 女性生殖道多部位原發癌//曹澤毅. 中華婦產科學(下冊). 北京: 人民衛生出版社, 1999: 2085-2092.
15. 程易凡, 彭芝蘭, 王平, 等. 女性生殖系統多部位原發惡性腫瘤 15 例分析. 四川大學學報: 醫學版, 2003, 34(2): 374-375.
16. 沈鏗. 女性生殖道多部位原發癌//曹澤毅. 中華婦產科學(下冊). 3版. 北京: 人民衛生出版社, 2014: 2549-2553.
17. Woodruff JD, Solomon D, Sullivant H. Multifocal disease in the upper genital canal. Obstet Gynecol, 1985, 65(5): 695-698.
18. Zaino R, Whitney C, Brady MF, et al. Simultaneously detected endometrial and ovarian carcinomas--a prospective clinicopathologic study of 74 cases: a gynecologic oncology group study. Gynecol Oncol, 2001, 83(2): 355-362.
19. Alfsen GC, Thoresen SO, Kristensen GB, et al. Histopathologic subtyping of cervical adenocarcinoma reveals increasing incidence rates of endometrioid tumors in all age groups: a population based study with review of all nonsquamous cervical carcinomas in norway from 1966 to 1970, 1976 to 1980, and 1986 to 1990. Cancer, 2000, 89(6): 1291-1299.
20. Chung HH, Hwang S Y, Jung KW, et al. Ovarian cancer incidence and survival in Korea: 1993-2002. Int J Gynecol Cancer, 2007, 17(3): 595-600.
21. 馬紹康, 孫建衡. 子宮頸癌卵巢轉移 17 例分析. 中華婦產科雜志, 1996, 31(5): 305-305.
22. 聞強, 邵株燕, 方素華. 宮頸腺癌 321 例卵巢轉移情況的臨床分析. 現代婦產科進展, 2015, 24(7): 501-503.
23. Samaila M, Adesiyun AG, Oluwole P. Metastatic ovarian squamous cell carcinoma. Singapore Med J, 2008, 49(5): E139-E141.
24. Ronnett BM, Yemelyanova AV, Vang R, et al. Endocervical adenocarcinomas with ovarian metastases: analysis of 29 cases with emphasis on minimally invasive cervical tumors and the ability of the metastases to simulate primary ovarian neoplasms. Am J Surg Pathol, 2008, 32(12): 1835-1853.
25. 梅泉, 李雙, 馬丁. 宮頸癌卵巢轉移研究進展. 中國實用婦科與產科雜志, 2010(3): 238-240.
26. Shimada M, Kigawa J, Nishimura R, et al. Ovarian metastasis in carcinoma of the uterine cervix. Gynecol Oncol, 2006, 101(2): 234-237.
27. Yamamoto R, Okamoto K, Yukiharu T, et al. A study of risk factors for ovarian metastases in stage Ⅰb-Ⅲb cervical carcinoma and analysis of ovarian function after a transposition. Gynecol Oncol, 2001, 82(2): 312-316.
28. Ivanov S, Zervoudis S. Metastatic cancer in transposed ovaries after radical Wertheim-Meigs hysterectomy for a stageⅠB and ⅡA cervical cancer. Akush Ginekol(Sofiia), 2003, 42(5): 22-24.
29. Sanjuán A, Martínez Román S, Martínez-Zamora MA, et al. Bilateral ovarian metastasis on transposed ovaries from cervical carcinoma. Int J Gynaecol Obstet, 2007, 99(1): 64-65.
30. Piketty M, Barranger E, Najat M, et al. Ovarian recurrence after radical trachelectomy for adenocarcinoma of the cervix. Am J Obstet Gynecol, 2005, 193(4): 1382-1383.
31. Krasevi? M, Haller H, Rupci? S, et al. Massive edema of the ovary: a report of two cases due to lymphatic permeation by metastatic carcinoma from the uterine cervix. Gynecol Oncol, 2004, 93(2): 564-567.
32. Landoni F, Zanagnolo V, Lovato-Diaz L, et al. Ovarian metastases in early-stage cervical cancer (ⅠA 2-ⅡA): a multicenter retrospective study of 1965 patients (a cooperative task force study). Int J Gynecol Cancer, 2007, 17(3): 623-628.
33. Nakanishi T, Wakai K, Ishikawa H, et al. A comparison of ovarian metastasis between squamous cell carcinoma and adenocarcinoma of the uterine cervix. Gynecol Oncol, 2001, 82(3): 504-509.
34. 勾金海, 李征宇. 宮頸癌診治中的幾個熱點問題. 華西醫學, 2014, 29(2): 377-381.

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West China Medical Journal

宮頸卵巢原發性雙癌和宮頸癌卵巢轉移的臨床分析

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