Analysis of Allergens of Melanosis in 56 Cases_West China Medical Journal

Authors：

 HuaXia ^1,2 , ZhouHui ¹ ,  ZhangYizhi ¹

1. Department of Dermatology & Venerology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. Department of Dermatology, Chengdu Second People’s Hospital, Chengdu, Sichuan 610017, P. R. China;

Corresponding?author：

ZhangYizhi, Email: yizhi5202@sina.com

Keywords：

Melanosis; Metal; Clinical analysis

DOI：

10.7507/1002-0179.201600239

Video：

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Objective To analyze the contact allergens of melanosis. Methods Fifty-six patients confirmed with melanosis between June 2010 and October 2013 received patch test and BICOM test, and the results were analyzed statistically and clinical data of the included patients were retrospectively analyzed. Results Of the 56 patients, 50 patch tests and 40 BICOM tests were positive. The top three chemical allergic resources in patch test of these patients were nickel sulfate (33.9%), aluminum (21.4%), and potassium dichromate (16.1%). The positive rates of male patients with aluminum, rubber compounds and cobalt chloride were significantly higher than those of females. The positive rate of female patients with nickel sulfate was significantly higher than that of males. The differences were all significant (P＜0.05) . Conclusion Nickel sulfate, aluminum and potassium dichromate may be the main allergens of melanosis.

Citation： HuaXia, ZhouHui, ZhangYizhi. Analysis of Allergens of Melanosis in 56 Cases. West China Medical Journal, 2016, 31(5): 880-884. doi: 10.7507/1002-0179.201600239 Copy

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1. 王文嶺, 楊蓉婭. 28例皮膚黑變病例臨床、病理和診斷研究[J]. 實用皮膚病學雜志, 2011, 4(1) : 9-11.
2. 趙辨. 中國臨床皮膚病學[M]. 南京: 江蘇科學技術出版社, 2010: 243-1250.
3. 陳新, 王洋, 王慧娟, 等. 還原型谷胱甘肽聯合多烯磷脂酰膽堿治療職業性黑變病療效[J]. 中國職業醫學, 2013, 40(3) : 216-217.
4. Imokawa G, Ishida K. Inhibitors of intracellular signaling pathways that lead to stimulated epidermal pigmentation: perspective of antipigmenting agents[J]. Int J Mol Sci, 2014, 15(5) : 8293-8315.
5. 胡瑚, 劉秀紅. 黑變病臨床分析[J]. 云南醫藥, 2013, 34(6) : 511.
6. 楊國亮, 王俠生. 現代皮膚病學[M]. 上海: 上海醫科大學出版社, 1998: 449．.
7. Seghers AC, Lee JS, Tan CS, et al. atopic dirty neck or acquired atopic hyperpigmentation? An epidemiological and clinical study from the National Skin Centre in Singapore[J]. Dermatology, 2014 , 229(3) : 174.
8. 孫玉德. １例黑變病愈后復發的病因分析[J]. 齊齊哈爾醫學院學報, 2012, 33(6) : 838.
9. 宋月星, 高煥學, 鄒先彪. 職業性黑變病一例[J]. 實用皮膚病學雜志, 2014, 7(1) : 63-64.
10. 王朋, 權哲, 黃簡抒. 苯并呋喃酮致職業性接觸性皮炎20例臨床分析[J]. 工業衛生與職業病雜志, 2012, 38(2) : 118-119.
11. 聶靈聰, 吳詠蘭. 中毒性黑變病11例臨床分析[J]. 內蒙古醫學雜志, 2002, 34(5) : 458.
12. 陳捷, 韋建華, 覃衛平, 等. 20例職業性黑變病臨床觀察[J]. 中國職業醫學, 2010, 37(5) : 398-400.
13. 蘭雅璐, 王璐, 李巍. 面部皮炎患者123例斑貼試驗分析[J]. 中國美容醫學, 2013, 22(7) : 743-746.
14. Hallab NJ, Caicedo M, Epstein R. Invitro reactivity to implant metals demonstrates a person-dependent association with both T-Cell and B-Cell activation[J]. J Biomed Mater Res, 2010, 92(2) : 667-682．.
15. 胡燕, 夏汝山, 陸雪芬, 等. 顏面再發性皮炎665例接觸性變應原分析[J]. 中國皮膚性病學雜志, 2013, 27(5) : 472-474.
16. Hostynek J. Sensitization to nickel etiology, epidemiology, immune reactions, prevention, and therapy[J]. Rev Environ Health, 2006, 21(4) : 253-280.
17. Wang L, Xu AE. Four views of Riehl’s melanosis: clinical appearance, dermoscopy, confocal microscopy and histopathology[J]. J Eur Acad Dermatol Venereol, 2014 , 28(9) : 1199-1206.
18. 李波, 譚軍, 鐘茜, 等. 調Q1064nm激光治療面部皮膚黑變病臨床觀察[J]. 中國美容醫學, 2014, 23(7) : 551-553.

West China Medical Journal

Analysis of Allergens of Melanosis in 56 Cases

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