The cultivation of scientific research ability of undergraduate medical students is an important direction of medical education reform. At present, there are many problems in medical undergraduate scientific research education, such as heavy curriculum burden, weak scientific research foundation, and one-sided evaluation of training effect. The teaching faculty of Department of Thoracic Surgery of West China Hospital of Sichuan University tried to advance the systematic scientific research training to the early stage of undergraduate course, put forward the “advanced systematic research” teaching model, and explored the practical path to solve the bottleneck problems such as high threshold and poor coherence of scientific research training through hierarchical curriculum design, dynamic management and comprehensive evaluation system. This article will systematically review the exploration process of the advanced scientific research mode of undergraduate medical students at home and abroad, summarize its limitations, and share the practical experience of the above “advanced systematic research” teaching model, so as to provide references and ideas for optimizing the scientific research education of medical undergraduate.