Effect of early antiretroviral therapy on acquired immune deficiency syndrome in Butuo County, Liangshan Autonomous Prefecture_West China Medical Journal

Authors：

YANG Chengbin ¹ ,  YANG Wen ² , ZENG Yali ² , GU Xiande ¹ , BIAN Shichao ³ , WU Min ¹ , ZHU Zhengde ¹ , LUO Xuewen ¹

1. Department of Medicine, People’s Hospital of Butuo County, Butuo, Sichuan 616350, P. R. China;
2. Sichuan Provincial Center for AIDS/STD Control and Prevention, Chengdu, Sichuan 610041, P. R. China;
3. Clinical Laboratory, Center for Disease Control and Prevention of Liangshan Autonomous Prefecture, Xichang, Sichuan 615000, P. R. China;

Corresponding?author：

YANG Wen, Email: yangwenn@yeah.net

Keywords：

Acquired immune deficiency syndrome; Early antiretroviral treatment; Therapeutic effect

DOI：

10.7507/1002-0179.201511052

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Objective To assess the effect of early antiretroviral therapy on acquired immune deficiency syndrome in Butuo County, Liangshan Autonomous Prefecture. Methods A total of 1 037 patients who underwent antiretroviral therapy between January 1st 2012 and December 31st 2013 in Butuo Coungty were divided into 2 groups. The early treatment group (with CD4⁺ lymphocyte count >350 /mm³) was group A (n=459) and delayed treatment group (with CD4⁺ lymphocyte count≤350 /mm³) was group B. After 18-month treatment, the treatment retention rate, clinical effect and the side effects of medication in two groups were observed and analyzed. Results After 18 months, there were 297 (64.7%) and 320 (55.4%) patients who were persisting in treatment in group A and B, respectively; while the mortality was 6.1% (28/459) and 14.4% (83/578), respectively in group A and B. The differences were significant (P<0.001). The rate of virological suppression in group A and B was 64.0% (190/297) and 63.8% (204/320) respectively without any significant difference (P>0.05). Compared with baseline CD4⁺ T lymphocyte counts, the growth rate of CD4⁺ T lymphocyte count in group A and B was 5.7% and 37.5%, respectively; the difference was significant (P<0.001) Conclusions Early treatment for acquired immune deficiency syndrome in Butuo County, Liangshan Autonomous Prefecture is effective, however, its growth rate of CD4⁺ T lymphocyte count is lower than that of delayed treatment. Early treatment doesn’t cause the increasement of the risk of common adverse reactions of medication, and it can reduce the mortality.

Citation： YANG Chengbin, YANG Wen, ZENG Yali, GU Xiande, BIAN Shichao, WU Min, ZHU Zhengde, LUO Xuewen. Effect of early antiretroviral therapy on acquired immune deficiency syndrome in Butuo County, Liangshan Autonomous Prefecture. West China Medical Journal, 2017, 32(6): 867-870. doi: 10.7507/1002-0179.201511052 Copy

1.	李東升, 劉佳, 王哲. 抗病毒治療作為預防控制 HIV 傳播的新策略研究進展. 中國艾滋病性病, 2016, 22(9): 133-137.
2.	國家衛生計生委辦公廳. 國家衛生計生委辦公廳關于修訂艾滋病患者免費抗病毒治療標準的通(2014-04-18)[2015-01-01]. http://www.nhfpc.gov.cn/yzygj/s3593/201405/95edf9ac8abb4e1a9f3482501b0ae4be.shtml.
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8.	趙燕, 張福杰, 劉中夫, 等. 人類免疫缺陷病毒感染者/艾滋病患者抗病毒治療的公共衛生意義及策略進展. 中華傳染病雜志, 2011, 29(7): 442-446.
9.	Cohen MS, Chen YQ, Mccauley M, et al. Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med, 2011, 365(6): 493-505.
10.	楊紹基, 李蘭娟, 任紅, 等. 傳染病學. 8 版. 北京: 人民衛生出版社, 2013: 108-118.
11.	楊文杰, 安偉鋒, 馬彥民, 等. 早期抗病毒治療對艾滋病患者生存狀況的影響. 中華流行病學雜志, 2014, 35(9): 1065-1068.
12.	陳仕曉, 毛碧容, 朱帆, 等. 51 例艾滋病抗病毒治療的療效分析. 華西醫學, 2009, 19(3): 661-663.
13.	樓金成, 李惠琴, 勞云飛, 等. 云南省成人 AIDS 病人抗病毒治療的療效分析. 中國艾滋病性病, 2013, 19(8): 557-559.
14.	Lichtenstein KA, Armon C, Buchacz K, et al. Initiation of antiretroviral therapy at CD4 cell counts≥350 cells/mm³ does not increase incidence or risk of peripheral neuropathy, anemia, or renal insufficiency. J Acquir Immune Defic Syndr, 2008, 47(1): 27-35.
15.	李俠, 樓金城, 勞云飛, 等. 云龍省 HIV/AIDS 病人早期抗病毒治療的有效性和安全性分析. 中國艾滋病性病, 2014, 20(3): 165-168.

1. 李東升, 劉佳, 王哲. 抗病毒治療作為預防控制 HIV 傳播的新策略研究進展. 中國艾滋病性病, 2016, 22(9): 133-137.
2. 國家衛生計生委辦公廳. 國家衛生計生委辦公廳關于修訂艾滋病患者免費抗病毒治療標準的通(2014-04-18)[2015-01-01]. http://www.nhfpc.gov.cn/yzygj/s3593/201405/95edf9ac8abb4e1a9f3482501b0ae4be.shtml.
3. 李蘭娟, 李德新, 吳尊友. 重大傳染病社區綜合防治實施方案和操作規程(試行版). 北京: 科學出版社, 2012.
4. 衛生部艾滋病臨床專家工作組. 國家免費艾滋病抗病毒治療手冊. 3 版. 北京: 人民衛生出版社, 2012: 25-133.
5. 衛生部艾滋病臨床專家工作組. 國家免費艾滋病抗病毒治療手冊. 4 版. 北京: 人民衛生出版社, 2016: 47-52.
6. Dabis F, Newell ML, Hirschel B. HIV drugs for treatment, and for prevention. Lancet, 2010, 375(9731): 2056-2057.
7. 中華醫學會感染病學分會艾滋病學組. 艾滋病診療指南 (2011 版) 中華臨床感染病雜志, 2011, 4(6): 321-330.
8. 趙燕, 張福杰, 劉中夫, 等. 人類免疫缺陷病毒感染者/艾滋病患者抗病毒治療的公共衛生意義及策略進展. 中華傳染病雜志, 2011, 29(7): 442-446.
9. Cohen MS, Chen YQ, Mccauley M, et al. Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med, 2011, 365(6): 493-505.
10. 楊紹基, 李蘭娟, 任紅, 等. 傳染病學. 8 版. 北京: 人民衛生出版社, 2013: 108-118.
11. 楊文杰, 安偉鋒, 馬彥民, 等. 早期抗病毒治療對艾滋病患者生存狀況的影響. 中華流行病學雜志, 2014, 35(9): 1065-1068.
12. 陳仕曉, 毛碧容, 朱帆, 等. 51 例艾滋病抗病毒治療的療效分析. 華西醫學, 2009, 19(3): 661-663.
13. 樓金成, 李惠琴, 勞云飛, 等. 云南省成人 AIDS 病人抗病毒治療的療效分析. 中國艾滋病性病, 2013, 19(8): 557-559.
14. Lichtenstein KA, Armon C, Buchacz K, et al. Initiation of antiretroviral therapy at CD4 cell counts≥350 cells/mm³ does not increase incidence or risk of peripheral neuropathy, anemia, or renal insufficiency. J Acquir Immune Defic Syndr, 2008, 47(1): 27-35.
15. 李俠, 樓金城, 勞云飛, 等. 云龍省 HIV/AIDS 病人早期抗病毒治療的有效性和安全性分析. 中國艾滋病性病, 2014, 20(3): 165-168.

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Effect of early antiretroviral therapy on acquired immune deficiency syndrome in Butuo County, Liangshan Autonomous Prefecture

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