目的 總結多導睡眠監測的監測方法及護理要點。 方法 2010年3月－2011年3月采用美國偉康多導睡眠呼吸監測儀對睡眠中心78例患者進行不少于7 h的整夜連續監測和護理。 結果 76例患者順利完成監測，確診阻塞性睡眠呼吸暫停低通氣綜合征73例（重度17例，中度31例，輕度25例），單純鼾癥3例。1例因環境陌生、導聯多無法入睡而監測失敗，另1例因鼻氣流導管脫落而監測失敗。 結論 對癥有效的護理方法是多導睡眠監測得以順利完成的根本保證。
Objective To explore potential host-derived biomarkers for active pulmonary tuberculosis and optimize early diagnosis and treatment monitoring strategies for tuberculosis. Methods Integrated analysis of two whole blood gene expression datasets (GSE19444 and GSE42830) from the GEO database (37 tuberculosis patients and 50 healthy controls) was performed. Differentially expressed genes (DEGs) were screened using GEO2R, and gene ontology enrichment, pathway analysis, and protein-protein interaction network construction were conducted using Metascape and STRING to identify key gene modules. Core genes were identified based on MCODE scores (≥10) and T-tests/ANOVA, and their expression trends and diagnostic efficacy were validated in independent datasets (GSE152532, GSE19435). The sensitivity and specificity of candidate biomarkers were assessed using receiver operating characteristic (ROC) curves. Results A total of 70 common DEGs were identified (59 upregulated and 11 downregulated), significantly enriched in type Ⅱ interferon signaling pathways and innate immune responses. Module analysis revealed 16 core genes (e.g., RTP4, GBP4, TRIM22) forming a high-confidence interaction network. Validation showed that the three genes were significantly overexpressed in tuberculosis patients (P<0.05) and dynamically downregulated with treatment. ROC curve analysis indicated that RTP4 had the best diagnostic efficacy with an area under curve (AUC) of 0.952 (sensitivity 100%, specificity 79%), while the three-gene combination (TBscore) had an AUC of 0.933 (sensitivity 100%, specificity 81%). Conclusion RTP4, GBP4, and TRIM22 are potential diagnostic biomarkers for active pulmonary tuberculosis, and their combination model (TBscore) exhibits high sensitivity and specificity, with dynamic expression levels reflecting treatment efficacy, providing new targets for precise diagnosis and treatment of tuberculosis.