外用噻嗎洛爾治療嬰幼兒血管瘤的臨床研究_West China Medical Journal

Authors：

 杜繼宇 , 郭軍 , 董金容 , 張毅 ,  余靜

綿陽市中心醫院兒科, 四川綿陽 621000;

Corresponding?author：

杜繼宇, Email: 913293628@qq.com; 余靜, Email: yujingjing62666@163.com

Keywords：

噻嗎洛爾; 嬰幼兒血管瘤; 治療效果

DOI：

10.7507/1002-0179.201600295

Video：

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目的研究外用噻嗎洛爾用于治療嬰幼兒血管瘤（IH）的臨床效果。方法選擇 2012 年 5 月-2014年 5 月共 90 例 IH 患兒治療前行相關檢查排除禁忌證，通過超聲檢查分為淺表型（n=40）、深部型（n=20）及混合性（n=30）3 組，均采用外用噻嗎洛爾治療，每月復查 1 次，通過用藥前及用藥后 3 個月進行療效評價，采用 Achauer 療效評定法進行分級評定。結果所有治療患兒均無不良反應發生，淺表型 IH 治療后Ⅲ級以上療效率達 82.5%，深部型 IH 治療后Ⅲ級以上療效率為 20%，而混合型 IH 治療后Ⅲ級以上療效率為 50%，噻嗎洛爾治療淺表型 IH 療效明顯優于深部型 IH（P<0.05）。結論外用噻嗎洛爾治療淺表型 IH 安全有效。

Citation： 杜繼宇, 郭軍, 董金容, 張毅, 余靜. 外用噻嗎洛爾治療嬰幼兒血管瘤的臨床研究. West China Medical Journal, 2016, 31(6): 1095-1096. doi: 10.7507/1002-0179.201600295 Copy

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1. Drolet B, Esterly NB, Frieden IJ. Hemangiomas in children[J]. N Engl J Med, 1999, 341(3) :173-181.
2. Metry D. Update on hemangiomas of infancy[J]. Curr Opin Pediatr, 2004, 16(4) :373-377.
3. Zimmermann AP, Wiegand S, Werner JA, et al. Propranolol therapy for infantile haemangiomas:review of the literature[J]. Int J Pediatr Otorhinolaryngol, 2010, 74(4) :338-342.
4. 池晨. 臨床應用普萘洛爾的注意事項[J]. 中國藥物與臨床, 2004, 4(2) :139.
5. Waner M, Suen JY. A classification of congenital vascular lesions[M]//Waner M, Suen JY. Hemangiomas and vascular malformations of the head and neck. New York:Wiley-Liss,1999:1-12.
6. Achauer BM, Chang CJ, Vander Kam VM. Management of hemangioma of infancy:review of 245 patients[J]. Plast Reconstr Surg, 1997, 99(5) :1301-1308.
7. Léauté-Labrèze C, Dumas de la Roque E, Hubiche T, et al. Propranolol for severe hemangiomas of infancy[J]. N Engl J Med, 2008, 358(24) :2649-2651.
8. Guo S, Ni N. Topical treatment for capillary hemangioma of the eyelid using beta-blocker solution[J]. Arch Ophthalmol, 2010, 128(2) :255-256.
9. Semkova K, Kazandjieva J. Topical timolol maleate for treatment of infantile haemangiomas:preliminary results of a prospective study[J]. Clin Exp Dermatol, 2013, 38(2) :143-146.

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外用噻嗎洛爾治療嬰幼兒血管瘤的臨床研究

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