Analysis on outcomes of laser photocoagulation for retinopathy of prematurity_Chinese Journal of Ocular Fundus Diseases

Authors：

LiManhong , ZhangZifeng ,  WangYusheng , 王靜 , 王曉婕 , 樊靜 , 李樹志 , 張志紅

Department of Ophthalmology, Eye Institute of Chinese PLA, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China;

Corresponding?author：

WangYusheng, Email: wangys003@126.com

Keywords：

Retinopathy of prematurity/therapy; Laser coagulation

DOI：

10.3760/cma.j.issn.1005-1015.2014.01.007

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To observe clinical outcomes of laser photocoagulation on retinopathy of prematurity (ROP). Methods Clinical data of 64 cases of ROP infants (127 eyes) were studied retrospectively. Fifteen infants (30 eyes) were diagnosed of pre-threshold ROP (type Ⅰ, 23.6%) and 49 cases (97 eyes) of threshold ROP (76.4%). All the eyes underwent photocoagulation through binocular indirect ophthalmoscope (532 nm or 810 nm) within 72 hours after the confirmation ROP. In all the 15 cases (30 eyes) of pre-threshold ROP (type Ⅰ), 6 of them (12 eyes) were photocoagulated by laser of 532 nm, and the other 9 ones (18 eyes) were treated with 810 nm. In 49 threshold ROP infants (97 eyes), 37 cases (73 eyes) and 12 ones (24 eyes) were treated with laser of 532 nm or 810 nm respectively. All the infants were followed up 12-36 months (18.4 months) since photocoagulation to investigate regression of ROP. All the data of ROP infants photocoagulated, such as recovery rate of one-time photocoagulation, repeat rate, unfavorable outcomes, and complications, were analyzed statistically according to the severity of ROP and wave length of laser employed. Results In all the 127 photocoagulation treated eyes, ROP regressed completely in 125 eyes (98.4%), temporal retinal traction remained in 2 eyes (1.6%), and no retinal detachment was found. ROP regressed completely in 118 eyes (92.9%) after one-time photocoagulation, recovered totally in 6 eyes (4.7%) after repeating photocoagulation 2-3 times, and resorted to cryotherapy in 3 eyes (2.4%). Subconjunctiva hemorrhage, found in 12 eyes (9.4%), was the most common complication. During photocoagulation, anesthetic accident occurred in 1 infant (1.6%), and 1 eye developed cataract (0.8%). It was suggested from statistical analysis that there was no significant difference on efficiency or safety between pre-threshold (type Ⅰ) and threshold ROP photocoagulated by laser of 532 nm or 810 nm. However, almost all of the ROP infants need repeat photocoagulation or additional cryotherapy, and patients with unfavorable outcomes or severe complications, occurred in threshold ROP treated with 532 nm laser. Conclusion Photocoagulation with 532 nm or 810 nm laser is effective for type Ⅰ pre-threshold or threshold ROP.

Citation： LiManhong, ZhangZifeng, WangYusheng. Analysis on outcomes of laser photocoagulation for retinopathy of prematurity. Chinese Journal of Ocular Fundus Diseases, 2014, 30(1): 24-27. doi: 10.3760/cma.j.issn.1005-1015.2014.01.007 Copy

1.	?Good WV, Hardy RJ, Dobson V, et al. The incidence and course of retinopathy of prematurity:findings from the early treatment for retinopathy of prematurity study[J]. Pediatrics, 2005, 116:15-23.
2.	Chen Y, Li X. Characteristics of severe retinopathy of prematurity patients in China:a repeat of the first epidemic?[J]. Br J Ophthalmol, 2006, 90:268-271.
3.	Cryotherapy for Retinopathy of Prematurity Cooperative Group. Multicenter trial of cryotherapy for retinopathy of prematurity:ophthalmological outcomes at 10 years[J]. Arch Ophthalmol, 2001, 119:1110-1118.
4.	Early Treatment for Retinopathy of Prematurity Cooperative Group. Revised indications for the treatment of retinopathy of prematurity:results of the early treatment for retinopathy of prematurity randomized trial[J]. Arch Ophthalmol, 2003, 121:1684-1694.
5.	趙培泉, 費萍. 早產兒視網膜病變診斷治療研究現狀、問題及展望[J]. 中華眼底病雜志, 2012, 28:3-7.
6.	中華醫學會. 早產兒治療用氧和視網膜病變防治指南[J]. 中華眼科雜志, 2005, 41:375-376.
7.	黎曉新, 陳宜. 積極推動早產兒視網膜病變的防治[J]. 中華眼底病雜志, 2008, 24:1-4.
8.	王雨生, 李蓉. 重視我國早產兒視網膜病變的防治工作[J]. 中華眼科雜志, 2011, 47:483-486.
9.	尹虹, 黎曉新, 趙明威, 等. 早產兒視網膜病變激光治療的療效分析[J]. 眼科研究, 2007, 25:208-210.
10.	倪穎勤, 黃欣, 單海冬, 等. 早產兒視網膜病變七年篩查治療結果臨床分析[J]. 中華眼底病雜志, 2012, 28:45-48.
11.	張國明, 曾鍵, 黃麗娜, 等. 廣角數碼兒童視網膜成像系統引導下激光光凝治療早產兒視網膜病變[J]. 中華眼底病雜志, 2008, 24:17-19.
12.	王雨生,張自峰,李曼紅,等. 西安地區早產兒視網膜病變篩查的初步結果[J]. 中華眼科雜志, 2010, 46:119-124.
13.	International Committee for the Classification of Retinopathy of Prematurity. The international classification of retinopathy of prematurity revisited[J]. Arch Ophthalmol, 2005, 123:991-999.
14.	Reynolds JD. 王雨生, 譯. 小兒視網膜. 西安:第四軍醫大學出版社, 2013:91-127.
15.	Houston SK, Wykoff CC, Berrocal AM, et al. Laser treatment for retinopathy of prematurity[J]. Lasers Med Sci, 2013, 28:683-692.
16.	李秋平,王宗華,章晟,等. 新生兒重癥監護病房床旁激光治療嚴重早產兒視網膜病變103例報告[J]. 中華兒科雜志, 2013,51:12-15.
17.	李曼紅,張自峰,王雨生,等. 早產兒視網膜病變激光光凝治療后白內障一例[J].中華眼底病雜志, 2012, 28:89-90.
18.	李曼紅,張自峰,王雨生,等.早產兒視網膜病變篩查相關意外和并發癥分析[J].中華眼底病雜志, 2012, 28:73-74.

1. ?Good WV, Hardy RJ, Dobson V, et al. The incidence and course of retinopathy of prematurity:findings from the early treatment for retinopathy of prematurity study[J]. Pediatrics, 2005, 116:15-23.
2. Chen Y, Li X. Characteristics of severe retinopathy of prematurity patients in China:a repeat of the first epidemic?[J]. Br J Ophthalmol, 2006, 90:268-271.
3. Cryotherapy for Retinopathy of Prematurity Cooperative Group. Multicenter trial of cryotherapy for retinopathy of prematurity:ophthalmological outcomes at 10 years[J]. Arch Ophthalmol, 2001, 119:1110-1118.
4. Early Treatment for Retinopathy of Prematurity Cooperative Group. Revised indications for the treatment of retinopathy of prematurity:results of the early treatment for retinopathy of prematurity randomized trial[J]. Arch Ophthalmol, 2003, 121:1684-1694.
5. 趙培泉, 費萍. 早產兒視網膜病變診斷治療研究現狀、問題及展望[J]. 中華眼底病雜志, 2012, 28:3-7.
6. 中華醫學會. 早產兒治療用氧和視網膜病變防治指南[J]. 中華眼科雜志, 2005, 41:375-376.
7. 黎曉新, 陳宜. 積極推動早產兒視網膜病變的防治[J]. 中華眼底病雜志, 2008, 24:1-4.
8. 王雨生, 李蓉. 重視我國早產兒視網膜病變的防治工作[J]. 中華眼科雜志, 2011, 47:483-486.
9. 尹虹, 黎曉新, 趙明威, 等. 早產兒視網膜病變激光治療的療效分析[J]. 眼科研究, 2007, 25:208-210.
10. 倪穎勤, 黃欣, 單海冬, 等. 早產兒視網膜病變七年篩查治療結果臨床分析[J]. 中華眼底病雜志, 2012, 28:45-48.
11. 張國明, 曾鍵, 黃麗娜, 等. 廣角數碼兒童視網膜成像系統引導下激光光凝治療早產兒視網膜病變[J]. 中華眼底病雜志, 2008, 24:17-19.
12. 王雨生,張自峰,李曼紅,等. 西安地區早產兒視網膜病變篩查的初步結果[J]. 中華眼科雜志, 2010, 46:119-124.
13. International Committee for the Classification of Retinopathy of Prematurity. The international classification of retinopathy of prematurity revisited[J]. Arch Ophthalmol, 2005, 123:991-999.
14. Reynolds JD. 王雨生, 譯. 小兒視網膜. 西安:第四軍醫大學出版社, 2013:91-127.
15. Houston SK, Wykoff CC, Berrocal AM, et al. Laser treatment for retinopathy of prematurity[J]. Lasers Med Sci, 2013, 28:683-692.
16. 李秋平,王宗華,章晟,等. 新生兒重癥監護病房床旁激光治療嚴重早產兒視網膜病變103例報告[J]. 中華兒科雜志, 2013,51:12-15.
17. 李曼紅,張自峰,王雨生,等. 早產兒視網膜病變激光光凝治療后白內障一例[J].中華眼底病雜志, 2012, 28:89-90.
18. 李曼紅,張自峰,王雨生,等.早產兒視網膜病變篩查相關意外和并發癥分析[J].中華眼底病雜志, 2012, 28:73-74.

Chinese Journal of Ocular Fundus Diseases

Analysis on outcomes of laser photocoagulation for retinopathy of prematurity

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content