Influence of the Infusion Speed of Agkistrodon Halys Antivenin on the Coagulation Function of the Victim Suffering from the Snake-bite_West China Medical Journal

Authors：

 WANGSong-yang ,  ZOULi-qun

Department of Emergency, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding?author：

ZOULi-qun, Email: zz921221@163.com

Keywords：

Agkistrodon halys antivenin; Infusion speed; Coagulation function

DOI：

10.7507/1002-0179.20140317

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To explore the use of agkistrodon halys antivenin, and the influence of its infusion time on the coagulation function of the patient bitten by agkistrodon halys. Methods We retrospectively analyzed the clinical data of patients suffering from pit viper bites and first diagnosed and treated in the emergency department of our hospital between April 1 and November 30, 2013. According to the allergy test results, patients were divided into two groups: negative and positive. Based on the infusion time, the negative patients were divided into ≤1.5 hours and >1.5 hours groups, and the positive patients were divided into ≤3 hours and >3 hours groups. All patients' gender, age, infusion time, and PT, APTT, TT, FIB, D-DIMER before and after infusion of antivenomous serum were recorded, and blood coagulation indicators before and after infusion of antivenomous serum and the impact of infusion time were compared among different groups. Results For both the negative and positive groups, PT, APTT, TT, FIB, and D-DIMER were statistically improved after infusion of antivenomous serum. The blood coagulation indicators of infusion time ≤1.5 hours group and ≤3 hours group were significantly better than those of infusion time >1.5 hours and >3 hours groups. Conclusion Antivenomous serum can correct coagulation and the faster infusion rate, the more obvious the effect is.

Citation： WANGSong-yang, ZOULi-qun. Influence of the Infusion Speed of Agkistrodon Halys Antivenin on the Coagulation Function of the Victim Suffering from the Snake-bite. West China Medical Journal, 2014, 29(6): 1037-1039. doi: 10.7507/1002-0179.20140317 Copy

1.	藍海.我國蛇傷治療研究中的現狀分析與探討[J].中國現代醫生, 2008, 46(15): 1-3.
2.	賈艷, 胡延春, 張乃生. 蛇毒的毒性成分及其應用研究[J].蛇志, 2004, 16(2): 23-32.
3.	肖毅仁, 董丁貴, 黃春明, 等.蛇咬傷16例救治體會[J].云南醫藥, 2012, 33(4): 385-386.
4.	覃公平.中國毒蛇學[M]. 2版. 南寧: 廣西科學技術出版社, 1998: 678-772.
5.	劉曉慧, 廖華偉,張捷.蛇傷患者凝血、抗凝、纖溶系統的變化及臨床意義[J].華西醫學, 2009, 24(5): 1163-1164.
6.	賴應昌, 鄧念強, 陳小林, 等.竹葉青蛇咬傷中毒合并彌散性血管內凝血的治療探討[J].臨床醫學, 2002, 22(4): 8-9.
7.	梁廣佳, 陳生, 王曉忠, 等.蛇毒對人體凝血系統的影響[J]. 江西醫學檢驗, 2005, 23(6): 567-568.
8.	陳建峰, 何少娟.蛇咬傷患者的臨床急護研究[J].中國高等醫學教育, 2011(3): 125, 138.
9.	毛小龍, 實用蛇傷急救醫學[M].南昌: 江西科學技術出版社, 2003: 71.
10.	林軍, 王乃平, 李其斌.抗蛇毒血清的問題及其發展[J].蛇志, 1991, 3(4): 43-45.
11.	劉書元, 羅潔珍, 馮恒基, 等.中西醫結合搶救重、危重型毒蛇咬傷體會[J]. 廣東醫學, 2004, 25(9): 1099-1101.
12.	任菡霖.抗蛇毒血清治療蛇毒咬傷患者的觀察和護理[J].現代中西結合雜志, 2005, 14(16): 2195-2196.
13.	付秋紅, 鄧立普.蝮蛇咬傷中毒的機制與治療新進展[J].蛇志, 2007, 19(1): 51-54.
14.	陽濤. 92例蝮蛇咬傷的救治及護理[J].中國醫學導報, 2010, 7(6): 113-114.
15.	程青, 楊劍虹, 唐忠志, 等. 109例蛇咬傷臨床綜合救治分析[J].臨床急診雜志, 2012, 13(6): 425-426.
16.	程祖耀.抗蛇毒血清的應用與并發癥處理[J].浙江醫學院學報, 2005, 29(5): 72.
17.	游劍明, 許建德.抗蛇毒血清致過敏性休克的特點及救治[J]. 蛇志, 2008, 20(2): 117-118.
18.	李宏健, 李桂敏, 王革, 等.抗蛇毒藥物的研究進展[J]. 蛇志, 2007, 19(1): 48-51.
19.	吳卯斌, 吳國理, 吳國琴.抗蛇毒血清蛇咬傷1569例[J].蛇志, 2005, 17(1): 13-14.
20.	劉明祥.毒蛇咬傷78例治療體會[J].中國醫藥指南, 2013, 11(17): 581-582.

1. 藍海.我國蛇傷治療研究中的現狀分析與探討[J].中國現代醫生, 2008, 46(15): 1-3.
2. 賈艷, 胡延春, 張乃生. 蛇毒的毒性成分及其應用研究[J].蛇志, 2004, 16(2): 23-32.
3. 肖毅仁, 董丁貴, 黃春明, 等.蛇咬傷16例救治體會[J].云南醫藥, 2012, 33(4): 385-386.
4. 覃公平.中國毒蛇學[M]. 2版. 南寧: 廣西科學技術出版社, 1998: 678-772.
5. 劉曉慧, 廖華偉,張捷.蛇傷患者凝血、抗凝、纖溶系統的變化及臨床意義[J].華西醫學, 2009, 24(5): 1163-1164.
6. 賴應昌, 鄧念強, 陳小林, 等.竹葉青蛇咬傷中毒合并彌散性血管內凝血的治療探討[J].臨床醫學, 2002, 22(4): 8-9.
7. 梁廣佳, 陳生, 王曉忠, 等.蛇毒對人體凝血系統的影響[J]. 江西醫學檢驗, 2005, 23(6): 567-568.
8. 陳建峰, 何少娟.蛇咬傷患者的臨床急護研究[J].中國高等醫學教育, 2011(3): 125, 138.
9. 毛小龍, 實用蛇傷急救醫學[M].南昌: 江西科學技術出版社, 2003: 71.
10. 林軍, 王乃平, 李其斌.抗蛇毒血清的問題及其發展[J].蛇志, 1991, 3(4): 43-45.
11. 劉書元, 羅潔珍, 馮恒基, 等.中西醫結合搶救重、危重型毒蛇咬傷體會[J]. 廣東醫學, 2004, 25(9): 1099-1101.
12. 任菡霖.抗蛇毒血清治療蛇毒咬傷患者的觀察和護理[J].現代中西結合雜志, 2005, 14(16): 2195-2196.
13. 付秋紅, 鄧立普.蝮蛇咬傷中毒的機制與治療新進展[J].蛇志, 2007, 19(1): 51-54.
14. 陽濤. 92例蝮蛇咬傷的救治及護理[J].中國醫學導報, 2010, 7(6): 113-114.
15. 程青, 楊劍虹, 唐忠志, 等. 109例蛇咬傷臨床綜合救治分析[J].臨床急診雜志, 2012, 13(6): 425-426.
16. 程祖耀.抗蛇毒血清的應用與并發癥處理[J].浙江醫學院學報, 2005, 29(5): 72.
17. 游劍明, 許建德.抗蛇毒血清致過敏性休克的特點及救治[J]. 蛇志, 2008, 20(2): 117-118.
18. 李宏健, 李桂敏, 王革, 等.抗蛇毒藥物的研究進展[J]. 蛇志, 2007, 19(1): 48-51.
19. 吳卯斌, 吳國理, 吳國琴.抗蛇毒血清蛇咬傷1569例[J].蛇志, 2005, 17(1): 13-14.
20. 劉明祥.毒蛇咬傷78例治療體會[J].中國醫藥指南, 2013, 11(17): 581-582.

West China Medical Journal

Influence of the Infusion Speed of Agkistrodon Halys Antivenin on the Coagulation Function of the Victim Suffering from the Snake-bite

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content