Clinical and Imaging Manifestation Analysis of Congenital Cystic Adenomatoid Malformation of the Lung in Children_West China Medical Journal

Authors：

 CHENGGuo-tao , YUANJin-song , SHIJiao-hua , NIEWei-wei , WUYi-gen

Department of Radiology, Xianning Central Hospital, Xianning, Hubei 437100, P. R. China;

Corresponding?author：

Keywords：

Cystic adenomatoid malformation of lung; Congenital; Children

DOI：

10.7507/1002-0179.20140084

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Objective To study the clinical features,pathogenesis and differential diagnosis,and explore the imaging characteristics of congenital cystic adenomatoid malformation of the lung (CCAM) in children,in order to improve the knowledge of imaging findings of the disease. Methods We retrospectively analyzed the clinical data and imaging characteristics of three patients proven to have CCAM of the lung both by surgery and pathology between March 2011 and March 2013.Related literature was also reviewed,and two out of the three patients were followed up for two years. Results All CCAM lesions in this study involved unilateral lower lobe,including two left lung and one right.Two patients had multiple large cysts containing gas,and one had multiple honeycomb-shaped vesicles.Histopathological examination showed that two cases were classified as Stocker type I and one as type Ⅱ,without type Ⅲ cases.Surgeries proved that the malformation was unilateral in all patients without connection with the bronchia.All patients with CCAM got complete cure by operation.The two-year postoperative follow-up showed an excellent recovery in all the patients. Conclusion Imaging examination is the main basis for discovery and diagnosis of CCAM.The CT manifestations of CCAM are featured,and according to CT examination,pathological subtypes of the disease can be predicted.Being familiar with these characteristics is helpful for its diagnosis.

Citation： CHENGGuo-tao, YUANJin-song, SHIJiao-hua, NIEWei-wei, WUYi-gen. Clinical and Imaging Manifestation Analysis of Congenital Cystic Adenomatoid Malformation of the Lung in Children. West China Medical Journal, 2014, 29(2): 273-276. doi: 10.7507/1002-0179.20140084 Copy

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3.	郭志偉,彭瑞鵬.先天性肺臟囊腫腺瘤畸形[J].臨床醫學,1998,41(1):92-95.
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12.	Griffin N,Devaraj A,Goldst raw P,et al.CT and histopat hological correlation of congenital cystic pulmonary lesions:a commonpat hogenesis[J].Clin Radiol,2008,63(9):995-1005.
13.	Lima M,Gargano T,Ruggeri G,et al.Clinical spectrum and management of congenital pulmonary cystic lesions[J].Pediatr Med Chir,2008,30(1):79-88.
14.	盧根,申昆玲,胡英惠,等.小兒先天性肺囊性腺瘤樣畸形23例診治分析[J].中國實用兒科雜志,2009,24(7):539-541.
15.	Tsai AY,Liechty KW,Hedrick HL,et al.Outcomes after postnatal resection of prenatally diagnosed asymptomatic cystic lung lesions[J].J Pediatr Surg,2008,43(4):513-517.
16.	郭志平,武端清.小兒先天性肺囊性腺瘤樣畸形手術診療體會[J].天津醫藥,2012,40(11):1171-1172.

1. Chin KY,Tang MY.Congenital adenomatoid malformation of one lobe of a lung with general anasarca[J].Arch Pathol,1949,48(2):221-229.
2. Stocker JT,Madewell JE,Drake RM.Congenital adenomatoid malformation of the lung:classification and morphologic spectrum[J].Hum Pathol,1977,8(2):155-171.
3. 郭志偉,彭瑞鵬.先天性肺臟囊腫腺瘤畸形[J].臨床醫學,1998,41(1):92-95.
4. Moerman P,Fryns JP,Vandenberghe K,et al.Pathogenesis of congenital cystic adenomatoid malformation of the lung[J].Histopathology,1992,21(3):315-321.
5. Boglino C,Inserra A,Serventi P,et al.Neurotensin localization in adenomatoid cystic malformation versus normal lung:preliminary report of six consecutive cases[J].J Pediatr Surg,1992,27(1):57.
6. Peranteau WH,Merchant AM,Hedrick HL,et al.Prenatal course and postnatal management of peripheral bronchial atresia:association with congenital cystic adenomatoid malformation of the lung[J].Fetal Diagn Ther,2008,24(3):190-196.
7. Cass DL,Quinn TM,Yang EY,et al.Increased cell proliferation and decreased apoptosis characterize congenital cystic adenomatoid malformation of the lung[J].J Pediatr Surg,1998,33(7):1043-1046.
8. 董春鴿,鄭海紅,吳亮,等.先天性肺囊性腺瘤樣畸形Ⅱ型1例并文獻復習[J].溫州醫學院學報,2009,39(6):619-621.
9. 房惠瓊,李啟明,陶祥.成人先天性肺囊性腺瘤樣畸形伴類癌一例[J].中華病理學雜志,2008,37(10):713-715.
10. 曹辛,吳駿,洪偉.小兒先天性肺囊性腺瘤樣畸形的手術治療[J].中國醫師進修雜志,2009,32(36):51-53.
11. Williams HJ,Johnson,KJ.Imaging of congenital cystic lung lesions[J].Paediatr Respir Rev,2002,3(2):120-127.
12. Griffin N,Devaraj A,Goldst raw P,et al.CT and histopat hological correlation of congenital cystic pulmonary lesions:a commonpat hogenesis[J].Clin Radiol,2008,63(9):995-1005.
13. Lima M,Gargano T,Ruggeri G,et al.Clinical spectrum and management of congenital pulmonary cystic lesions[J].Pediatr Med Chir,2008,30(1):79-88.
14. 盧根,申昆玲,胡英惠,等.小兒先天性肺囊性腺瘤樣畸形23例診治分析[J].中國實用兒科雜志,2009,24(7):539-541.
15. Tsai AY,Liechty KW,Hedrick HL,et al.Outcomes after postnatal resection of prenatally diagnosed asymptomatic cystic lung lesions[J].J Pediatr Surg,2008,43(4):513-517.
16. 郭志平,武端清.小兒先天性肺囊性腺瘤樣畸形手術診療體會[J].天津醫藥,2012,40(11):1171-1172.

West China Medical Journal

Clinical and Imaging Manifestation Analysis of Congenital Cystic Adenomatoid Malformation of the Lung in Children

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