Clinical Study on the Treatment of Early Patellofemoral Osteoarthritis by the Combination of Glucosamine Hydrochloride with Exercise Therapy and Traditional Chinese Medicine Hot Compress_West China Medical Journal

Authors：

 ZhangYun ¹ , ZengYu ² , LuoYong ¹

1. Department of Traditional Chinese Medicine Orthopedics, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, P. R. China;
2. Department of Hyperbaric Oxygen, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, P. R. China;

Corresponding?author：

Keywords：

Early patellofemoral osteoarthritis; Glucosamine hydrochloride; Exercise therapy; Traditional Chinese medicine hot compress

DOI：

10.7507/1002-0179.201600323

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To study the clinical effect of the combination of glucosamine hydrochloride with exercise therapy and traditional Chinese medicine hot compress in the treatment of early patellofemoral osteoarthritis. Methods A total of 126 patients with early patellofemoral osteoarthritis treated between June 2013 and April 2015 were divided into group A (n=43), B (n=42) and C (n=41) with the method of random number table. Oral administration of glucosamine hydrochloride tablets, exercise therapy of knee joints and traditional Chinese medicine hot compress were applied for the 43 patients in group A. Oral administration of glucosamine hydrochloride tablets and exercise therapy of knee joints were applied for the 42 patients in group B. Exercise therapy of knee joints and traditional Chinese medicine hot compress were applied for the 41 patients in group C. Chen's Scoring was applied before the treatment and 2, 4, 12 and 24 weeks after the treatment. Results The differences of Chen's scores at the time points after treatment and those before treatment of the same group had statistical significance (P<0.05). The differences of Chen's scores at the time points after treatment in group A and those in group B and C had statistical significance (P<0.05). There were no obvious adverse effects due to administration of glucosamine hydrochloride tablets in group A and B. Five patients in group A and 4 patients in group C suffered from the symptoms of local erythema, light cutaneous pruritus and other contact dermatitis after traditional Chinese medicine hot compress. Those symptoms disappeared automatically several hours later without any special treatment. Conclusion The treatment of early patellofemoral osteoarthritis by the combination of glucosamine hydrochloride tablets with exercise therapy and traditional Chinese medicine hot compress can rapidly relieve joint pain, and maintain efficacy for a long time.

Citation： ZhangYun, ZengYu, LuoYong. Clinical Study on the Treatment of Early Patellofemoral Osteoarthritis by the Combination of Glucosamine Hydrochloride with Exercise Therapy and Traditional Chinese Medicine Hot Compress. West China Medical Journal, 2016, 31(7): 1185-1188. doi: 10.7507/1002-0179.201600323 Copy

1.	Hong E, Kraft MC. Evaluating anterior knee pain[J]. Med Clin North Am, 2014, 98(4):697-717, xi.
2.	Chan VO, Moran DE, Mwangi I, et al. Prevalence and clinical significance of chondromalacia isolated to the anterior margin of the lateral femoral condyle as a component of patellofemoral disease:observations at Mr imaging[J]. Skeletal Radiol, 2013, 42(8):1127-1133.
3.	Rathleff MS, Rasmussen S, Olesen JL. Unsatisfactory long-term prognosis of conservative treatment of patellofemoral pain syndrome[J]. Ugeskr Laeger, 2012, 174(15):1008-1013.
4.	蒲云青. 中藥離子導入聯合玻璃酸鈉關節腔注射治療髕股關節早期骨關節炎43例總結[J]. 湖南中醫雜志, 2015, 31(4):78-79.
5.	國家中醫藥管理局. 中醫病癥診斷療效標準[M]. 南京:南京大學出版社, 1994:198.
6.	陳大宇, 曹亞飛, 麥慶春, 等. 中藥熱奄包治療膝骨關節炎的臨床觀察[J]. 中醫正骨, 2011, 23(6):6-8, 12.
7.	李光輝, 高宏鷹. 髕股關節早期骨關節炎的研究進展[J]. 中國當代醫藥, 2015, 22(26):22-25.
8.	Macmull S, Jaiswal PK, Bentley G, et al. The role of autologous chondrocyte implantation in the treatment of symptomatic chondromalacia patellae[J]. Int Orthop, 2012, 36(7):1371-1377.
9.	李圖力·古爾. 氨基葡萄糖治療髕股關節早期骨關節炎的療效分析[J]. 海峽藥學, 2013, 25(12):164-165.
10.	徐佑軍. 硫酸氨基葡萄糖膠囊治療膝骨關節炎的療效觀察[J]. 中國當代醫藥, 2010, 17(18):47, 50.
11.	李江, 楊陽, 呂穎. 中西醫結合治療髕股關節早期骨關節炎86 例[J]. 河南中醫, 2013, 33(7):1129-1130.
12.	Chen S, Huang Y, Chen W, et al. Protective effects of the Tougu Xiaotong capsule on morphology and osteoprotegerin/nuclear factor-kappaB ligand expression in rabbits with knee osteoarthritis[J]. Mol Med Rep, 2016, 13(1):419-425.
13.	陳世菊, 劉源, 石桂秀. 氨基葡萄糖治療亞洲人群骨關節炎的Meta分析[J]. 華西醫學, 2015, 30(9):1627-1632.
14.	陳潔, 蘭由玉, 劉偉, 等. 鹽酸氨基葡萄糖與雙醋瑞因治療骨關節炎的臨床對照研究[J]. 華西醫學, 2014, 29(6):1111-1114.
15.	劉學妮, 林惠釵. 股四頭肌訓練對溫針灸治療膝關節退行性骨關節病遠期療效的影響[J]. 中國實用醫藥, 2015, 10(23):273-274.
16.	練偉東. 獨活寄生湯聯合股四頭肌訓練治療膝關節骨性關節炎30例臨床觀察[J]. 河北中醫, 2015, 37(4):553-555.
17.	韋漢容. 中藥塌漬、TDP、超短波結合股四頭肌訓練治療膝骨關節炎22例[J]. 江西中醫藥, 2015, 46(2):34-36.
18.	陸志夫, 吳清琳, 劉永利. 蠲痹湯加減結合中藥熏洗治療髕股關節早期骨關節炎57例療效觀察[J]. 中醫藥導報, 2014, 20(8):68-70.
19.	葉啟彬, 吳志宏, 王以朋, 等. 髕股關節早期骨關節炎的病因、診斷和治療探索[J]. 中國醫學科學院學報, 2001, 23(2):181-183.
20.	黃建, 楊麗薇. 電針配合鹽酸氨基葡萄糖治療膝骨關節炎的臨床研究[J]. 華西醫學, 2014, 29(1):30-33.
21.	邱貴興, 翁習生, 張克, 等. 鹽酸、硫酸氨基葡萄糖治療骨關節炎的平行對照臨床研究[J]. 中華醫學雜志, 2005, 85(43):3067-3070.
22.	文瓊芳, 黃烽. 氨基葡萄糖治療骨關節炎的爭議探討[J]. 中國藥物應用與監測, 2015, 12(4):246-250.

1. Hong E, Kraft MC. Evaluating anterior knee pain[J]. Med Clin North Am, 2014, 98(4):697-717, xi.
2. Chan VO, Moran DE, Mwangi I, et al. Prevalence and clinical significance of chondromalacia isolated to the anterior margin of the lateral femoral condyle as a component of patellofemoral disease:observations at Mr imaging[J]. Skeletal Radiol, 2013, 42(8):1127-1133.
3. Rathleff MS, Rasmussen S, Olesen JL. Unsatisfactory long-term prognosis of conservative treatment of patellofemoral pain syndrome[J]. Ugeskr Laeger, 2012, 174(15):1008-1013.
4. 蒲云青. 中藥離子導入聯合玻璃酸鈉關節腔注射治療髕股關節早期骨關節炎43例總結[J]. 湖南中醫雜志, 2015, 31(4):78-79.
5. 國家中醫藥管理局. 中醫病癥診斷療效標準[M]. 南京:南京大學出版社, 1994:198.
6. 陳大宇, 曹亞飛, 麥慶春, 等. 中藥熱奄包治療膝骨關節炎的臨床觀察[J]. 中醫正骨, 2011, 23(6):6-8, 12.
7. 李光輝, 高宏鷹. 髕股關節早期骨關節炎的研究進展[J]. 中國當代醫藥, 2015, 22(26):22-25.
8. Macmull S, Jaiswal PK, Bentley G, et al. The role of autologous chondrocyte implantation in the treatment of symptomatic chondromalacia patellae[J]. Int Orthop, 2012, 36(7):1371-1377.
9. 李圖力·古爾. 氨基葡萄糖治療髕股關節早期骨關節炎的療效分析[J]. 海峽藥學, 2013, 25(12):164-165.
10. 徐佑軍. 硫酸氨基葡萄糖膠囊治療膝骨關節炎的療效觀察[J]. 中國當代醫藥, 2010, 17(18):47, 50.
11. 李江, 楊陽, 呂穎. 中西醫結合治療髕股關節早期骨關節炎86 例[J]. 河南中醫, 2013, 33(7):1129-1130.
12. Chen S, Huang Y, Chen W, et al. Protective effects of the Tougu Xiaotong capsule on morphology and osteoprotegerin/nuclear factor-kappaB ligand expression in rabbits with knee osteoarthritis[J]. Mol Med Rep, 2016, 13(1):419-425.
13. 陳世菊, 劉源, 石桂秀. 氨基葡萄糖治療亞洲人群骨關節炎的Meta分析[J]. 華西醫學, 2015, 30(9):1627-1632.
14. 陳潔, 蘭由玉, 劉偉, 等. 鹽酸氨基葡萄糖與雙醋瑞因治療骨關節炎的臨床對照研究[J]. 華西醫學, 2014, 29(6):1111-1114.
15. 劉學妮, 林惠釵. 股四頭肌訓練對溫針灸治療膝關節退行性骨關節病遠期療效的影響[J]. 中國實用醫藥, 2015, 10(23):273-274.
16. 練偉東. 獨活寄生湯聯合股四頭肌訓練治療膝關節骨性關節炎30例臨床觀察[J]. 河北中醫, 2015, 37(4):553-555.
17. 韋漢容. 中藥塌漬、TDP、超短波結合股四頭肌訓練治療膝骨關節炎22例[J]. 江西中醫藥, 2015, 46(2):34-36.
18. 陸志夫, 吳清琳, 劉永利. 蠲痹湯加減結合中藥熏洗治療髕股關節早期骨關節炎57例療效觀察[J]. 中醫藥導報, 2014, 20(8):68-70.
19. 葉啟彬, 吳志宏, 王以朋, 等. 髕股關節早期骨關節炎的病因、診斷和治療探索[J]. 中國醫學科學院學報, 2001, 23(2):181-183.
20. 黃建, 楊麗薇. 電針配合鹽酸氨基葡萄糖治療膝骨關節炎的臨床研究[J]. 華西醫學, 2014, 29(1):30-33.
21. 邱貴興, 翁習生, 張克, 等. 鹽酸、硫酸氨基葡萄糖治療骨關節炎的平行對照臨床研究[J]. 中華醫學雜志, 2005, 85(43):3067-3070.
22. 文瓊芳, 黃烽. 氨基葡萄糖治療骨關節炎的爭議探討[J]. 中國藥物應用與監測, 2015, 12(4):246-250.

West China Medical Journal

Clinical Study on the Treatment of Early Patellofemoral Osteoarthritis by the Combination of Glucosamine Hydrochloride with Exercise Therapy and Traditional Chinese Medicine Hot Compress

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content