Periwound skin, as an indicator of the wound healing monitoring process, is one of the most important components of wound management. Effective management of periwound skin is a major professional challenge. In practice, healthcare professionals usually focus on the wound site and pay little attention to the periwound skin. Inappropriate management of periwound skin will delay the wound healing process, increase the economic costs of the patients, and decrease the patients’ satisfaction with medical care. This article summarizes the clinical symptoms, assessment tools, and management strategies of periwound skin, aiming to provide new ideas and references for clinical wound management.