ObjectiveTo explore the relationship between pregnancy-associated plasma protein-A (PAPP-A) and different types of coronary heart disease (CHD) in Chinese. MethodsThe papers about the relationship between the PAPP-A level and coronary heart disease in Chinese published before December 2013 were searched from electronic databases, including PubMed, EMbase, China National Knowledge Infrastructure, Wanfang and VIP. Statistical analysis was carried out using Stata 12.0 software. ResultsA total of 44 papers were included in this meta-analysis. The number of cases was 3 628, including 1 137 stable angina pectoris (SAP) patients, 1 368 unstable angina pectoris (UAP) patients and 1 123 acute myocardial infarction (AMI) patients. The number of control was 1 177. This meta-analysis indicated that the levels of PAPP-A were higher in different types of CHD patients than those in the control group[SAP group:SMD=0.38, 95% CI (0.25, 0.50), P < 0.001; UAP group:SMD=2.84, 95% CI (2.36, 3.32), P < 0.001; AMI group:SMD=3.31, 95% CI (2.78, 3.85), P < 0.001, respectively]. The levels of PAPP-A were higher in AMI group than UAP group[SMD=0.56, 95% CI (0.33, 0.80), P < 0.001]. At the same time, the levels of PAPP-A in patients with disease of one, two and three coronary arteries were higher than those in the control group[SMD=2.40, 95% CI (1.49, 3.31), P < 0.001; SMD=2.27, 95% CI (1.44, 3.09), P < 0.001; SMD=2.30, 95% CI (1.35, 3.24), P < 0.001, respectively]. The levels of PAPP-A were higher in patients with disease of two arteries than in those of one artery[SMD=0.29, 95% CI (0.01, 0.58), P=0.042], but there was no significant difference between patients with disease of three arteries and those of 1 or 2 arteries(P > 0.05). ConclusionsThe levels of PAPP-A are significantly higher in CHD patients and are positively related with the severity of CHD. The levels of PAPP-A can be regarded as the indicator for judging the severity of CHD
Objective To explore the association between plasma proteins and the risk of Addison’s disease using the Mendelian randomization (MR) method. Methods Plasma protein quantitative trait loci data from the deCODE cohort, along with genome-wide association study summary statistics for Addison’s disease comprising 1 223 cases and 4 097 controls from Sweden and Norway, were analyzed in a two-sample two-way MR framework. The primary causal inference was performed using inverse variance weighting, with MR-Egger regression, weighted median, and maximum likelihood methods employed as sensitivity analyses to assess the robustness of the findings. To mitigate reverse causality, MR analysis was conducted with Addison’s disease as the exposure factor and plasma proteins as the outcome variables. Results A total of 105 plasma protein closely associated with Addison’s disease were included in the forward study. Among them, sialic acid binding Ig like lectin 5, poly ADP-ribose polymerase, ectonucleotide pyrophosphatase/phosphodiesterase family member 5, butyrophilin subfamily 3 member A3, collagen type Ⅺ alpha 2 chain (COL11A2) and calsyntenin-1 still exhibited certain associations after multiple corrections (P<0.05). In the reverse study, only COL11A2 closely associated with Addison’s disease [odds ratio=0.98, 95% confidence interval (0.96, 1.00), P=0.026]. Conclusions This research discovers that sialic acid binding Ig like lectin 5, poly ADP-ribose polymerase, and ectonucleotide pyrophosphatase/phosphodiesterase family member 5 significantly enhance the risk of Addison’s disease, whereas butyrophilin subfamily 3 member A3, COL11A2, and calsyntenin-1 decrease the risk of Addison’s disease. Moreover, there is a potential reverse causal relationship between Addison’s disease and COL11A2.