Objective To evaluate the efficacy of direct vision guided lithotripsy with SpyGlass DS in the treatment of pancreatic duct obstruction caused by chronic calcified pancreatitis and pancreatic duct stones. Methods The clinical data of 9 patients with chronic calcified pancreatitis and pancreatic duct stone who underwent direct-vision guided pancreatic duct stone lithotripsy with SpyGlass DS from July 2017 to September 2017 in the Department of Gastroenterology of Jilin People’s Hospital were retrospectively analyzed, then assessment of technical success rate, clinical success rate, and incidence of adverse event were performed. Results A total of 13 times of intervention were performed in 9 patients, the overall technical success rate of SpyGlass DS direct vision lithotripsy and drainage was 88.9% (8/9). Three of the 9 patients (30.3%) had adverse reactions, including self-limiting bleeding after sphincterotomy (n=1), post-encoscopic retrograde cholangio-pancreatography pancreatitis (n=2), and mild abdominal pain (n=2). Nine patients were followed-up for 3－50 months (median of 21 months), 8 patients (88.89%) reported improvement in abdominal pain, and the mean visual analogue scale score decreased from 6.22±1.47 to 2.78±1.23, P<0.01. Eight patients (88.9%) patients achieved clinical success. Conclusion The SpyGlass DS direct vision-guided lithotripsy is safe and effective for patients with pancreatic duct stones.