Efficacy and Safety of Compound Flumetasone Ointment for Neurodermatitis and Chronic Eczema:A Systematic Review_West China Medical Journal

Authors：

 XIAOBi-huan , WUYan , SUNYan ,  GAOXing-hua

Department of Dermatology, the First Hospital of China Medical University, Key Laboratory of Immunodermatology, Ministry of Health, Shenyang, Liaoning 110001, P. R. China;

Corresponding?author：

GAOXing-hua, Email: gaobarry@hotmail.com

Keywords：

Compound flumetasone ointment; Dermatitis; Eczema; Randomized controlled trials; Systematic review

DOI：

10.7507/1002-0179.20140209

Video：

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Objective To assess the efficacy and safety of compound flumetasone ointment for neurodermatitis and chronic eczema. Methods We searched the Medline, Cochrane Central Register of Controlled Trials, EMbase, CBM, CNKI and Wanfang Data to collect randomized controlled trials (RCTs) of compound flumetasone ointment for neurodermatitis and chronic eczema; the retrieval time started from founded date to December 2012. The language was confined to English and Chinese. We performed meta-analyses using the Cochrane Collaboration's RevMan 5.0 Software. Results A total of 22 RCTs involving 2 049 patients with neurodermatitis and chronic eczema were included and assessed. At the end of the 2nd, 3rd and 4th week, the efficacy of topical compound flumetasone ointment (or combined with oral antihistamines) was obviously higher than that of other topical corticosteroid preparations[RR=1.39, 95%CI(1.30, 1.50), P<0.000 01; RR=1.25, 95%CI(1.15, 1.37), P<0.000 01; RR=1.21, 95%CI(1.11, 1.33), P<0.000 1]. Only temporary and slight adverse effects, such as erythema, desquamation, burning and tingling were observed, whereas no serious adverse effects were reported. Conclusion The limited evidence demonstrates that topical compound flumetasone ointment (or combined with oral antihistamines) is safe and efficient. More large sampled and multiple central RCTs are required to verify these conclusions owing to the limitations of the present study.

Citation： XIAOBi-huan, WUYan, SUNYan, GAOXing-hua. Efficacy and Safety of Compound Flumetasone Ointment for Neurodermatitis and Chronic Eczema:A Systematic Review. West China Medical Journal, 2014, 29(4): 692-701. doi: 10.7507/1002-0179.20140209 Copy

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2.	陳小紅, 彭世瑜. 水楊酸在銀屑病治療中的作用[J]. 國外醫學·皮膚性病學分冊, 2000, 26(3):172-175.
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16.	何秋波. 復方氟米松軟膏治療手足角化性濕疹臨床觀察[J]. 醫藥論壇雜志, 2010, 31(8):116.
17.	徐潔. 氯雷他定聯合復方氟米松治療慢性濕疹的臨床觀察[J]. 臨床合理用藥雜志, 2010, 3(9):87.
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21.	柯丹, 刁慶春, 伍津津, 等. 復方氟米松軟膏治療108例神經性皮炎患者的臨床療效和安全性評價[J]. 重慶醫學, 2010, 39(23):3219-3220.
22.	王秀峰, 劉紅霞, 張玉仙. 復方氟米松軟膏治療慢性濕疹和神經性皮炎的療效觀察[J].臨床合理用藥, 2010, 3(21):42.
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24.	多守元. 鹵米松三氯生軟膏和復方氟米松治療慢性濕疹療效對比[J]. 西南軍醫, 2011, 13(6):1021-1022.
25.	曹素芬. 復方氟米松軟膏聯合紫外負離子噴霧治療神經性皮炎療效觀察[J]. 重慶醫學, 2010, 39(3):377-378.
26.	王云娜, 黎波, 杜元灝, 等. 針灸治療神經性皮炎臨床隨機對照試驗療效及安全性評價[J]. 遼寧中醫雜志, 2009, 36(12):2160-2163.
27.	楊芳, 王義亮, 郭強, 等. 針灸治療神經性皮炎的文獻系統評價[J]. 針灸臨床雜志, 2010, 26(8):1-7.
28.	陳建宏, 黃妙珠, 關倩雅, 等. 中藥內服治療濕疹的隨機對照試驗的系統評價[J]. 中國現代醫生, 2010, 48(13):83-84.
29.	楊志波, 賴彬, 黃迎玉. 中藥洗劑治療濕疹的系統評價[J]. 中醫藥導報, 2010, 16(9):21-25.
30.	Ashcroft DM, Chen LC, Garside R. Topical pimecrolimus for eczema[J]. Cochrane Database Syst Rev, 2007(4):CD005500.
31.	Stege H. Ultraviolet therapy in patients with chronic hand eczema[J]. Hautarzt, 2008, 59(9):696-702.
32.	Boyle RJ, Bath-Hextall FJ, Leonardi-Bee J, et al. Probiotics for the treatment of eczema:a systematic review[J]. Clin Exp Allergy, 2009, 39(8):1117-1127.
33.	Boyle RJ, Both-Hextall FJ, Leonardi-Bee J, et al. Probiotics for treating eczema[J]. Cochrane Database Syst Rev, 2008, 8(4):CD006135.
34.	Bath-Hextall FJ, Birnie AJ, Ravenscroft JC, et al. Interventions to reduce Staphylococcus aureus in the management of atopic eczema:an updated Cochrane review[J]. Br J Dermatol, 2010, 163(1):12-26.
35.	Wienert V, Heusinger JH. Local treatment of hemorrhoidal disease and perianal eczema-Meta-analysis of the efficacy and safety of an Escherichia coli culture suspension alone or in combination with hydrocortisone[J]. Arzneimittelforschung, 2002, 52(7):515-523.
36.	Schmitt J, Schmitt N, Meurer M. Cyclosporin in the treatment of patients with atopic eczema-a systematic review and meta-analysis[J]. J Eur Acad Dermatol Venereol, 2007, 21(5):606-619.
37.	Kerscher MJ, Korting HC. Treatment of atopic eczema with evening primrose oil:rationale and clinical results[J]. Clin Investig, 1992, 70(2):167-171.
38.	Morse NL, Clough PM. A meta-analysis of randomized, placebo-controlled clinical trials of Efamol(R)evening primrose oil in atopic eczema. Where do we go from here in light of more recent discoveries?[J]. Curr Pharmaceut Biotechnol, 2006, 7(6):503-524.
39.	Armstrong NC, Ernst E. The treatment of eczema with Chinese herbs:a systematic review of randomized clinical trials[J]. Br J Clin Pharmacol, 1999, 48(2):262-264.
40.	吳滿平, 蔣惠平, 王雪萍. 復方氟米松軟膏治療慢性濕疹、神經性皮炎的臨床療效觀察[J]. 中國醫院用藥評價與分析, 2009, 9(9):704-705.
41.	顏艷, 鞠梅, 于建斌, 等. 復方氟米松軟膏治療濕疹皮炎類皮膚病臨床療效觀察[J]. 中華皮膚科雜志, 2006, 39(2):116-117.
42.	Lynch PJ. Lichen simplex chronicus (atopic/neurodermatitis) of the anogenital region[J]. Dermatol Ther, 2004, 17(1):8-19.

1. 張石革. 皮炎與糖皮質激素[J]. 中國藥房, 2002, 13(9):575.
2. 陳小紅, 彭世瑜. 水楊酸在銀屑病治療中的作用[J]. 國外醫學·皮膚性病學分冊, 2000, 26(3):172-175.
3. 董玲英. 復方氟米松軟膏治療播散型神經性皮炎60例[J]. 中國藥業, 2009, 18(17):59.
4. 李世林. 復方氟米松軟膏治療神經性皮炎臨床觀察[J]. 中國藥房, 2008, 19(11):852-853.
5. 屈雅麗. 復方氟米松軟膏治療慢性濕疹及神經性皮炎的臨床觀察[J]. 中外醫療, 2008(25):77.
6. 李鴻國. 復方氟米松軟膏治療慢性濕疹臨床觀察及實驗研究[D]. 大連:大連醫科大學, 2009.
7. 梁靜. 復方氟米松軟膏治療慢性手部濕疹42例療效觀察[D]. 大連:大連醫科大學, 2009.
8. 彭安厚. 復方氟米松軟膏治療掌跖部慢性濕疹臨床觀察[J]. 中國皮膚性病學雜志, 2008, 22(5):318-319.
9. 左娟, 王雅芳, 李英弟. 復方氟米松軟膏治療慢性濕疹效果觀察[J]. 寧夏醫學雜志, 2009, 31(2):167-168.
10. 李蓮花, 金哲虎. 復方氟米松軟膏治療皮炎濕疹療效觀察[J]. 中國皮膚性病學雜志, 2009, 23(10):687-688.
11. 余兵, 肖文. 阿維A膠囊聯合復方氟米松軟膏治療掌跖角化性濕疹的臨床研究[J]. 廣西醫學, 2009, 31(11):1640-1641.
12. 趙瑋. 奧深聯合左西替利嗪治療慢性濕疹40例臨床觀察[J]. 中國醫藥導報, 2009, 6(16):76-77.
13. 倫振新, 蘇偉團, 戚志東. 復方氟米松軟膏治療慢性肥厚型濕疹60例臨床觀察[J]. 海南醫學, 2010, 21(5):50-51.
14. 孫玉娥, 孫亞琴, 崔斌, 等. 復方氟米松軟膏治療慢性單純性苔蘚和皸裂性濕疹臨床觀察[J]. 江蘇醫藥, 2010, 36(18):2221-2222.
15. 楊越楠, 焦林君, 徐凌忠. 復方氟米松軟膏治療神經性皮炎的療效觀察[J]. 包頭醫學院學報, 2009, 25(6):62-63.
16. 何秋波. 復方氟米松軟膏治療手足角化性濕疹臨床觀察[J]. 醫藥論壇雜志, 2010, 31(8):116.
17. 徐潔. 氯雷他定聯合復方氟米松治療慢性濕疹的臨床觀察[J]. 臨床合理用藥雜志, 2010, 3(9):87.
18. 吳波, 余振東, 劉顏. 復方氟米松軟膏治療慢性四肢及掌跖部濕疹臨床觀察[J]. 海南醫學, 2009, 20(7):94-95.
19. 葉霞, 黃丹. 復方氟米松軟膏聯合地氯雷他定治療慢性濕疹臨床觀察[J]. 中國現代醫生, 2010, 48(22):145.
20. 劉純卉. 復方氟米松軟膏治療慢性濕疹及神經性皮炎的臨床觀察[J]. 中國煤炭工業醫學雜志, 2008, 11(9):1356.
21. 柯丹, 刁慶春, 伍津津, 等. 復方氟米松軟膏治療108例神經性皮炎患者的臨床療效和安全性評價[J]. 重慶醫學, 2010, 39(23):3219-3220.
22. 王秀峰, 劉紅霞, 張玉仙. 復方氟米松軟膏治療慢性濕疹和神經性皮炎的療效觀察[J].臨床合理用藥, 2010, 3(21):42.
23. 張海萍. 復方氟米松軟膏治療慢性濕疹療效觀察[J]. 中國社區醫師·醫學專業, 2011, 13(272):140.
24. 多守元. 鹵米松三氯生軟膏和復方氟米松治療慢性濕疹療效對比[J]. 西南軍醫, 2011, 13(6):1021-1022.
25. 曹素芬. 復方氟米松軟膏聯合紫外負離子噴霧治療神經性皮炎療效觀察[J]. 重慶醫學, 2010, 39(3):377-378.
26. 王云娜, 黎波, 杜元灝, 等. 針灸治療神經性皮炎臨床隨機對照試驗療效及安全性評價[J]. 遼寧中醫雜志, 2009, 36(12):2160-2163.
27. 楊芳, 王義亮, 郭強, 等. 針灸治療神經性皮炎的文獻系統評價[J]. 針灸臨床雜志, 2010, 26(8):1-7.
28. 陳建宏, 黃妙珠, 關倩雅, 等. 中藥內服治療濕疹的隨機對照試驗的系統評價[J]. 中國現代醫生, 2010, 48(13):83-84.
29. 楊志波, 賴彬, 黃迎玉. 中藥洗劑治療濕疹的系統評價[J]. 中醫藥導報, 2010, 16(9):21-25.
30. Ashcroft DM, Chen LC, Garside R. Topical pimecrolimus for eczema[J]. Cochrane Database Syst Rev, 2007(4):CD005500.
31. Stege H. Ultraviolet therapy in patients with chronic hand eczema[J]. Hautarzt, 2008, 59(9):696-702.
32. Boyle RJ, Bath-Hextall FJ, Leonardi-Bee J, et al. Probiotics for the treatment of eczema:a systematic review[J]. Clin Exp Allergy, 2009, 39(8):1117-1127.
33. Boyle RJ, Both-Hextall FJ, Leonardi-Bee J, et al. Probiotics for treating eczema[J]. Cochrane Database Syst Rev, 2008, 8(4):CD006135.
34. Bath-Hextall FJ, Birnie AJ, Ravenscroft JC, et al. Interventions to reduce Staphylococcus aureus in the management of atopic eczema:an updated Cochrane review[J]. Br J Dermatol, 2010, 163(1):12-26.
35. Wienert V, Heusinger JH. Local treatment of hemorrhoidal disease and perianal eczema-Meta-analysis of the efficacy and safety of an Escherichia coli culture suspension alone or in combination with hydrocortisone[J]. Arzneimittelforschung, 2002, 52(7):515-523.
36. Schmitt J, Schmitt N, Meurer M. Cyclosporin in the treatment of patients with atopic eczema-a systematic review and meta-analysis[J]. J Eur Acad Dermatol Venereol, 2007, 21(5):606-619.
37. Kerscher MJ, Korting HC. Treatment of atopic eczema with evening primrose oil:rationale and clinical results[J]. Clin Investig, 1992, 70(2):167-171.
38. Morse NL, Clough PM. A meta-analysis of randomized, placebo-controlled clinical trials of Efamol(R)evening primrose oil in atopic eczema. Where do we go from here in light of more recent discoveries?[J]. Curr Pharmaceut Biotechnol, 2006, 7(6):503-524.
39. Armstrong NC, Ernst E. The treatment of eczema with Chinese herbs:a systematic review of randomized clinical trials[J]. Br J Clin Pharmacol, 1999, 48(2):262-264.
40. 吳滿平, 蔣惠平, 王雪萍. 復方氟米松軟膏治療慢性濕疹、神經性皮炎的臨床療效觀察[J]. 中國醫院用藥評價與分析, 2009, 9(9):704-705.
41. 顏艷, 鞠梅, 于建斌, 等. 復方氟米松軟膏治療濕疹皮炎類皮膚病臨床療效觀察[J]. 中華皮膚科雜志, 2006, 39(2):116-117.
42. Lynch PJ. Lichen simplex chronicus (atopic/neurodermatitis) of the anogenital region[J]. Dermatol Ther, 2004, 17(1):8-19.

West China Medical Journal

Efficacy and Safety of Compound Flumetasone Ointment for Neurodermatitis and Chronic Eczema:A Systematic Review

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