Postmenopausal osteoporosis is a type of osteoporosis with high bone transformation rate, caused by a decrease of estrogen in the body, which is a systemic bone disease characterized by decreased bone mass and increased risk of fracture. In recent years, as a kind of non-pharmacologic treatment of osteoporosis, defined by whole-body vibration less than 1 g (g = 9.81 m/s2), low magnitude whole-body vibration is widely concerned, mainly because of its small side effects, simple operation and relative safety. Studies have shown that low magnitude whole-body vibration can improve bone strength, bone volume and bone density. But a lot of research found that, the therapeutic effects of low magnitude whole-body vibration are different depending on ages and hormone levels of subjects for animal models or human patients. There has been no definite vibration therapy can be applied to each subject so far. Studies of whole-body and cellular level suggest that low magnitude whole-body vibration stimulation is likely to be associated with changes of hormone levels and directed differentiation of stem cells. Based on the analysis of related literature in recent years, this paper made a review from vibration parameters, vibration effects and the mechanisms, to provide scientific basis and clinical guidance for the treatment of postmenopausal osteoporosis with low magnitude whole-body vibration.
Objective To retrieve and summarize evidence of non-pharmacological interventions for sleep disorders in patients with osteoarthritis (OA), and to organize and evaluate the extracted evidence to provide evidence-based interventions for sleep disorders in patients with OA. Methods The relevant literature on non-pharmacological interventions for sleep disorders in patients with OA in BMJ Best Practice, UpToDate, JBI evidence-based healthcare center database, National Institute for Health and Clinical Excellence, Registered Nurses’ Association of Ontario, Guidelines International Network, Medlive guidelines network, Cochrane Library, PubMed, Web of Science, China National Knowledge Infrastructure and Wanfang was systematically searched. The search deadline was June 30th, 2024. The retrieved results were integrated and analyzed to form evidence of non pharmacological interventions for sleep disorders in patients with OA. Results A total of 13 articles were included, including 1 evidence report, 5 guidelines, 2 expert consensus papers, 3 systematic reviews, and 2 randomized controlled trials. The summarized evidence involves six aspects of sleep screening, specialist visits, assessment tools, cognitive behavioral therapy, exercise therapy, and other measures, totaling 20 pieces of evidence. Conclusion Non-pharmacological interventions for sleep disorders of patients with OA include multiple aspects, and this evidence can provide theoretical basis for developing intervention plans for sleep disorder of patients with OA, thereby improving their sleep quality and enhancing quality of life.
Objective To evaluate the effect of different non-pharmacological interventions on the cognitive function of elderly people with cognitive decline, and provide useful reference for improving cognitive function of the elderly. Methods Computer searches of PubMed, Embase, the Cochrane Library, Web of Science, China National Knowledge Infrastructure, VIP Database, Wanfang Data, and China Biomedical Literature Database for randomized controlled trials on non-pharmacological interventions for aged adults with cognitive decline were conducted, all with a search time frame from database inception to October 9th, 2023. Literature screening, information extraction and bias risk assessment using RevMan 5.4 software were performed by two evaluators independently, and Stata 16.0 and R 4.3.0 software was used for network meta-analysis. Results A total of 27 articles involving 2149 elderly patients and 7 intervention protocols were included. Among the 27 articles, 8 were graded A and 19 were graded B for quality. The network meta-analysis revealed that, using the Montreal Cognitive Assessment (MoCA) as the evaluating metric, virtual reality [mean difference (MD)=6.01, 95% confidence interval (CI) (0.90, 10.75)], cognitive training [MD=4.99, 95%CI (0.56, 9.12)], and exercise training [MD=3.88, 95%CI (0.47, 7.27)] were better than community services, respectively (P<0.05), and exercise training was also better than conventional care [MD=3.05, 95%CI (0.92, 5.12), P<0.05]; using the Mini-Mental State Examination (MMSE) as the evaluation indicator, multimodal exercise [MD=3.00, 95%CI (0.89, 4.96)], cognitive training [MD=2.50, 95%CI (0.27, 4.82)], traditional Chinese exercise [MD=2.30, 95%CI (0.34, 4.28)], psychotherapy [MD=1.76, 95%CI (0.56, 2.96)], and exercise training [MD=1.36, 95%CI (0.18, 2.59)] were better than conventional care, respectively (P<0.05), and multimodal exercise [MD=3.32, 95%CI (0.62, 5.81)], cognitive training [MD=2.82, 95%CI (0.75, 4.90)], and traditional Chinese exercise [MD=2.63, 95%CI (0.08, 5.13)] were also better than community service, respectively (P<0.05). The results of the cumulative probability ranking showed that virtual reality had the highest probability of being the best intervention in terms of improving MoCA metrics (0.863), and multimodal exercise had the highest probability of being the best intervention in terms of improving MMSE metrics (0.868). Conclusion Using MoCA as an evaluation indicator, virtual reality may be the best non-pharmacological intervention; using MMSE as an evaluation indicator, multimodal exercise may be the best non-pharmacological intervention.
Due to the aging population intensifies, the number of people suffering from mild cognitive impairment (MCI) or dementia is expected to increase, which may lead to a series of public health and social health problems. In the absence of drugs to prevent the transformation of MCI into dementia, it is urgent to find effective non-pharmacological therapies to delay the progress of cognitive impairment. This article will review the diagnosis of MCI and the research progress of non-pharmacological therapies, focusing on the non-pharmacological therapies related to MCI in recent years, including exercise intervention, cognitive intervention, physical and mental exercise, dietary intervention, electroacupuncture, repeated transcranial magnetic stimulation, and multi-component intervention, in order to provide an effective treatment for preventing or delaying the progression of MCI to dementia.
ObjectiveTo systematically evaluate the efficacy of different non-pharmacological interventions in relieving acute pain after lung cancer surgery, and to provide high-level evidence-based basis for formulating precise analgesic nursing plans in clinical practice. MethodsSystematic searches were conducted in Chinese and English core databases including CNKI, Wanfang Data, VIP Database, CBM, PubMed, Embase, Cochrane Library, and Web of Science. Relevant randomized controlled trials (RCTs) published from the establishment of the databases to October 2025 were collected, with supplementary retrieval through reference tracing. Two researchers independently conducted literature screening and data extraction. The quality of the included literature was evaluated using the Cochrane risk of bias assessment tool, and a network meta-analysis was performed using Stata 18.0 software. ResultsA total of 34 RCTs involving 3019 postoperative lung cancer patients and 15 types of non-pharmacological interventions were included. Network meta-analysis showed that compared with conventional nursing, relaxation therapy [MD=?2.55, 95%CI (?3.66, ?1.44)], fire cupping combined with music therapy [MD=?2.32, 95%CI (?4.05, ?0.59)], psychological therapy [MD=?1.45, 95%CI (?2.05, ?0.85)], and transcutaneous electrical acupoint stimulation [MD=?1.38, 95%CI (?2.02, ?0.75)] had significant pain relief effects (all P<0.05). The surface under the cumulative ranking curve (SUCRA) analysis indicated that relaxation therapy was the optimal intervention (SUCRA=93.6%). ConclusionRelaxation therapy has the best effect in relieving acute pain after lung cancer surgery and can be used as the preferred option in clinical nursing. However, the conclusion still needs to be further verified by a large number of high-quality and large-sample RCTs.
Patients with lung cancer commonly experience multiple interrelated symptoms during chemotherapy, including fatigue, pain, and sleep disturbance, which together form a core symptom cluster and substantially impair daily functioning, treatment experience, and quality of life. At present, evidence regarding the non-pharmacological management of this core symptom cluster remains fragmented, and there is a lack of standardized, comprehensible, and practical guidance tools designed for patients and their caregivers. This guideline was developed using an evidence-based methodological framework. Stakeholders’ health-related needs and concerns were identified through qualitative interviews and on-site questionnaire surveys. In accordance with predefined inclusion and exclusion criteria, systematic searches were conducted across domestic and international guideline repositories, websites of relevant professional associations, and comprehensive databases. The included literature was subjected to quality appraisal, and recommendations were extracted, synthesized, and graded to produce a summary of the best available evidence. Based on the identified health concerns and the evidence summary, preliminary recommendations for the patient guideline were formulated. These recommendations were subsequently revised through two rounds of Delphi expert consultation, during which consensus was reached on the strength of each recommendation. The final guideline comprises four major domains: screening and assessment of the core symptom cluster, daily management, intervention strategies, and indications for referral. Its core content covers nine areas: symptom-cluster screening, assessment, lifestyle modification, dietary interventions, sleep environment optimization, exercise interventions, psychological interventions, Traditional Chinese Medicine interventions, and referral criteria. The development of this patient guideline followed a rigorous process and fully incorporated patients’ needs, which demonstrates good feasibility, appropriateness, and clinical relevance, and can provide a decision-making basis for the self-management of the core symptom cluster among patients with lung cancer undergoing chemotherapy.
ObjectiveTo systematically evaluate the comparative efficacy of different non-pharmacological interventions on sleep quality in patients with lung cancer. MethodsWe searched major domestic and international databases for randomized controlled trial (RCT) on non-pharmacological interventions from inception to June 2026. Risk of bias for the included studies was assessed using the RoB 2.0 tool. A network meta-analysis was performed using R 4.5.1. Intervention effects were ranked by the surface under the cumulative ranking curve (SUCRA). ResultsA total of 61 RCTs involving 6210 patients were included, covering 16 interventions, of which 68.85% were studies with low risk of bias. Compared with usual care, mindfulness (MF) combined with progressive muscle relaxation (PMR) [MD=?3.67, 95%CI (?5.74, ?1.59)], PMR combined with cognitive behavioral therapy (CBT) [MD=?2.92, 95%CI (?5.72, ?0.15)], aerobic exercise (AET) combined with psychological intervention (PIT) [MD=?2.77, 95%CI (?4.66, ?0.89)], breathing therapy (BT) [MD=?2.45, 95%CI (?4.56, ?0.34)], AET [MD=?2.30, 95%CI (?3.68, ?0.90)], PIT [MD=?2.08, 95%CI (?3.06, ?1.10)], and MF [MD=?1.71, 95%CI (?2.93, ?0.49)] all significantly improved sleep quality in lung cancer patients (all P<0.05). SUCRA ranking indicated that MF+PMR had the highest probability of being the best intervention (88.89%). ConclusionUnder the current body of evidence, MF+PMR appears to show a relative advantage in improving sleep quality in patients with lung cancer, and combined interventions may be more effective overall than single interventions. However, these conclusions still require further confirmation through more high-quality studies.